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YU84791A - Biciklicni 1-aza-cikloalkalni - Google Patents

Biciklicni 1-aza-cikloalkalni

Info

Publication number
YU84791A
YU84791A YU84791A YU84791A YU84791A YU 84791 A YU84791 A YU 84791A YU 84791 A YU84791 A YU 84791A YU 84791 A YU84791 A YU 84791A YU 84791 A YU84791 A YU 84791A
Authority
YU
Yugoslavia
Prior art keywords
optionally substituted
carbon atoms
phenyl
aza
radical
Prior art date
Application number
YU84791A
Other languages
English (en)
Inventor
G. Walther
U. Kuefner-Muehl
W. Stransky
K.H. Weber
H. Ensinger
F.J. Kuhn
E. Mueller
Original Assignee
Boehringer Ingelheim Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg. filed Critical Boehringer Ingelheim Kg.
Publication of YU84791A publication Critical patent/YU84791A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Izum se nanaša na nove biciklične 1-aza-cikloalkane, s splošno formulo I kjer lahko pomeni R alkilni ostanek z 1 do 6 ogljikovimi atomi, alkenilni ostanek s 3 do 6 ogljikovimi atomi, alkinilni ostanek s 3 do 6 ogljikovimi atomi, pri čemer je lahko alkilni, alkenilni ali alkinilni ostanek substituiran s fenilom, substituiranim fenilom, v danem primeru substituiranim bifenilom, v danem primeru substituiranim oksetanom ali v danem primeru substituiranim 5-, 6- ali 7-členskim heterociklom, ali R pomeni v danem primeru substituiran fenil, v danem primeru substituiran bifenil, v danem primeru substituiran 5-, 6- ali 7-členski heterocikel; X pomeni kisik ali žveplo, A, B in C neodvisno drug od drugega pomenijo CH2 ali enojno vez in n = 0, 1 ali 2 postopke za njihovo pripravo kot tudi na njihovo uporabo kot zdravila s holinometskimi lastnostmi.
YU84791A 1990-05-19 1991-05-15 Biciklicni 1-aza-cikloalkalni YU84791A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4016212 1990-05-19
DE4018886 1990-06-13

Publications (1)

Publication Number Publication Date
YU84791A true YU84791A (sh) 1994-06-10

Family

ID=25893382

Family Applications (1)

Application Number Title Priority Date Filing Date
YU84791A YU84791A (sh) 1990-05-19 1991-05-15 Biciklicni 1-aza-cikloalkalni

Country Status (14)

Country Link
EP (1) EP0458214A1 (sh)
JP (1) JP2853837B2 (sh)
KR (1) KR910020009A (sh)
AU (1) AU648789B2 (sh)
CA (1) CA2042860A1 (sh)
CZ (1) CZ281837B6 (sh)
FI (1) FI912409A (sh)
HU (1) HUT58091A (sh)
IE (1) IE911688A1 (sh)
IL (1) IL98176A0 (sh)
NO (1) NO911934L (sh)
PT (1) PT97703A (sh)
SK (1) SK279168B6 (sh)
YU (1) YU84791A (sh)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE65997B1 (en) * 1990-05-11 1995-11-29 Sankyo Co Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives their preparation and their therapeutic use
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
US5612352A (en) * 1992-04-10 1997-03-18 Zeneca Limited Heterocyclic compounds
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
IT1255179B (it) * 1992-06-26 1995-10-20 Enzo Cereda Azaciclo e azabiciclo alchiliden idrossilamine
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
IL107184A (en) * 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
DE4236331A1 (de) * 1992-10-28 1994-05-05 Boehringer Ingelheim Kg Synergistische Kombination
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
IL109451A0 (en) * 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
US5998404A (en) * 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5512574A (en) * 1994-12-21 1996-04-30 American Home Products Corporation Quinuclidine and azabicyclo 2.2.1! heptane pyrazinyl ethers as muscarinic agonists
AU4712696A (en) * 1995-02-17 1996-09-04 Novo Nordisk A/S The use of heterocyclic compounds
US6040442A (en) * 1995-06-01 2000-03-21 Eli Lilly And Company Process for preparing 1,2,5-thiadiazole containing ethers
US5998434A (en) * 1995-12-06 1999-12-07 Eli Lilly And Company Composition for treating pain
CA2252573A1 (en) * 1996-04-23 1997-10-30 Celia Ann Whitesitt Heterocyclic compounds
KR20050055711A (ko) * 2002-08-14 2005-06-13 뉴로서치 에이/에스 신규한 퀴누클리딘 유도체 및 이를 포함하는 약제학적 조성물
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
EP1656375B1 (en) 2003-08-13 2011-01-19 NeuroSearch A/S Novel quinuclidine derivatives and their pharmaceutical use
US7655657B2 (en) 2003-12-22 2010-02-02 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
US20050137203A1 (en) * 2003-12-22 2005-06-23 Jianguo Ji 3-quinuclidinyl amino-substituted biaryl derivatives
US7160876B2 (en) 2003-12-22 2007-01-09 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
PE20060437A1 (es) 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
CN1922176A (zh) * 2004-12-10 2007-02-28 艾博特公司 稠合的双环杂环取代的奎宁环衍生物
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
JP7429799B2 (ja) 2020-02-18 2024-02-08 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス化合物
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
EP4323362A1 (en) 2021-04-16 2024-02-21 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides
CA3228162A1 (en) 2021-08-18 2023-02-23 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE321933B (sh) * 1967-10-05 1970-03-23 Astra Ab
FR2014831A1 (en) * 1968-08-01 1970-04-24 Sogeras Quinuclidinyl and quinuclidinylalkyl ethers with cholino - lytic, antihistaminic and neurosedative activity
GB8615785D0 (en) * 1986-06-27 1986-08-06 Beecham Group Plc Compounds
ATE133415T1 (de) * 1987-04-15 1996-02-15 Beecham Group Plc Am brückenkopf substituierte azabicyclenderivate
GB8718445D0 (en) * 1987-08-04 1987-09-09 Wyeth John & Brother Ltd Pyridyl-ethers
CA1307790C (en) * 1987-08-04 1992-09-22 Ian Anthony Cliffe Ethers
DE3839385A1 (de) * 1988-11-22 1990-05-23 Boehringer Ingelheim Kg Neue quinuclidine, ihre herstellung als arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
SK279168B6 (sk) 1998-07-08
NO911934L (no) 1991-11-20
AU7713091A (en) 1991-11-21
CZ281837B6 (cs) 1997-02-12
CS144891A3 (en) 1992-05-13
KR910020009A (ko) 1991-12-19
EP0458214A1 (de) 1991-11-27
CA2042860A1 (en) 1991-11-20
FI912409A (fi) 1991-11-20
IE911688A1 (en) 1991-11-20
NO911934D0 (no) 1991-05-16
IL98176A0 (en) 1992-06-21
JPH04226981A (ja) 1992-08-17
FI912409A0 (fi) 1991-05-17
AU648789B2 (en) 1994-05-05
HUT58091A (en) 1992-01-28
JP2853837B2 (ja) 1999-02-03
PT97703A (pt) 1992-02-28
HU911663D0 (en) 1991-11-28

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