ZA832672B - Gestagenically active 11 -chloro-steroids and their manufacture and use - Google Patents
Gestagenically active 11 -chloro-steroids and their manufacture and useInfo
- Publication number
- ZA832672B ZA832672B ZA832672A ZA832672A ZA832672B ZA 832672 B ZA832672 B ZA 832672B ZA 832672 A ZA832672 A ZA 832672A ZA 832672 A ZA832672 A ZA 832672A ZA 832672 B ZA832672 B ZA 832672B
- Authority
- ZA
- South Africa
- Prior art keywords
- general formula
- group
- see diagramm
- beta
- hydrogen
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 organometallic chloroethynyl compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
(for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) 1. 11 beta-chlorosteroids of general formula I see diagramm : EP0092173,P6,F1 wherein R is hydrogen or an acyl group of an organic carboxylic acid of up to 15 carbon atoms. (for the Contracting : AT) Process for the preparation of 11 beta-chlorosteroids of general formula I see diagramm : EP0092173,P7,F1 wherein R is hydrogen or an acyl group of an organic carboxylic acid of up 15 carbon atoms characterized in that a 11 beta-chloro-17-oxosteroid of the general formula II see diagramm : EP0092173,P7,F2 wherein, Y is a free oxo group of a hydrolyzable protected oxo group and see diagramm : EP0092173,P7,F3 is a double bond in the 4,5-, 5,6- or 5,10-positions or two double bonds in the 3- and 5-positions, is converted, in a known manner, with an organometallic chloroethynyl compound to a compound of general formula I in which R is hydrogen, a primary introduced 3-oxo protecting group is hydrolyzed and depending on the finally desired meaning of R, the 17-hydroxy group is optionally esterified, before or after removal of the protecting group.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823214689 DE3214689A1 (en) | 1982-04-16 | 1982-04-16 | 11SS CHLORINE STEROIDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA832672B true ZA832672B (en) | 1983-12-28 |
Family
ID=6161447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA832672A ZA832672B (en) | 1982-04-16 | 1983-04-15 | Gestagenically active 11 -chloro-steroids and their manufacture and use |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0092173B1 (en) |
| JP (1) | JPS58188899A (en) |
| AT (1) | ATE18407T1 (en) |
| AU (1) | AU555284B2 (en) |
| CA (1) | CA1242697A (en) |
| DD (1) | DD209635A5 (en) |
| DE (2) | DE3214689A1 (en) |
| DK (1) | DK92283A (en) |
| ES (1) | ES520207A0 (en) |
| GR (1) | GR78212B (en) |
| HU (1) | HU186687B (en) |
| ZA (1) | ZA832672B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4232521A1 (en) * | 1992-09-22 | 1994-03-24 | Schering Ag | Progestagenic 4,5; 11,12-estradienes, processes for their preparation, medicaments containing these estradienes and their use for the production of medicaments |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE651797A (en) * | 1962-10-17 | |||
| US3665021A (en) * | 1966-07-29 | 1972-05-23 | Glaxo Lab Ltd | 9alpha-unsubstituted-11beta-chloro-l9 nos-steroids |
| NL7209299A (en) * | 1972-07-01 | 1974-01-03 | Delta-4-3-oxo-11-beta-halo steroids - with hormonal activity |
-
1982
- 1982-04-16 DE DE19823214689 patent/DE3214689A1/en not_active Withdrawn
-
1983
- 1983-02-25 DK DK92283A patent/DK92283A/en not_active Application Discontinuation
- 1983-03-01 ES ES520207A patent/ES520207A0/en active Granted
- 1983-03-16 AU AU12487/83A patent/AU555284B2/en not_active Ceased
- 1983-04-13 JP JP58063807A patent/JPS58188899A/en active Pending
- 1983-04-14 DD DD83249873A patent/DD209635A5/en unknown
- 1983-04-14 AT AT83103604T patent/ATE18407T1/en not_active IP Right Cessation
- 1983-04-14 EP EP83103604A patent/EP0092173B1/en not_active Expired
- 1983-04-14 GR GR71089A patent/GR78212B/el unknown
- 1983-04-14 DE DE8383103604T patent/DE3362380D1/en not_active Expired
- 1983-04-15 CA CA000426012A patent/CA1242697A/en not_active Expired
- 1983-04-15 ZA ZA832672A patent/ZA832672B/en unknown
- 1983-04-15 HU HU831327A patent/HU186687B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES8401096A1 (en) | 1983-12-01 |
| DK92283A (en) | 1983-10-17 |
| DK92283D0 (en) | 1983-02-25 |
| GR78212B (en) | 1984-09-26 |
| CA1242697A (en) | 1988-10-04 |
| ATE18407T1 (en) | 1986-03-15 |
| DD209635A5 (en) | 1984-05-16 |
| EP0092173B1 (en) | 1986-03-05 |
| AU555284B2 (en) | 1986-09-18 |
| EP0092173A1 (en) | 1983-10-26 |
| ES520207A0 (en) | 1983-12-01 |
| AU1248783A (en) | 1983-10-20 |
| DE3362380D1 (en) | 1986-04-10 |
| HU186687B (en) | 1985-09-30 |
| DE3214689A1 (en) | 1983-10-27 |
| JPS58188899A (en) | 1983-11-04 |
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