ZA200402104B - Methods for treating or preventing vascular inflammation using sterol absorption inhibitors - Google Patents
Methods for treating or preventing vascular inflammation using sterol absorption inhibitors Download PDFInfo
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- ZA200402104B ZA200402104B ZA2004/02104A ZA200402104A ZA200402104B ZA 200402104 B ZA200402104 B ZA 200402104B ZA 2004/02104 A ZA2004/02104 A ZA 2004/02104A ZA 200402104 A ZA200402104 A ZA 200402104A ZA 200402104 B ZA200402104 B ZA 200402104B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- group
- independently selected
- aryl
- substituted
- Prior art date
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- 239000003112 inhibitor Substances 0.000 title claims description 115
- 238000010521 absorption reaction Methods 0.000 title claims description 80
- 229930182558 Sterol Natural products 0.000 title claims description 59
- 235000003702 sterols Nutrition 0.000 title claims description 59
- 150000003432 sterols Chemical class 0.000 title claims description 58
- 238000000034 method Methods 0.000 title claims description 41
- 208000035868 Vascular inflammations Diseases 0.000 title claims description 29
- 125000000217 alkyl group Chemical group 0.000 claims description 138
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 58
- 125000003118 aryl group Chemical group 0.000 claims description 57
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 53
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- 239000000203 mixture Substances 0.000 claims description 34
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- 125000001424 substituent group Chemical group 0.000 claims description 32
- 108010074051 C-Reactive Protein Proteins 0.000 claims description 31
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- -1 (C4-C Chemical group 0.000 claims description 24
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
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- 125000002971 oxazolyl group Chemical group 0.000 claims 3
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- 125000003821 2-(trimethylsilyl)ethoxymethyl group Chemical group [H]C([H])([H])[Si](C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(OC([H])([H])[*])([H])[H] 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32393701P | 2001-09-21 | 2001-09-21 | |
| PCT/US2002/029756 WO2003026644A1 (en) | 2001-09-21 | 2002-09-19 | Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200402104B true ZA200402104B (en) | 2005-06-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2004/02104A ZA200402104B (en) | 2001-09-21 | 2004-03-16 | Methods for treating or preventing vascular inflammation using sterol absorption inhibitors |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20030119757A1 (zh) |
| EP (1) | EP1427409B1 (zh) |
| JP (2) | JP4395370B2 (zh) |
| CN (2) | CN101785772A (zh) |
| AT (1) | ATE411018T1 (zh) |
| AU (2) | AU2002335770B2 (zh) |
| BR (1) | BR0212907A (zh) |
| CA (1) | CA2460344A1 (zh) |
| CY (1) | CY1110894T1 (zh) |
| DE (1) | DE60229406D1 (zh) |
| DK (1) | DK1427409T3 (zh) |
| ES (1) | ES2312624T3 (zh) |
| HU (1) | HUP0401501A3 (zh) |
| MX (1) | MXPA04002572A (zh) |
| NO (1) | NO333968B1 (zh) |
| NZ (1) | NZ531060A (zh) |
| PT (1) | PT1427409E (zh) |
| SI (1) | SI1427409T1 (zh) |
| WO (1) | WO2003026644A1 (zh) |
| ZA (1) | ZA200402104B (zh) |
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| MEP27808A (en) | 2001-01-26 | 2010-10-10 | Schering Corp | Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| ATE345793T1 (de) * | 2001-09-21 | 2006-12-15 | Schering Corp | Behandlung von xanthom mittels azetidinon- derivate als hemmer der sterol absorption |
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| EP1551382A4 (en) * | 2002-09-27 | 2007-01-24 | Martek Biosciences Corp | PROPHYLACTIC TREATMENT WITH DOCOSAHEXAENIC ACID FOR PATIENTS WITH SUBCLINIC INFLAMMATION |
| CA2504916A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
| ES2311806T3 (es) | 2003-03-07 | 2009-02-16 | Schering Corporation | Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
| WO2004081003A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholeterolemia |
| WO2004081004A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| US20070003600A1 (en) * | 2003-06-11 | 2007-01-04 | Carolyn Moore | Methods for reducing c-reactive protein |
| US20050096307A1 (en) * | 2003-11-05 | 2005-05-05 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
