ZA912015B - Substituted purines,processes for their preparation and their use as antiviral agents - Google Patents

Substituted purines,processes for their preparation and their use as antiviral agents

Info

Publication number: ZA912015B
Authority: ZA; South Africa
Prior art keywords: ch2ph; alkyl; dialkylamino; processes; preparation
Prior art date: 1990-03-20

Application number

ZA912015A

Other languages

English (en)

Inventor

Gerhard Jaehne

Jaehne Gerhard

Manfred Roesner

Roesner Manfred

Irvin Winkler

Winkler Irvin

Matthias Helsberg

Helsberg Matthias

Thomas Scholl

Scholl Thomas

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-20

Filing date

1991-03-19

Publication date

1991-12-24

1991-03-19 Application filed by Hoechst Ag filed Critical Hoechst Ag

1991-12-24 Publication of ZA912015B publication Critical patent/ZA912015B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)

ZA912015A 1990-03-20 1991-03-19 Substituted purines,processes for their preparation and their use as antiviral agents ZA912015B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4008858A DE4008858A1 (de)	1990-03-20	1990-03-20	Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel

Publications (1)

Publication Number	Publication Date
ZA912015B true ZA912015B (en)	1991-12-24

Family

ID=6402601

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA912015A ZA912015B (en)	1990-03-20	1991-03-19	Substituted purines,processes for their preparation and their use as antiviral agents

Country Status (19)

Country	Link
EP (1)	EP0452680B1 (hu)
JP (1)	JP3146423B2 (hu)
KR (1)	KR910016751A (hu)
CN (1)	CN1054982A (hu)
AT (1)	ATE144984T1 (hu)
AU (1)	AU644414B2 (hu)
CA (1)	CA2038589A1 (hu)
CS (1)	CS70891A2 (hu)
DE (2)	DE4008858A1 (hu)
DK (1)	DK0452680T3 (hu)
ES (1)	ES2093651T3 (hu)
FI (1)	FI911310L (hu)
GR (1)	GR3021591T3 (hu)
HU (1)	HUT57764A (hu)
IE (1)	IE910908A1 (hu)
IL (1)	IL97586A0 (hu)
NO (1)	NO911081L (hu)
PT (1)	PT97080A (hu)
ZA (1)	ZA912015B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4210221A1 (de) *	1992-03-28	1993-09-30	Hoechst Ag	Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung
EP0589335B1 (de) *	1992-09-24	2003-06-18	Hoechst Aktiengesellschaft	N1-Substituierte 1H-1,2,3-Triazolo[4,5-d]pyrimidine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
DE4311801A1 (de) *	1993-04-09	1994-10-13	Hoechst Ag	Neue Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung
DE19536164A1 (de) *	1995-09-28	1997-04-03	Boehringer Ingelheim Kg	Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
US5891881A (en) *	1997-11-21	1999-04-06	Clarion Pharmaceuticals Inc.	Aminoheterocycle-substituted glycerols
FR2793794B1 (fr) *	1999-05-21	2001-07-27	Hoechst Marion Roussel Inc	Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
PE20030008A1 (es)	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1523865A (en) *	1974-09-02	1978-09-06	Wellcome Found	Purine compunds and salts thereof
US4816447A (en) *	1981-08-26	1989-03-28	Merck & Co., Inc.	Anti-viral guanine compounds
DE3627024A1 (de) *	1985-09-24	1987-04-02	Hoechst Ag	In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.

