ZA964647B - Novel crystal form of anhydrous 7-([1α,5α,6α]-6-amino-3-Azabicyclo[3.1.0]hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphtyridine-3-carboxylic acid, methanesulfonic acid salt. - Google Patents

Novel crystal form of anhydrous 7-([1α,5α,6α]-6-amino-3-Azabicyclo[3.1.0]hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphtyridine-3-carboxylic acid, methanesulfonic acid salt.

Info

Publication number: ZA964647B
Authority: ZA; South Africa
Prior art keywords: naphtyridine; azabicyclo; difluorophenyl; hex; dihydro
Prior art date: 1995-06-06

Application number

ZA9604647A

Other languages

English (en)

Inventor

Lynne A Handanyan

Robert L Hendrickson

Phillip J Johnson

Thomas A Morris

Timothy Norris

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-06

Filing date

1996-06-05

Publication date

1997-10-22

1996-06-05 Application filed by Pfizer filed Critical Pfizer

1997-10-22 Publication of ZA964647B publication Critical patent/ZA964647B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA9604647A 1995-06-06 1996-06-05 Novel crystal form of anhydrous 7-([1α,5α,6α]-6-amino-3-Azabicyclo[3.1.0]hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphtyridine-3-carboxylic acid, methanesulfonic acid salt. ZA964647B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1995/007211 WO1996039406A1 (en)	1995-06-06	1995-06-06	NOVEL CRYSTAL FORM OF ANHYDROUS 7-([1α, 5α, 6α]-6-AMINO-3-AZABICYCLO[3.1.0]HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, METHANESULFONIC ACID SALT

Publications (1)

Publication Number	Publication Date
ZA964647B true ZA964647B (en)	1997-10-22

Family

ID=39431076

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9604647A ZA964647B (en)	1995-06-06	1996-06-05	Novel crystal form of anhydrous 7-([1α,5α,6α]-6-amino-3-Azabicyclo[3.1.0]hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphtyridine-3-carboxylic acid, methanesulfonic acid salt.

Country Status (38)

Country	Link
US (1)	US5763454A (lv)
EP (1)	EP0789697B1 (lv)
JP (1)	JP3145715B2 (lv)
KR (1)	KR100191989B1 (lv)
CN (1)	CN1055474C (lv)
AR (1)	AR002753A1 (lv)
AU (1)	AU703634B2 (lv)
BG (1)	BG62443B1 (lv)
BR (1)	BR9602630A (lv)
CA (1)	CA2223404C (lv)
CZ (1)	CZ285878B6 (lv)
DE (1)	DE69503066T2 (lv)
DK (1)	DK0789697T3 (lv)
DZ (1)	DZ2046A1 (lv)
ES (1)	ES2117426T3 (lv)
FI (1)	FI974441A (lv)
HR (1)	HRP960267B1 (lv)
HU (1)	HUP9601540A3 (lv)
IL (1)	IL118488A (lv)
IS (1)	IS4351A (lv)
LV (1)	LV11619B (lv)
MA (1)	MA23892A1 (lv)
NO (1)	NO305599B1 (lv)
NZ (1)	NZ286735A (lv)
OA (1)	OA10293A (lv)
PE (1)	PE38097A1 (lv)
PL (1)	PL314604A1 (lv)
RU (1)	RU2125571C1 (lv)
SG (1)	SG54339A1 (lv)
SI (1)	SI9600185A (lv)
SK (1)	SK280535B6 (lv)
TN (1)	TNSN96084A1 (lv)
TW (2)	TW403751B (lv)
UA (1)	UA44718C2 (lv)
UY (1)	UY25459A1 (lv)
WO (1)	WO1996039406A1 (lv)
YU (1)	YU34596A (lv)
ZA (1)	ZA964647B (lv)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MA24500A1 (fr)	1997-03-21	1998-10-01	Lg Life Sciences Ltd	Derive du sel d'acide carboxylique de naphthyridine .
US20020032216A1 (en)	1997-03-21	2002-03-14	Lg Chemical Ltd.	Salt of naphthyridine carboxylic acid derivative
HN1998000106A (es)	1997-08-01	1999-01-08	Pfizer Prod Inc	Composiciones parenterales de alatroflaxacino
DE19800214A1 (de) *	1998-01-06	1999-07-15	Knoll Ag	Verfahren zur Herstellung von Doxazosin-Mcsylat in einer als Form A bezeichneten Kristallmodifikation und ein Zwischenprodukt dafür
US7019142B2 (en) *	1998-01-16	2006-03-28	Pfizer Inc.	Process for preparing naphthyridones and intermediates
GB9818258D0 (en) *	1998-08-21	1998-10-14	Pfizer Ltd	Antifungal compositions
HN1999000141A (es) *	1998-09-03	2000-06-19	Pfizer Prod Inc	Procedimiento para preparar sales de trovafloxacina de adicion de acidos.
GB9820405D0 (en)	1998-09-18	1998-11-11	Smithkline Beecham Plc	Process
ES2164520B1 (es) *	1999-03-16	2003-04-01	Medichem Sa	"procedimiento de obtencion del polimorfo a del mesilato de doxazosina"
US6239141B1 (en)	1999-06-04	2001-05-29	Pfizer Inc.	Trovafloxacin oral suspensions
GB9920917D0 (en)	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel process
GB9920919D0 (en)	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel compound
US6657061B2 (en)	2001-06-29	2003-12-02	Grayson Walker Stowell	Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en)	2001-06-29	2003-06-03	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en)	2001-06-29	2003-12-09	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en)	2001-06-29	2002-05-14	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en)	2001-06-29	2003-07-22	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en)	2001-06-29	2003-03-11	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
KR100517638B1 (ko)	2002-04-08	2005-09-28	주식회사 엘지생명과학	게미플록사신 산염의 새로운 제조방법
CN102512364A (zh) *	2011-12-30	2012-06-27	天津市嵩锐医药科技有限公司	一种供注射用的甲磺酸阿拉曲伐沙星药物组合物
CN104884364B (zh) *	2013-01-11	2017-10-03	参天制药株式会社	内塞和具备该内塞的液体收容容器、以及喷嘴的前端构造和具备该构造的液体收容容器

