YU99703A - Kristalni antiholinergik, postupak za njegovo pripremanje i njegova primena u proizvodnji leka - Google Patents
Kristalni antiholinergik, postupak za njegovo pripremanje i njegova primena u proizvodnji lekaInfo
- Publication number
- YU99703A YU99703A YU99703A YUP99703A YU99703A YU 99703 A YU99703 A YU 99703A YU 99703 A YU99703 A YU 99703A YU P99703 A YUP99703 A YU P99703A YU 99703 A YU99703 A YU 99703A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- production
- drug
- crystalline
- anticholinergic
- crystalline anticholinergic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
Pronalazak se odnosi na kristalni, bezvodni (1α,2ГЎ,4ГЎ,5α,7ГЎ)-7-[(hidroksidi-2-tienil-acetil)oksi]-9,9-dimetil-3-oksa-9-azoniatriciklo[3.3.1.02,4]nonan-bromid, na postupak za njegovo pripremanje, kao i na njegovu primenu za pripremanje leka, naročito za proizvodnju leka sa antiholinergijskim dejstvom.[The invention relates to crystalline, water-free (1α,2ГЎ,4ГЎ,5α,7ГЎ)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9- azoniatricyclo[3.3.1.02,4]nonane-bromide, to a method for its production, and to the use thereof in the production of a drug, especially in the production of an anticholinergic drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MEP-2008-620A ME00412B (me) | 2001-06-22 | 2002-06-08 | Kristalni antiholinergik , postupak za njegovo pripremanje i njegova primjena u proizvodnji lijeka |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10129710 | 2001-06-22 | ||
| DE10215436 | 2002-04-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU99703A true YU99703A (sh) | 2006-05-25 |
| RS50441B RS50441B (sr) | 2010-03-02 |
Family
ID=26009556
Country Status (38)
| Country | Link |
|---|---|
| EP (1) | EP1401445B1 (sh) |
| JP (1) | JP2005504015A (sh) |
| KR (2) | KR100971616B1 (sh) |
| CN (1) | CN100586948C (sh) |
| AR (1) | AR037491A1 (sh) |
| AT (1) | ATE337006T1 (sh) |
| AU (1) | AU2002345016B2 (sh) |
| BG (1) | BG66303B1 (sh) |
| BR (1) | BR0210537A (sh) |
| CA (1) | CA2450961C (sh) |
| CO (1) | CO5550423A2 (sh) |
| CY (1) | CY1105223T1 (sh) |
| CZ (1) | CZ302786B6 (sh) |
| DE (1) | DE50207943D1 (sh) |
| DK (1) | DK1401445T3 (sh) |
| EA (1) | EA005813B1 (sh) |
| EE (1) | EE05316B1 (sh) |
| EG (1) | EG24851A (sh) |
| ES (1) | ES2271280T3 (sh) |
| HK (1) | HK1068540A1 (sh) |
| HR (1) | HRP20031066B1 (sh) |
| HU (1) | HUP0400333A3 (sh) |
| IL (2) | IL159238A0 (sh) |
| ME (1) | ME00412B (sh) |
| MX (1) | MXPA03011718A (sh) |
| MY (1) | MY122779A (sh) |
| NO (1) | NO334301B1 (sh) |
| NZ (1) | NZ530690A (sh) |
| PE (2) | PE20081305A1 (sh) |
| PL (1) | PL208137B1 (sh) |
| PT (1) | PT1401445E (sh) |
| RS (1) | RS50441B (sh) |
| SA (1) | SA02230255B1 (sh) |
| SI (1) | SI1401445T1 (sh) |
| SK (1) | SK287262B6 (sh) |
| TW (2) | TWI261589B (sh) |
| UY (1) | UY27342A1 (sh) |
| WO (1) | WO2003000265A1 (sh) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10212264A1 (de) | 2002-03-20 | 2003-10-02 | Boehringer Ingelheim Pharma | Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels |
| US7056916B2 (en) | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
| US20050038004A1 (en) * | 2003-07-31 | 2005-02-17 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| RS20060291A (en) * | 2003-11-03 | 2008-06-05 | Boehringer Ingelheim International Gmbh., | Novel crystalline anhydride with anticholinergic effect |
