ZA828641B - Tridigitoxosides, processes for their preparation and pharmaceutical compositions thereof - Google Patents
Tridigitoxosides, processes for their preparation and pharmaceutical compositions thereofInfo
- Publication number
- ZA828641B ZA828641B ZA828641A ZA828641A ZA828641B ZA 828641 B ZA828641 B ZA 828641B ZA 828641 A ZA828641 A ZA 828641A ZA 828641 A ZA828641 A ZA 828641A ZA 828641 B ZA828641 B ZA 828641B
- Authority
- ZA
- South Africa
- Prior art keywords
- preparation
- tridigitoxosides
- processes
- pharmaceutical compositions
- oximes
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- HCUOEKSZWPGJIM-YBRHCDHNSA-N (e,2e)-2-hydroxyimino-6-methoxy-4-methyl-5-nitrohex-3-enamide Chemical compound COCC([N+]([O-])=O)\C(C)=C\C(=N/O)\C(N)=O HCUOEKSZWPGJIM-YBRHCDHNSA-N 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 101001109689 Homo sapiens Nuclear receptor subfamily 4 group A member 3 Proteins 0.000 abstract 1
- 101000598778 Homo sapiens Protein OSCP1 Proteins 0.000 abstract 1
- 101001067395 Mus musculus Phospholipid scramblase 1 Proteins 0.000 abstract 1
- 102100022673 Nuclear receptor subfamily 4 group A member 3 Human genes 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 125000005646 oximino group Chemical group 0.000 abstract 1
- -1 tridigitoxoside oximes Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813146898 DE3146898A1 (de) | 1981-11-26 | 1981-11-26 | Neue oxime von 3'''-dehydro-cardenolid-tridigitoxosiden, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA828641B true ZA828641B (en) | 1983-10-26 |
Family
ID=6147266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA828641A ZA828641B (en) | 1981-11-26 | 1982-11-24 | Tridigitoxosides, processes for their preparation and pharmaceutical compositions thereof |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4461763A (cs) |
| EP (1) | EP0080674B1 (cs) |
| JP (1) | JPS5892700A (cs) |
| KR (1) | KR840002411A (cs) |
| AT (1) | ATE12240T1 (cs) |
| AU (1) | AU9075482A (cs) |
| CA (1) | CA1205072A (cs) |
| CS (1) | CS229946B2 (cs) |
| DD (1) | DD204929A5 (cs) |
| DE (2) | DE3146898A1 (cs) |
| DK (1) | DK523482A (cs) |
| ES (1) | ES8307838A1 (cs) |
| FI (1) | FI824061L (cs) |
| GR (1) | GR77740B (cs) |
| HU (1) | HU186171B (cs) |
| IL (1) | IL67323A0 (cs) |
| PT (1) | PT75900B (cs) |
| ZA (1) | ZA828641B (cs) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2233147A1 (de) * | 1972-07-06 | 1974-01-24 | Boehringer Mannheim Gmbh | Dihydrodigoxin-derivate |
| DE2343400C3 (de) * | 1973-08-29 | 1979-11-08 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur 12 ß -Hydroxylierung von Digitalis-Glykosiden der A-Reihe |
| US3981862A (en) * | 1974-04-13 | 1976-09-21 | Boehringer Mannheim G.M.B.H. | Preparation of C22-alkyl derivative of digoxin |
| US4021546A (en) * | 1976-03-08 | 1977-05-03 | Interx Research Corporation | Pro-drug forms of digoxin and method of preparing and using same |
| DE2926026A1 (de) * | 1979-06-28 | 1981-01-08 | Boehringer Mannheim Gmbh | Neue digoxin-derivate und verfahren zu ihrer herstellung |
-
1981
- 1981-11-26 DE DE19813146898 patent/DE3146898A1/de not_active Withdrawn
-
1982
- 1982-11-05 US US06/439,654 patent/US4461763A/en not_active Expired - Fee Related
- 1982-11-19 AU AU90754/82A patent/AU9075482A/en not_active Abandoned
- 1982-11-19 GR GR69862A patent/GR77740B/el unknown
- 1982-11-20 DE DE8282110728T patent/DE3262706D1/de not_active Expired
- 1982-11-20 EP EP82110728A patent/EP0080674B1/de not_active Expired
- 1982-11-20 AT AT82110728T patent/ATE12240T1/de not_active IP Right Cessation
- 1982-11-22 JP JP57203837A patent/JPS5892700A/ja active Pending
- 1982-11-22 KR KR1019820005258A patent/KR840002411A/ko unknown
- 1982-11-22 IL IL67323A patent/IL67323A0/xx unknown
- 1982-11-24 ZA ZA828641A patent/ZA828641B/xx unknown
- 1982-11-24 DK DK523482A patent/DK523482A/da not_active Application Discontinuation
- 1982-11-24 CS CS828427A patent/CS229946B2/cs unknown
- 1982-11-25 HU HU823794A patent/HU186171B/hu unknown
- 1982-11-25 CA CA000416399A patent/CA1205072A/en not_active Expired
- 1982-11-25 FI FI824061A patent/FI824061L/fi not_active Application Discontinuation
- 1982-11-25 PT PT75900A patent/PT75900B/pt unknown
- 1982-11-25 ES ES517674A patent/ES8307838A1/es not_active Expired
- 1982-11-25 DD DD82245218A patent/DD204929A5/de unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR77740B (cs) | 1984-09-25 |
| PT75900A (de) | 1982-12-01 |
| ES517674A0 (es) | 1983-08-16 |
| DK523482A (da) | 1983-05-27 |
| JPS5892700A (ja) | 1983-06-02 |
| EP0080674B1 (de) | 1985-03-20 |
| FI824061A0 (fi) | 1982-11-25 |
| HU186171B (en) | 1985-06-28 |
| KR840002411A (ko) | 1984-07-02 |
| PT75900B (de) | 1985-10-04 |
| US4461763A (en) | 1984-07-24 |
| AU9075482A (en) | 1983-06-02 |
| CS229946B2 (en) | 1984-07-16 |
| DE3146898A1 (de) | 1983-06-01 |
| DD204929A5 (de) | 1983-12-14 |
| CA1205072A (en) | 1986-05-27 |
| DE3262706D1 (en) | 1985-04-25 |
| ATE12240T1 (de) | 1985-04-15 |
| FI824061L (fi) | 1983-05-27 |
| EP0080674A1 (de) | 1983-06-08 |
| ES8307838A1 (es) | 1983-08-16 |
| IL67323A0 (en) | 1983-03-31 |
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