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YU48063B - Novi derivati 3,4-dihidroizohinolina i postupci za njihovo pripremanje - Google Patents

Novi derivati 3,4-dihidroizohinolina i postupci za njihovo pripremanje

Info

Publication number
YU48063B
YU48063B YU197591A YU197591A YU48063B YU 48063 B YU48063 B YU 48063B YU 197591 A YU197591 A YU 197591A YU 197591 A YU197591 A YU 197591A YU 48063 B YU48063 B YU 48063B
Authority
YU
Yugoslavia
Prior art keywords
opt
substd
alkyl
formula
new
Prior art date
Application number
YU197591A
Other languages
English (en)
Other versions
YU197591A (sh
Inventor
W. Losel
O. Roos
D. Arndts
F.J. Kuhn
I. Streller
Original Assignee
Boehringer Ingelheim Kg.
Null, Null
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg., Null, Null filed Critical Boehringer Ingelheim Kg.
Priority to SI9111975A priority Critical patent/SI9111975B/sl
Publication of YU197591A publication Critical patent/YU197591A/sh
Priority to HRP-1975/91A priority patent/HRP940721B1/xx
Publication of YU48063B publication Critical patent/YU48063B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pretreatment Of Seeds And Plants (AREA)

Abstract

NOVI DERIVAT 3,4-DIHIDROIZOHINOLINA I POSTUPCI ZA NJIHOVO PRIPREMANJE, opšte formule I u kojoj je X u kojima je X1 sa trifluormetil- ili etoksi-grupom mono- ili di-supstituisana fenil-grupa, sa metoksi-grupom i fluorom supstituisana fenil ili 2-metoksifenil-grupa, X2 -CH2-CH2- ili -CH2-CH(CH3)-, a X3 2,3,4-trimetoksifenil-, 2,3-dimetoksifenil-, 2,6-dimetok-sifenil-, 3,6-dimetoksifenil-, tienil-grupa, sa trifluormetil- ili etoksi-grupom, mono- ili di-supstituisan afenil-grupa, ili sa metoksi grupom ili fluorom supstituisana fenil-grupa, ili njegova farmaceutski prihvatljiva so. Prijava sadrži još 1 nezavisan i 1 zavisan zahtev.
YU197591A 1990-12-22 1991-12-23 Novi derivati 3,4-dihidroizohinolina i postupci za njihovo pripremanje YU48063B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9111975A SI9111975B (en) 1990-12-22 1991-12-23 Novel derivatives of 3,4-dihydroisoquinoline, processes for their preparation and pharmaceutical compositions containing novel compounds
HRP-1975/91A HRP940721B1 (en) 1990-12-22 1994-10-21 New 3,4-dihydroisoquinoline derivatives, processes for the preparation thereof and pharmaceutical ingredients containing new compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4041482A DE4041482A1 (de) 1990-12-22 1990-12-22 Neue pharmazeutische verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine

Publications (2)

Publication Number Publication Date
YU197591A YU197591A (sh) 1994-06-24
YU48063B true YU48063B (sh) 1996-10-18

Family

ID=6421218

Family Applications (1)

Application Number Title Priority Date Filing Date
YU197591A YU48063B (sh) 1990-12-22 1991-12-23 Novi derivati 3,4-dihidroizohinolina i postupci za njihovo pripremanje

Country Status (33)

