ZA200307411B - Process for the industrial synthesis of tetraesters of 5-[Bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates. - Google Patents

Process for the industrial synthesis of tetraesters of 5-[Bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates.

Info

Publication number: ZA200307411B
Authority: ZA; South Africa
Prior art keywords: carboxymethyl; synthesis; acid; tetraesters; hydrates
Prior art date: 2002-09-24

Application number

ZA200307411A

Other languages

English (en)

Inventor

Lucile Vaysse-Ludot

Jean-Pierre Lecouve

Pascal Langlois

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-24

Filing date

2003-09-23

Publication date

2004-07-07

2003-09-23 Application filed by Servier Lab filed Critical Servier Lab

2004-07-07 Publication of ZA200307411B publication Critical patent/ZA200307411B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

ZA200307411A 2002-09-24 2003-09-23 Process for the industrial synthesis of tetraesters of 5-[Bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates. ZA200307411B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0211765A FR2844797B1 (fr)	2002-09-24	2002-09-24	Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Publications (1)

Publication Number	Publication Date
ZA200307411B true ZA200307411B (en)	2004-07-07

Family

ID=29415191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200307411A ZA200307411B (en)	2002-09-24	2003-09-23	Process for the industrial synthesis of tetraesters of 5-[Bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates.

Country Status (39)

Country	Link
US (1)	US7091364B2 (sl)
EP (1)	EP1403265B1 (sl)
JP (1)	JP4136866B2 (sl)
KR (1)	KR100551502B1 (sl)
CN (1)	CN1280286C (sl)
AP (1)	AP1972A (sl)
AR (1)	AR041357A1 (sl)
AT (1)	ATE449767T1 (sl)
AU (2)	AU2003299095A1 (sl)
BR (1)	BR0304203A (sl)
CA (1)	CA2442881C (sl)
CY (1)	CY1109831T1 (sl)
DE (1)	DE60330213D1 (sl)
DK (1)	DK1403265T3 (sl)
EA (1)	EA007108B1 (sl)
EC (1)	ECSP055743A (sl)
ES (1)	ES2337348T3 (sl)
FR (1)	FR2844797B1 (sl)
GE (1)	GEP20074139B (sl)
HK (1)	HK1061846A1 (sl)
HR (1)	HRP20050361B1 (sl)
IL (1)	IL167315A (sl)
IS (1)	IS2728B (sl)
MA (1)	MA26100A1 (sl)
ME (1)	ME00453B (sl)
MX (1)	MXPA03008647A (sl)
MY (1)	MY134924A (sl)
NO (1)	NO328626B1 (sl)
NZ (1)	NZ528401A (sl)
OA (1)	OA12932A (sl)
PL (1)	PL215879B1 (sl)
PT (1)	PT1403265E (sl)
RS (1)	RS51551B (sl)
SG (1)	SG110069A1 (sl)
SI (1)	SI1403265T1 (sl)
TN (1)	TNSN05088A1 (sl)
UA (1)	UA79157C2 (sl)
WO (1)	WO2004029034A1 (sl)
ZA (1)	ZA200307411B (sl)

Families Citing this family (20)

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FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844795B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
AU2004237438B2 (en) *	2003-05-07	2011-01-20	Osteologix A/S	Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions
PL1745791T3 (pl) *	2003-05-07	2013-11-29	Osteologix As	Leczenie chorób chrząstki/kości za pomocą rozpuszczalnych w wodzie soli strontu
US20050085531A1 (en) *	2003-10-03	2005-04-21	Hodge Carl N.	Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
AU2005216596B2 (en) *	2004-02-26	2011-03-24	Osteologix A/S	Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
MXPA06015187A (es)	2004-06-25	2007-09-27	Strontin Aps	Composiciones que comprenden estroncio y vitamina d y usos de las mismas.
FR2875807B1 (fr) *	2004-09-30	2006-11-17	Servier Lab	Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN100391955C (zh) *	2005-04-30	2008-06-04	河北医科大学	一种雷尼酸锶中间体的合成方法
US20070292535A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating arthritic and or osteoporitic conditions
US20070292529A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating osteoporotic conditions
FR2921367B1 (fr)	2007-09-26	2009-10-30	Servier Lab	Nouveau procede de synthese du ranelate de strontium et de ses hydrates
US20120123131A1 (en) *	2008-08-22	2012-05-17	Koilpillai Joseph Prabahar	Process for the preparation of strontium ranelate
CN101665483B (zh) *	2008-09-01	2013-01-23	河北医科大学	一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011124992A1 (en) *	2010-03-24	2011-10-13	Actavis Group Ptc Ehf	Substantially pure strontium ranelate
CN101812048B (zh) *	2010-04-06	2012-11-14	浙江东亚药业有限公司	雷尼酸锶及其水合物的合成方法
EP2602248A1 (en)	2011-12-05	2013-06-12	University Of Leicester	Novel pyrrole compounds
WO2013113319A1 (en)	2012-01-31	2013-08-08	Pharmathen S.A.	Process for the preparation of strontium ranelate, intermediate or hydrates thereof
EP2756841B1 (en)	2013-01-21	2015-05-13	Galenicum Health S.L.	Pharmaceutical compositions comprising an acid salt
GB201310126D0 (en) *	2013-06-06	2013-07-24	Univ Leicester	Novel pyrrole derivatives

