ZA938137B - 5-arylindole derivatives - Google Patents

5-arylindole derivatives

Info

Publication number: ZA938137B
Authority: ZA; South Africa
Prior art keywords: alkyl; aryl; hydrogen; ring; membered
Prior art date: 1992-11-02

Application number

ZA938137A

Other languages

English (en)

Inventor

John Eugene Macor

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-02

Filing date

1993-11-01

Publication date

1995-05-02

1993-11-01 Application filed by Pfizer filed Critical Pfizer

1995-05-02 Publication of ZA938137B publication Critical patent/ZA938137B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)

ZA938137A 1992-11-02 1993-11-01 5-arylindole derivatives ZA938137B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US97075892A	1992-11-02	1992-11-02

Publications (1)

Publication Number	Publication Date
ZA938137B true ZA938137B (en)	1995-05-02

Family

ID=25517470

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA938137A ZA938137B (en)	1992-11-02	1993-11-01	5-arylindole derivatives

Country Status (27)

Country	Link
US (1)	US5886008A (sv)
EP (2)	EP1094064A1 (sv)
JP (1)	JP2788551B2 (sv)
KR (1)	KR0163371B1 (sv)
CN (1)	CN1051313C (sv)
AT (1)	ATE202102T1 (sv)
AU (1)	AU685066B2 (sv)
BR (1)	BR9307348A (sv)
CA (2)	CA2148380C (sv)
CZ (1)	CZ283001B6 (sv)
DE (1)	DE69330351T2 (sv)
DK (1)	DK0666858T3 (sv)
EG (1)	EG20396A (sv)
ES (1)	ES2157224T3 (sv)
FI (2)	FI111257B (sv)
GR (1)	GR3036579T3 (sv)
HU (1)	HU222235B1 (sv)
IL (1)	IL107386A (sv)
MY (1)	MY109696A (sv)
NO (1)	NO309652B1 (sv)
NZ (1)	NZ257059A (sv)
PL (1)	PL176091B1 (sv)
PT (1)	PT666858E (sv)
RU (1)	RU2134266C1 (sv)
TW (1)	TW251284B (sv)
WO (1)	WO1994010171A1 (sv)
ZA (1)	ZA938137B (sv)

