ZA911258B - Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz(cd)indole - Google Patents

Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz(cd)indole

Info

Publication number: ZA911258B
Authority: ZA; South Africa
Prior art keywords: tetrahydrobenz; aminocarbonyl; propyl; amino; indole
Prior art date: 1990-02-26

Application number

ZA911258A

Other languages

English (en)

Inventor

Thomas Joseph Kress

Joseph Kress Thomas

David Lee Varie

Lee Varie David

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-26

Filing date

1991-02-20

Publication date

1992-10-28

1991-02-20 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1992-10-28 Publication of ZA911258B publication Critical patent/ZA911258B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA911258A 1990-02-26 1991-02-20 Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz(cd)indole ZA911258B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48518590A	1990-02-26	1990-02-26

Publications (1)

Publication Number	Publication Date
ZA911258B true ZA911258B (en)	1992-10-28

Family

ID=23927224

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA911258A ZA911258B (en)	1990-02-26	1991-02-20	Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz(cd)indole

Country Status (28)

Country	Link
US (1)	US5397799A (xx)
EP (1)	EP0444852B1 (xx)
JP (1)	JP3157007B2 (xx)
KR (1)	KR100208114B1 (xx)
CN (1)	CN1027503C (xx)
AT (1)	ATE126506T1 (xx)
AU (1)	AU629453B2 (xx)
BR (1)	BR9100767A (xx)
CA (1)	CA2037099C (xx)
CY (1)	CY1887A (xx)
DE (1)	DE69112099T2 (xx)
DK (1)	DK0444852T3 (xx)
ES (1)	ES2077796T3 (xx)
FI (1)	FI95464C (xx)
GR (1)	GR3017940T3 (xx)
HK (1)	HK175495A (xx)
HU (1)	HU217118B (xx)
IE (1)	IE67801B1 (xx)
IL (1)	IL97306A (xx)
LV (1)	LV10251B (xx)
NO (1)	NO174149C (xx)
NZ (1)	NZ237181A (xx)
PT (1)	PT96852B (xx)
RU (2)	RU2034837C1 (xx)
SG (1)	SG69975A1 (xx)
TW (1)	TW219933B (xx)
YU (1)	YU47594B (xx)
ZA (1)	ZA911258B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5302612A (en) *	1990-02-26	1994-04-12	Eli Lilly And Company	6-substituted-hexahydrobenz[cd]indoles
IL97308A (en) *	1990-02-26	1996-10-31	Lilly Co Eli	Xahydrobenz [DC] Induced indoles in position 6, their preparation process and pharmaceutical preparations containing them
IL97309A (en) *	1990-02-26	1996-11-14	Lilly Co Eli	Intermediates for hexahydrobenz] [DC indoles and a process for making their pure enantiomers
US5364856A (en) *	1991-03-28	1994-11-15	Eli Lilly And Company	6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5654324A (en) *	1991-03-28	1997-08-05	Eli Lilly And Company	6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[cd]indoles
TW248556B (xx) *	1993-01-18	1995-06-01	Takeda Pharm Industry Co
US7588924B2 (en)	2006-03-07	2009-09-15	Procter & Gamble Company	Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
PL2044005T3 (pl)	2006-06-26	2011-04-29	Akebia Therapeutics Inc	Inhibitory hydroksylazy prolilowej oraz metody ich wykorzystania
EP2496082B1 (en)	2009-11-06	2016-10-12	Aerpio Therapeutics, Inc.	Methods for increasing the stabilization of hypoxia inducible factor-1 alpha
NO2686520T3 (xx)	2011-06-06	2018-03-17
AU2012268400C1 (en)	2011-06-06	2016-12-22	Akebia Therapeutics Inc.	Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
CA2914662C (en)	2013-06-13	2022-05-31	Robert Shalwitz	Compositions and methods for treating anemia
CR20200220A (es)	2013-11-15	2020-11-18	Akebia Therapeutics Inc	FORMAS SÓLIDAS DE ÁCIDO {[5-(3-CLOROFENIL)-3-HIDROXIPIRIDIN-2-CARBONIL]AMINO}ACÉTICO, COMPOSICIONES, Y USOS DE LAS MISMAS (Divisional 2016-0222)
US10150734B2 (en)	2015-01-23	2018-12-11	Akebia Therapeutics, Inc.	Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
KR20240038132A (ko)	2015-04-01	2024-03-22	아케비아 테라퓨틱스 인코포레이티드	빈혈 치료용 조성물 및 방법
CA3097219A1 (en)	2018-05-09	2019-11-14	Akebia Therapeutics, Inc.	Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US11524939B2 (en)	2019-11-13	2022-12-13	Akebia Therapeutics, Inc.	Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4110339A (en) *	1977-11-25	1978-08-29	Eli Lilly And Company	4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) *	1984-02-06	1986-03-18	Eli Lilly And Company	6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) *	1987-03-12	1988-05-17	Eli Lilly And Company	Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) *	1988-03-18	1989-09-28	Bayer Ag	1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) *	1989-04-11	1993-04-20	Eli Lilly And Company	Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) *	1990-08-15	1993-07-20	Eli Lilly And Company	6-substituted-tetrahydrobenz[cd]indoles

