ZA200205879B - Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors. - Google Patents

Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors. Download PDF

Info

Publication number: ZA200205879B
Authority: ZA; South Africa
Prior art keywords: pyrido; pyrimidin; product; found; compound
Prior art date: 2000-01-25

Application number

ZA200205879A

Other languages

English (en)

Inventor

Booth Richard John

Dobrusin Ellen Myra

Josyula Vara Prasad V Nagendra

Mcnamara Dennis Joseph

Toogood Peter Laurence

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2002-07-23

Publication date

2003-09-29

2002-07-23 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2003-09-29 Publication of ZA200205879B publication Critical patent/ZA200205879B/en

Links

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229940043355 kinase inhibitor Drugs 0.000 title description 2
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125000004093 cyano group Chemical group *C#N 0.000 claims description 9
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230000019491 signal transduction Effects 0.000 description 1
XGVXKJKTISMIOW-ZDUSSCGKSA-N simurosertib Chemical compound N1N=CC(C=2SC=3C(=O)NC(=NC=3C=2)[C@H]2N3CCC(CC3)C2)=C1C XGVXKJKTISMIOW-ZDUSSCGKSA-N 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
150000003384 small molecules Chemical class 0.000 description 1
150000003385 sodium Chemical class 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
CMZUMMUJMWNLFH-UHFFFAOYSA-N sodium metavanadate Chemical compound [Na+].[O-][V](=O)=O CMZUMMUJMWNLFH-UHFFFAOYSA-N 0.000 description 1
MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000012453 solvate Substances 0.000 description 1
206010041823 squamous cell carcinoma Diseases 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000005017 substituted alkenyl group Chemical group 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
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229940095064 tartrate Drugs 0.000 description 1
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SFCPIVBCNGQUJZ-OYRHEFFESA-N tert-butyl (2r,6s)-4-[4-[[7-(cyclohexylcarbamoylamino)pyrido[2,3-d]pyrimidin-2-yl]amino]phenyl]-2,6-dimethylpiperazine-1-carboxylate Chemical group C1[C@@H](C)N(C(=O)OC(C)(C)C)[C@@H](C)CN1C(C=C1)=CC=C1NC1=NC=C(C=CC(NC(=O)NC2CCCCC2)=N2)C2=N1 SFCPIVBCNGQUJZ-OYRHEFFESA-N 0.000 description 1
GSALRQQUCCLTEJ-BETUJISGSA-N tert-butyl (2s,6r)-4-(4-aminophenyl)-2,6-dimethylpiperazine-1-carboxylate Chemical compound C1[C@@H](C)N(C(=O)OC(C)(C)C)[C@@H](C)CN1C1=CC=C(N)C=C1 GSALRQQUCCLTEJ-BETUJISGSA-N 0.000 description 1
UOUFRTFWWBCVPV-UHFFFAOYSA-N tert-butyl 4-(2,4-dioxo-1H-thieno[3,2-d]pyrimidin-3-yl)piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(CC1)n1c(=O)[nH]c2ccsc2c1=O UOUFRTFWWBCVPV-UHFFFAOYSA-N 0.000 description 1
QUKABSSPBMVPRN-UHFFFAOYSA-N tert-butyl 4-(4-aminophenyl)-2,2-dimethylpiperazine-1-carboxylate Chemical compound C1C(C)(C)N(C(=O)OC(C)(C)C)CCN1C1=CC=C(N)C=C1 QUKABSSPBMVPRN-UHFFFAOYSA-N 0.000 description 1
MGYCIJUTYLUYJM-UHFFFAOYSA-N tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=C([N+]([O-])=O)C=C1 MGYCIJUTYLUYJM-UHFFFAOYSA-N 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
208000030901 thyroid gland follicular carcinoma Diseases 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
125000006000 trichloroethyl group Chemical group 0.000 description 1
RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
231100000588 tumorigenic Toxicity 0.000 description 1
230000000381 tumorigenic effect Effects 0.000 description 1
208000010576 undifferentiated carcinoma Diseases 0.000 description 1
150000003672 ureas Chemical class 0.000 description 1
208000010570 urinary bladder carcinoma Diseases 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000011345 viscous material Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1
229910000166 zirconium phosphate Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

ZA200205879A 2000-01-25 2002-07-23 Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors. ZA200205879B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25

Publications (1)

Publication Number	Publication Date
ZA200205879B true ZA200205879B (en)	2003-09-29

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200205879A ZA200205879B (en)	2000-01-25	2002-07-23	Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors.