| DE102004016179A1 (de) * | 2004-03-30 | 2005-10-20 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von proliferativen Prozessen |
| PT1781298E (pt) | 2004-04-22 | 2012-02-03 | Boehringer Ingelheim Int | Combinações farmacêuticas contendo benzoxazinas para o tratamento de doenças respiratórias |
| DE102004024454A1 (de) | 2004-05-14 | 2005-12-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| US7220742B2 (en) | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
| ATE427108T1 (de) | 2004-08-11 | 2009-04-15 | Boehringer Ingelheim Pharma | Anticholinergika enthaltende arzneimittel zur behandlung von krankheiten der ableitenden harnwege |
| US20060079544A1 (en) * | 2004-08-13 | 2006-04-13 | Boehringer Ingelheim International Gmbh | Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic |
| DE102004048389A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa |
| AU2006237354B2 (en) | 2005-04-21 | 2012-03-01 | Boehringer Ingelheim International Gmbh | Dihydrothienopyrimidines for the treatment of inflammatory diseases |
| BRPI0609899A2 (pt) | 2005-04-28 | 2010-05-11 | Boehringer Ingelheim International Gmbh | compostos para o tratamento de doenças inflamatórias, uso dos mesmos, formulações farmacêuticas, combinações medicamentosas e produtos intermediários |
| EP1879888A2 (en) * | 2005-05-02 | 2008-01-23 | Boehringer Ingelheim International GmbH | Crystalline forms of tiotropium bromide |
| PL1881980T3 (pl) * | 2005-05-02 | 2013-01-31 | Boehringer Ingelheim Int | Nowe krystaliczne formy bromku tiotropium |
| DE102005030733A1 (de) | 2005-07-01 | 2007-01-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff |
| JP5270343B2 (ja) | 2005-08-15 | 2013-08-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベータミメティックスの製造方法 |
| TWI396541B (zh) | 2005-10-10 | 2013-05-21 | Boehringer Ingelheim Int | 用於治療呼吸疾病之新穎藥物組合 |
| US7423146B2 (en) | 2005-11-09 | 2008-09-09 | Boehringer Ingelheim International Gmbh | Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones |
| WO2007075858A2 (en) * | 2005-12-19 | 2007-07-05 | Sicor Inc. | Novel forms of tiotropium bromide and processes for preparation thereof |
| US9108962B2 (en) | 2005-12-19 | 2015-08-18 | Sicor, Inc. | Forms of tiotropium bromide and processes for preparation thereof |
| CN100999521B (zh) * | 2006-01-13 | 2010-12-08 | 江苏正大天晴药业股份有限公司 | 结晶性抗胆碱药噻托溴铵 |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| CA2660186A1 (en) | 2006-08-07 | 2008-02-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of respiratory diseases |
| UY30550A1 (es) | 2006-08-22 | 2008-03-31 | Boehringer Ingelheim Int | Nuevos beta-agonistas enantioméricamente puros, procedimientos para su preparacion y su uso como medicamentos |
| GB0716026D0 (en) | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
| ATE542825T1 (de) | 2007-10-19 | 2012-02-15 | Boehringer Ingelheim Int | Substituierte piperidino-dihydrothienopyrimidine |
| EP2093219A1 (de) | 2008-02-22 | 2009-08-26 | Boehringer Ingelheim International Gmbh | Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel |
| WO2010070032A1 (en) | 2008-12-19 | 2010-06-24 | Boehringer Ingelheim International Gmbh | Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd |
| EP2403851B1 (en) | 2009-03-06 | 2015-06-17 | Mahmut Bilgic | New crystalline forms of tiotropium bromide |
| SI2513093T1 (sl) | 2009-12-17 | 2014-11-28 | Boehringer Ingelheim International Gmbh | Novi CCR2 receptorski antagonisti in njihove uporabe |