| EP1682499B1 (en) * | 2003-11-10 | 2007-08-08 | Microbia, Inc. | 4-biarylyl-1-phenylazetidin-2-ones |
| BRPI0418004A (pt) * | 2003-12-23 | 2007-04-17 | Astrazeneca Ab | composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis, métodos para tratar ou prevenir condições hiperlipidêmicas, aterosclerose, mal de alzheimer, e tumores associados com colesterol, formulação farmacêutica, combinação, e, processo para preparar um composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis |
| GB0329778D0 (en) * | 2003-12-23 | 2004-01-28 | Astrazeneca Ab | Chemical compounds |
| US7803838B2 (en) * | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| BRPI0514193A (pt) * | 2004-08-09 | 2008-06-03 | Takeda Pharmaceutical | agente de diminuição de crp, método para previnir e/ou tratar uma doença envolvida em elevação de crp, e, uso de um composto tendo uma atividade inibitória de esqualeno sintase, ou uma pró-droga do mesmo, ou um sal do mesmo |
| UY29607A1 (es) * | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | Compuestos quimicos |
| AR057072A1 (es) * | 2005-06-22 | 2007-11-14 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto |
| AR054482A1 (es) * | 2005-06-22 | 2007-06-27 | Astrazeneca Ab | Derivados de azetidinona para el tratamiento de hiperlipidemias |
| AR057383A1 (es) * | 2005-06-22 | 2007-12-05 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto |
| AR057380A1 (es) * | 2005-06-22 | 2007-11-28 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona y uso terapeutico de los mismos |
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-
2002
- 2002-09-19 MX MXPA04002572A patent/MXPA04002572A/es active IP Right Grant
- 2002-09-19 EP EP02770534A patent/EP1427409B1/en not_active Expired - Lifetime
- 2002-09-19 AU AU2002335770A patent/AU2002335770B2/en not_active Ceased
- 2002-09-19 SI SI200230758T patent/SI1427409T1/sl unknown
- 2002-09-19 US US10/247,032 patent/US20030119757A1/en not_active Abandoned
- 2002-09-19 ES ES02770534T patent/ES2312624T3/es not_active Expired - Lifetime
- 2002-09-19 DK DK02770534T patent/DK1427409T3/da active
- 2002-09-19 BR BR0212907-8A patent/BR0212907A/pt not_active Application Discontinuation
- 2002-09-19 WO PCT/US2002/029756 patent/WO2003026644A1/en active IP Right Grant
- 2002-09-19 HU HU0401501A patent/HUP0401501A3/hu unknown
- 2002-09-19 NZ NZ531060A patent/NZ531060A/en not_active IP Right Cessation
- 2002-09-19 PT PT02770534T patent/PT1427409E/pt unknown
- 2002-09-19 DE DE60229406T patent/DE60229406D1/de not_active Expired - Lifetime
- 2002-09-19 CN CN200910261594A patent/CN101785772A/zh active Pending
- 2002-09-19 JP JP2003530281A patent/JP4395370B2/ja not_active Expired - Fee Related
- 2002-09-19 CN CNA028184343A patent/CN1556700A/zh active Pending
- 2002-09-19 CA CA002460344A patent/CA2460344A1/en not_active Abandoned
- 2002-09-19 AT AT02770534T patent/ATE411018T1/de active
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2004
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2005
- 2005-11-18 AU AU2005234666A patent/AU2005234666B2/en not_active Ceased
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2008
- 2008-12-08 CY CY20081101419T patent/CY1110894T1/el unknown
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2009
- 2009-09-11 JP JP2009211106A patent/JP2009286801A/ja not_active Withdrawn
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|---|---|
| HUP0401501A3 (en) | 2012-02-28 |
| AU2005234666B2 (en) | 2006-09-21 |
| DK1427409T3 (da) | 2009-01-12 |
| JP2005504092A (ja) | 2005-02-10 |
| CA2460344A1 (en) | 2003-04-03 |
| EP1427409B1 (en) | 2008-10-15 |
| WO2003026644A1 (en) | 2003-04-03 |
| BR0212907A (pt) | 2004-10-13 |
| NO333968B1 (no) | 2013-11-04 |
| CN101785772A (zh) | 2010-07-28 |
| AU2002335770B2 (en) | 2005-08-18 |
| CY1110894T1 (el) | 2015-06-10 |
| HUP0401501A2 (hu) | 2004-12-28 |
| NO20041598L (no) | 2004-06-17 |
| ES2312624T3 (es) | 2009-03-01 |
| JP4395370B2 (ja) | 2010-01-06 |
| ATE411018T1 (de) | 2008-10-15 |
| CN1556700A (zh) | 2004-12-22 |
| MXPA04002572A (es) | 2004-05-31 |
| AU2005234666A1 (en) | 2005-12-08 |
| US20030119757A1 (en) | 2003-06-26 |
| JP2009286801A (ja) | 2009-12-10 |
| NZ531060A (en) | 2006-06-30 |
| SI1427409T1 (sl) | 2009-02-28 |
| HK1064950A1 (zh) | 2005-02-08 |
| EP1427409A1 (en) | 2004-06-16 |
| DE60229406D1 (de) | 2008-11-27 |
| PT1427409E (pt) | 2008-11-27 |
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