ZA921804B - Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them. - Google Patents

Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them.

Info

Publication number: ZA921804B
Authority: ZA; South Africa
Prior art keywords: preparing; processes; pharmaceutical compositions; compositions containing; compounds
Prior art date: 1991-03-12

Application number

ZA921804A

Other languages

English (en)

Inventor

Frank Himmelsbach

Helmut Pieper

Volkhard Austel

Guenter Linz

Thomas Mueller

Johannes Weisenberger

Wolfgang Eisert

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-12

Filing date

1992-03-11

Publication date

1993-09-13

1992-03-11 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1993-09-13 Publication of ZA921804B publication Critical patent/ZA921804B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Silicon Polymers (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA921804A 1991-03-12 1992-03-11 Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them. ZA921804B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4107857A DE4107857A1 (de)	1991-03-12	1991-03-12	Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (1)

Publication Number	Publication Date
ZA921804B true ZA921804B (en)	1993-09-13

Family

ID=6427033

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA921804A ZA921804B (en)	1991-03-12	1992-03-11	Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them.

Country Status (23)

Country	Link
US (3)	US5276049A (xx)
EP (1)	EP0503548B1 (xx)
JP (1)	JPH04368372A (xx)
KR (1)	KR920018031A (xx)
AT (1)	ATE154013T1 (xx)
AU (1)	AU654340B2 (xx)
CA (1)	CA2062655A1 (xx)
CZ (1)	CZ74592A3 (xx)
DE (2)	DE4107857A1 (xx)
DK (1)	DK0503548T3 (xx)
ES (1)	ES2104754T3 (xx)
FI (1)	FI921030A (xx)
GR (1)	GR3024504T3 (xx)
HU (1)	HUT60722A (xx)
IE (1)	IE920781A1 (xx)
IL (1)	IL101203A (xx)
MX (1)	MX9201068A (xx)
NO (1)	NO920957L (xx)
NZ (1)	NZ241928A (xx)
PL (1)	PL293795A1 (xx)
SK (1)	SK74592A3 (xx)
TW (1)	TW221811B (xx)
ZA (1)	ZA921804B (xx)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
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DE4134467A1 (de) *	1991-10-18	1993-04-22	Thomae Gmbh Dr K	Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4124942A1 (de) *	1991-07-27	1993-01-28	Thomae Gmbh Dr K	5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
USRE37781E1 (en)	1991-10-11	2002-07-02	Dupont Pharmaceuticals Company	Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
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DE4213919A1 (de) *	1992-04-28	1993-11-04	Thomae Gmbh Dr K	Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ES2092170T3 (es) *	1992-04-28	1996-11-16	Thomae Gmbh Dr K	Antagonistas de receptores de fibrinogeno marcados con tritio, su utilizacion y procedimiento para su preparacion.
DE4213931A1 (de) *	1992-04-28	1993-11-04	Thomae Gmbh Dr K	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
SK94393A3 (en) *	1992-09-11	1994-08-10	Thomae Gmbh Dr K	Cyclic derivatives of urea, process for their production and their pharmaceutical agents with the content of those
FR2700337B1 (fr) *	1993-01-11	1995-04-14	Lafon Labor	Dérivés d'imidazopyridine-2-one, leur procédé de préparation et leur utilisation en thérapeutique.
DE4332168A1 (de) *	1993-02-22	1995-03-23	Thomae Gmbh Dr K	Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
GB9406144D0 (en) *	1993-03-29	1994-05-18	Zeneca Ltd	Heterocyclic compounds
US5750754A (en) *	1993-03-29	1998-05-12	Zeneca Limited	Heterocyclic compounds
US5753659A (en) *	1993-03-29	1998-05-19	Zeneca Limited	Heterocyclic compouds
US5652242A (en) *	1993-03-29	1997-07-29	Zeneca Limited	Heterocyclic derivatives
TW276254B (xx) *	1993-03-29	1996-05-21	Zeneca Ltd
GB9313268D0 (en) *	1993-06-28	1993-08-11	Zeneca Ltd	Chemical compounds
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US5563158A (en) *	1993-12-28	1996-10-08	The Dupont Merck Pharmaceutical Company	Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
DE4407961A1 (de) *	1994-03-10	1995-09-14	Thomae Gmbh Dr K	Imidazolidin-2-one, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
RU2156763C2 (ru) *	1994-07-15	2000-09-27	Мейдзи Сейка Кабусики Кайся	Азотсодержащие гетероциклические производные, фармацевтическая композиция на их основе и способ лечения или профилактики тромботических заболеваний