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GB9210400D0 (en) *	1992-05-15	1992-07-01	Merck Sharp & Dohme	Therapeutic agents
CZ59996A3 (en) *	1993-08-31	1996-06-12	Pfizer	5-arylindole derivatives per se and for treating diseases, intermediates for their preparation and pharmaceutical compositions based thereon
NZ276172A (en) *	1994-02-10	1998-02-26	Pfizer	5-heteroarylindole derivatives as benzodiazepine receptor site agonists and antagonists, 5-(hetero)arylaminoindole intermediates
GB9420529D0 (en)	1994-10-12	1994-11-30	Pfizer Ltd	Indoles
NZ305166A (en) *	1995-03-20	1998-12-23	Lilly Co Eli	5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles; preparation and medicaments
CA2234166A1 (en) *	1995-10-10	1997-04-17	Patric James Hahn	N-¬2-substituted-3-(2-aminoethyl)-1h-indol-5-yl\|-amides: new 5-ht1f agonists
AU746706B2 (en) *	1997-07-03	2002-05-02	Du Pont Pharmaceuticals Company	Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
US6465484B1 (en)	1997-09-26	2002-10-15	Merck & Co., Inc.	Angiogenesis inhibitors
US7189753B1 (en)	1997-11-06	2007-03-13	Cady Roger K	Preemptive prophylaxis of migraine
JP2002519321A (ja) *	1998-06-30	2002-07-02	イーライ・リリー・アンド・カンパニー	セロトニン関連系に効果を有するピロリジン、及び、ピロリン誘導体
US6365589B1 (en)	1998-07-02	2002-04-02	Bristol-Myers Squibb Pharma Company	Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US5994352A (en) *	1998-11-13	1999-11-30	Pfizer Inc.	5-arylindole derivatives
PE20030008A1 (es)	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4
US20040102360A1 (en) *	2002-10-30	2004-05-27	Barnett Stanley F.	Combination therapy
CA2501365C (en)	2002-10-30	2011-05-31	Merck & Co., Inc.	Inhibitors of akt activity
US7332508B2 (en) *	2002-12-18	2008-02-19	Novo Nordisk A/S	Substituted homopiperidine, piperidine or pyrrolidine derivatives
AU2004233827B2 (en)	2003-04-24	2009-05-28	Merck Sharp & Dohme Corp.	Inhibitors of Akt activity
DE10337184A1 (de)	2003-08-13	2005-03-10	Gruenenthal Gmbh	Substituierte 3-Pyrrolidin-Indol-Derivate
US7442709B2 (en) *	2003-08-21	2008-10-28	Osi Pharmaceuticals, Inc.	N3-substituted imidazopyridine c-Kit inhibitors
EP1658289B1 (en) *	2003-08-21	2009-03-18	OSI Pharmaceuticals, Inc.	3-substituted imidazopyridine-derivatives as c-kit inhibitors
BRPI0414856A (pt)	2003-10-03	2006-11-21	3M Innovative Properties Co	imidazoquinolinas alcóxi-substituìdas
EP1687307B1 (en)	2003-11-25	2016-01-06	3M Innovative Properties Company	Substituted imidazo ring systems and methods
DE102004014304A1 (de) *	2004-03-22	2005-10-06	Grünenthal GmbH	Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
US9248127B2 (en)	2005-02-04	2016-02-02	3M Innovative Properties Company	Aqueous gel formulations containing immune response modifiers
WO2014078568A1 (en)	2012-11-14	2014-05-22	The Johns Hopkins University	Methods and compositions for treating schizophrenia
EP2968237A4 (en)	2013-03-15	2016-08-31	Univ Johns Hopkins	METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
US11160785B2 (en)	2013-03-15	2021-11-02	Agenebio Inc.	Methods and compositions for improving cognitive function
CN107567452B (zh)	2015-04-29	2020-07-07	詹森药业有限公司	咪唑并哌嗪和吡唑并嘧啶以及它们作为ampa受体调节剂的用途
JO3654B1 (ar)	2015-04-29	2020-08-27	Janssen Pharmaceutica Nv	مركبات ازا بنزيميدازول واستخدامها كمعدلات للمستقبلات ذات النمط الإمبائي (ampa)
US10604484B2 (en)	2015-04-29	2020-03-31	Janssen Pharmaceutica Nv	Indolone compounds and their use as AMPA receptor modulators
US10611730B2 (en)	2015-04-29	2020-04-07	Janssen Pharmaceutica Nv	Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators
MX2017014774A (es)	2015-05-22	2018-02-15	Agenebio Inc	Composiciones farmaceuticas de levetiracetam de liberacion extendida.
JP6857653B2 (ja)	2015-11-06	2021-04-14	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	Ｃｎｓ及び関連障害の治療において使用するためのインドリン−２−オン誘導体
JP6839184B2 (ja)	2015-11-06	2021-03-03	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	インドリン−２−オン誘導体
WO2017076932A1 (en)	2015-11-06	2017-05-11	F. Hoffmann-La Roche Ag	Indolin-2-one derivatives useful in the treatment of cns diseases
PL3371168T3 (pl)	2015-11-06	2020-11-02	F. Hoffmann-La Roche Ag	Pochodne indolin-2-onu
CN111822047B (zh) *	2020-07-17	2022-05-27	曲阜师范大学	一种磁性介孔聚合离子液体负载催化合成吲哚类衍生物的方法