| WO2011073155A1 (en) | 2009-12-17 | 2011-06-23 | Boehringer Ingelheim International Gmbh | Novel antagonists for ccr2 and uses thereof |
| BR112012018865A2 (pt) | 2010-01-29 | 2016-04-12 | Boehringer Ingelheim Int | naftiridinas substituídas e seu uso como inibidores de quinase syk |
| EP2569298B1 (en) | 2010-05-12 | 2015-11-25 | Boehringer Ingelheim International GmbH | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| EP2569295B1 (en) | 2010-05-12 | 2014-11-19 | Boehringer Ingelheim International GmbH | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| EP2571870B1 (en) | 2010-05-17 | 2015-01-21 | Boehringer Ingelheim International GmbH | Ccr2 antagonists and uses thereof |
| WO2011147772A1 (en) | 2010-05-25 | 2011-12-01 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists |
| EP2576538B1 (en) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | New CCR2 antagonists |
| TR201007108A2 (tr) * | 2010-08-25 | 2012-03-21 | B�Lg�� Mahmut | Yeni tiotropyum bromür kristali ve üretim yöntemi.@ |
| WO2012101013A1 (en) | 2011-01-28 | 2012-08-02 | Boehringer Ingelheim International Gmbh | Substituted pyridinyl-pyrimidines and their use as medicaments |
| TR201101897A2 (tr) | 2011-02-28 | 2012-09-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür içeren kristal madde |
| TR201111589A2 (tr) * | 2011-03-03 | 2012-09-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür susuz kristal formu. |
| TR201102068A2 (tr) | 2011-03-03 | 2012-09-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür içeren kristal maddeler |
| JP5786257B2 (ja) | 2011-06-16 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の選択的ｃｃｒ２拮抗薬 |
| EP2731941B1 (en) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Novel and selective ccr2 antagonists |
| AU2012288969B2 (en) | 2011-07-26 | 2017-02-23 | Boehringer Ingelheim International Gmbh | Substituted quinolines and their use as medicaments |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| CA2856706C (en) | 2011-11-25 | 2020-06-16 | Bayer Pharma Aktiengesellschaft | Method for producing substituted 5-fluoro-1h-pyrazolopyridines |
| CZ304368B6 (cs) | 2011-11-28 | 2014-04-02 | Zentiva, K.S. | Směsný solvát tiotropium bromidu a způsob jeho přípravy |
| GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
| PT106142B (pt) * | 2012-02-10 | 2014-07-18 | Hovione Farmaci Ncia S A | Processo para a preparação de brometo de tiotrópio |
| US9096579B2 (en) | 2012-04-20 | 2015-08-04 | Boehringer Ingelheim International Gmbh | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
| WO2014042605A1 (en) * | 2012-09-11 | 2014-03-20 | Mahmut Bilgic | New tiotropium bromide crystalline form |
| HUE032455T2 (en) | 2012-11-05 | 2017-09-28 | Zentiva Ks | Stabilization of thiotropium solvates |
| CN104341412A (zh) * | 2013-07-29 | 2015-02-11 | 天津金耀集团有限公司 | 一种无水噻托溴铵结晶的制备方法 |
| AU2015233654B2 (en) | 2014-03-19 | 2018-12-06 | Boehringer Ingelheim International Gmbh | Heteroaryl Syk inhibitors |
| US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
| HUE051693T2 (hu) | 2014-10-21 | 2021-03-29 | Ariad Pharma Inc | 5-Klór-N4-[2-(dimetilfoszforil)-fenil]-N2-{2-metoxi-4-[4-(4-metilpiperazin-1-il)-piperidin-1-il] -pirimidin-2,4-diamin kristályos formái |
