ZA200604968B - Pyrrole derivatives - Google Patents

Info

Publication number

ZA200604968B

ZA200604968B ZA200604968A ZA200604968A ZA200604968B ZA 200604968 B ZA200604968 B ZA 200604968B ZA 200604968 A ZA200604968 A ZA 200604968A ZA 200604968 A ZA200604968 A ZA 200604968A ZA 200604968 B ZA200604968 B ZA 200604968B

Authority

ZA

South Africa

Prior art keywords

denotes

het

nha

cancer

hal

Prior art date

2003-11-19

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• 150000003233 pyrroles Chemical class 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims description 143
• 150000003839 salts Chemical class 0.000 claims description 69
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• 239000000203 mixture Substances 0.000 claims description 64
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 36
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• 238000000034 method Methods 0.000 claims description 23
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• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 22
• 125000004430 oxygen atom Chemical group O* 0.000 claims description 21
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• 229910052801 chlorine Inorganic materials 0.000 claims description 20
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• 125000004434 sulfur atom Chemical group 0.000 claims description 15
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• 101710141955 RAF proto-oncogene serine/threonine-protein kinase Proteins 0.000 claims description 14
• 125000000217 alkyl group Chemical group 0.000 claims description 14
• 125000004432 carbon atom Chemical group C* 0.000 claims description 14
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 14
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• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 10
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• KKVYYGGCHJGEFJ-UHFFFAOYSA-N 1-n-(4-chlorophenyl)-6-methyl-5-n-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine Chemical compound N=1C=CC2=C(NC=3C(=CC=CN=3)C=3C=4N=CNC=4N=CN=3)C(C)=CC=C2C=1NC1=CC=C(Cl)C=C1 KKVYYGGCHJGEFJ-UHFFFAOYSA-N 0.000 claims description 9
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• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 2
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• 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 2
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• 125000002971 oxazolyl group Chemical group 0.000 claims description 2
• 125000003226 pyrazolyl group Chemical group 0.000 claims description 2
• 125000002098 pyridazinyl group Chemical group 0.000 claims description 2
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 2
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• 125000001544 thienyl group Chemical group 0.000 claims description 2
• 125000000896 monocarboxylic acid group Chemical group 0.000 claims 3
• GFZZSZFOCFEULX-UHFFFAOYSA-N 4-[3-[5-[[5-chloro-2-(methoxymethyl)phenyl]carbamoyl]-1h-pyrrol-3-yl]phenoxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(C=CC=2)C=2C=C(NC=2)C(=O)NC=2C(=CC=C(Cl)C=2)COC)=C1 GFZZSZFOCFEULX-UHFFFAOYSA-N 0.000 claims 1
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