ZA201803661B - Compositions and methods for decreasing tau expression - Google Patents
Compositions and methods for decreasing tau expressionInfo
- Publication number
- ZA201803661B ZA201803661B ZA2018/03661A ZA201803661A ZA201803661B ZA 201803661 B ZA201803661 B ZA 201803661B ZA 2018/03661 A ZA2018/03661 A ZA 2018/03661A ZA 201803661 A ZA201803661 A ZA 201803661A ZA 201803661 B ZA201803661 B ZA 201803661B
- Authority
- ZA
- South Africa
- Prior art keywords
- compositions
- methods
- tau expression
- decreasing tau
- decreasing
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000003247 decreasing effect Effects 0.000 title abstract 2
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/30—Chemical structure
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
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Abstract
Provided herein are compositions and methods for decreasing tau mRNA and protein expression. These compositions and methods are useful in treating tau-related diseases and disorders.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562270165P | 2015-12-21 | 2015-12-21 | |
PCT/IB2016/057794 WO2017109679A1 (en) | 2015-12-21 | 2016-12-19 | Compositions and methods for decreasing tau expression |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA201803661B true ZA201803661B (en) | 2024-08-28 |
Family
ID=57758674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA2018/03661A ZA201803661B (en) | 2015-12-21 | 2018-06-01 | Compositions and methods for decreasing tau expression |
Country Status (39)
Country | Link |
---|---|
US (2) | US11473083B2 (en) |
EP (2) | EP3394259B1 (en) |
JP (4) | JP7027328B2 (en) |
CN (2) | CN109072237B (en) |
AR (1) | AR107579A1 (en) |
AU (2) | AU2016376034B2 (en) |
CA (1) | CA3008094A1 (en) |
CL (3) | CL2018001652A1 (en) |
CO (1) | CO2018006297A2 (en) |
CR (1) | CR20200609A (en) |
CU (1) | CU24574B1 (en) |
DK (1) | DK3394259T3 (en) |
DO (1) | DOP2018000151A (en) |
EA (2) | EA202091865A1 (en) |
EC (1) | ECSP18050575A (en) |
ES (1) | ES2984631T3 (en) |
FI (1) | FI3394259T3 (en) |
HR (1) | HRP20240672T1 (en) |
HU (1) | HUE066548T2 (en) |
IL (3) | IL296844B2 (en) |
JO (2) | JOP20200228A1 (en) |
LT (1) | LT3394259T (en) |
MA (2) | MA44426B1 (en) |
MX (2) | MX2018007726A (en) |
MY (1) | MY191737A (en) |
PE (2) | PE20241069A1 (en) |
PH (1) | PH12018501207B1 (en) |
PL (1) | PL3394259T3 (en) |
PT (1) | PT3394259T (en) |
RS (1) | RS65535B1 (en) |
RU (1) | RU2747734C2 (en) |
SA (1) | SA518391831B1 (en) |
SG (2) | SG11201804704PA (en) |
SI (1) | SI3394259T1 (en) |
SV (1) | SV2018005714A (en) |
TW (2) | TWI787163B (en) |
UY (1) | UY37038A (en) |
WO (1) | WO2017109679A1 (en) |
ZA (1) | ZA201803661B (en) |
Families Citing this family (12)
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TW202246503A (en) | 2013-07-19 | 2022-12-01 | 美商百健Ma公司 | Compositions for modulating tau expression |
JOP20190065A1 (en) | 2016-09-29 | 2019-03-28 | Ionis Pharmaceuticals Inc | Compounds and methods for reducing tau expression |
CA3091979A1 (en) * | 2018-03-13 | 2019-09-19 | Janssen Pharmaceutica Nv | Modified oligonucleotides and methods of use in tauopathies |
JP7102557B2 (en) | 2018-07-03 | 2022-07-19 | エフ.ホフマン-ラ ロシュ アーゲー | Oligonucleotide for TAU expression regulation |
IL296851A (en) * | 2020-03-30 | 2022-11-01 | Alnylam Pharmaceuticals Inc | Compositions of tau protein RNA material associated with microtubules and methods of using them |
CN113817728A (en) * | 2020-06-19 | 2021-12-21 | 四川大学华西医院 | A recombinant lentivirus that effectively interferes with the expression of Tau protein and its application |
MX2023015242A (en) * | 2021-06-16 | 2024-03-11 | Empirico Inc | Treatment of mtres1 related diseases and disorders. |
WO2024091874A1 (en) * | 2022-10-25 | 2024-05-02 | Empirico Inc. | Gene therapy treatment of mtres1 related diseases and disorders |
WO2024155739A1 (en) * | 2023-01-18 | 2024-07-25 | Aptah Bio, Inc. | Polynucleotide compositions and methods for treatment of neurodegenerative diseases |
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