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AP9400679A0 - Method of inhibiting binding of reticulocytes to endothelium by interfering with VLA-4/VCAM-1 interactions. - Google Patents

Method of inhibiting binding of reticulocytes to endothelium by interfering with VLA-4/VCAM-1 interactions.

Info

Publication number
AP9400679A0
AP9400679A0 APAP/P/1994/000679A AP9400679A AP9400679A0 AP 9400679 A0 AP9400679 A0 AP 9400679A0 AP 9400679 A AP9400679 A AP 9400679A AP 9400679 A0 AP9400679 A0 AP 9400679A0
Authority
AP
ARIPO
Prior art keywords
reticulocytes
vcam
vla
endothelium
interfering
Prior art date
Application number
APAP/P/1994/000679A
Inventor
Robert A Swerlick
James R Eckman
Timothy M Wick
Original Assignee
Univ Emory
Georgia Tech Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory, Georgia Tech Res Inst filed Critical Univ Emory
Publication of AP9400679A0 publication Critical patent/AP9400679A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70542—CD106
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention provides an experimental model for studying the role of increased capillary transit
APAP/P/1994/000679A 1993-09-15 1994-09-13 Method of inhibiting binding of reticulocytes to endothelium by interfering with VLA-4/VCAM-1 interactions. AP9400679A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12222893A 1993-09-15 1993-09-15

Publications (1)

Publication Number Publication Date
AP9400679A0 true AP9400679A0 (en) 1996-03-13

Family

ID=22401460

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1994/000679A AP9400679A0 (en) 1993-09-15 1994-09-13 Method of inhibiting binding of reticulocytes to endothelium by interfering with VLA-4/VCAM-1 interactions.

Country Status (5)

Country Link
EP (1) EP0720486A1 (en)
AP (1) AP9400679A0 (en)
AU (1) AU7835294A (en)
WO (1) WO1995007717A1 (en)
ZA (1) ZA947006B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11560433B2 (en) * 2016-05-27 2023-01-24 Albert Einstein College Of Medicine Methods of treatment by targeting VCAM1 and MAEA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL113261A (en) * 1989-09-01 1996-10-16 Hutchinson Fred Cancer Res Inhibition by peptides of lymphocyte adherence to vascular endothelium utilizing an extracellular matrix receptor-ligand interaction and pharmaceutical compositions containing said peptides
CA2127462C (en) * 1992-01-13 1999-03-23 Roy R. Lobb Treatment for asthma
ES2103468T3 (en) * 1992-02-12 1997-09-16 Biogen Inc TREATMENT OF INTESTINAL INFLAMMATION.

Also Published As

Publication number Publication date
WO1995007717A1 (en) 1995-03-23
ZA947006B (en) 1995-05-02
EP0720486A1 (en) 1996-07-10
AU7835294A (en) 1995-04-03

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