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ZA947006B - Method of inhibiting binding of reticulocytes to endothelium by interfering with vla-4/vcam-1 interactions - Google Patents

Method of inhibiting binding of reticulocytes to endothelium by interfering with vla-4/vcam-1 interactions

Info

Publication number
ZA947006B
ZA947006B ZA947006A ZA947006A ZA947006B ZA 947006 B ZA947006 B ZA 947006B ZA 947006 A ZA947006 A ZA 947006A ZA 947006 A ZA947006 A ZA 947006A ZA 947006 B ZA947006 B ZA 947006B
Authority
ZA
South Africa
Prior art keywords
reticulocytes
vcam
vla
endothelium
interfering
Prior art date
Application number
ZA947006A
Inventor
Robert A Swerlick
James R Eckman
Timothy M Wick
Original Assignee
Univ Emory
Georgia Tech Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory, Georgia Tech Res Inst filed Critical Univ Emory
Publication of ZA947006B publication Critical patent/ZA947006B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70542CD106
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ZA947006A 1993-09-15 1994-09-12 Method of inhibiting binding of reticulocytes to endothelium by interfering with vla-4/vcam-1 interactions ZA947006B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12222893A 1993-09-15 1993-09-15

Publications (1)

Publication Number Publication Date
ZA947006B true ZA947006B (en) 1995-05-02

Family

ID=22401460

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA947006A ZA947006B (en) 1993-09-15 1994-09-12 Method of inhibiting binding of reticulocytes to endothelium by interfering with vla-4/vcam-1 interactions

Country Status (5)

Country Link
EP (1) EP0720486A1 (en)
AP (1) AP9400679A0 (en)
AU (1) AU7835294A (en)
WO (1) WO1995007717A1 (en)
ZA (1) ZA947006B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11560433B2 (en) * 2016-05-27 2023-01-24 Albert Einstein College Of Medicine Methods of treatment by targeting VCAM1 and MAEA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL113261A (en) * 1989-09-01 1996-10-16 Hutchinson Fred Cancer Res Repression by peptides of lymphocyte binding to vascular endothelium by interaction of extracellular uterine capacitor with connective tissue, and pharmaceutical preparations containing
ES2102009T5 (en) * 1992-01-13 2004-12-16 Biogen Inc TREATMENT FOR ASTHMA.
ATE151642T1 (en) * 1992-02-12 1997-05-15 Biogen Inc TREATMENT FOR INFLAMMATORY DISEASE OF THE INTESTINAL

Also Published As

Publication number Publication date
AU7835294A (en) 1995-04-03
WO1995007717A1 (en) 1995-03-23
AP9400679A0 (en) 1996-03-13
EP0720486A1 (en) 1996-07-10

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