IL159238A0 - Crystalline anticholinergic, method for its production, and use thereof in the production of a drug - Google Patents

Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Info

Publication number: IL159238A0
Authority: IL; Israel
Prior art keywords: production; drug; anticholinergic; crystalline; crystalline anticholinergic
Prior art date: 2001-06-22

Application number

IL15923802A

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-22

Filing date

2002-06-08

Publication date

2004-06-01

2002-06-08 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2004-06-01 Publication of IL159238A0 publication Critical patent/IL159238A0/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pulmonology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

IL15923802A 2001-06-22 2002-06-08 Crystalline anticholinergic, method for its production, and use thereof in the production of a drug IL159238A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10129710		2001-06-22
DE10215436		2002-04-08
PCT/EP2002/006291 WO2003000265A1 (en)	2001-06-22	2002-06-08	Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Publications (1)

Publication Number	Publication Date
IL159238A0 true IL159238A0 (en)	2004-06-01

Family

ID=26009556

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL15923802A IL159238A0 (en)	2001-06-22	2002-06-08	Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
IL159238A IL159238A (en)	2001-06-22	2003-12-08	Crystalline anticholinergic, method for its production and use thereof in the production of a drug

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL159238A IL159238A (en)	2001-06-22	2003-12-08	Crystalline anticholinergic, method for its production and use thereof in the production of a drug

Country Status (38)

Country	Link
EP (1)	EP1401445B1 (en)
JP (1)	JP2005504015A (en)
KR (2)	KR100971616B1 (en)
CN (1)	CN100586948C (en)
AR (1)	AR037491A1 (en)
AT (1)	ATE337006T1 (en)
AU (1)	AU2002345016B2 (en)
BG (1)	BG66303B1 (en)
BR (1)	BR0210537A (en)
CA (1)	CA2450961C (en)
CO (1)	CO5550423A2 (en)
CY (1)	CY1105223T1 (en)
CZ (1)	CZ302786B6 (en)
DE (1)	DE50207943D1 (en)
DK (1)	DK1401445T3 (en)
EA (1)	EA005813B1 (en)
EE (1)	EE05316B1 (en)
EG (1)	EG24851A (en)
ES (1)	ES2271280T3 (en)
HK (1)	HK1068540A1 (en)
HR (1)	HRP20031066B1 (en)
HU (1)	HUP0400333A3 (en)
IL (2)	IL159238A0 (en)
ME (1)	ME00412B (en)
MX (1)	MXPA03011718A (en)
MY (1)	MY122779A (en)
NO (1)	NO334301B1 (en)
NZ (1)	NZ530690A (en)
PE (2)	PE20081305A1 (en)
PL (1)	PL208137B1 (en)
PT (1)	PT1401445E (en)
RS (1)	RS50441B (en)
SA (1)	SA02230255B1 (en)
SI (1)	SI1401445T1 (en)
SK (1)	SK287262B6 (en)
TW (2)	TWI261589B (en)
UY (1)	UY27342A1 (en)
WO (1)	WO2003000265A1 (en)