1990
- 1990-06-26 TW TW079105258A patent/TW219933B/zh active
1991
- 1991-02-20 ZA ZA911258A patent/ZA911258B/xx unknown
- 1991-02-20 IL IL9730691A patent/IL97306A/en not_active IP Right Cessation
- 1991-02-21 NZ NZ237181A patent/NZ237181A/en unknown
- 1991-02-22 PT PT96852A patent/PT96852B/pt not_active IP Right Cessation
- 1991-02-22 JP JP05064391A patent/JP3157007B2/ja not_active Expired - Fee Related
- 1991-02-25 YU YU32791A patent/YU47594B/sh unknown
- 1991-02-25 HU HU91629A patent/HU217118B/hu unknown
- 1991-02-25 RU SU914894699A patent/RU2034837C1/ru not_active IP Right Cessation
- 1991-02-25 KR KR1019910003029A patent/KR100208114B1/ko not_active IP Right Cessation
- 1991-02-25 IE IE62591A patent/IE67801B1/en not_active IP Right Cessation
- 1991-02-25 FI FI910895A patent/FI95464C/fi active
- 1991-02-25 AU AU71971/91A patent/AU629453B2/en not_active Ceased
- 1991-02-25 NO NO910735A patent/NO174149C/no unknown
- 1991-02-26 AT AT91301501T patent/ATE126506T1/de not_active IP Right Cessation
- 1991-02-26 CN CN91101296A patent/CN1027503C/zh not_active Expired - Fee Related
- 1991-02-26 SG SG1996007257A patent/SG69975A1/en unknown
- 1991-02-26 CA CA002037099A patent/CA2037099C/en not_active Expired - Fee Related
- 1991-02-26 DE DE69112099T patent/DE69112099T2/de not_active Expired - Fee Related
- 1991-02-26 EP EP91301501A patent/EP0444852B1/en not_active Expired - Lifetime
- 1991-02-26 BR BR919100767A patent/BR9100767A/pt not_active Application Discontinuation
- 1991-02-26 DK DK91301501.2T patent/DK0444852T3/da active
- 1991-02-26 ES ES91301501T patent/ES2077796T3/es not_active Expired - Lifetime
1992
- 1992-12-03 RU RU9292004575A patent/RU2083561C1/ru not_active IP Right Cessation
1993
- 1993-05-19 US US08/064,539 patent/US5397799A/en not_active Expired - Lifetime
- 1993-06-08 LV LVP-93-509A patent/LV10251B/xx unknown
1995
- 1995-11-01 GR GR950403048T patent/GR3017940T3/el unknown
- 1995-11-16 HK HK175495A patent/HK175495A/xx not_active IP Right Cessation
1996
- 1996-04-05 CY CY188796A patent/CY1887A/xx unknown