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (xx)
JP (1)	JP4047010B2 (xx)
KR (1)	KR20020065939A (xx)
CN (1)	CN1395578A (xx)
AP (1)	AP2002002586A0 (xx)
AR (1)	AR030044A1 (xx)
AU (1)	AU2542501A (xx)
BG (1)	BG106850A (xx)
BR (1)	BR0107751A (xx)
CA (1)	CA2397961C (xx)
CO (1)	CO5261549A1 (xx)
CR (1)	CR6706A (xx)
CZ (1)	CZ20022475A3 (xx)
DZ (1)	DZ3266A1 (xx)
EA (1)	EA200200643A1 (xx)
EE (1)	EE200200405A (xx)
GT (1)	GT200100016A (xx)
HN (1)	HN2001000013A (xx)
HU (1)	HUP0204141A3 (xx)
IL (1)	IL150545A0 (xx)
IS (1)	IS6443A (xx)
MA (1)	MA26868A1 (xx)
MX (1)	MXPA02007221A (xx)
NO (1)	NO20023527L (xx)
OA (1)	OA12161A (xx)
PA (1)	PA8510701A1 (xx)
PE (1)	PE20011066A1 (xx)
PL (1)	PL356802A1 (xx)
SK (1)	SK10632002A3 (xx)
SV (1)	SV2002000294A (xx)
TN (1)	TNSN01014A1 (xx)
WO (1)	WO2001055147A1 (xx)
YU (1)	YU50402A (xx)
ZA (1)	ZA200205879B (xx)

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US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US7323472B2 (en)	2000-10-23	2008-01-29	Smithkline Beecham Corporation	2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds
PE20030008A1 (es) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4
CN1646131A (zh)	2002-04-19	2005-07-27	史密丝克莱恩比彻姆公司	新化合物
US7504410B2 (en) *	2002-11-28	2009-03-17	Schering Aktiengesellschaft	Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en)	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (fr)	2004-07-15	2007-11-23	Sanofi Synthelabo	Derives de pyrido-pyrimidine, leur application en therapeutique
WO2006032452A1 (en) *	2004-09-21	2006-03-30	F. Hoffmann-La Roche Ag	6-(2-alkyl-phenyl) - pyrido[2,3-d] pyrimidines useful as proteine kinase inhibitors
US20090137550A1 (en)	2005-03-25	2009-05-28	Glaxo Group Limited	Novel Compounds
UY29440A1 (es)	2005-03-25	2006-10-02	Glaxo Group Ltd	Nuevos compuestos
EA200702073A1 (ru)	2005-03-25	2008-12-30	Глэксо Груп Лимитед	Способ получения пиридо[2,3-d]пиримидин-7-оновых и 3,4-дигидропиримидо[4,5-d]пиримидин-2(1н)-оновых производных
PE20100741A1 (es)	2005-03-25	2010-11-25	Glaxo Group Ltd	COMPUESTOS DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2(1H)-ONA COMO INHIBIDORES DE QUINASA p38
FR2887882B1 (fr)	2005-07-01	2007-09-07	Sanofi Aventis Sa	Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
ATE449097T1 (de) *	2005-07-21	2009-12-15	Hoffmann La Roche	Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer
JP2009504665A (ja)	2005-08-09	2009-02-05	アイアールエム・リミテッド・ライアビリティ・カンパニー	タンパク質キナーゼ阻害剤としての化合物および組成物
FR2896246B1 (fr)	2006-01-13	2008-08-15	Sanofi Aventis Sa	Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
EP1914234A1 (en)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
JO2985B1 (ar)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	مثبطات كينازmapk/erk
FR2910813B1 (fr) *	2006-12-28	2009-02-06	Sanofi Aventis Sa	Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2112150B1 (en)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Improved raf inhibitors
WO2010063352A1 (en) *	2008-12-01	2010-06-10	Merck Patent Gmbh	2, 5-diamino-substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors against cancer
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
WO2014151682A1 (en) *	2013-03-14	2014-09-25	Icahn School Of Medicine At Mount Sinai	Pyrimidine compounds as kinase inhibitors
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (ko) *	2014-09-02	2016-11-02	한국원자력의학원	항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107286180B (zh) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

