ZA904231B - Antihyperlipidemic and antiatherosclerotic urea compounds - Google Patents
Antihyperlipidemic and antiatherosclerotic urea compoundsInfo
- Publication number
- ZA904231B ZA904231B ZA904231A ZA904231A ZA904231B ZA 904231 B ZA904231 B ZA 904231B ZA 904231 A ZA904231 A ZA 904231A ZA 904231 A ZA904231 A ZA 904231A ZA 904231 B ZA904231 B ZA 904231B
- Authority
- ZA
- South Africa
- Prior art keywords
- antiatherosclerotic
- antihyperlipidemic
- urea compounds
- cholesterol
- thiourea
- Prior art date
Links
- 150000003672 ureas Chemical class 0.000 title abstract 2
- 230000000879 anti-atherosclerotic effect Effects 0.000 title 1
- 230000001315 anti-hyperlipaemic effect Effects 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical class NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical class NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000031891 intestinal absorption Effects 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003558 thiocarbamic acid derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/359,830 US5015644A (en) | 1987-06-02 | 1989-06-01 | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA904231B true ZA904231B (en) | 1992-02-26 |
Family
ID=23415467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA904231A ZA904231B (en) | 1989-06-01 | 1990-06-01 | Antihyperlipidemic and antiatherosclerotic urea compounds |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5015644A (xx) |
| EP (1) | EP0474733B1 (xx) |
| JP (1) | JP2799242B2 (xx) |
| AT (1) | ATE110713T1 (xx) |
| AU (1) | AU5675990A (xx) |
| CA (1) | CA2054209C (xx) |
| DE (1) | DE69012116T2 (xx) |
| DK (1) | DK0474733T3 (xx) |
| IE (1) | IE64603B1 (xx) |
| PT (1) | PT94231A (xx) |
| WO (1) | WO1990015048A1 (xx) |
| ZA (1) | ZA904231B (xx) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
| IL100915A (en) * | 1991-02-19 | 1996-03-31 | Erba Carlo Spa | Disubstituted ureas and thioureas their preparation and pharmaceutical compositions containing them |
| FR2679555B1 (fr) * | 1991-07-25 | 1993-11-19 | Fabre Medicament Pierre | Nouveaux derives de l'uree, leur preparation et leur application en therapeutique. |
| RU94046149A (ru) * | 1992-05-28 | 1996-11-27 | Пфайзер Инк. (US) | Новые n-арил и n-гетероарил производные мочевины как ингибиторы ацил кофермента а:холестерин ацил трансферазы (асат) фармацевтическая композиция, способ ингибирования (асат) |
| AU672699B2 (en) * | 1993-06-30 | 1996-10-10 | Sankyo Company Limited | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses |
| US5362744A (en) * | 1993-11-22 | 1994-11-08 | Warner-Lambert Company | Tetrazole-substituted urea acat inhibitors |
| US5441984A (en) * | 1994-01-06 | 1995-08-15 | Eli Lilly And Company | Urea, thiourea and guanidine derivatives |
| US5461049A (en) * | 1994-05-27 | 1995-10-24 | Warner-Lambert Company | Amide tetrazole ACAT inhibitors |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| EP0742208A1 (en) * | 1995-05-05 | 1996-11-13 | Grelan Pharmaceutical Co., Ltd. | 2-Ureido-benzamide derivatives |
| US6127422A (en) * | 1996-05-06 | 2000-10-03 | Eli Lilly And Company | Anti-viral method |
| US6156924A (en) * | 1996-05-06 | 2000-12-05 | Eli Lilly And Company | Anti-viral compounds |