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DE10212264A1 (en)	2002-03-20	2003-10-02	Boehringer Ingelheim Pharma	Crystalline micronisate, process for its preparation and its use for the manufacture of a medicament
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RS20060291A (en) *	2003-11-03	2008-06-05	Boehringer Ingelheim International Gmbh.,	Novel crystalline anhydride with anticholinergic effect
DE102004016179A1 (en) *	2004-03-30	2005-10-20	Boehringer Ingelheim Pharma	Compounds for the treatment of proliferative processes
PT1781298E (en)	2004-04-22	2012-02-03	Boehringer Ingelheim Int	Pharmaceutical combinations containing benzoxazine for treating respiratory diseases
DE102004024454A1 (en)	2004-05-14	2005-12-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Novel enantiomerically pure beta agonists, process for their preparation and their use as pharmaceuticals
US7220742B2 (en)	2004-05-14	2007-05-22	Boehringer Ingelheim International Gmbh	Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
ATE427108T1 (en)	2004-08-11	2009-04-15	Boehringer Ingelheim Pharma	MEDICINAL PRODUCTS CONTAINING ANTICHOLINERGICS FOR THE TREATMENT OF DISEASES OF THE URINARY TRACT
US20060079544A1 (en) *	2004-08-13	2006-04-13	Boehringer Ingelheim International Gmbh	Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (en)	2004-10-01	2006-04-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Modification of surfaces of lactose as adjuvant for use with powder inhalants
AU2006237354B2 (en)	2005-04-21	2012-03-01	Boehringer Ingelheim International Gmbh	Dihydrothienopyrimidines for the treatment of inflammatory diseases
BRPI0609899A2 (en)	2005-04-28	2010-05-11	Boehringer Ingelheim International Gmbh	compounds for the treatment of inflammatory diseases, their use, pharmaceutical formulations, drug combinations and intermediate products
EP1879888A2 (en) *	2005-05-02	2008-01-23	Boehringer Ingelheim International GmbH	Crystalline forms of tiotropium bromide
PL1881980T3 (en) *	2005-05-02	2013-01-31	Boehringer Ingelheim Int	Novel crystalline forms of tiotropium bromide
DE102005030733A1 (en)	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient
JP5270343B2 (en)	2005-08-15	2013-08-21	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Beta mimetic manufacturing method
TWI396541B (en)	2005-10-10	2013-05-21	Boehringer Ingelheim Int	Novel combinations of medicaments for the treatment of respiratory diseases
US7423146B2 (en)	2005-11-09	2008-09-09	Boehringer Ingelheim International Gmbh	Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
WO2007075858A2 (en) *	2005-12-19	2007-07-05	Sicor Inc.	Novel forms of tiotropium bromide and processes for preparation thereof
US9108962B2 (en)	2005-12-19	2015-08-18	Sicor, Inc.	Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (en) *	2006-01-13	2010-12-08	江苏正大天晴药业股份有限公司	Crystal anti-choline medicine thiatropic bromoammonium
EP1847543A1 (en)	2006-04-19	2007-10-24	Boehringer Ingelheim Pharma GmbH & Co. KG	Dihydrothienopyrimidines for the treatment of inflammatory diseases
CA2660186A1 (en)	2006-08-07	2008-02-14	Boehringer Ingelheim International Gmbh	Pharmaceutical combinations for the treatment of respiratory diseases
UY30550A1 (en)	2006-08-22	2008-03-31	Boehringer Ingelheim Int	NEW BETA-AGANISTAS ENANTIOMÉRICAMENTE PUROS, PROCEDURES FOR ITS PREPARATION AND ITS USE AS MEDICATIONS
GB0716026D0 (en)	2007-08-16	2007-09-26	Norton Healthcare Ltd	An inhalable medicament
ATE542825T1 (en)	2007-10-19	2012-02-15	Boehringer Ingelheim Int	SUBSTITUTED PIPERIDINO-DIHYDROTHIENOPYRIMIDINES
EP2093219A1 (en)	2008-02-22	2009-08-26	Boehringer Ingelheim International Gmbh	Crystalline enantiomer free salt form of a betamimetic and its use as medicine
WO2010070032A1 (en)	2008-12-19	2010-06-24	Boehringer Ingelheim International Gmbh	Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
EP2403851B1 (en)	2009-03-06	2015-06-17	Mahmut Bilgic	New crystalline forms of tiotropium bromide
SI2513093T1 (en)	2009-12-17	2014-11-28	Boehringer Ingelheim International Gmbh	New ccr2 receptor antagonists and uses thereof
WO2011073155A1 (en)	2009-12-17	2011-06-23	Boehringer Ingelheim International Gmbh	Novel antagonists for ccr2 and uses thereof
BR112012018865A2 (en)	2010-01-29	2016-04-12	Boehringer Ingelheim Int	substituted naphthyridines and their use as syk kinase inhibitors
EP2569298B1 (en)	2010-05-12	2015-11-25	Boehringer Ingelheim International GmbH	Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2569295B1 (en)	2010-05-12	2014-11-19	Boehringer Ingelheim International GmbH	New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2571870B1 (en)	2010-05-17	2015-01-21	Boehringer Ingelheim International GmbH	Ccr2 antagonists and uses thereof