DE4424974A1 (de) *	1994-07-15	1996-01-18	Thomae Gmbh Dr K	Harnstoff- und Carbaminsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4427838A1 (de) *	1994-08-05	1996-02-08	Thomae Gmbh Dr K	Kondensierte Azepinderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4429079A1 (de) *	1994-08-17	1996-02-22	Thomae Gmbh Dr K	Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
ZA963391B (en) *	1995-05-24	1997-10-29	Du Pont Merck Pharma	Isoxazoline fibrinogen receptor antagonists.
US5612363A (en) *	1995-06-02	1997-03-18	Berlex Laboratories, Inc.	N,N-di(aryl) cyclic urea derivatives as anti-coagulants
AU6318896A (en) *	1995-07-06	1997-02-05	Japan Tobacco Inc.	Benzamidoxime derivatives and medicinal use thereof
ZA966885B (en) *	1995-08-22	1998-02-16	Du Pont Merck Pharma	Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors.
US5925635A (en) *	1996-04-17	1999-07-20	Dupont Pharmaceuticals Company	N-(amidinophenyl) cyclourea analogs as factor XA inhibitors
ES2218677T3 (es) *	1996-04-17	2004-11-16	Bristol-Myers Squibb Pharma Company	Derivados de n-(amidinofenil)-n'-(subst.)-3h-2,4-benzodiazepin-3-ona como inhibidores del factor xa.
US5935598A (en) *	1996-06-19	1999-08-10	Becton Dickinson Research Center	Iontophoretic delivery of cell adhesion inhibitors
US6340687B1 (en)	1997-09-03	2002-01-22	American Home Products Corporation	Substituted tetrahydro-pyrimidine-2(1H)-thione HDL-C elevators useful as antiatherosclerotic agents
AU9126098A (en) *	1997-09-03	1999-03-22	American Home Products Corporation	Substituted tetrahydro-pyrimidine-2(1h)-thione hdl-c elevators useful as antiatherosclerotic agents
TWI239847B (en) *	1997-12-02	2005-09-21	Elan Pharm Inc	N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6313110B1 (en)	1999-06-02	2001-11-06	Dupont Pharmaceuticals Company	Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor
DK1295870T3 (da) *	2001-04-16	2008-01-28	Taiho Pharmaceutical Co Ltd	Suplatasttosilatkrystaller
CN1592739A (zh)	2001-11-26	2005-03-09	先灵公司	用于治疗肥胖和cns疾病的基于哌啶的mch拮抗剂
US7141561B2 (en)	2002-07-25	2006-11-28	Sanofi-Aventis Deutschland Gmbh	Substituted diaryl heterocycles, process for their preparation and their use as medicaments
DE10233817A1 (de) *	2002-07-25	2004-02-12	Aventis Pharma Deutschland Gmbh	Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
KR20050026023A (ko) *	2002-07-31	2005-03-14	유로-셀티큐 에스.에이.	아릴 치환된 히단토인 화합물 및 그들의 나트륨 채널차단제로서의 용도
US7354933B2 (en)	2003-01-31	2008-04-08	Aventis Pharma Sa	Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
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1991
- 1991-03-12 DE DE4107857A patent/DE4107857A1/de not_active Withdrawn
1992
- 1992-03-10 DE DE59208559T patent/DE59208559D1/de not_active Expired - Fee Related
- 1992-03-10 AT AT92104045T patent/ATE154013T1/de not_active IP Right Cessation
- 1992-03-10 DK DK92104045.7T patent/DK0503548T3/da active
- 1992-03-10 FI FI921030A patent/FI921030A/fi unknown
- 1992-03-10 EP EP92104045A patent/EP0503548B1/de not_active Expired - Lifetime
- 1992-03-10 ES ES92104045T patent/ES2104754T3/es not_active Expired - Lifetime
- 1992-03-11 CA CA002062655A patent/CA2062655A1/en not_active Abandoned
- 1992-03-11 AU AU12803/92A patent/AU654340B2/en not_active Ceased
- 1992-03-11 ZA ZA921804A patent/ZA921804B/xx unknown
- 1992-03-11 HU HU9200823A patent/HUT60722A/hu unknown
- 1992-03-11 IE IE078192A patent/IE920781A1/en not_active Application Discontinuation
- 1992-03-11 KR KR1019920003953A patent/KR920018031A/ko not_active Application Discontinuation
- 1992-03-11 PL PL29379592A patent/PL293795A1/xx unknown
- 1992-03-11 IL IL10120392A patent/IL101203A/en not_active IP Right Cessation
- 1992-03-11 US US07/849,557 patent/US5276049A/en not_active Expired - Fee Related
- 1992-03-11 NO NO92920957A patent/NO920957L/no unknown
- 1992-03-11 MX MX9201068A patent/MX9201068A/es unknown
- 1992-03-11 NZ NZ241928A patent/NZ241928A/en unknown
- 1992-03-12 TW TW081101892A patent/TW221811B/zh active
- 1992-03-12 CZ CS92745A patent/CZ74592A3/cs unknown
- 1992-03-12 JP JP4053171A patent/JPH04368372A/ja active Pending
- 1992-03-12 SK SK745-92A patent/SK74592A3/sk unknown
1993
- 1993-10-28 US US08/144,909 patent/US5478942A/en not_active Expired - Fee Related
1995
- 1995-08-29 US US08/521,338 patent/US5650424A/en not_active Expired - Fee Related
1997
- 1997-08-21 GR GR970402143T patent/GR3024504T3/el unknown