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ZA795239B (en) *	1978-10-12	1980-11-26	Glaxo Group Ltd	Heterocyclic compounds
BE889931A (fr) *	1980-08-12	1982-02-11	Glaxo Group Ltd	Derives indoliques, leur preparation et leurs applications en tant que medicaments
US4983622A (en) *	1984-02-06	1991-01-08	Eli Lilly And Company	6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
GB8600397D0 (en) *	1986-01-08	1986-02-12	Glaxo Group Ltd	Chemical compounds
GB8719167D0 (en) *	1987-08-13	1987-09-23	Glaxo Group Ltd	Chemical compounds
GB8724912D0 (en) *	1987-10-23	1987-11-25	Wellcome Found	Indole derivatives
GB8819024D0 (en) *	1988-08-10	1988-09-14	Glaxo Group Ltd	Chemical compounds
IL96891A0 (en) *	1990-01-17	1992-03-29	Merck Sharp & Dohme	Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
US5340838A (en) *	1990-05-04	1994-08-23	Eli Lilly And Company	Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines
CA2042295A1 (fr) *	1990-05-15	1991-11-16	Jacques Chauveau	Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
IL114690A (en) *	1990-06-07	1997-02-18	Wellcome Found	Antimigraine oxazolidinone substituted indole derivatives
DK158590D0 (da) *	1990-07-02	1990-07-02	Lundbeck & Co As H	Indolderivater
JP2575272B2 (ja) *	1990-10-15	1997-01-22	フアイザー・インコーポレイテツド	インドール誘導体
CZ283018B6 (cs) *	1991-02-01	1997-12-17	Merck Sharp And Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
FR2672602B1 (fr) *	1991-02-12	1993-06-04	Centre Nat Rech Scient	Composes derives des beta-carbolines ligands du recepteur des benzodiazepines ayant un effet agoniste inverse et antagoniste vis-a-vis des benzodiazepines et medicaments les contenant.
US5229401A (en) *	1991-09-23	1993-07-20	Hoechst-Roussel Pharmaceuticals Incorporated	Substituted pyridinylamino benzo[b]thiophene compounds
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GB9210400D0 (en) *	1992-05-15	1992-07-01	Merck Sharp & Dohme	Therapeutic agents
US5378846A (en) *	1993-06-11	1995-01-03	Russian-American Institute For New Drug Development	1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives

