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ZA200110479B - Respiratory syncytial virus replication inhibitors. - Google Patents

Respiratory syncytial virus replication inhibitors.

Info

Publication number
ZA200110479B
ZA200110479B ZA200110479A ZA200110479A ZA200110479B ZA 200110479 B ZA200110479 B ZA 200110479B ZA 200110479 A ZA200110479 A ZA 200110479A ZA 200110479 A ZA200110479 A ZA 200110479A ZA 200110479 B ZA200110479 B ZA 200110479B
Authority
ZA
South Africa
Prior art keywords
respiratory syncytial
syncytial virus
virus replication
replication inhibitors
inhibitors
Prior art date
Application number
ZA200110479A
Other languages
English (en)
Inventor
Frans Eduard Janssens
Kathleen Petrus Marie Meersman
Francois Maria Sommen
Koenraad Josef Lodewij Andries
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA200110479B publication Critical patent/ZA200110479B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA200110479A 1999-06-28 2001-12-20 Respiratory syncytial virus replication inhibitors. ZA200110479B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99202088 1999-06-28

Publications (1)

Publication Number Publication Date
ZA200110479B true ZA200110479B (en) 2003-03-20

Family

ID=8240373

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200110479A ZA200110479B (en) 1999-06-28 2001-12-20 Respiratory syncytial virus replication inhibitors.

Country Status (33)

Country Link
US (3) US6747028B1 (zh)
EP (1) EP1196409B1 (zh)
JP (1) JP2003503402A (zh)
KR (1) KR100731271B1 (zh)
CN (1) CN1210275C (zh)
AR (1) AR035991A1 (zh)
AT (1) ATE258928T1 (zh)
AU (1) AU778218B2 (zh)
BG (1) BG65328B1 (zh)
BR (1) BR0012047A (zh)
CA (1) CA2376676C (zh)
DE (1) DE60008112T2 (zh)
DK (1) DK1196409T3 (zh)
EA (1) EA005027B1 (zh)
EE (1) EE04591B1 (zh)
ES (1) ES2215683T3 (zh)
HK (1) HK1045997A1 (zh)
HR (1) HRP20010935A2 (zh)
HU (1) HUP0201869A3 (zh)
IL (2) IL147327A0 (zh)
MX (1) MXPA02000120A (zh)
MY (1) MY127687A (zh)
NO (1) NO322458B1 (zh)
NZ (1) NZ515664A (zh)
PL (1) PL200674B1 (zh)
PT (1) PT1196409E (zh)
SI (1) SI1196409T1 (zh)
SK (1) SK19122001A3 (zh)
TR (1) TR200103806T2 (zh)
TW (1) TWI278454B (zh)
UA (1) UA74787C2 (zh)
WO (1) WO2001000612A2 (zh)
ZA (1) ZA200110479B (zh)

