ZA923063B - Glycine anhydride diemethylol as a biocide and preservative - Google Patents
Glycine anhydride diemethylol as a biocide and preservativeInfo
- Publication number
- ZA923063B ZA923063B ZA923063A ZA923063A ZA923063B ZA 923063 B ZA923063 B ZA 923063B ZA 923063 A ZA923063 A ZA 923063A ZA 923063 A ZA923063 A ZA 923063A ZA 923063 B ZA923063 B ZA 923063B
- Authority
- ZA
- South Africa
- Prior art keywords
- diemethylol
- biocide
- preservative
- glycine anhydride
- glycine
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title 1
- 239000003139 biocide Substances 0.000 title 1
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycine anhydride Natural products [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 title 1
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 title 1
- 239000003755 preservative agent Substances 0.000 title 1
- 230000002335 preservative effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
- A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
- A23B2/729—Organic compounds; Microorganisms; Enzymes
- A23B2/771—Organic compounds containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/50—Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Birds (AREA)
- Water Supply & Treatment (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Environmental & Geological Engineering (AREA)
- Hydrology & Water Resources (AREA)
- Environmental Sciences (AREA)
- Dermatology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/694,252 US5244653A (en) | 1991-05-01 | 1991-05-01 | Glycine anhydride dimethylol as a biocide and preservative |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA923063B true ZA923063B (en) | 1993-04-28 |
Family
ID=24788047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA923063A ZA923063B (en) | 1991-05-01 | 1992-04-28 | Glycine anhydride diemethylol as a biocide and preservative |
Country Status (12)
Country | Link |
---|---|
US (3) | US5244653A (pt) |
EP (1) | EP0583357A4 (pt) |
JP (1) | JPH06507403A (pt) |
CN (1) | CN1066170A (pt) |
AU (1) | AU654192B2 (pt) |
BR (1) | BR9205953A (pt) |
CA (1) | CA2109418A1 (pt) |
CZ (1) | CZ230193A3 (pt) |
MX (1) | MX9201988A (pt) |
NO (1) | NO933894D0 (pt) |
WO (1) | WO1992019212A2 (pt) |
ZA (1) | ZA923063B (pt) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5714167A (en) | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
US6099856A (en) | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
US5578323A (en) | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
US5541155A (en) | 1994-04-22 | 1996-07-30 | Emisphere Technologies, Inc. | Acids and acid salts and their use in delivery systems |
US5443841A (en) | 1992-06-15 | 1995-08-22 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
US5693338A (en) | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
US6221367B1 (en) | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
US6331318B1 (en) * | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
US5629020A (en) * | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
US5244653A (en) * | 1991-05-01 | 1993-09-14 | Isp Chemicals Inc. | Glycine anhydride dimethylol as a biocide and preservative |
US5811127A (en) | 1992-06-15 | 1998-09-22 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
US5792451A (en) | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
US5401516A (en) | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
US5709861A (en) | 1993-04-22 | 1998-01-20 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
US5958457A (en) | 1993-04-22 | 1999-09-28 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
ATE298561T1 (de) | 1993-04-22 | 2005-07-15 | Emisphere Tech Inc | Orale dareichungsform |
US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5552425A (en) * | 1994-04-28 | 1996-09-03 | Isp Chemicals Inc. | Synergistic water soluble preservative compositions of biocidal mixtures |
US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
US5965121A (en) | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5989539A (en) | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
CN1151836C (zh) | 1995-03-31 | 2004-06-02 | 艾米斯菲尔技术有限公司 | 用作传送活性剂的化合物和组合物 |