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PT790997E (pt) *	1994-11-14	2000-06-30	Warner Lambert Co	6-aril pirido¬2,3-d\|pirimidinas e naftiridinas para inibir a proliferacao celular mediada pela quinase da tirosina proteica
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
NZ508268A (en) *	1998-05-26	2004-02-27	Warner Lambert Co	Bicyclic pyrimidines and bicyclic 3,4- dihydropyrimidines as inhibitors of cellular proliferation

2001
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/es not_active Application Discontinuation
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/cs unknown
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/es not_active Application Discontinuation
- 2001-01-23 EE EEP200200405A patent/EE200200405A/xx unknown
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/es unknown
- 2001-01-23 YU YU50402A patent/YU50402A/sh unknown
- 2001-01-23 PL PL01356802A patent/PL356802A1/xx not_active Application Discontinuation
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/pt not_active IP Right Cessation
- 2001-01-23 CN CN01804048A patent/CN1395578A/zh active Pending
- 2001-01-23 EP EP01900591A patent/EP1254137A1/en not_active Withdrawn
- 2001-01-23 AR ARP010100285A patent/AR030044A1/es not_active Application Discontinuation
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/ko not_active Application Discontinuation
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/fr active
- 2001-01-23 EA EA200200643A patent/EA200200643A1/ru unknown
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/ja not_active Expired - Fee Related
- 2001-01-23 CA CA002397961A patent/CA2397961C/en not_active Expired - Fee Related
- 2001-01-23 GT GT200100016A patent/GT200100016A/es unknown
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/en not_active Application Discontinuation
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/hu unknown
- 2001-01-23 IL IL15054501A patent/IL150545A0/xx unknown
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/sk not_active Application Discontinuation
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/es unknown
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/es not_active Application Discontinuation
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/fr unknown
- 2001-01-24 CO CO01005268A patent/CO5261549A1/es not_active Application Discontinuation
2002
- 2002-06-20 BG BG106850A patent/BG106850A/bg unknown
- 2002-06-25 IS IS6443A patent/IS6443A/is unknown
- 2002-07-17 CR CR6706A patent/CR6706A/es not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/fr unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EE200200405A (et)	2003-12-15
JP2003523357A (ja)	2003-08-05
MA26868A1 (fr)	2004-12-20
WO2001055147A1 (en)	2001-08-02
MXPA02007221A (es)	2002-11-29
TNSN01014A1 (fr)	2005-11-10
OA12161A (en)	2006-05-08
CA2397961C (en)	2008-08-26
GT200100016A (es)	2001-10-19
NO20023527D0 (no)	2002-07-24
PL356802A1 (en)	2004-07-12
CZ20022475A3 (cs)	2003-03-12
EP1254137A1 (en)	2002-11-06
EA200200643A1 (ru)	2002-12-26
AP2002002586A0 (en)	2002-09-30
HUP0204141A3 (en)	2005-03-29
NO20023527L (no)	2002-09-10
AU2542501A (en)	2001-08-07
CN1395578A (zh)	2003-02-05
HN2001000013A (es)	2001-06-18
YU50402A (sh)	2005-11-28
SV2002000294A (es)	2002-07-16
PE20011066A1 (es)	2001-10-22
BG106850A (bg)	2003-02-28
IS6443A (is)	2002-06-25
AR030044A1 (es)	2003-08-13
BR0107751A (pt)	2002-11-12
JP4047010B2 (ja)	2008-02-13
DZ3266A1 (fr)	2001-08-02
PA8510701A1 (es)	2002-12-11
IL150545A0 (en)	2003-02-12
KR20020065939A (ko)	2002-08-14
CO5261549A1 (es)	2003-03-31
CR6706A (es)	2005-04-04
CA2397961A1 (en)	2001-08-02
HUP0204141A2 (hu)	2003-04-28
SK10632002A3 (sk)	2003-06-03

Publication	Publication Date	Title
ZA200205879B (en)	2003-09-29	Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors.
US7053070B2 (en)	2006-05-30	Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
CA2329703C (en)	2005-12-20	Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
AU777468B2 (en)	2004-10-21	Pteridinones as kinase inhibitors
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