| WO2017138896A1 (en) * | 2016-02-11 | 2017-08-17 | Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti | Crystalline form of tiotropium bromide anhydrate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| BR0114584A (pt) * | 2000-10-12 | 2003-08-26 | Boehringer Ingelheim Pharma | Monohidrato cristalino, processos para a sua preparação e sua aplicação para a preparação de um medicamento |
| DE10064816A1 (de) * | 2000-12-22 | 2002-06-27 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung eines Anticholinergikums |
-
2002
- 2002-06-08 KR KR1020037016769A patent/KR100971616B1/ko active IP Right Grant
- 2002-06-08 ME MEP-2008-620A patent/ME00412B/me unknown
- 2002-06-08 MX MXPA03011718A patent/MXPA03011718A/es active IP Right Grant
- 2002-06-08 SK SK52-2004A patent/SK287262B6/sk unknown
- 2002-06-08 JP JP2003506910A patent/JP2005504015A/ja active Pending
- 2002-06-08 RS YUP-997/03A patent/RS50441B/sr unknown
- 2002-06-08 HU HU0400333A patent/HUP0400333A3/hu unknown
- 2002-06-08 PT PT02743165T patent/PT1401445E/pt unknown
- 2002-06-08 DE DE50207943T patent/DE50207943D1/de not_active Expired - Lifetime
- 2002-06-08 IL IL15923802A patent/IL159238A0/xx unknown
- 2002-06-08 EE EEP200400029A patent/EE05316B1/xx unknown
- 2002-06-08 WO PCT/EP2002/006291 patent/WO2003000265A1/de active Application Filing
- 2002-06-08 DK DK02743165T patent/DK1401445T3/da active
- 2002-06-08 NZ NZ530690A patent/NZ530690A/en not_active IP Right Cessation
- 2002-06-08 SI SI200230431T patent/SI1401445T1/sl unknown
- 2002-06-08 EP EP02743165A patent/EP1401445B1/de not_active Expired - Lifetime
- 2002-06-08 KR KR1020097004823A patent/KR101011353B1/ko active IP Right Grant
- 2002-06-08 PL PL364489A patent/PL208137B1/pl unknown
- 2002-06-08 CZ CZ20040120A patent/CZ302786B6/cs not_active IP Right Cessation
- 2002-06-08 ES ES02743165T patent/ES2271280T3/es not_active Expired - Lifetime
- 2002-06-08 CN CN02812303A patent/CN100586948C/zh not_active Expired - Lifetime
- 2002-06-08 BR BR0210537-3A patent/BR0210537A/pt active Pending
- 2002-06-08 AU AU2002345016A patent/AU2002345016B2/en not_active Expired
- 2002-06-08 CA CA2450961A patent/CA2450961C/en not_active Expired - Fee Related
- 2002-06-08 AT AT02743165T patent/ATE337006T1/de active
- 2002-06-08 EA EA200301293A patent/EA005813B1/ru not_active IP Right Cessation
- 2002-06-19 EG EG2002060698A patent/EG24851A/xx active
- 2002-06-19 TW TW091113373A patent/TWI261589B/zh not_active IP Right Cessation
- 2002-06-19 TW TW095100968A patent/TW200617007A/zh unknown
- 2002-06-20 MY MYPI20022316A patent/MY122779A/en unknown
- 2002-06-20 UY UY27342A patent/UY27342A1/es not_active Application Discontinuation
- 2002-06-21 PE PE2007000660A patent/PE20081305A1/es not_active Application Discontinuation
- 2002-06-21 PE PE2002000538A patent/PE20030130A1/es active IP Right Grant
- 2002-06-21 AR ARP020102337A patent/AR037491A1/es not_active Ceased/Invalidation/Refusal/Rejection/Nullification
- 2002-08-19 SA SA2230255A patent/SA02230255B1/ar unknown
-
2003
- 2003-12-08 IL IL159238A patent/IL159238A/en active IP Right Grant
- 2003-12-12 BG BG108440A patent/BG66303B1/bg active Active
- 2003-12-19 NO NO20035696A patent/NO334301B1/no not_active IP Right Cessation
- 2003-12-19 HR HR20031066A patent/HRP20031066B1/xx not_active IP Right Cessation
-
2004
- 2004-01-20 CO CO04003764A patent/CO5550423A2/es not_active Application Discontinuation
-
2005
- 2005-01-29 HK HK05100780.9A patent/HK1068540A1/xx not_active IP Right Cessation
-
2006
- 2006-09-20 CY CY20061101339T patent/CY1105223T1/el unknown
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