Family Cites Families (7)

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Publication number	Priority date	Publication date	Assignee	Title
DE3624304A1 (de)	1986-07-18	1988-01-28	Bayer Ag	Fungizide verwendung von substituierten thienylaminen
GB8715925D0 (en) *	1987-07-07	1987-08-12	Shell Int Research	Thiapentanamide derivatives
FR2651497B1 (fr) *	1989-09-01	1991-10-25	Adir	Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE19528380A1 (de) *	1995-08-02	1997-02-06	Hoechst Ag	Heterogene Vinylacetat/Ethylen-Dispersion
FR2749759B1 (fr) *	1996-06-17	1999-11-26	Adir	Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
DE19650196A1 (de) *	1996-12-04	1998-06-10	Bayer Ag	Thienylsulfonylamino(thio)carbonylverbindungen
US6835745B2 (en) *	2002-01-15	2004-12-28	Wyeth	Phenyl substituted thiophenes as estrogenic agents

2002
- 2002-09-24 FR FR0211765A patent/FR2844797B1/fr not_active Expired - Fee Related
2003
- 2003-09-17 MY MYPI20033533A patent/MY134924A/en unknown
- 2003-09-22 DK DK03292318.7T patent/DK1403265T3/da active
- 2003-09-22 ME MEP-2008-687A patent/ME00453B/me unknown
- 2003-09-22 PT PT03292318T patent/PT1403265E/pt unknown
- 2003-09-22 UA UAA200503860A patent/UA79157C2/uk unknown
- 2003-09-22 JP JP2003330439A patent/JP4136866B2/ja not_active Expired - Fee Related
- 2003-09-22 SI SI200331715T patent/SI1403265T1/sl unknown
- 2003-09-22 WO PCT/FR2003/002775 patent/WO2004029034A1/fr not_active Application Discontinuation
- 2003-09-22 ES ES03292318T patent/ES2337348T3/es not_active Expired - Lifetime
- 2003-09-22 RS YUP-2005/0241A patent/RS51551B/en unknown
- 2003-09-22 AP AP2005003255A patent/AP1972A/xx active
- 2003-09-22 AU AU2003299095A patent/AU2003299095A1/en not_active Abandoned
- 2003-09-22 AT AT03292318T patent/ATE449767T1/de active
- 2003-09-22 AU AU2003248280A patent/AU2003248280B2/en not_active Ceased
- 2003-09-22 GE GEAP20038759A patent/GEP20074139B/en unknown
- 2003-09-22 DE DE60330213T patent/DE60330213D1/de not_active Expired - Lifetime
- 2003-09-22 OA OA1200500081A patent/OA12932A/en unknown
- 2003-09-22 EP EP03292318A patent/EP1403265B1/fr not_active Expired - Lifetime
- 2003-09-23 NO NO20034236A patent/NO328626B1/no not_active IP Right Cessation
- 2003-09-23 PL PL362366A patent/PL215879B1/pl unknown
- 2003-09-23 KR KR1020030065784A patent/KR100551502B1/ko not_active Expired - Fee Related
- 2003-09-23 AR ARP030103455A patent/AR041357A1/es not_active Application Discontinuation
- 2003-09-23 BR BR0304203-0A patent/BR0304203A/pt not_active Application Discontinuation
- 2003-09-23 MX MXPA03008647A patent/MXPA03008647A/es active IP Right Grant
- 2003-09-23 NZ NZ528401A patent/NZ528401A/en not_active IP Right Cessation
- 2003-09-23 EA EA200300927A patent/EA007108B1/ru not_active IP Right Cessation
- 2003-09-23 CA CA2442881A patent/CA2442881C/fr not_active Expired - Fee Related
- 2003-09-23 ZA ZA200307411A patent/ZA200307411B/xx unknown
- 2003-09-24 CN CNB031348122A patent/CN1280286C/zh not_active Expired - Fee Related
- 2003-09-24 SG SG200305553A patent/SG110069A1/en unknown
- 2003-09-24 US US10/669,302 patent/US7091364B2/en not_active Expired - Fee Related
- 2003-09-24 MA MA27319A patent/MA26100A1/fr unknown
2004
- 2004-07-05 HK HK04104809A patent/HK1061846A1/xx not_active IP Right Cessation
2005
- 2005-03-08 IL IL167315A patent/IL167315A/en not_active IP Right Cessation
- 2005-03-23 TN TNP2005000088A patent/TNSN05088A1/fr unknown
- 2005-04-18 IS IS7803A patent/IS2728B/is unknown
- 2005-04-21 HR HRP20050361AA patent/HRP20050361B1/hr not_active IP Right Cessation
- 2005-04-22 EC EC2005005743A patent/ECSP055743A/es unknown
2010
- 2010-01-19 CY CY20101100055T patent/CY1109831T1/el unknown