US6090958A (en) | 1995-03-31 | 2000-07-18 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5820881A (en) | 1995-04-28 | 1998-10-13 | Emisphere Technologies, Inc. | Microspheres of diamide-dicarboxylic acids |
US6051258A (en) | 1995-06-07 | 2000-04-18 | Emisphere Technologies, Inc. | Proteinoid emulsions and methods for preparation and use thereof |
US5824345A (en) | 1995-06-07 | 1998-10-20 | Emisphere Technologies, Inc. | Fragrances and flavorants |
US5750147A (en) | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
US5667806A (en) | 1995-06-07 | 1997-09-16 | Emisphere Technologies, Inc. | Spray drying method and apparatus |
GB2320248B (en) | 1995-09-11 | 1999-04-14 | Emisphere Tech Inc | Method for preparing omega-aminoalkanoic acid derivatives from cycloalkanones |
GB9600661D0 (en) * | 1996-01-12 | 1996-03-13 | Woolard Trevor | Bactericidal compostions and articles containing them |
WO1997047288A1 (en) | 1996-06-14 | 1997-12-18 | Emisphere Technologies, Inc. | Microencapsulated fragrances and method for preparation |
US5869436A (en) * | 1996-10-15 | 1999-02-09 | American Eagle Technologies, Inc. | Non-toxic antimicrobial lubricant |
US5876710A (en) | 1997-02-07 | 1999-03-02 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
US5804688A (en) | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6060513A (en) | 1997-02-07 | 2000-05-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5939381A (en) | 1997-02-07 | 1999-08-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6313088B1 (en) | 1997-02-07 | 2001-11-06 | Emisphere Technologies, Inc. | 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents |
US5990166A (en) | 1997-02-07 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5863944A (en) | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5962710A (en) | 1997-05-09 | 1999-10-05 | Emisphere Technologies, Inc. | Method of preparing salicyloylamino acids |
US6004909A (en) * | 1997-07-18 | 1999-12-21 | American Eagle Technologies, Inc. | Non-toxic antimicrobial lubricant |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US6688539B2 (en) * | 2001-10-19 | 2004-02-10 | Nelson Irrigation Corporation | Water distribution plate for rotating sprinklers |
PT1494732E (pt) | 2002-03-20 | 2008-03-20 | Mannkind Corp | Aparelho de inalação |
BRPI0514263B8 (pt) | 2004-08-20 | 2021-05-25 | Mannkind Corp | método para a síntese de bis-3,6-[4-aminobutil]-2,5-dicetopiperazina n-protegida |
CA2578175C (en) | 2004-08-23 | 2014-10-14 | Mannkind Corporation | Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery |
EP1629724A1 (en) * | 2004-08-27 | 2006-03-01 | PURAC Biochem BV | The use of glycine and/or a glycine derivative as antibacterial agent in foods and/or drinks |
US20090124634A1 (en) * | 2005-06-10 | 2009-05-14 | Viogard Ab | Novel dipodazine compounds and applications |
EP1937219B1 (en) | 2005-09-14 | 2015-11-11 | MannKind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
IN2015DN00888A (pt) | 2006-02-22 | 2015-07-10 | Mannkind Corp | |
WO2011163272A1 (en) | 2010-06-21 | 2011-12-29 | Mannkind Corporation | Dry powder drug delivery system and methods |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
PL2293833T3 (pl) | 2008-06-13 | 2016-08-31 | Mannkind Corp | Inhalator proszkowy i układ do dostarczania leku |
DK2609954T3 (da) | 2008-06-20 | 2022-02-14 | Mannkind Corp | Interaktivt apparat til realtidsafbildning af inhalationspræstationer |
TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
PL2163577T3 (pl) | 2008-09-15 | 2013-01-31 | Armacell Entpr Gmbh & Co Kg | Przedłużacze łańcucha i spienione termoplastyczne materiały komórkowe otrzymywane w procesie wytłaczania reaktywnego za pomocą tych przedłużaczy łańcucha |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
PL2405963T3 (pl) | 2009-03-11 | 2014-04-30 | Mannkind Corp | Urządzenie, układ i sposób pomiaru oporu inhalatora |
KR102584844B1 (ko) | 2009-06-12 | 2023-10-04 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
JP5784622B2 (ja) | 2009-11-03 | 2015-09-24 | マンカインド コーポレ−ション | 吸入活動をシミュレートするための装置及び方法 |