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5164402A (en) *	1989-08-16	1992-11-17	Pfizer Inc	Azabicyclo quinolone and naphthyridinone carboxylic acids
PL166381B1 (pl) *	1989-08-16	1995-05-31	Pfizer	Sposób wytwarzania nowych podstawionych kwasów 7-azabicyklochinolonokarboksylowych PL PL PL PL
EP0740667A1 (en) *	1994-01-18	1996-11-06	Pfizer Inc.	Process and intermediates for preparing naphthyridonecarboxylic acid salts
GB2289674A (en) *	1994-05-23	1995-11-29	Pfizer	Antibacterial naphthyridine

1995
- 1995-06-06 ES ES95922240T patent/ES2117426T3/es not_active Expired - Lifetime
- 1995-06-06 DE DE69503066T patent/DE69503066T2/de not_active Expired - Fee Related
- 1995-06-06 SK SK719-96A patent/SK280535B6/sk unknown
- 1995-06-06 EP EP95922240A patent/EP0789697B1/en not_active Expired - Lifetime
- 1995-06-06 US US08/849,300 patent/US5763454A/en not_active Expired - Fee Related
- 1995-06-06 CA CA002223404A patent/CA2223404C/en not_active Expired - Fee Related
- 1995-06-06 WO PCT/US1995/007211 patent/WO1996039406A1/en active IP Right Grant
- 1995-06-06 DK DK95922240T patent/DK0789697T3/da active
- 1995-06-06 JP JP50037497A patent/JP3145715B2/ja not_active Expired - Fee Related
1996
- 1996-05-13 TW TW085105632A patent/TW403751B/zh not_active IP Right Cessation
- 1996-05-13 TW TW089107609A patent/TW580389B/zh not_active IP Right Cessation
- 1996-05-29 CN CN96110060A patent/CN1055474C/zh not_active Expired - Fee Related
- 1996-05-30 IL IL11848896A patent/IL118488A/en not_active IP Right Cessation
- 1996-05-31 AR ARP960102817A patent/AR002753A1/es unknown
- 1996-06-03 IS IS4351A patent/IS4351A/is unknown
- 1996-06-04 LV LVP-96-172A patent/LV11619B/en unknown
- 1996-06-04 UA UA96062190A patent/UA44718C2/uk unknown
- 1996-06-04 PL PL96314604A patent/PL314604A1/xx unknown
- 1996-06-04 BR BR9602630A patent/BR9602630A/pt not_active Application Discontinuation
- 1996-06-05 MA MA24262A patent/MA23892A1/fr unknown
- 1996-06-05 RU RU96111026A patent/RU2125571C1/ru not_active IP Right Cessation
- 1996-06-05 HU HU9601540A patent/HUP9601540A3/hu unknown
- 1996-06-05 NZ NZ286735A patent/NZ286735A/en unknown
- 1996-06-05 KR KR1019960020171A patent/KR100191989B1/ko not_active IP Right Cessation
- 1996-06-05 AU AU54749/96A patent/AU703634B2/en not_active Ceased
- 1996-06-05 BG BG100639A patent/BG62443B1/bg unknown
- 1996-06-05 SG SG1996009972A patent/SG54339A1/en unknown
- 1996-06-05 ZA ZA9604647A patent/ZA964647B/xx unknown
- 1996-06-05 CZ CZ961625A patent/CZ285878B6/cs not_active IP Right Cessation
- 1996-06-05 DZ DZ960090A patent/DZ2046A1/fr active
- 1996-06-05 NO NO962321A patent/NO305599B1/no not_active IP Right Cessation
- 1996-06-05 YU YU34596A patent/YU34596A/sh unknown
- 1996-06-05 TN TNTNSN96084A patent/TNSN96084A1/fr unknown
- 1996-06-06 PE PE1996000421A patent/PE38097A1/es not_active Application Discontinuation
- 1996-06-06 HR HR960267A patent/HRP960267B1/xx not_active IP Right Cessation
- 1996-06-06 OA OA60835A patent/OA10293A/fr unknown
- 1996-06-06 SI SI9600185A patent/SI9600185A/sl not_active IP Right Cessation
1997
- 1997-12-05 FI FI974441A patent/FI974441A/fi unknown
1999
- 1999-04-06 UY UY25459A patent/UY25459A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
HRP960267B1 (en)	2000-06-30
DZ2046A1 (fr)	2002-10-22
ES2117426T3 (es)	1998-08-01
UY25459A1 (es)	1999-11-17
KR100191989B1 (ko)	1999-06-15
HRP960267A2 (en)	1997-08-31
PE38097A1 (es)	1997-10-10
FI974441A0 (fi)	1997-12-05
OA10293A (en)	1997-09-19
CN1055474C (zh)	2000-08-16
HUP9601540A3 (en)	1997-05-28
SK280535B6 (sk)	2000-03-13
IS4351A (is)	1996-12-07
WO1996039406A1 (en)	1996-12-12
TW580389B (en)	2004-03-21
NO962321L (no)	1996-12-09
BG100639A (bg)	1997-02-28
TW403751B (en)	2000-09-01
SI9600185A (en)	1997-04-30
CN1148596A (zh)	1997-04-30
CA2223404A1 (en)	1996-12-12
IL118488A0 (en)	1996-09-12
EP0789697A1 (en)	1997-08-20
YU34596A (sh)	1999-03-04
NZ286735A (en)	1998-01-26
NO305599B1 (no)	1999-06-28
AU5474996A (en)	1996-12-19
FI974441A (fi)	1997-12-05
LV11619B (en)	1997-04-20
BR9602630A (pt)	1998-09-08
TNSN96084A1 (fr)	2005-03-15
BG62443B1 (bg)	1999-11-30
JPH10506650A (ja)	1998-06-30
CA2223404C (en)	2001-01-16
CZ285878B6 (cs)	1999-11-17
UA44718C2 (uk)	2002-03-15
LV11619A (lv)	1996-12-20
HU9601540D0 (en)	1996-07-29
SG54339A1 (en)	1998-11-16
KR970001352A (ko)	1997-01-24
HUP9601540A2 (en)	1997-02-28
AR002753A1 (es)	1998-04-29
RU2125571C1 (ru)	1999-01-27
DK0789697T3 (da)	1998-10-19
PL314604A1 (en)	1996-12-09
CZ162596A3 (cs)	1998-09-16
JP3145715B2 (ja)	2001-03-12
US5763454A (en)	1998-06-09
NO962321D0 (no)	1996-06-05
MX9709873A (es)	1998-03-31
SK71996A3 (en)	1997-03-05
EP0789697B1 (en)	1998-06-17
DE69503066D1 (de)	1998-07-23
IL118488A (en)	1999-01-26
DE69503066T2 (de)	1998-10-15
MA23892A1 (fr)	1996-12-31
AU703634B2 (en)	1999-03-25

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