WO2011147772A1 (en)	2010-05-25	2011-12-01	Boehringer Ingelheim International Gmbh	Ccr2 receptor antagonists
EP2576538B1 (en)	2010-06-01	2015-10-28	Boehringer Ingelheim International GmbH	New CCR2 antagonists
TR201007108A2 (en) *	2010-08-25	2012-03-21	B�Lg�� Mahmut	New tiotropium bromide crystal and production method.
WO2012101013A1 (en)	2011-01-28	2012-08-02	Boehringer Ingelheim International Gmbh	Substituted pyridinyl-pyrimidines and their use as medicaments
TR201101897A2 (en)	2011-02-28	2012-09-21	Bi̇lgi̇ç Mahmut	Crystal material containing tiotropium bromide
TR201111589A2 (en) *	2011-03-03	2012-09-21	Bi̇lgi̇ç Mahmut	Tiotropium bromide anhydrous crystal form.
TR201102068A2 (en)	2011-03-03	2012-09-21	Bi̇lgi̇ç Mahmut	Crystalline substances containing tiotropium bromide
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US20130059866A1 (en)	2011-08-24	2013-03-07	Boehringer Ingelheim International Gmbh	Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
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CZ304368B6 (en)	2011-11-28	2014-04-02	Zentiva, K.S.	Tiotropium bromide mixed solvate and process for preparing thereof
GB201200525D0 (en)	2011-12-19	2012-02-29	Teva Branded Pharmaceutical Prod R & D Inc	An inhalable medicament
PT106142B (en) *	2012-02-10	2014-07-18	Hovione Farmaci Ncia S A	PROCESS FOR THE PREPARATION OF TIOTROPE BROMIDE
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2002
- 2002-06-08 KR KR1020037016769A patent/KR100971616B1/en active IP Right Grant
- 2002-06-08 ME MEP-2008-620A patent/ME00412B/en unknown
- 2002-06-08 MX MXPA03011718A patent/MXPA03011718A/en active IP Right Grant
- 2002-06-08 SK SK52-2004A patent/SK287262B6/en unknown
- 2002-06-08 JP JP2003506910A patent/JP2005504015A/en active Pending
- 2002-06-08 RS YUP-997/03A patent/RS50441B/en unknown
- 2002-06-08 HU HU0400333A patent/HUP0400333A3/en unknown
- 2002-06-08 PT PT02743165T patent/PT1401445E/en unknown
- 2002-06-08 DE DE50207943T patent/DE50207943D1/en not_active Expired - Lifetime
- 2002-06-08 IL IL15923802A patent/IL159238A0/en unknown
- 2002-06-08 EE EEP200400029A patent/EE05316B1/en unknown
- 2002-06-08 WO PCT/EP2002/006291 patent/WO2003000265A1/en active Application Filing
- 2002-06-08 DK DK02743165T patent/DK1401445T3/en active
- 2002-06-08 NZ NZ530690A patent/NZ530690A/en not_active IP Right Cessation
- 2002-06-08 SI SI200230431T patent/SI1401445T1/en unknown
- 2002-06-08 EP EP02743165A patent/EP1401445B1/en not_active Expired - Lifetime
- 2002-06-08 KR KR1020097004823A patent/KR101011353B1/en active IP Right Grant
- 2002-06-08 PL PL364489A patent/PL208137B1/en unknown
- 2002-06-08 CZ CZ20040120A patent/CZ302786B6/en not_active IP Right Cessation
- 2002-06-08 ES ES02743165T patent/ES2271280T3/en not_active Expired - Lifetime
- 2002-06-08 CN CN02812303A patent/CN100586948C/en not_active Expired - Lifetime
- 2002-06-08 BR BR0210537-3A patent/BR0210537A/en active Pending
- 2002-06-08 AU AU2002345016A patent/AU2002345016B2/en not_active Expired
- 2002-06-08 CA CA2450961A patent/CA2450961C/en not_active Expired - Fee Related
- 2002-06-08 AT AT02743165T patent/ATE337006T1/en active
- 2002-06-08 EA EA200301293A patent/EA005813B1/en not_active IP Right Cessation
- 2002-06-19 EG EG2002060698A patent/EG24851A/en active
- 2002-06-19 TW TW091113373A patent/TWI261589B/en not_active IP Right Cessation
- 2002-06-19 TW TW095100968A patent/TW200617007A/en unknown
- 2002-06-20 MY MYPI20022316A patent/MY122779A/en unknown
- 2002-06-20 UY UY27342A patent/UY27342A1/en not_active Application Discontinuation
- 2002-06-21 PE PE2007000660A patent/PE20081305A1/en not_active Application Discontinuation
- 2002-06-21 PE PE2002000538A patent/PE20030130A1/en active IP Right Grant
- 2002-06-21 AR ARP020102337A patent/AR037491A1/en not_active Ceased/Invalidation/Refusal/Rejection/Nullification
- 2002-08-19 SA SA2230255A patent/SA02230255B1/en unknown
2003
- 2003-12-08 IL IL159238A patent/IL159238A/en active IP Right Grant
- 2003-12-12 BG BG108440A patent/BG66303B1/en active Active
- 2003-12-19 NO NO20035696A patent/NO334301B1/en not_active IP Right Cessation
- 2003-12-19 HR HR20031066A patent/HRP20031066B1/en not_active IP Right Cessation
2004
- 2004-01-20 CO CO04003764A patent/CO5550423A2/en not_active Application Discontinuation
2005
- 2005-01-29 HK HK05100780.9A patent/HK1068540A1/en not_active IP Right Cessation
2006
- 2006-09-20 CY CY20061101339T patent/CY1105223T1/en unknown