SG10201606220QA (en) | 2011-04-01 | 2016-09-29 | Mannkind Corp | Blister package for pharmaceutical cartridges |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
US9233159B2 (en) | 2011-10-24 | 2016-01-12 | Mannkind Corporation | Methods and compositions for treating pain |
CN104619369B (zh) | 2012-07-12 | 2018-01-30 | 曼金德公司 | 干粉药物输送系统和方法 |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
BR112015023168B1 (pt) | 2013-03-15 | 2021-08-10 | Mannkind Corporation | Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina |
CA2918369C (en) | 2013-07-18 | 2021-06-29 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
US9681313B2 (en) | 2015-04-15 | 2017-06-13 | Corning Optical Communications Wireless Ltd | Optimizing remote antenna unit performance using an alternative data channel |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3142530A (en) * | 1961-05-04 | 1964-07-28 | Wyandotte Chemicals Corp | Method of bleaching cotton fabrics with nu, nu'-dichloro-2, 5-diketopiperazines |
US3350317A (en) * | 1965-09-24 | 1967-10-31 | Monsanto Co | Sterilizing, disinfecting, oxidizing and bleaching composition |
US5041457A (en) * | 1989-03-10 | 1991-08-20 | Rohm And Haas Company | Synergistic microbicidal combinations containing 2-n-octyl-3-isothiazolone and certain commercial biocides |
US5244653A (en) * | 1991-05-01 | 1993-09-14 | Isp Chemicals Inc. | Glycine anhydride dimethylol as a biocide and preservative |
US5428050A (en) * | 1994-04-28 | 1995-06-27 | Isp Chemicals Inc. | Synergistic water soluble preservative compositions of biocidal mixtures |
-
1991
- 1991-05-01 US US07/694,252 patent/US5244653A/en not_active Expired - Fee Related
-
1992
- 1992-04-28 ZA ZA923063A patent/ZA923063B/xx unknown
- 1992-04-29 MX MX9201988A patent/MX9201988A/es unknown
- 1992-04-30 BR BR9205953A patent/BR9205953A/pt not_active Application Discontinuation
- 1992-04-30 AU AU19169/92A patent/AU654192B2/en not_active Ceased
- 1992-04-30 EP EP19920911282 patent/EP0583357A4/en not_active Withdrawn
- 1992-04-30 CA CA002109418A patent/CA2109418A1/en not_active Abandoned
- 1992-04-30 CN CN92103219A patent/CN1066170A/zh active Pending
- 1992-04-30 JP JP4511432A patent/JPH06507403A/ja active Pending
- 1992-04-30 WO PCT/US1992/003442 patent/WO1992019212A2/en not_active Application Discontinuation
- 1992-04-30 CZ CS932301A patent/CZ230193A3/cs unknown
-
1993
- 1993-05-10 US US08/058,238 patent/US5707993A/en not_active Expired - Fee Related
- 1993-10-28 NO NO1993933894A patent/NO933894D0/no unknown
-
1995
- 1995-04-24 US US08/427,267 patent/US5593681A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU654192B2 (en) | 1994-10-27 |
NO933894L (no) | 1993-10-28 |
MX9201988A (es) | 1992-11-01 |
US5707993A (en) | 1998-01-13 |
JPH06507403A (ja) | 1994-08-25 |
US5593681A (en) | 1997-01-14 |
BR9205953A (pt) | 1994-09-27 |
EP0583357A1 (en) | 1994-02-23 |
EP0583357A4 (en) | 1994-05-18 |
CN1066170A (zh) | 1992-11-18 |
NO933894D0 (no) | 1993-10-28 |
AU1916992A (en) | 1992-12-21 |
WO1992019212A2 (en) | 1992-11-12 |
US5244653A (en) | 1993-09-14 |
CZ230193A3 (en) | 1994-07-13 |
CA2109418A1 (en) | 1992-11-02 |
WO1992019212A3 (en) | 1993-01-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA923063B (en) | Glycine anhydride diemethylol as a biocide and preservative | |
HU9200229D0 (en) | Herbicide preparatives | |
PL296208A1 (en) | Fungicide | |
GB2271496B (en) | Vine stake | |
GB2259927B (en) | Tent | |
PL294458A1 (en) | Pesticide | |
PL297064A1 (en) | Fungicide | |
ZA933374B (en) | Synergistic herbicide combinations | |
PL294754A1 (en) | Fungicide | |
PL296584A1 (en) | Herbicide | |
PL294310A1 (en) | Fungicide | |
PL294002A1 (en) | Pesticide | |
PL294564A1 (en) | Herbicide | |
EP0514331A3 (en) | Wood preservative | |
PL293535A1 (en) | Pesticide | |
EP0540980A3 (en) | Potentiometer | |
EP0499080A3 (en) | Aminoacid derivatibes | |
PL295868A1 (en) | Herbicide | |
PL294566A1 (en) | Herbicide | |
AU398P (en) | 9641 Glycine max | |
AU402P (en) | 9791 Glycine max | |
AU397P (en) | 9582 Glycine max | |
GB9109286D0 (en) | Gardening game | |
PL284418A1 (en) | Fodder preservative | |
GB9105157D0 (en) | Pharmaceutical preservative |