1990
- 1990-03-20 DE DE4008858A patent/DE4008858A1/de not_active Withdrawn
1991
- 1991-03-18 IL IL97586A patent/IL97586A0/xx unknown
- 1991-03-18 AT AT91104126T patent/ATE144984T1/de not_active IP Right Cessation
- 1991-03-18 DK DK91104126.7T patent/DK0452680T3/da active
- 1991-03-18 DE DE59108319T patent/DE59108319D1/de not_active Expired - Lifetime
- 1991-03-18 CS CS91708A patent/CS70891A2/cs unknown
- 1991-03-18 EP EP91104126A patent/EP0452680B1/de not_active Expired - Lifetime
- 1991-03-18 FI FI911310A patent/FI911310L/fi unknown
- 1991-03-18 ES ES91104126T patent/ES2093651T3/es not_active Expired - Lifetime
- 1991-03-19 CA CA002038589A patent/CA2038589A1/en not_active Abandoned
- 1991-03-19 CN CN91101664A patent/CN1054982A/zh active Pending
- 1991-03-19 IE IE090891A patent/IE910908A1/en unknown
- 1991-03-19 PT PT97080A patent/PT97080A/pt not_active Application Discontinuation
- 1991-03-19 KR KR1019910004302A patent/KR910016751A/ko not_active Withdrawn
- 1991-03-19 NO NO91911081A patent/NO911081L/no unknown
- 1991-03-19 AU AU73514/91A patent/AU644414B2/en not_active Ceased
- 1991-03-19 ZA ZA912015A patent/ZA912015B/xx unknown
- 1991-03-19 JP JP07829291A patent/JP3146423B2/ja not_active Expired - Lifetime
- 1991-03-20 HU HU91928A patent/HUT57764A/hu unknown
1996
- 1996-11-08 GR GR960402968T patent/GR3021591T3/el unknown

Also Published As

Publication number	Publication date
CA2038589A1 (en)	1991-09-21
JPH04217984A (ja)	1992-08-07
IE910908A1 (en)	1991-09-25
CS70891A2 (en)	1991-11-12
EP0452680A1 (de)	1991-10-23
ATE144984T1 (de)	1996-11-15
AU7351491A (en)	1991-09-26
NO911081L (no)	1991-09-23
ES2093651T3 (es)	1997-01-01
AU644414B2 (en)	1993-12-09
IL97586A0 (en)	1992-06-21
HUT57764A (en)	1991-12-30
FI911310L (fi)	1991-09-21
JP3146423B2 (ja)	2001-03-19
FI911310A0 (fi)	1991-03-18
NO911081D0 (no)	1991-03-19
DK0452680T3 (da)	1997-04-07
PT97080A (pt)	1991-11-29
DE59108319D1 (de)	1996-12-12
KR910016751A (ko)	1991-11-05
HU910928D0 (en)	1991-10-28
DE4008858A1 (de)	1991-09-26
EP0452680B1 (de)	1996-11-06
CN1054982A (zh)	1991-10-02
GR3021591T3 (en)	1997-02-28

Publication	Publication Date	Title
YU218788A (en)	1990-12-31	Process for preparing substituted propan-phosphinic acids
GR3023130T3 (en)	1997-07-30	Phosphotriester-type biologically active compounds.
IE872650L (en)	1988-04-07	Imidazopyridine derivatives, their production, and¹pharmaceutical compositions containing them
PL247394A1 (en)	1984-10-22	Process for preparing derivatives of purine
HK1097776A1 (en)	2007-07-06	ß-L-2'-DEOXY-NUCLEOSIDES FOR THE TREATMENT OF HEPATITIS B
ZA912015B (en)	1991-12-24	Substituted purines,processes for their preparation and their use as antiviral agents
DE3376325D1 (en)	1988-05-26	Antiviral purine derivatives
DE68929277D1 (de)	2001-02-08	Verfahren zur Herstellung von Purinderivaten
EP0371139A4 (en)	1991-08-28	6-substituted acyclicpyrimidine nucleoside derivatives and antiviral agents containing same as active ingredients
EP0310673A4 (en)	1990-10-10	2'-alkylidenepyrimidine nucleoside derivatives, process for their preparation, and their use
ES2013379A6 (es)	1990-05-01	Procedimiento para preparar 6-sulfenamido-6, sulfinamido- y 6-sulfonamido-purinas, nucleosidos de purinas y nucleotidos de purinas antitumorales.
AU2631188A (en)	1989-06-15	9-(2-(Phosphonomethoxy)Ethoxy) Purine derivatives, intermediates and use as pharmaceuticals
AU5042896A (en)	1996-10-31	Nitric esters from derivatives of 2-(2-6-dihalophenylamino) phenylacetoxyacetic acid and their preparation process
GR3023261T3 (en)	1997-07-30	Process for the preparation of carbohydrate derived surfactants and their precursors
GB2016002A (en)	1979-09-19	Amino derivatives of pyrazolo[1,5-A]S.triazine
AR032573A1 (es)	2003-11-12	Analogo de nucleosido de pirrolo [2,3-d] pirimidina
FR2449087A2 (fr)	1980-09-12	Nouveaux derives de l'isoquinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent