ZA200806646B - Pyrazoloquinolones are potent parp inhibitors - Google Patents

Pyrazoloquinolones are potent parp inhibitors

Info

Publication number: ZA200806646B
Authority: ZA; South Africa
Prior art keywords: pyrazoloquinolones; parp inhibitors; potent parp; potent; inhibitors
Prior art date: 2006-02-15

Application number

ZA200806646A

Other languages

English (en)

Inventor

Thomas D Penning

Gui-Dong Zhu

Virajkumar B Gandhi

Jianchun Gong

Vincent L Giranda

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-02-15

Filing date

2008-07-30

Publication date

2010-01-27

2008-07-30 Application filed by Abbott Lab filed Critical Abbott Lab

2010-01-27 Publication of ZA200806646B publication Critical patent/ZA200806646B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Oncology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
Psychology (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Dermatology (AREA)

ZA200806646A 2006-02-15 2008-07-30 Pyrazoloquinolones are potent parp inhibitors ZA200806646B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US77351306P	2006-02-15	2006-02-15

Publications (1)

Publication Number	Publication Date
ZA200806646B true ZA200806646B (en)	2010-01-27

Family

ID=38229340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200806646A ZA200806646B (en)	2006-02-15	2008-07-30	Pyrazoloquinolones are potent parp inhibitors

Country Status (18)

Country	Link
US (2)	US8546368B2 (es)
EP (2)	EP2468748B1 (es)
JP (1)	JP5242419B2 (es)
KR (1)	KR20080094729A (es)
CN (1)	CN101421268B (es)
AU (1)	AU2007214411B2 (es)
BR (1)	BRPI0707902A2 (es)
CA (1)	CA2641776C (es)
CR (1)	CR10277A (es)
EC (1)	ECSP088676A (es)
ES (2)	ES2473344T3 (es)
GT (1)	GT200800158A (es)
IL (1)	IL193272A0 (es)
NO (1)	NO20083923L (es)
RU (1)	RU2008136784A (es)
TW (1)	TW200811173A (es)
WO (1)	WO2007095628A1 (es)
ZA (1)	ZA200806646B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0416206A (pt)	2003-11-20	2006-12-26	Janssen Pharmaceutica Nv	2-quinolinonas e 2-quinoxalinonas substituìdas por 6-alquenila e 6-fenilalquila como inibidores de polimerase de poli(adp-ribose)
US7928104B2 (en)	2003-11-20	2011-04-19	Dominique Jean-Pierre Mabire	7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
AU2005259189B2 (en)	2004-06-30	2011-04-21	Janssen Pharmaceutica N.V.	Phthalazine derivatives as PARP inhibitors
AU2005259190B2 (en)	2004-06-30	2011-05-12	Janssen Pharmaceutica N.V.	Quinazolinedione derivatives as PARP inhibitors
JP4836946B2 (ja)	2004-06-30	2011-12-14	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｐａｒｐ阻害剤としての置換２−アルキルキナゾリノン誘導体
WO2008107478A1 (en)	2007-03-08	2008-09-12	Janssen Pharmaceutica Nv	Quinolinone derivatives as parp and tank inhibitors
PL2215075T3 (pl)	2007-10-26	2014-04-30	Janssen Pharmaceutica Nv	Pochodne chinolinonu jako inhibitory PARP
CA2716088C (en)	2008-03-27	2017-03-07	Eddy Jean Edgard Freyne	Quinazolinone derivatives as tubulin polymerization inhibitors
MX2010010406A (es) *	2008-03-27	2010-10-25	Janssen Pharmaceutica Nv	Tetrahidrofenantridinonas y tetrahidrociclopentaquinolinonas como inhibidores de la polimerizacion de poli(adp-ribosa)polimerasa-1 y tubulina.
RU2470934C1 (ru) *	2008-11-11	2012-12-27	Дзе Ил Фармасьютикал Ко., Лтд.	Новое трициклическое производное или его фармацевтически приемлемые соли, способ их получения и содержащая их фармацевтическая композиция
US8263610B2 (en)	2008-12-30	2012-09-11	Arqule, Inc.	Substituted imidazolyl-5,6-dihydrobenzo[N]isoquinoline compounds
KR101714799B1 (ko)	2008-12-30	2017-03-09	아르퀼 인코포레이티드	치환된 5,6-디히드로-6-페닐벤조［ｆ］이소퀴놀린-2-아민 화합물
US7741350B1 (en) *	2009-01-28	2010-06-22	Cara Therapeutics, Inc.	Bicyclic pyrazolo-heterocycles
EP2391627B1 (en)	2009-01-28	2013-12-25	Cara Therapeutics, Inc.	Bicyclic pyrazolo-heterocycles
SG10201407976UA (en) *	2009-12-01	2015-01-29	Abbvie Inc	Novel tricyclic compounds
ES2601900T3 (es) *	2010-05-24	2017-02-16	Hande Starlake Bioscience Co., Ltd.	Derivados de pirazol
JP6871169B2 (ja)	2015-03-02	2021-05-12	シナイヘルスシステム	相同組換え因子
CN112010850A (zh) *	2019-05-31	2020-12-01	江苏天士力帝益药业有限公司	一种parp抑制剂的中间体tsl-1502m及其制备方法
CN114053271B (zh) *	2020-07-30	2024-05-07	江苏天士力帝益药业有限公司	一种含有tsl-1502m的药物组合物及其应用
CN114053276B (zh) *	2020-07-30	2024-05-07	江苏天士力帝益药业有限公司	一种parp抑制剂tsl-1502中间体tsl-1502m的用途
WO2024121262A1 (en)	2022-12-09	2024-06-13	Syngenta Crop Protection Ag	Insecticidal compound based on pyrazole derivatives
WO2024121264A1 (en)	2022-12-09	2024-06-13	Syngenta Crop Protection Ag	Insecticidal compound based on pyrazole derivatives

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4601580A (en)	1982-08-18	1986-07-22	University Of Southampton	Measurement of oscillatory and vibrational motion
IT1154024B (it)	1982-09-22	1987-01-21	Lepetit Spa	Derivati pridinici e procedimento per la loro produzione
US5212310A (en) *	1991-12-19	1993-05-18	Neurogen Corporation	Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands
US5677309A (en) *	1996-03-22	1997-10-14	Neurogen Corporation	1,2,4-triazolo 4,3-c! quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones; a new class of GABA brain receptor ligands
GB2321130B (en) *	1997-12-23	1998-12-23	Bookham Technology Ltd	An integrated optical transceiver
JP2000319278A (ja)	1999-05-11	2000-11-21	Ono Pharmaceut Co Ltd	縮合ピラジン化合物およびその化合物を有効成分とする薬剤
CO5271670A1 (es) *	1999-10-29	2003-04-30	Pfizer Prod Inc	Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas
TWI271406B (en) *	1999-12-13	2007-01-21	Eisai Co Ltd	Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
GB9929685D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
AU2223501A (en) *	1999-12-24	2001-07-09	Kyowa Hakko Kogyo Co. Ltd.	Fused purine derivatives
US6949648B2 (en) *	2000-03-27	2005-09-27	Takeda Pharmaceutical Company Limited	Condensed pyrazole derivatives, process for producing the same and use thereof
AUPS019702A0 (en) *	2002-01-29	2002-02-21	Fujisawa Pharmaceutical Co., Ltd.	Condensed heterocyclic compounds
AUPS137402A0 (en) *	2002-03-26	2002-05-09	Fujisawa Pharmaceutical Co., Ltd.	Novel tricyclic compounds
US7222827B2 (en) *	2002-04-19	2007-05-29	Crain Enterprises, Inc.	Telescoping leg lock with thumb actuator
CA2507027C (en) *	2002-11-22	2012-05-08	Mitsubishi Pharma Corporation	Isoquinoline compounds and medicinal use thereof
US7169926B1 (en) *	2003-08-13	2007-01-30	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
WO2005087775A1 (ja)	2004-03-15	2005-09-22	Ono Pharmaceutical Co., Ltd.	三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物
US8466144B2 (en) *	2004-07-16	2013-06-18	Proteosys Ag	Muscarinic antagonists with parp and sir modulating activity as cytoprotective agents
CA2603063A1 (en)	2005-04-01	2006-10-12	Coley Pharmaceutical Group, Inc.	Pyrazolo[3,4-c]quinolines, pyrazolo[3,4-c]naphthyridines, analogs thereof, and methods
JPWO2006112331A1 (ja)	2005-04-13	2008-12-11	大日本住友製薬株式会社	新規縮合ピロール誘導体
AU2006289838B2 (en)	2005-09-15	2011-08-18	Aska Pharmaceutical Co., Ltd.	Heterocyclic compound, and production process and use thereof