Also Published As

Publication number	Publication date
IL97306A0 (en)	1992-05-25
RU2083561C1 (ru)	1997-07-10
HUT56542A (en)	1991-09-30
FI95464C (fi)	1996-02-12
YU47594B (sh)	1995-10-24
DE69112099T2 (de)	1996-02-08
PT96852A (pt)	1991-10-31
US5397799A (en)	1995-03-14
CA2037099A1 (en)	1991-08-27
SG69975A1 (en)	2000-01-25
AU7197191A (en)	1991-08-29
IL97306A (en)	1996-10-16
NO910735D0 (no)	1991-02-25
NO174149C (no)	1994-03-23
IE67801B1 (en)	1996-05-01
DK0444852T3 (da)	1995-12-11
FI910895A (fi)	1991-08-27
TW219933B (xx)	1994-02-01
JPH04217662A (ja)	1992-08-07
CN1054589A (zh)	1991-09-18
EP0444852A2 (en)	1991-09-04
LV10251B (en)	1995-04-20
FI910895A0 (fi)	1991-02-25
CN1027503C (zh)	1995-01-25
LV10251A (lv)	1994-10-20
NO174149B (no)	1993-12-13
ES2077796T3 (es)	1995-12-01
GR3017940T3 (en)	1996-02-29
YU32791A (sh)	1994-01-20
DE69112099D1 (de)	1995-09-21
CY1887A (en)	1996-04-05
HK175495A (en)	1995-11-24
HU217118B (hu)	1999-11-29
ATE126506T1 (de)	1995-09-15
EP0444852A3 (en)	1992-02-19
NO910735L (no)	1991-08-27
EP0444852B1 (en)	1995-08-16
CA2037099C (en)	2001-09-11
FI95464B (fi)	1995-10-31
AU629453B2 (en)	1992-10-01
KR910021375A (ko)	1991-12-20
NZ237181A (en)	1992-06-25
JP3157007B2 (ja)	2001-04-16
RU2034837C1 (ru)	1995-05-10
BR9100767A (pt)	1991-10-29
IE910625A1 (en)	1991-08-28
PT96852B (pt)	1998-07-31
KR100208114B1 (ko)	1999-07-15

Publication	Publication Date	Title
CY1887A (en)	1996-04-05	Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl- 1,3,4,5-tetrahydrobenz(cd)indole
IE782325L (en)	1979-05-25	TETRAHYDROBENZ £cd\| INDOLES
YU16989A (en)	1991-10-31	Amfiregulin - new bifunctional glicoprotein for growth modulation
EP0429257A3 (en)	1992-01-29	Indole derivatives
PL295148A1 (en)	1993-06-14	Method of obtaining novel derivatives of (3 r,4 s)-azetydynone-2
AU2867689A (en)	1989-07-20	Felt-like implant
AP9400706A0 (en)	1995-01-31	Indole derivatives, method of preparation and use
RU92004575A (ru)	1995-09-27	Кристаллическая соль 4-(ди-н-пропил) амино-6-аминокарбонил-1,3,4,5-тетрагидробенз (cd) индола и ее 4p и 4s-изомеры
ZA905524B (en)	1991-05-29	Indole derivatives
HU9302749D0 (en)	1993-12-28	6-heterocyclic-4-amino-1`,3,4,5-tetrahydrobenz/cd/indoles
AU8240791A (en)	1992-02-20	6-substituted-hexahydrobenz(cd)indoles
AU7418887A (en)	1987-12-17	Indole derivatives
AU7476787A (en)	1988-01-07	Indole derivatives
AU590603B2 (en)	1989-11-09	A method of preparing indoles or indole derivatives, coupled via position 4, 5, 6, or 7, the indoles or indole derivatives concerned, as well as the use thereof
AU589745B2 (en)	1989-10-19	2', 3', 4', 10'-tetrahydro-10'-substituted-10'-hydroxy-spiro ((cycloalkane or heterocyclic)-pyrimido(1,2a)indoles
YU48489A (en)	1991-10-31	Indole derivatives and process for preparing thereof
PL286424A1 (en)	1992-06-26	Method of obtaining novel indole derivatives
PL274219A1 (en)	1990-02-19	Method of obtaining novel derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline
GB8912329D0 (en)	1989-07-12	Indole derivatives
IE862252L (en)	1987-02-23	"a method of preparing indoles or indole derivatives,¹coupled via position 4,5,6, or 7, the indoles or indole¹derivatives concerned, as well as the use thereof"
HRP940625A2 (en)	1996-06-30	Indole derivatives