[go: up one dir, main page]

LV11619B - Novel crystal form of anhydrous 7-(£1a,5a,6a|-6-amino-3-azabicyclo£3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt - Google Patents

Novel crystal form of anhydrous 7-(£1a,5a,6a|-6-amino-3-azabicyclo£3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt Download PDF

Info

Publication number
LV11619B
LV11619B LVP-96-172A LV960172A LV11619B LV 11619 B LV11619 B LV 11619B LV 960172 A LV960172 A LV 960172A LV 11619 B LV11619 B LV 11619B
Authority
LV
Latvia
Prior art keywords
oxo
fluoro
amino
dihydro
azabicyclo
Prior art date
Application number
LVP-96-172A
Other languages
English (en)
Other versions
LV11619A (lv
Inventor
Lynne A Handanyan
Robert L Hendrickson
Phillip J Johnson
Thomas A Morris
Timothy Norris
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of LV11619A publication Critical patent/LV11619A/lv
Publication of LV11619B publication Critical patent/LV11619B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (4)

1 LV 11619 Izgudrojuma formula 1. 7-([1a,5a,6a]-6-amino-3-azabiciklo[3.1.0]heks-3-il)-6-fluor-1-(2,4- difluor-fenil)-1,4-dihidro-4-okso-1 ,8-naftiricfīn-3-karbonskābe, metānsulfon-skābes sāls, kas raksturojama ar šādiem galvenajiem maksimumiem tās pulvera rentgenstaru difrakcijas ainā: Maks. numurs 1 2 3 4 5 6 7 8 2Θ (°) Cu 4,5 7,7 9,1 13,6 15,0 18,2 18,6 22,8 Starpplakņu attālumi d 19,5 11,5 9,7 6,5 5,9 4,9 4,8 3,9
2. Farmaceitiskā kompozīcija ar antibakteriālu aktivitāti, kas satur savienojumu pēc 1. punkta bakteriālās infekcijas ārstēšanai efektīvā daudzumā un farmaceitiski pieņemamu nesēju.
3. Savienojuma pēc 1. punkta pielietojums tāda ārstniecības līdzekļa ražošanai, kas paredzēts bakteriālās infekcijas ārstēšanai.
4. Paņēmiens savienojuma pēc 1. punkta iegūšanai, kas ietver 7-([1 a,5a,6a]-6-amino-3-azabiciklo[3.1.0]heks-3-il)-6-fluor-1 -(2,4-difIuor-fenil)-1,4-dihidro-4-okso-1,8-naftiridīn-3-karbonskābes, metānsulfonskābes sāls vai tās monohidrāta sildīšanu spirtā vai tā maisījumā ar aprotonu šķīdinātāju.
LVP-96-172A 1995-06-06 1996-06-04 Novel crystal form of anhydrous 7-(£1a,5a,6a|-6-amino-3-azabicyclo£3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt LV11619B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1995/007211 WO1996039406A1 (en) 1995-06-06 1995-06-06 NOVEL CRYSTAL FORM OF ANHYDROUS 7-([1α, 5α, 6α]-6-AMINO-3-AZABICYCLO[3.1.0]HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, METHANESULFONIC ACID SALT

Publications (2)

Publication Number Publication Date
LV11619A LV11619A (lv) 1996-12-20
LV11619B true LV11619B (en) 1997-04-20

Family

ID=39431076

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-96-172A LV11619B (en) 1995-06-06 1996-06-04 Novel crystal form of anhydrous 7-(£1a,5a,6a|-6-amino-3-azabicyclo£3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt

Country Status (38)

Country Link
US (1) US5763454A (lv)
EP (1) EP0789697B1 (lv)
JP (1) JP3145715B2 (lv)
KR (1) KR100191989B1 (lv)
CN (1) CN1055474C (lv)
AR (1) AR002753A1 (lv)
AU (1) AU703634B2 (lv)
BG (1) BG62443B1 (lv)
BR (1) BR9602630A (lv)
CA (1) CA2223404C (lv)
CZ (1) CZ285878B6 (lv)
DE (1) DE69503066T2 (lv)
DK (1) DK0789697T3 (lv)
DZ (1) DZ2046A1 (lv)
ES (1) ES2117426T3 (lv)
FI (1) FI974441A (lv)
HR (1) HRP960267B1 (lv)
HU (1) HUP9601540A3 (lv)
IL (1) IL118488A (lv)
IS (1) IS4351A (lv)
LV (1) LV11619B (lv)
MA (1) MA23892A1 (lv)
NO (1) NO305599B1 (lv)
NZ (1) NZ286735A (lv)
OA (1) OA10293A (lv)
PE (1) PE38097A1 (lv)
PL (1) PL314604A1 (lv)
RU (1) RU2125571C1 (lv)
SG (1) SG54339A1 (lv)
SI (1) SI9600185A (lv)
SK (1) SK280535B6 (lv)
TN (1) TNSN96084A1 (lv)
TW (2) TW403751B (lv)
UA (1) UA44718C2 (lv)
UY (1) UY25459A1 (lv)
WO (1) WO1996039406A1 (lv)
YU (1) YU34596A (lv)
ZA (1) ZA964647B (lv)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA24500A1 (fr) 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
HN1998000106A (es) 1997-08-01 1999-01-08 Pfizer Prod Inc Composiciones parenterales de alatroflaxacino
DE19800214A1 (de) * 1998-01-06 1999-07-15 Knoll Ag Verfahren zur Herstellung von Doxazosin-Mcsylat in einer als Form A bezeichneten Kristallmodifikation und ein Zwischenprodukt dafür
US7019142B2 (en) * 1998-01-16 2006-03-28 Pfizer Inc. Process for preparing naphthyridones and intermediates
GB9818258D0 (en) * 1998-08-21 1998-10-14 Pfizer Ltd Antifungal compositions
HN1999000141A (es) * 1998-09-03 2000-06-19 Pfizer Prod Inc Procedimiento para preparar sales de trovafloxacina de adicion de acidos.
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
ES2164520B1 (es) * 1999-03-16 2003-04-01 Medichem Sa "procedimiento de obtencion del polimorfo a del mesilato de doxazosina"
US6239141B1 (en) 1999-06-04 2001-05-29 Pfizer Inc. Trovafloxacin oral suspensions
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
CN102512364A (zh) * 2011-12-30 2012-06-27 天津市嵩锐医药科技有限公司 一种供注射用的甲磺酸阿拉曲伐沙星药物组合物
CN104884364B (zh) * 2013-01-11 2017-10-03 参天制药株式会社 内塞和具备该内塞的液体收容容器、以及喷嘴的前端构造和具备该构造的液体收容容器

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164402A (en) * 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
PL166381B1 (pl) * 1989-08-16 1995-05-31 Pfizer Sposób wytwarzania nowych podstawionych kwasów 7-azabicyklochinolonokarboksylowych PL PL PL PL
EP0740667A1 (en) * 1994-01-18 1996-11-06 Pfizer Inc. Process and intermediates for preparing naphthyridonecarboxylic acid salts
GB2289674A (en) * 1994-05-23 1995-11-29 Pfizer Antibacterial naphthyridine

Also Published As

Publication number Publication date
HRP960267B1 (en) 2000-06-30
DZ2046A1 (fr) 2002-10-22
ES2117426T3 (es) 1998-08-01
UY25459A1 (es) 1999-11-17
KR100191989B1 (ko) 1999-06-15
HRP960267A2 (en) 1997-08-31
PE38097A1 (es) 1997-10-10
FI974441A0 (fi) 1997-12-05
OA10293A (en) 1997-09-19
CN1055474C (zh) 2000-08-16
HUP9601540A3 (en) 1997-05-28
SK280535B6 (sk) 2000-03-13
IS4351A (is) 1996-12-07
WO1996039406A1 (en) 1996-12-12
TW580389B (en) 2004-03-21
NO962321L (no) 1996-12-09
BG100639A (bg) 1997-02-28
TW403751B (en) 2000-09-01
SI9600185A (en) 1997-04-30
CN1148596A (zh) 1997-04-30
CA2223404A1 (en) 1996-12-12
IL118488A0 (en) 1996-09-12
ZA964647B (en) 1997-10-22
EP0789697A1 (en) 1997-08-20
YU34596A (sh) 1999-03-04
NZ286735A (en) 1998-01-26
NO305599B1 (no) 1999-06-28
AU5474996A (en) 1996-12-19
FI974441A (fi) 1997-12-05
BR9602630A (pt) 1998-09-08
TNSN96084A1 (fr) 2005-03-15
BG62443B1 (bg) 1999-11-30
JPH10506650A (ja) 1998-06-30
CA2223404C (en) 2001-01-16
CZ285878B6 (cs) 1999-11-17
UA44718C2 (uk) 2002-03-15
LV11619A (lv) 1996-12-20
HU9601540D0 (en) 1996-07-29
SG54339A1 (en) 1998-11-16
KR970001352A (ko) 1997-01-24
HUP9601540A2 (en) 1997-02-28
AR002753A1 (es) 1998-04-29
RU2125571C1 (ru) 1999-01-27
DK0789697T3 (da) 1998-10-19
PL314604A1 (en) 1996-12-09
CZ162596A3 (cs) 1998-09-16
JP3145715B2 (ja) 2001-03-12
US5763454A (en) 1998-06-09
NO962321D0 (no) 1996-06-05
MX9709873A (es) 1998-03-31
SK71996A3 (en) 1997-03-05
EP0789697B1 (en) 1998-06-17
DE69503066D1 (de) 1998-07-23
IL118488A (en) 1999-01-26
DE69503066T2 (de) 1998-10-15
MA23892A1 (fr) 1996-12-31
AU703634B2 (en) 1999-03-25

Similar Documents

Publication Publication Date Title
LV11619B (en) Novel crystal form of anhydrous 7-(£1a,5a,6a|-6-amino-3-azabicyclo£3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt
KR100245938B1 (ko) 트리아졸릴티오메틸티오 세팔로스포린 염산염, 그의 결정성 수화물 및 이들의 제조방법
DE60216952T2 (de) Beta-carbolin-derivate als ptp-inhibitoren
US6121280A (en) Azabicyclic rotomase inhibitors
AU704115B2 (en) Zwitterionic forms of trovafloxacin
AP788A (en) Novel crystal form of anhydrous 7-(1a, 5a, 6a)-6-Amino-3-Azabicyclo(3.1.0) hex-3-YI)-6-Fluoro-1-(2,4- Difluorophenyl)-1,4-Dihydro-4-Oxo-1, 8-Naphthyridine-3-Carboxylic Acid, Methanesulfonic acid salt.
EP0847400B1 (en) Polymorphs of the prodrug 6-n-(l-ala-l-ala)-trovafloxacin
US4607046A (en) 4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate and pharmaceutical compositions
US6066647A (en) Zwitterionic forms of trovafloxacin
US5321035A (en) Piperidine derivatives and process for preparation thereof
HU195214B (en) Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds
MXPA98001665A (en) Polymorphoses of profarmaco of 6-n- (l-ala-l-ala) -trovafloxacin, procedure for its preparation and use of mis
MXPA97009873A (en) New crystaline form of acid 7 ([1alfa, 5alfa6alfa] -6-amino-3-azabiciclo [3.1.0] hex-3-il) -6-fluor-1- (2,4-difluorofenil) 1,4-dihydro -4-oxo-1,8-naftiridin-3-carboxilico anihdro, salt of acidomethane-sulfonico, compositions that contains it