2007
- 2007-02-15 ES ES07757073.7T patent/ES2473344T3/es active Active
- 2007-02-15 ES ES12160548.9T patent/ES2587827T3/es active Active
- 2007-02-15 CN CN200780013585.9A patent/CN101421268B/zh not_active Expired - Fee Related
- 2007-02-15 CA CA2641776A patent/CA2641776C/en not_active Expired - Fee Related
- 2007-02-15 KR KR1020087022538A patent/KR20080094729A/ko not_active Ceased
- 2007-02-15 RU RU2008136784/04A patent/RU2008136784A/ru not_active Application Discontinuation
- 2007-02-15 EP EP12160548.9A patent/EP2468748B1/en active Active
- 2007-02-15 AU AU2007214411A patent/AU2007214411B2/en not_active Expired - Fee Related
- 2007-02-15 TW TW096105972A patent/TW200811173A/zh unknown
- 2007-02-15 JP JP2008555496A patent/JP5242419B2/ja not_active Expired - Fee Related
- 2007-02-15 US US11/675,570 patent/US8546368B2/en active Active
- 2007-02-15 WO PCT/US2007/062260 patent/WO2007095628A1/en active Application Filing
- 2007-02-15 EP EP07757073.7A patent/EP1989204B1/en active Active
- 2007-02-15 BR BRPI0707902-8A patent/BRPI0707902A2/pt not_active IP Right Cessation
2008
- 2008-07-30 ZA ZA200806646A patent/ZA200806646B/xx unknown
- 2008-08-05 IL IL193272A patent/IL193272A0/en unknown
- 2008-08-12 EC EC2008008676A patent/ECSP088676A/es unknown
- 2008-08-14 GT GT200800158A patent/GT200800158A/es unknown
- 2008-09-09 CR CR10277A patent/CR10277A/es not_active Application Discontinuation
- 2008-09-15 NO NO20083923A patent/NO20083923L/no not_active Application Discontinuation
2013
- 2013-08-27 US US14/011,374 patent/US20140213610A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2587827T3 (es)	2016-10-27
CN101421268A (zh)	2009-04-29
ES2473344T3 (es)	2014-07-04
JP2009526869A (ja)	2009-07-23
TW200811173A (en)	2008-03-01
WO2007095628A1 (en)	2007-08-23
CA2641776A1 (en)	2007-08-23
GT200800158A (es)	2009-07-09
US20070249597A1 (en)	2007-10-25
JP5242419B2 (ja)	2013-07-24
CR10277A (es)	2008-10-13
EP1989204B1 (en)	2014-05-21
NO20083923L (no)	2008-11-04
BRPI0707902A2 (pt)	2011-05-17
RU2008136784A (ru)	2010-03-20
AU2007214411A1 (en)	2007-08-23
ECSP088676A (es)	2008-09-29
IL193272A0 (en)	2009-02-11
EP1989204A1 (en)	2008-11-12
KR20080094729A (ko)	2008-10-23
EP2468748B1 (en)	2016-05-25
CN101421268B (zh)	2016-01-06
US20140213610A1 (en)	2014-07-31
US8546368B2 (en)	2013-10-01
AU2007214411B2 (en)	2010-07-01
CA2641776C (en)	2014-04-08
EP2468748A1 (en)	2012-06-27

Publication	Publication Date	Title
ZA200806646B (en)	2010-01-27	Pyrazoloquinolones are potent parp inhibitors
PL2017278T3 (pl)	2017-10-31	Pochodne dihydropirazolopirymidynonu
EP2009005A4 (en)	2010-06-02	AZOLECARBOXAMIDE DERIVATIVE
IL193638A0 (en)	2009-05-04	Amine derivatives
IL196543A0 (en)	2009-11-18	Pyridizinone derivatives
IL193641A0 (en)	2009-05-04	Spiroindolinone derivatives
IL195013A0 (en)	2009-08-03	Pyridopyrimidinone derivatives
IL195422A0 (en)	2009-08-03	2-pyrazinecarboxamide derivatives
HRP20130144T1 (en)	2013-03-31	Renin inhibitors
SI2078001T1 (sl)	2010-07-30	Derivati diazepan-acetamida kot selektivni zaviralci 11 -hsd1
IL196364A0 (en)	2009-09-22	Aminoindazolylurea derivatives
IL193211A0 (en)	2009-02-11	Indazole-heteroaryl derivatives
IL198645A0 (en)	2010-02-17	5-hydroxymethyl-oxazolidin-2-one derivatives
IL196000A0 (en)	2009-09-01	2-arylindole derivatives as npges-i inhibitors
ZA200904920B (en)	2010-09-29	Benzimidazole TRPV1 inhibitors
IL193981A0 (en)	2009-08-03	Novel heterocyclic nf-kb inhibitors
GB0622702D0 (en)	2006-12-27	Selective glycosidase inhibitors
IL197981A0 (en)	2009-12-24	Kinase inhibitors
IL196807A0 (en)	2009-11-18	Inhibitors for glyt-1
GB0714941D0 (en)	2007-09-12	Inhibitors
HK1120516A (en)	2009-04-03	Pyrazoloquinolones are potent parp inhibitors
GB0713152D0 (en)	2007-08-15	Phosphodlesterase inhibitors
GB0622367D0 (en)	2006-12-20	Phosphodiesterase inhibitors
HU0600193V0 (en)	2006-10-30	Latch-cover for water-network
ZA200807679B (en)	2009-08-26	Amine derivatives