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US8202896B2 (en) 2002-08-09 2012-06-19 Microdose Therapeutx, Inc. Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
CA2495245A1 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
WO2004035549A1 (en) * 2002-10-17 2004-04-29 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
CA2541618C (en) 2003-10-30 2011-12-13 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
TWI378926B (en) * 2003-12-18 2012-12-11 Tibotec Pharm Ltd Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication
EP1697343B1 (en) * 2003-12-18 2009-07-01 Tibotec Pharmaceuticals Ltd. Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
EP1697347B1 (en) * 2003-12-18 2011-02-23 Tibotec Pharmaceuticals 5- or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
MXPA06007110A (es) 2003-12-18 2006-08-23 Tibotec Pharm Ltd Derivados de los amino-bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio.
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
DK1723136T3 (da) 2003-12-18 2011-06-27 Tibotec Pharm Ltd Piperidinamino-benzimidazol-derivat som inhibitorer af replikation af respiratorisk syncytial virus
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BRPI0606278B8 (pt) 2005-03-17 2021-05-25 Janssen R & D Ireland aminas de 1,3-diidro-benzimidazol-2-ilideno como inibidores de replicação de vírus sincicial respiratório, seu processo de preparação e composição farmacêutica
CN101203507B (zh) 2005-06-20 2012-05-23 泰博特克药品有限公司 2-取代的苯并咪唑
RU2434000C2 (ru) * 2005-06-20 2011-11-20 Тиботек Фармасьютикалз Лтд. 1-(2-амино-3-(замещенный алкил)-3н-бензимидазоилметил)-3-замещенные-1,3-дигидробензоимидазол-2-оны с активностью в отношении респираторно-синцитиального вируса
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WO2011097607A1 (en) * 2010-02-08 2011-08-11 Southern Research Institute Anti-viral treatment and assay to screen for anti-viral agent
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
WO2013102145A1 (en) 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
HRP20171665T1 (hr) 2011-12-28 2017-12-15 Global Blood Therapeutics, Inc. Supstituirani spojevi benzaldehida i metode za njihovu primjenu u povećanju oksigenacije tkiva
ES2632914T3 (es) 2012-06-15 2017-09-18 Janssen Sciences Ireland Uc Derivados de 1,3-dihidro-2H-bencimidazol-2-ona sustituidos con heterociclos como agentes antivirales para el virus respiratorio sincicial
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EP2968299B1 (en) 2013-03-15 2021-01-20 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EP3919056B1 (en) 2013-03-15 2024-08-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
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TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
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JP2023528969A (ja) 2020-06-11 2023-07-06 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ３－（｛５－クロロ－１－［３－（メチルスルホニル）プロピル］－１Ｈ－インドール－２ イル｝メチル）－１－（２，２，２－トリフルオロエチル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オンのヘミ（Ｌ）－酒石酸塩形態及びそれを含む医薬組成物

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Also Published As

Publication number Publication date
TWI278454B (en) 2007-04-11
CN1210275C (zh) 2005-07-13
IL147327A0 (en) 2002-08-14
US20070015747A1 (en) 2007-01-18
AR035991A1 (es) 2004-08-04
AU5816600A (en) 2001-01-31
PT1196409E (pt) 2004-06-30
SK19122001A3 (sk) 2003-01-09
CA2376676A1 (en) 2001-01-04
CA2376676C (en) 2009-01-20
HK1045997A1 (zh) 2002-12-20
NO20016369D0 (no) 2001-12-27
EA005027B1 (ru) 2004-10-28
MY127687A (en) 2006-12-29
DE60008112D1 (en) 2004-03-11
DE60008112T2 (de) 2004-09-16
DK1196409T3 (da) 2004-06-07
US20070135404A1 (en) 2007-06-14
WO2001000612A3 (en) 2001-03-29
ES2215683T3 (es) 2004-10-16
NZ515664A (en) 2004-01-30
HUP0201869A3 (en) 2003-12-29
CN1358181A (zh) 2002-07-10
TR200103806T2 (tr) 2002-06-21
JP2003503402A (ja) 2003-01-28
EA200200088A1 (ru) 2002-06-27
EE200100688A (et) 2003-04-15
AU778218B2 (en) 2004-11-25
KR100731271B1 (ko) 2007-06-21
PL200674B1 (pl) 2009-01-30
HRP20010935A2 (en) 2003-06-30
KR20020003884A (ko) 2002-01-15
ATE258928T1 (de) 2004-02-15
BG65328B1 (bg) 2008-02-29
EE04591B1 (et) 2006-02-15
EP1196409B1 (en) 2004-02-04
BG106286A (en) 2002-10-31
WO2001000612A2 (en) 2001-01-04
SI1196409T1 (en) 2004-06-30
US7179811B2 (en) 2007-02-20
MXPA02000120A (es) 2002-07-02
NO322458B1 (no) 2006-10-09
EP1196409A2 (en) 2002-04-17
PL352378A1 (en) 2003-08-25
US7528149B2 (en) 2009-05-05
US6747028B1 (en) 2004-06-08
NO20016369L (no) 2002-02-20
UA74787C2 (en) 2006-02-15
IL147327A (en) 2007-06-03
HUP0201869A2 (hu) 2002-11-28
BR0012047A (pt) 2002-03-12

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