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ZA200806799B - Novel pyrone-indole derivatives and process for their preparation - Google Patents

Novel pyrone-indole derivatives and process for their preparation

Info

Publication number
ZA200806799B
ZA200806799B ZA200806799A ZA200806799A ZA200806799B ZA 200806799 B ZA200806799 B ZA 200806799B ZA 200806799 A ZA200806799 A ZA 200806799A ZA 200806799 A ZA200806799 A ZA 200806799A ZA 200806799 B ZA200806799 B ZA 200806799B
Authority
ZA
South Africa
Prior art keywords
preparation
indole derivatives
pyrone
novel
novel pyrone
Prior art date
Application number
ZA200806799A
Other languages
English (en)
Inventor
Laudon Moshe
Peleg-Shulman Tal
Original Assignee
Neurim Pharma 1991
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurim Pharma 1991 filed Critical Neurim Pharma 1991
Publication of ZA200806799B publication Critical patent/ZA200806799B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
ZA200806799A 2006-02-15 2008-08-06 Novel pyrone-indole derivatives and process for their preparation ZA200806799B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77332206P 2006-02-15 2006-02-15

Publications (1)

Publication Number Publication Date
ZA200806799B true ZA200806799B (en) 2009-10-28

Family

ID=38283075

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200806799A ZA200806799B (en) 2006-02-15 2008-08-06 Novel pyrone-indole derivatives and process for their preparation

Country Status (21)

Country Link
US (3) US7635710B2 (no)
EP (1) EP1991541B1 (no)
JP (1) JP5248332B2 (no)
KR (1) KR101207736B1 (no)
CN (1) CN101374833B (no)
AU (1) AU2007216226B2 (no)
BR (1) BRPI0706992C8 (no)
CA (1) CA2642465C (no)
DK (1) DK1991541T3 (no)
EA (1) EA015605B1 (no)
ES (1) ES2428873T3 (no)
IL (1) IL193236A (no)
NO (1) NO339826B1 (no)
NZ (1) NZ569797A (no)
PL (1) PL1991541T3 (no)
PT (1) PT1991541E (no)
SI (1) SI1991541T1 (no)
TW (1) TWI501960B (no)
UA (1) UA104988C2 (no)
WO (1) WO2007093880A2 (no)
ZA (1) ZA200806799B (no)