Also Published As

Publication number	Publication date
DE60330213D1 (de)	2010-01-07
JP2004269496A (ja)	2004-09-30
AU2003299095A1 (en)	2004-04-19
WO2004029034A1 (fr)	2004-04-08
CY1109831T1 (el)	2014-09-10
SI1403265T1 (sl)	2010-01-29
US7091364B2 (en)	2006-08-15
CA2442881C (fr)	2010-06-29
HRP20050361B1 (hr)	2014-03-14
RS51551B (en)	2011-06-30
CA2442881A1 (fr)	2004-03-24
OA12932A (en)	2006-10-13
PL215879B1 (pl)	2014-02-28
FR2844797B1 (fr)	2004-10-22
IS2728B (is)	2011-04-15
BR0304203A (pt)	2004-08-24
AU2003248280A1 (en)	2004-04-08
IS7803A (is)	2005-04-18
JP4136866B2 (ja)	2008-08-20
PL362366A1 (en)	2004-04-05
AR041357A1 (es)	2005-05-11
UA79157C2 (en)	2007-05-25
AU2003248280B2 (en)	2009-01-08
RS20050241A (en)	2007-06-04
EP1403265A1 (fr)	2004-03-31
IL167315A (en)	2009-08-03
AP2005003255A0 (en)	2005-03-31
AP1972A (en)	2009-03-12
GEP20074139B (en)	2007-06-25
NO328626B1 (no)	2010-04-12
NZ528401A (en)	2004-05-28
HK1061846A1 (en)	2004-10-08
US20040059134A1 (en)	2004-03-25
CN1500784A (zh)	2004-06-02
EA007108B1 (ru)	2006-06-30
PT1403265E (pt)	2009-12-16
ES2337348T3 (es)	2010-04-23
ECSP055743A (es)	2005-07-06
ATE449767T1 (de)	2009-12-15
NO20034236D0 (no)	2003-09-23
EA200300927A1 (ru)	2004-04-29
HRP20050361A2 (en)	2005-06-30
KR20040026626A (ko)	2004-03-31
FR2844797A1 (fr)	2004-03-26
MY134924A (en)	2008-01-31
NO20034236L (no)	2004-03-25
ME00453B (me)	2011-10-10
CN1280286C (zh)	2006-10-18
EP1403265B1 (fr)	2009-11-25
TNSN05088A1 (fr)	2007-05-14
MA26100A1 (fr)	2004-04-01
MXPA03008647A (es)	2005-04-19
SG110069A1 (en)	2005-04-28
DK1403265T3 (da)	2010-04-06
KR100551502B1 (ko)	2006-02-13

Publication	Publication Date	Title
AP1972A (en)	2009-03-12	New process for the industrial synthesis of tetraesters of 5-[bis(carboxymethyl)amino]-3carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates.
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WO2007030361A3 (en)	2007-05-31	Benzimidazole thiophene compounds as plk inhibitors
AP2005003256A0 (en)	2005-03-31	New process for the industrial synthesis of strontium ranelate and its hydrates.
UA97638C2 (ru)	2012-03-12	Способ синтеза ранелата стронция и его гидратов
AP1942A (en)	2009-01-28	New process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates.
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