| SI0806408T1 (en) * | 1996-05-06 | 2001-04-30 | Lilly Co Eli | Anti-viral compounds |
| EP0806205A3 (en) * | 1996-05-06 | 1997-11-19 | Eli Lilly And Company | Urea, thiourea and guanidine compounds and their use as anti-viral agents |
| PT811599E (pt) | 1996-05-06 | 2001-06-29 | Lilly Co Eli | Compostos anti-virais |
| US6103923A (en) * | 1996-05-06 | 2000-08-15 | Eli Lilly And Company | Anti-viral compounds |
| CA2253857A1 (en) * | 1996-05-06 | 1997-11-13 | Scott Carl Mauldin | Anti-viral compounds |
| US6096917A (en) * | 1997-05-02 | 2000-08-01 | Eli Lilly And Company | Anti-viral compounds |
| PT1047678E (pt) * | 1997-12-16 | 2004-12-31 | Warner Lambert Co | Derivados do 1-aminometil-cicloalcano substituido em 1 (=analogos da gabapentina) sua preparacao e sua utilizacao no tratamento de disturbios neurologicos |
| US6605623B1 (en) | 1998-12-18 | 2003-08-12 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| WO2001017953A1 (en) * | 1999-09-08 | 2001-03-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
| SK10972002A3 (sk) * | 2000-02-02 | 2003-07-01 | Warner-Lambert Company | Duálne inhibítory cholesterylesteru a syntéza voskového esteru na liečenie ochorení tukových žliaz |
| US6175034B1 (en) | 2000-04-10 | 2001-01-16 | Eli Lilly And Company | Anti-viral compounds |
| GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
| CA2435829A1 (en) | 2001-01-25 | 2002-08-01 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
| US20040072903A1 (en) * | 2001-05-08 | 2004-04-15 | Auerbach Bruce Jeffrey | Carboxyalkylether-acat inhibitors combinations |
| US7173151B2 (en) * | 2003-02-27 | 2007-02-06 | Sanofi-Aventisdeutschand Gmbh | Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals |
| DK1725234T4 (en) | 2004-03-05 | 2016-05-09 | Univ Pennsylvania | METHODS OF TREATING DISEASES OR DISEASES CONNECTED WITH HYPERLIPIDEMIA AND HYPERCOLESTEROLYMIA WITH MINIMIZATION OF SIDE EFFECTS |
| KR101294014B1 (ko) * | 2006-01-06 | 2013-08-09 | 선오비온 파마슈티컬스 인코포레이티드 | 모노아민 재흡수 저해제로서의 시클로알킬아민 |
| US7989500B2 (en) | 2006-09-15 | 2011-08-02 | Reviva Pharmaceuticals, Inc. | Synthesis, methods of using, and compositions of cycloalkylmethylamines |
| WO2008045564A2 (en) * | 2006-10-12 | 2008-04-17 | Epix Delaware, Inc. | Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor |
| US20080161279A1 (en) * | 2006-12-21 | 2008-07-03 | Wisler Gerald L | Methods of Treating Obesity |
| KR20100102646A (ko) | 2007-12-11 | 2010-09-24 | 가부시키가이샤 사이토파스파인더 | 카르복스아미드 화합물 및 케모카인 수용체 길항제로서의 이의 용도 |
| EP3025727A1 (en) | 2008-10-02 | 2016-06-01 | The J. David Gladstone Institutes | Methods of treating liver disease |
| WO2012003501A2 (en) | 2010-07-02 | 2012-01-05 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives |
| NZ630828A (en) | 2012-03-22 | 2016-10-28 | Univ Michigan | Compounds and methods for treating aberrant adrenocartical cell disorders |
| DK3102195T3 (da) | 2014-02-03 | 2021-12-20 | Quadriga Biosciences Inc | Beta-substituerede beta-aminosyrer og analoger som kemoterapeutiske midler |
| BR112016017993A2 (pt) | 2014-02-03 | 2017-08-08 | Quadriga Biosciences Inc | Gama-aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos |