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* Cited by examiner, † Cited by third party
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US7576131B2 (en) 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
CN103319467B (zh) * 2013-06-15 2015-10-14 湖南科技大学 一种4-[5-羟基-4-吡喃酮-2-基亚甲氨基]-3-巯基-1,2,4-三唑化合物及用途
EP3095781B1 (en) * 2014-01-14 2018-10-03 Astellas Pharma Inc. Indole compound
RU2561045C1 (ru) * 2014-07-15 2015-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") Нейропротекторное фармакологическое средство
US9567510B2 (en) 2014-09-11 2017-02-14 Halliburton Energy Services, Inc. Cyanamide-based carbon dioxide and/or hydrogen sulfide scavengers and methods of use in subterranean operations
CA3204599A1 (en) 2015-02-25 2016-09-01 The Regents Of The University Of California 5ht agonists for treating disorders
JP6910424B2 (ja) * 2016-08-23 2021-07-28 ニューリム・ファーマシューティカルズ・リミテッドＮｅｕｒｉｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． 掻痒症および／または痒みの治療方法
AU2018309049A1 (en) 2017-08-04 2020-02-27 Ovid Therapeutics Inc. Use of gaboxadol in the treatment of diabetes and related conditions
US11666888B2 (en) 2018-02-05 2023-06-06 Bio-Rad Laboratories, Inc. Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand
US10765666B2 (en) 2018-09-20 2020-09-08 Ovid Therapeutics Inc Use of gaboxadol for the treatment of Tourette syndrome, tics and stuttering
CN113423399A (zh) 2018-12-17 2021-09-21 奥维德医疗公司 加波沙朵用于治疗非24小时睡眠-觉醒障碍的用途
EP4149458A4 (en) * 2020-05-11 2024-06-05 B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University COMPOSITIONS OF TRYPTOPHOL DERIVATIVES AND 4-ETHYL-PHENOL DERIVATIVES, AND METHODS OF USE THEREOF
US11840731B2 (en) 2021-05-11 2023-12-12 Neurim Pharmaceuticals (1991) Ltd. Method for diagnosing and treating subjects having single nucleotide polymorphisms in chromosome 2, 2:107,510,000-107,540,000 locus
TW202444347A (zh) 2023-01-13 2024-11-16 以色列商琉璃藥品（１９９１）有限公司 使用吡美拉汀(piromelatine)治療與rem睡眠鬆弛喪失相關之異睡症之方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA222247A (en) 1922-08-15 Hubert Rogers Reginald Pocket container for confections
IT1196849B (it) 1986-12-16 1988-11-25 Rotta Research Lab Nuovi derivati degli acidi 5 pentilammino 5 oxo pentaoico e 4 pentilammino 4 oxo butanoico ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
AU8876591A (en) 1990-11-02 1992-05-26 Upjohn Company, The Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
US5840751A (en) * 1993-11-19 1998-11-24 Warner-Lambert Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
KR19990022058A (ko) * 1996-03-27 1999-03-25 마에다 가쯔노스께 케톤유도체 및 그 의약용도
IL130169A (en) 1999-05-27 2006-08-20 Neurim Pharma 1991 Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them
WO2001079187A2 (en) * 2000-04-18 2001-10-25 Cytovia, Inc. Substituted 1,4-thiazepine and analogs and their use as activators of caspases
PE20060303A1 (es) 2004-06-23 2006-05-19 Wyeth Corp Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6
US7834050B2 (en) * 2006-03-29 2010-11-16 Duke University Small molecule insulin mimetics absent quinones

Also Published As

Publication number Publication date
TWI501960B (zh) 2015-10-01
WO2007093880A2 (en) 2007-08-23
PL1991541T3 (pl) 2013-12-31
WO2007093880A3 (en) 2007-11-01
TW200835690A (en) 2008-09-01
US20080027121A1 (en) 2008-01-31
BRPI0706992B1 (pt) 2021-05-04
KR101207736B1 (ko) 2012-12-03
NO20083905L (no) 2008-09-12
IL193236A (en) 2012-08-30
AU2007216226B2 (en) 2011-02-24
DK1991541T3 (da) 2013-10-28
US8242163B2 (en) 2012-08-14
HK1126760A1 (en) 2009-09-11
KR20080094945A (ko) 2008-10-27
CA2642465C (en) 2012-08-07
BRPI0706992C8 (pt) 2021-05-25
NO339826B1 (no) 2017-02-06
CN101374833B (zh) 2012-06-27
EA200801580A1 (ru) 2009-02-27
EA015605B1 (ru) 2011-10-31
BRPI0706992A2 (pt) 2011-04-12
JP2009526831A (ja) 2009-07-23
ES2428873T3 (es) 2013-11-12
CA2642465A1 (en) 2007-08-23
AU2007216226A2 (en) 2009-05-14
EP1991541B1 (en) 2013-07-24
PT1991541E (pt) 2013-10-02
US20100048662A1 (en) 2010-02-25
US20120302620A1 (en) 2012-11-29
BRPI0706992C1 (pt) 2021-05-18
SI1991541T1 (sl) 2014-02-28
UA104988C2 (uk) 2014-04-10
EP1991541A2 (en) 2008-11-19
US8569355B2 (en) 2013-10-29
AU2007216226A1 (en) 2007-08-23
JP5248332B2 (ja) 2013-07-31
NZ569797A (en) 2010-06-25
CN101374833A (zh) 2009-02-25
IL193236A0 (en) 2009-02-11
US7635710B2 (en) 2009-12-22

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