1993
- 1993-10-16 TW TW082108604A patent/TW251284B/zh active
- 1993-10-19 CZ CZ951108A patent/CZ283001B6/cs not_active IP Right Cessation
- 1993-10-19 EP EP00124422A patent/EP1094064A1/en not_active Withdrawn
- 1993-10-19 PT PT93923389T patent/PT666858E/pt unknown
- 1993-10-19 EP EP93923389A patent/EP0666858B1/en not_active Expired - Lifetime
- 1993-10-19 ES ES93923389T patent/ES2157224T3/es not_active Expired - Lifetime
- 1993-10-19 CA CA002148380A patent/CA2148380C/en not_active Expired - Fee Related
- 1993-10-19 CA CA002340999A patent/CA2340999C/en not_active Expired - Fee Related
- 1993-10-19 DK DK93923389T patent/DK0666858T3/da active
- 1993-10-19 JP JP6511101A patent/JP2788551B2/ja not_active Expired - Lifetime
- 1993-10-19 RU RU95109927/04A patent/RU2134266C1/ru not_active IP Right Cessation
- 1993-10-19 BR BR9307348A patent/BR9307348A/pt not_active Application Discontinuation
- 1993-10-19 AU AU53294/94A patent/AU685066B2/en not_active Ceased
- 1993-10-19 KR KR1019950701729A patent/KR0163371B1/ko not_active Expired - Fee Related
- 1993-10-19 WO PCT/US1993/009790 patent/WO1994010171A1/en active IP Right Grant
- 1993-10-19 AT AT93923389T patent/ATE202102T1/de not_active IP Right Cessation
- 1993-10-19 US US08/424,357 patent/US5886008A/en not_active Expired - Fee Related
- 1993-10-19 NZ NZ257059A patent/NZ257059A/en unknown
- 1993-10-19 DE DE69330351T patent/DE69330351T2/de not_active Expired - Fee Related
- 1993-10-25 IL IL10738693A patent/IL107386A/en not_active IP Right Cessation
- 1993-11-01 MY MYPI93002280A patent/MY109696A/en unknown
- 1993-11-01 ZA ZA938137A patent/ZA938137B/xx unknown
- 1993-11-01 FI FI934825A patent/FI111257B/sv not_active IP Right Cessation
- 1993-11-01 CN CN93120716A patent/CN1051313C/zh not_active Expired - Fee Related
- 1993-11-02 HU HU9303118A patent/HU222235B1/hu not_active IP Right Cessation
- 1993-11-02 EG EG69793A patent/EG20396A/xx active
1995
- 1995-04-28 NO NO951633A patent/NO309652B1/no not_active IP Right Cessation
- 1995-05-01 PL PL93308669A patent/PL176091B1/pl unknown
2000
- 2000-11-15 FI FI20002505A patent/FI20002505L/sv unknown
2001
- 2001-09-11 GR GR20010401436T patent/GR3036579T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL107386A0 (en)	1994-01-25
PL308669A1 (en)	1995-08-21
ES2157224T3 (es)	2001-08-16
CA2340999C (en)	2005-01-04
AU685066B2 (en)	1998-01-15
HU222235B1 (hu)	2003-05-28
CA2148380A1 (en)	1994-05-11
WO1994010171A1 (en)	1994-05-11
NO951633D0 (no)	1995-04-28
RU2134266C1 (ru)	1999-08-10
FI111257B (sv)	2003-06-30
NO951633L (no)	1995-04-28
CZ283001B6 (cs)	1997-12-17
FI934825L (fi)	1994-05-03
DK0666858T3 (da)	2001-08-27
CA2148380C (en)	2001-08-14
PT666858E (pt)	2001-09-28
DE69330351T2 (de)	2001-09-20
KR0163371B1 (ko)	1998-12-01
JP2788551B2 (ja)	1998-08-20
AU5329494A (en)	1994-05-24
BR9307348A (pt)	1999-05-11
EP0666858B1 (en)	2001-06-13
RU95109927A (ru)	1997-01-10
PL176091B1 (pl)	1999-04-30
NZ257059A (en)	1997-07-27
TW251284B (sv)	1995-07-11
MY109696A (en)	1997-04-30
FI934825A0 (fi)	1993-11-01
CN1094727A (zh)	1994-11-09
ATE202102T1 (de)	2001-06-15
EP0666858A1 (en)	1995-08-16
CN1051313C (zh)	2000-04-12
CZ110895A3 (en)	1995-11-15
EP1094064A1 (en)	2001-04-25
HUT66011A (en)	1994-08-29
KR950704313A (ko)	1995-11-17
DE69330351D1 (de)	2001-07-19
EG20396A (en)	1999-02-28
NO309652B1 (no)	2001-03-05
FI20002505L (sv)	2000-11-15
GR3036579T3 (en)	2001-12-31
JPH07508759A (ja)	1995-09-28
CA2340999A1 (en)	1994-05-11
US5886008A (en)	1999-03-23
IL107386A (en)	1999-03-12

Publication	Publication Date	Title
TW251284B (sv)	1995-07-11
DE69505470D1 (de)	1998-11-26	Pyrrolocarbazol
DE69810373D1 (de)	2003-02-06	Pyrrolidin Derivate, Anti-ulcus und Antibakterielle Arzneimittel
GB2254324B (en)	1994-06-22	Piperazine derivatives
ES2112470T3 (es)	1998-04-01	Derivados de piridazinona, procedimientos de produccion y utilizacion.
ATE134607T1 (de)	1996-03-15	Tetrahydronaphtalenderivate, ihre herstellung und ihre therapeutische verwendung
ES2077697T3 (es)	1995-12-01	Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.