| CA2962597A1 (en) * | 2014-09-26 | 2016-03-31 | Millendo Therapeutics, Inc. | Solid drug form of n-(2,6-bis(1-methylethyl)phenyl)-n'-((1-(4-(dimethylamino)phenyl)cyclopentyl) methyl)urea hydrochloride and compositions, methods and kits related thereto |
| US20160287565A1 (en) | 2015-04-06 | 2016-10-06 | Millendo Therapeutics, Inc. | Combination therapy for treating disorders associated with excess cortisol production |
| CN108026026B (zh) | 2015-08-03 | 2021-02-09 | 夸德里加生物科学公司 | 作为化疗剂的β-取代的β-氨基酸和类似物及其应用 |
| CN112441941B (zh) * | 2020-12-03 | 2022-08-02 | 浙江荣耀生物科技股份有限公司 | 一种1-(4-氨基苯基)环戊基甲腈的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3852343A (en) * | 1970-07-22 | 1974-12-03 | Labofina Sa | A process for the production of benzene carboxylic acids from ethyl substituted benzens |
| EP0049538A3 (de) * | 1979-07-14 | 1982-10-13 | Bayer Ag | Verwendung von Thioharnstoffderivaten als Arzneimittel bei der Behandlung von Fettstoffwechselstörungen |
| DE2945530A1 (de) * | 1979-11-10 | 1981-06-04 | Chemische Werke Hüls AG, 4370 Marl | Harnstoffe mit cyclischen substituenten, ihre herstellung und verwendung als herbizide |
| GB2080808B (en) * | 1980-01-25 | 1984-01-04 | Reanal Finomvegyszergyar | Process for the preparation of n-aryl-n-(mono- or disubstituted)-urea derivatives |
| US4397868A (en) * | 1982-01-26 | 1983-08-09 | American Cyanamid Company | Method of treating atherosclerosis with trisubstituted ureas |
| US4387105A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Methods of treating atherosclerosis with dialkylureas and dialkylthioureas |
| US4623662A (en) * | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
| IE61716B1 (en) * | 1987-06-02 | 1994-11-30 | Warner Lambert Co | Antihyperlipidemic and antiatherosclerotic urea compounds |
-
1989
- 1989-06-01 US US07/359,830 patent/US5015644A/en not_active Expired - Lifetime
-
1990
- 1990-05-31 WO PCT/US1990/003055 patent/WO1990015048A1/en active IP Right Grant
- 1990-05-31 CA CA002054209A patent/CA2054209C/en not_active Expired - Fee Related
- 1990-05-31 AU AU56759/90A patent/AU5675990A/en not_active Abandoned
- 1990-05-31 EP EP90908860A patent/EP0474733B1/en not_active Expired - Lifetime
- 1990-05-31 JP JP2508304A patent/JP2799242B2/ja not_active Expired - Fee Related
- 1990-05-31 DK DK90908860.1T patent/DK0474733T3/da active
- 1990-05-31 DE DE69012116T patent/DE69012116T2/de not_active Expired - Fee Related
- 1990-05-31 AT AT90908860T patent/ATE110713T1/de not_active IP Right Cessation
- 1990-06-01 ZA ZA904231A patent/ZA904231B/xx unknown
- 1990-06-01 IE IE198390A patent/IE64603B1/en not_active IP Right Cessation
- 1990-06-01 PT PT94231A patent/PT94231A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IE64603B1 (en) | 1995-08-23 |
| DK0474733T3 (da) | 1994-11-21 |
| EP0474733B1 (en) | 1994-08-31 |
| IE901983L (en) | 1990-12-01 |
| EP0474733A1 (en) | 1992-03-18 |
| US5015644A (en) | 1991-05-14 |
| WO1990015048A1 (en) | 1990-12-13 |
| DE69012116T2 (de) | 1994-12-22 |
| AU5675990A (en) | 1991-01-07 |
| CA2054209A1 (en) | 1990-12-02 |
| JPH04505617A (ja) | 1992-10-01 |
| JP2799242B2 (ja) | 1998-09-17 |
| DE69012116D1 (de) | 1994-10-06 |
| CA2054209C (en) | 2002-01-15 |
| ATE110713T1 (de) | 1994-09-15 |
| PT94231A (pt) | 1991-02-08 |
| IE901983A1 (en) | 1991-01-02 |
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