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ZA943520B - N-alkylthio polyamine derivatives as radioprotective agents. - Google Patents

N-alkylthio polyamine derivatives as radioprotective agents.

Info

Publication number
ZA943520B
ZA943520B ZA943520A ZA943520A ZA943520B ZA 943520 B ZA943520 B ZA 943520B ZA 943520 A ZA943520 A ZA 943520A ZA 943520 A ZA943520 A ZA 943520A ZA 943520 B ZA943520 B ZA 943520B
Authority
ZA
South Africa
Prior art keywords
alkylthio
radioprotective agents
polyamine derivatives
radioprotective
agents
Prior art date
Application number
ZA943520A
Other languages
English (en)
Inventor
Ronald D Snyder
Michael L Edwards
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA943520B publication Critical patent/ZA943520B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyamides (AREA)
  • Steroid Compounds (AREA)
ZA943520A 1993-05-26 1994-05-20 N-alkylthio polyamine derivatives as radioprotective agents. ZA943520B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6930293A 1993-05-26 1993-05-26

Publications (1)

Publication Number Publication Date
ZA943520B true ZA943520B (en) 1995-01-23

Family

ID=22088062

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA943520A ZA943520B (en) 1993-05-26 1994-05-20 N-alkylthio polyamine derivatives as radioprotective agents.

Country Status (19)

Country Link
US (1) US5434145A (sv)
EP (1) EP0700380B1 (sv)
KR (1) KR960702830A (sv)
CN (1) CN1124483A (sv)
AT (1) ATE167670T1 (sv)
AU (1) AU679236B2 (sv)
CA (1) CA2161869C (sv)
DE (1) DE69411271T2 (sv)
DK (1) DK0700380T3 (sv)
ES (1) ES2119203T3 (sv)
FI (1) FI955643A (sv)
GR (1) GR3027657T3 (sv)
HU (1) HUT73421A (sv)
IL (1) IL109720A (sv)
MX (1) MX9403915A (sv)
NO (1) NO306020B1 (sv)
NZ (1) NZ267211A (sv)
WO (1) WO1994027961A1 (sv)
ZA (1) ZA943520B (sv)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5393757A (en) * 1986-12-02 1995-02-28 University Of Florida Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment
US5677351A (en) * 1986-12-02 1997-10-14 University Of Florida Research Foundation, Inc. Sterically hindered tetraamines and method for their production
US5342945A (en) * 1986-12-02 1994-08-30 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5869338A (en) * 1992-03-13 1999-02-09 Arch Development Corporation Method for protection against genotoxic mutagenesis
US5567686A (en) * 1992-03-13 1996-10-22 Arch Development Corporation Method for protection against genotoxic mutagenesis
US5994409A (en) 1997-12-09 1999-11-30 U.S. Bioscience, Inc. Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
DE69919401T2 (de) * 1998-12-15 2005-07-14 The Gillette Co. (N.D.Ges.D. Staates Delaware), Boston Verschluss einer elektrochemischen zelle
US6794545B1 (en) 1999-04-30 2004-09-21 Slil Biomedical Corporation Conformationally restricted polyamine analogs as disease therapies
MXPA01011008A (es) * 1999-04-30 2003-06-30 Slil Biomedical Corp Conjugados analogos de poliamina y conjugados de quinona novedosos como terapia para canceres y enfermedades de la prostata.
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US6482943B1 (en) * 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
US6489312B1 (en) 1999-06-15 2002-12-03 Medimmune Oncology, Inc. Pharmaceutical formulations comprising aminoalkyl phosphorothioates
US6160022A (en) * 1999-07-19 2000-12-12 University Of Florida Chemical resection of pancreas
AU2001297817A1 (en) * 2000-11-08 2002-11-25 Eli Lilly And Company Antiviral therapies using polyamine or polyamine analog-amino acid conjugates
US7053072B2 (en) * 2001-05-11 2006-05-30 Medimmune Oncology, Inc. Methods for the administration of amifostine and related compounds
US7045550B2 (en) * 2001-08-07 2006-05-16 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
AU2002364539A1 (en) 2001-12-07 2003-06-23 Cellgate, Inc. Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
JP2005517004A (ja) 2002-02-07 2005-06-09 ウィスコンシン アルムニ リサーチ ファンデーション 癌治療に関連した使用に対するポリアミン化合物及び組成
WO2005014524A2 (en) * 2003-08-07 2005-02-17 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy
US7754463B2 (en) * 2006-06-20 2010-07-13 Dana-Farber Cancer Institute Inhibitors of USP1 Deubiquitinating Enzyme Complex
US20100049284A1 (en) * 2008-05-15 2010-02-25 The Catholic University Of America Use of heat to treat biological systems exposed to damaging radiation
WO2011137320A2 (en) 2010-04-30 2011-11-03 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of usp1 deubiquitinating enzyme activity
US9725425B1 (en) 2014-02-25 2017-08-08 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2653977A (en) * 1953-09-29 Chxnx
US2951092A (en) * 1956-12-13 1960-08-30 Olin Mathieson Triamine derivatives
US3892824A (en) * 1968-12-16 1975-07-01 Southern Res Inst S-{107 -({107 -aminoalkylamino)alkyl dihydrogen phosphorothioates
US5342945A (en) * 1986-12-02 1994-08-30 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5109024A (en) * 1987-02-03 1992-04-28 Merrell Dow Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents
US5217964A (en) * 1991-01-23 1993-06-08 Merrell Dow Pharmaceuticals Inc. Polyamine thiols as radioprotective agents
US5488042A (en) * 1992-03-13 1996-01-30 Arch Development Corporation Method for protection against genotoxic mutagenesis

Also Published As

Publication number Publication date
DE69411271D1 (de) 1998-07-30
FI955643A0 (sv) 1995-11-23
WO1994027961A1 (en) 1994-12-08
NO954768L (no) 1996-01-23
EP0700380B1 (en) 1998-06-24
AU6942894A (en) 1994-12-20
ES2119203T3 (es) 1998-10-01
ATE167670T1 (de) 1998-07-15
FI955643A (sv) 1995-11-23
NO954768D0 (no) 1995-11-24
CN1124483A (zh) 1996-06-12
US5434145A (en) 1995-07-18
NZ267211A (en) 1997-11-24
NO306020B1 (no) 1999-09-06
DE69411271T2 (de) 1998-11-05
CA2161869C (en) 2001-11-13
CA2161869A1 (en) 1994-12-08
KR960702830A (ko) 1996-05-23
MX9403915A (es) 1995-01-31
EP0700380A1 (en) 1996-03-13
HUT73421A (en) 1996-07-29
IL109720A0 (en) 1994-08-26
IL109720A (en) 1999-09-22
DK0700380T3 (da) 1998-11-09
AU679236B2 (en) 1997-06-26
HU9503370D0 (en) 1996-01-29
GR3027657T3 (en) 1998-11-30

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