Also Published As

Publication number	Publication date
HUT60722A (en)	1992-10-28
NZ241928A (en)	1994-06-27
US5478942A (en)	1995-12-26
SK74592A3 (en)	1993-12-08
PL293795A1 (en)	1993-03-08
DK0503548T3 (da)	1997-11-03
ATE154013T1 (de)	1997-06-15
KR920018031A (ko)	1992-10-21
AU1280392A (en)	1992-09-17
DE59208559D1 (de)	1997-07-10
IL101203A (en)	1995-12-31
IE920781A1 (en)	1992-09-23
DE4107857A1 (de)	1992-09-17
NO920957D0 (no)	1992-03-11
EP0503548A1 (de)	1992-09-16
CA2062655A1 (en)	1992-09-13
NO920957L (no)	1992-09-14
FI921030A (fi)	1992-09-13
ES2104754T3 (es)	1997-10-16
EP0503548B1 (de)	1997-06-04
FI921030A0 (fi)	1992-03-10
IL101203A0 (en)	1992-11-15
HU9200823D0 (en)	1992-05-28
AU654340B2 (en)	1994-11-03
TW221811B (xx)	1994-03-21
JPH04368372A (ja)	1992-12-21
US5276049A (en)	1994-01-04
US5650424A (en)	1997-07-22
CZ74592A3 (en)	1993-03-17
MX9201068A (es)	1992-09-01
GR3024504T3 (en)	1997-11-28

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GR3022116T3 (en)	1997-03-31	Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them
CY2121B1 (en)	2002-04-26	Derivatives of amidinophenylalanine procedure for their preparation their utilisation and compositions comprising them
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US4476308B1 (xx)	1987-03-10
GR3029406T3 (en)	1999-05-28	Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them.
IL112622A0 (en)	1995-05-26	Camptothecin derivatives, their preparation and pharmaceutical compositions containing them
DE3581566D1 (de)	1991-03-07	Oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte.
ZA917701B (en)	1992-06-24	Heterocycle-substituted alkylamines,process for preparing these and pharmaceutical compositions containing them
HUT71798A (en)	1996-02-28	Process for preparing pharmaceutical compositions of antidepressant activity containing 2-amino-6-a-propylamino-4,5,6,7-tetrahydrobenzothiazole (pramipexol)
GR1001597B (el)	1994-06-30	Νέα βιολογικώς δραστικά παράγωγα εμπουρναμενίνης, φαρμακευτικές συν?έσεις οι οποίες περιέχουν αυτά και μέ?οδος δια την παρασκευή αυτών.
NZ216048A (en)	1988-09-29	Quinolylglycinamide derivatives, and pharmaceutical compositions containing such
ZA932359B (en)	1994-06-15	3-Aminochroman spiro compounds processes for preparing them and pharmaceutical compositions containing them
TW252979B (xx)	1995-08-01
HUT60275A (en)	1992-08-28	Process for producing 7-acyl-3-(substituted carbamoyloxy)-cef-3-em-4-carboxylic acid derivatives and pharmaceutical compositions comprising such compounds
HUT49876A (en)	1989-11-28	Process for producing 6-oxopyridazine derivatives and pharmaceutical compositions comprising same
ZA941196B (en)	1994-09-20	Angiopeptin cyclopeptide compounds process for the preparation thereof and pharmaceutical compositions containing them
PL286188A1 (en)	1991-04-22	Method of obtaining renine retarding aminooligohydroxy derivatives
ES2049186A1 (es)	1994-04-01	Procedimiento para la preparacion de nuevos derivados de benzofuranil-imidazol.
ES8206544A1 (es)	1982-08-16	Procedimiento para la preparacion de 4-carbamoiloxi-oxaza- fosforinas
HUT75343A (en)	1997-05-28	Anthracycline disaccharides, process for their preparation, and pharmaceutical compositions containing the said compds.
ZA924888B (en)	1993-04-28	Process for the synthesis of enantiomers of 3-aminochroman compounds