IL150545A0 - PYRIDO [2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS - Google Patents

PYRIDO [2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS

Info

Publication number: IL150545A0
Authority: IL; Israel
Prior art keywords: pyrido; pyrimidine; diamine; kinase inhibitors; kinase
Prior art date: 2000-01-25

Application number

IL15054501A

Other languages

English (en)

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-23

Publication date

2003-02-12

2001-01-23 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2003-02-12 Publication of IL150545A0 publication Critical patent/IL150545A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

IL15054501A 2000-01-25 2001-01-23 PYRIDO [2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS IL150545A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25
PCT/IB2001/000069 WO2001055147A1 (en)	2000-01-25	2001-01-23	PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS

Publications (1)

Publication Number	Publication Date
IL150545A0 true IL150545A0 (en)	2003-02-12

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15054501A IL150545A0 (en)	2000-01-25	2001-01-23	PYRIDO [2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (xx)
JP (1)	JP4047010B2 (xx)
KR (1)	KR20020065939A (xx)
CN (1)	CN1395578A (xx)
AP (1)	AP2002002586A0 (xx)
AR (1)	AR030044A1 (xx)
AU (1)	AU2542501A (xx)
BG (1)	BG106850A (xx)
BR (1)	BR0107751A (xx)
CA (1)	CA2397961C (xx)
CO (1)	CO5261549A1 (xx)
CR (1)	CR6706A (xx)
CZ (1)	CZ20022475A3 (xx)
DZ (1)	DZ3266A1 (xx)
EA (1)	EA200200643A1 (xx)
EE (1)	EE200200405A (xx)
GT (1)	GT200100016A (xx)
HN (1)	HN2001000013A (xx)
HU (1)	HUP0204141A3 (xx)
IL (1)	IL150545A0 (xx)
IS (1)	IS6443A (xx)
MA (1)	MA26868A1 (xx)
MX (1)	MXPA02007221A (xx)
NO (1)	NO20023527L (xx)
OA (1)	OA12161A (xx)
PA (1)	PA8510701A1 (xx)
PE (1)	PE20011066A1 (xx)
PL (1)	PL356802A1 (xx)
SK (1)	SK10632002A3 (xx)
SV (1)	SV2002000294A (xx)
TN (1)	TNSN01014A1 (xx)
WO (1)	WO2001055147A1 (xx)
YU (1)	YU50402A (xx)
ZA (1)	ZA200205879B (xx)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
AU2002246855B2 (en)	2000-10-23	2005-12-22	Smithkline Beecham Corporation	Novel compounds
PE20030008A1 (es) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4
ATE370952T1 (de)	2002-04-19	2007-09-15	Smithkline Beecham Corp	Neue verbindungen
BR0316680A (pt) *	2002-11-28	2005-10-18	Schering Ag	Pirimidinas inibidoras de chk, pdk e akt, sua produção e uso como agentes farmacêuticos
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en) *	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (fr)	2004-07-15	2007-11-23	Sanofi Synthelabo	Derives de pyrido-pyrimidine, leur application en therapeutique
CN101014600A (zh) *	2004-09-21	2007-08-08	霍夫曼-拉罗奇有限公司	用作蛋白激酶抑制剂的6－(2－烷基－苯基)－吡啶并[2,3－d]嘧啶类
WO2006104917A2 (en)	2005-03-25	2006-10-05	Glaxo Group Limited	Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one derivatives
JP2008535822A (ja)	2005-03-25	2008-09-04	グラクソグループリミテッド	新規化合物
AR053346A1 (es)	2005-03-25	2007-05-02	Glaxo Group Ltd	Compuesto derivado de 8h -pirido (2,3-d) pirimidin -7 ona 2,4,8- trisustituida composicion farmaceutica y uso para preparar una composicion para tratamiento y profilxis de una enfermedad mediada por la quinasa csbp/ rk/p38
TW200724142A (en)	2005-03-25	2007-07-01	Glaxo Group Ltd	Novel compounds
FR2887882B1 (fr) *	2005-07-01	2007-09-07	Sanofi Aventis Sa	Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
BRPI0613604A2 (pt) *	2005-07-21	2011-01-18	Hoffmann La Roche	compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de ptp-1b, e utilização dos compostos
ES2351939T3 (es) *	2005-08-09	2011-02-14	Irm Llc	Compuestos y composiciones como inhibidores de proteínas cinasas.
FR2896246B1 (fr)	2006-01-13	2008-08-15	Sanofi Aventis Sa	Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
EP1914234A1 (en)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
JO2985B1 (ar)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	مثبطات كينازmapk/erk
FR2910813B1 (fr) *	2006-12-28	2009-02-06	Sanofi Aventis Sa	Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2112150B1 (en)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Improved raf inhibitors
MX2011005720A (es) *	2008-12-01	2011-06-17	Merck Patent Gmbh	Pirido [4,3-d] pirimidinas 2,5-diamino sustituidas como inhibidores de autotaxina contra cancer.
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
WO2014151682A1 (en) *	2013-03-14	2014-09-25	Icahn School Of Medicine At Mount Sinai	Pyrimidine compounds as kinase inhibitors
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (ko) *	2014-09-02	2016-11-02	한국원자력의학원	항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107286180B (zh) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GEP20012444B (en) *	1994-11-14	2001-05-25	Warner Lambert Company Us	6-Aryl Pyrido[2,3-d]Pyrimidines and Naphthyridines, Pharmaceutical Composition on Their Basis and Application for Inhibiting Cellular Proliferation
IL115256A0 (en) *	1994-11-14	1995-12-31	Warner Lambert Co	6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
DE69939168D1 (de) *	1998-05-26	2008-09-04	Warner Lambert Co	Bicyclische pyrimidine und bicyclische 3,4-dihydropyrimidine als inhibitoren der zellvermehrung