Also Published As

Publication number	Publication date
CA2450961A1 (en)	2003-01-03
MXPA03011718A (en)	2004-12-06
KR20090031638A (en)	2009-03-26
CZ302786B6 (en)	2011-11-09
EP1401445A1 (en)	2004-03-31
PL364489A1 (en)	2004-12-13
ATE337006T1 (en)	2006-09-15
CN100586948C (en)	2010-02-03
NZ530690A (en)	2005-05-27
SK522004A3 (en)	2004-06-08
ME00412B (en)	2011-10-10
PE20030130A1 (en)	2003-04-02
PL208137B1 (en)	2011-03-31
MEP62008A (en)	2011-05-10
BG108440A (en)	2004-08-31
AU2002345016B2 (en)	2008-04-17
EP1401445B1 (en)	2006-08-23
NO20035696D0 (en)	2003-12-19
YU99703A (en)	2006-05-25
HUP0400333A3 (en)	2012-10-29
SK287262B6 (en)	2010-04-07
EE200400029A (en)	2004-04-15
TW200617007A (en)	2006-06-01
BG66303B1 (en)	2013-03-29
CO5550423A2 (en)	2005-08-31
EA005813B1 (en)	2005-06-30
IL159238A (en)	2010-04-15
PT1401445E (en)	2006-10-31
DK1401445T3 (en)	2006-11-27
ES2271280T3 (en)	2007-04-16
HK1068540A1 (en)	2005-04-29
DE50207943D1 (en)	2006-10-05
CA2450961C (en)	2010-03-30
MY122779A (en)	2006-05-31
NO334301B1 (en)	2014-02-03
CY1105223T1 (en)	2010-03-03
CN1520294A (en)	2004-08-11
KR101011353B1 (en)	2011-01-28
KR20040018285A (en)	2004-03-02
HRP20031066B1 (en)	2011-10-31
AR037491A1 (en)	2004-11-17
KR100971616B1 (en)	2010-07-22
WO2003000265A1 (en)	2003-01-03
UY27342A1 (en)	2003-02-28
TWI261589B (en)	2006-09-11
SA02230255B1 (en)	2006-10-31
JP2005504015A (en)	2005-02-10
BR0210537A (en)	2004-06-22
PE20081305A1 (en)	2008-10-01
RS50441B (en)	2010-03-02
EE05316B1 (en)	2010-08-16
CZ2004120A3 (en)	2004-05-12
SI1401445T1 (en)	2007-02-28
EG24851A (en)	2010-10-27
EA200301293A1 (en)	2004-08-26
HRP20031066A2 (en)	2004-04-30
HUP0400333A2 (en)	2004-12-28

Publication	Publication Date	Title
HRP20031066A2 (en)	2004-04-30	Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
AU2002345016A1 (en)	2003-06-19	Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
AU1499602A (en)	2002-04-22	Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
AU2002214996A1 (en)	2002-06-27	Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
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