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ZA201803661B - Compositions and methods for decreasing tau expression - Google Patents

Compositions and methods for decreasing tau expression

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Publication number
ZA201803661B
ZA201803661B ZA2018/03661A ZA201803661A ZA201803661B ZA 201803661 B ZA201803661 B ZA 201803661B ZA 2018/03661 A ZA2018/03661 A ZA 2018/03661A ZA 201803661 A ZA201803661 A ZA 201803661A ZA 201803661 B ZA201803661 B ZA 201803661B
Authority
ZA
South Africa
Prior art keywords
compositions
methods
tau expression
decreasing tau
decreasing
Prior art date
Application number
ZA2018/03661A
Inventor
Ofengeim Manuela Polydoro
Jan Weiler
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA201803661B publication Critical patent/ZA201803661B/en

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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7125Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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Abstract

Provided herein are compositions and methods for decreasing tau mRNA and protein expression. These compositions and methods are useful in treating tau-related diseases and disorders.
ZA2018/03661A 2015-12-21 2018-06-01 Compositions and methods for decreasing tau expression ZA201803661B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562270165P 2015-12-21 2015-12-21
PCT/IB2016/057794 WO2017109679A1 (en) 2015-12-21 2016-12-19 Compositions and methods for decreasing tau expression

Publications (1)

Publication Number Publication Date
ZA201803661B true ZA201803661B (en) 2024-08-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2018/03661A ZA201803661B (en) 2015-12-21 2018-06-01 Compositions and methods for decreasing tau expression

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US (2) US11473083B2 (en)
EP (2) EP3394259B1 (en)
JP (4) JP7027328B2 (en)
CN (2) CN109072237B (en)
AR (1) AR107579A1 (en)
AU (2) AU2016376034B2 (en)
CA (1) CA3008094A1 (en)
CL (3) CL2018001652A1 (en)
CO (1) CO2018006297A2 (en)
CR (1) CR20200609A (en)
CU (1) CU24574B1 (en)
DK (1) DK3394259T3 (en)
DO (1) DOP2018000151A (en)
EA (2) EA202091865A1 (en)
EC (1) ECSP18050575A (en)
ES (1) ES2984631T3 (en)
FI (1) FI3394259T3 (en)
HR (1) HRP20240672T1 (en)
HU (1) HUE066548T2 (en)
IL (3) IL296844B2 (en)
JO (2) JOP20200228A1 (en)
LT (1) LT3394259T (en)
MA (2) MA44426B1 (en)
MX (2) MX2018007726A (en)
MY (1) MY191737A (en)
PE (2) PE20241069A1 (en)
PH (1) PH12018501207B1 (en)
PL (1) PL3394259T3 (en)
PT (1) PT3394259T (en)
RS (1) RS65535B1 (en)
RU (1) RU2747734C2 (en)
SA (1) SA518391831B1 (en)
SG (2) SG11201804704PA (en)
SI (1) SI3394259T1 (en)
SV (1) SV2018005714A (en)
TW (2) TWI787163B (en)
UY (1) UY37038A (en)
WO (1) WO2017109679A1 (en)
ZA (1) ZA201803661B (en)

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