2001
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/hu unknown
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/pt not_active IP Right Cessation
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/cs unknown
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 IL IL15054501A patent/IL150545A0/xx unknown
- 2001-01-23 PL PL01356802A patent/PL356802A1/xx not_active Application Discontinuation
- 2001-01-23 EP EP01900591A patent/EP1254137A1/en not_active Withdrawn
- 2001-01-23 GT GT200100016A patent/GT200100016A/es unknown
- 2001-01-23 CN CN01804048A patent/CN1395578A/zh active Pending
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/ja not_active Expired - Fee Related
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/es not_active Application Discontinuation
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/ko not_active Application Discontinuation
- 2001-01-23 AR ARP010100285A patent/AR030044A1/es not_active Application Discontinuation
- 2001-01-23 EA EA200200643A patent/EA200200643A1/ru unknown
- 2001-01-23 YU YU50402A patent/YU50402A/sh unknown
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/en not_active Application Discontinuation
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/sk not_active Application Discontinuation
- 2001-01-23 CA CA002397961A patent/CA2397961C/en not_active Expired - Fee Related
- 2001-01-23 EE EEP200200405A patent/EE200200405A/xx unknown
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/es not_active Application Discontinuation
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/fr active
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/es unknown
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/fr unknown
- 2001-01-24 CO CO01005268A patent/CO5261549A1/es not_active Application Discontinuation
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/es not_active Application Discontinuation
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/es unknown
2002
- 2002-06-20 BG BG106850A patent/BG106850A/bg unknown
- 2002-06-25 IS IS6443A patent/IS6443A/is unknown
- 2002-07-17 CR CR6706A patent/CR6706A/es not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/fr unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CR6706A (es)	2005-04-04
AU2542501A (en)	2001-08-07
WO2001055147A1 (en)	2001-08-02
PE20011066A1 (es)	2001-10-22
MXPA02007221A (es)	2002-11-29
BR0107751A (pt)	2002-11-12
HUP0204141A3 (en)	2005-03-29
KR20020065939A (ko)	2002-08-14
TNSN01014A1 (fr)	2005-11-10
AP2002002586A0 (en)	2002-09-30
PL356802A1 (en)	2004-07-12
BG106850A (bg)	2003-02-28
OA12161A (en)	2006-05-08
NO20023527L (no)	2002-09-10
EE200200405A (et)	2003-12-15
HN2001000013A (es)	2001-06-18
PA8510701A1 (es)	2002-12-11
IS6443A (is)	2002-06-25
CA2397961C (en)	2008-08-26
DZ3266A1 (fr)	2001-08-02
EP1254137A1 (en)	2002-11-06
EA200200643A1 (ru)	2002-12-26
NO20023527D0 (no)	2002-07-24
CZ20022475A3 (cs)	2003-03-12
CN1395578A (zh)	2003-02-05
GT200100016A (es)	2001-10-19
SV2002000294A (es)	2002-07-16
JP2003523357A (ja)	2003-08-05
CO5261549A1 (es)	2003-03-31
JP4047010B2 (ja)	2008-02-13
AR030044A1 (es)	2003-08-13
HUP0204141A2 (hu)	2003-04-28
ZA200205879B (en)	2003-09-29
MA26868A1 (fr)	2004-12-20
CA2397961A1 (en)	2001-08-02
SK10632002A3 (sk)	2003-06-03
YU50402A (sh)	2005-11-28

Publication	Publication Date	Title
IL150545A0 (en)	2003-02-12	PYRIDO [2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS
HRP20020798A2 (en)	2004-02-29	5-ALKYLPYRIDO[2,3-d]PYRIMIDINES TYROZINE KINASE INHIBITORS
IL159832A0 (en)	2004-06-20	4-amino-6-phenyl-pyrrolo[2,3-d] pyrimidine derivatives
PL357536A1 (en)	2004-07-26	Pyrazolo `4,3-d! pyrimidine derivatives
IL181957A0 (en)	2009-02-11	Pyrimidine-4-one derivatives as ldl-pla2 inhibitors
IL153754A0 (en)	2003-07-06	Pyrimidine derivatives
IL158697A0 (en)	2004-05-12	4-amino-5-phenyl-7-cyclobutyl-pyrrolo (2,3-d) pyrimidine derivatives
HUP0202713A3 (en)	2005-02-28	Pteridinones as kinase inhibitors
AU1041802A (en)	2002-01-30	Tetrahydro-heterocycloazepinyl pyrimidine derivatives
ZA200204510B (en)	2003-11-26	Imidazopyridine derivatives used as phosphodiesterase VII inhibitors.
HK1047434A1 (en)	2003-02-21	Thienopyrimidines as phosphodiesterase inhibitors.
DE50001191D1 (de)	2003-03-06	Pyrazolo[4, 3-d]pyrimidine
PL358551A1 (en)	2004-08-09	5-aminoalkyl-pyrazolo[4,3-d]pyrimidines
AU2792102A (en)	2002-06-03	Pyrimidine derivatives
MXPA03004498A (es)	2003-09-05	Uso de pirazolo (4,3-d)pirimidinas.
MXPA03004907A (es)	2003-09-05	Uso de pirazolo (4,3-d) pirimidinas.
AU8578501A (en)	2002-01-08	2-aminoalkyl-thieno(2,3-d)pyrimidines
IL155380A0 (en)	2003-11-23	SUBSTITUTED 3,4-DIHYDRO-PYRIDO[1,2-a] PYRIMIDINES
ZA200206528B (en)	2003-03-13	Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors.
SI1303496T1 (sl)	2007-12-31	Pirimidinski derivati