Country Link
US (3) US5665729A (sh)
EP (2) EP0781556A1 (sh)
JP (1) JP3283877B2 (sh)
KR (1) KR100227953B1 (sh)
AT (1) ATE177948T1 (sh)
AU (1) AU666107B2 (sh)
BR (1) BR1100520A (sh)
CA (1) CA2098917A1 (sh)
CZ (3) CZ284695A3 (sh)
DE (3) DE9017900U1 (sh)
DK (1) DK0563128T3 (sh)
ES (1) ES2129040T3 (sh)
FI (1) FI105026B (sh)
GR (1) GR3030341T3 (sh)
HK (1) HK1010683A1 (sh)
HR (1) HRP940721B1 (sh)
HU (1) HU217819B (sh)
ID (1) ID16001A (sh)
IE (3) IE914486A1 (sh)
IL (1) IL100450A (sh)
MX (1) MX9102765A (sh)
NO (1) NO179515C (sh)
NZ (1) NZ241140A (sh)
PL (1) PL172262B1 (sh)
PT (1) PT99901B (sh)
RU (2) RU2149000C1 (sh)
SG (1) SG43064A1 (sh)
SI (1) SI9111975B (sh)
SK (1) SK281017B6 (sh)
TW (1) TW283145B (sh)
WO (1) WO1992011010A1 (sh)
YU (1) YU48063B (sh)
ZA (1) ZA9110116B (sh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100291706B1 (ko) * 1992-06-22 2001-10-24 베링거 인겔하임 카게 폐환된디하이드로피리딘,이의제조방법및이를포함하는약제학적조성물
PT736012E (pt) * 1993-12-21 2001-03-30 Boehringer Ingelheim Pharma Di-hidropiridinas ciclizadas e sua utilizacao para a preparacao de composicoes farmaceuticas
DE4343683A1 (de) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
GB2341318A (en) * 1998-09-14 2000-03-15 Boehringer Ingelheim Pharma A Dihydroisoquinoline (LOE 908) and Traumatic Brain Injury.
US20040015104A1 (en) * 2002-02-11 2004-01-22 Gold-T Tech, Inc. Method for preventing thrombus formation
DE102004055633A1 (de) * 2004-11-12 2006-05-18 Schering Ag 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
CN101636378A (zh) * 2007-03-15 2010-01-27 弗·哈夫曼-拉罗切有限公司 作为食欲肽拮抗剂的丙二酰胺类
CZ302637B6 (cs) * 2010-01-05 2011-08-10 Zentiva, K. S Zpusob prípravy 6,7-dimethoxy-1-[2-(4-trifluormethylfenyl)ethyl]-3,4-dihydroisochinolinu
EP2420237A1 (en) 2010-08-11 2012-02-22 Ville Takio Fluorinated derivatives of endogenous isoquinolines for use in the treatment of diseases mediated through endogenous isoquinoline pathways
KR101645930B1 (ko) 2014-12-16 2016-08-05 (주) 우수 타월 거치대

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3013906A1 (de) * 1980-04-11 1981-10-15 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung
DE3621413A1 (de) * 1986-06-26 1988-01-07 Boehringer Ingelheim Kg Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung
IL86131A0 (en) * 1987-04-24 1988-11-15 Boehringer Ingelheim Kg Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
DE3827727A1 (de) * 1988-08-16 1990-02-22 Boehringer Ingelheim Kg Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion

Also Published As

Publication number Publication date
HUT74639A (en) 1997-01-28
DK0563128T3 (da) 1999-10-11
IE990430A1 (en) 2000-11-15
MX9102765A (es) 1994-03-31
GR3030341T3 (en) 1999-09-30
SG43064A1 (en) 1997-10-17
CZ282454B6 (cs) 1997-07-16
HRP940721A2 (en) 1996-12-31
PT99901A (pt) 1992-12-31
EP0563128B1 (de) 1999-03-24
CZ289685B6 (cs) 2002-03-13
AU666107B2 (en) 1996-02-01
EP0781556A1 (de) 1997-07-02
PT99901B (pt) 1999-06-30
NO179515B (no) 1996-07-15
WO1992011010A1 (de) 1992-07-09
AU9080291A (en) 1992-07-22
DE9017900U1 (de) 1993-01-28
FI932709A0 (fi) 1993-06-14
SI9111975B (en) 2001-06-30
NO932279D0 (no) 1993-06-21
EP0563128A1 (de) 1993-10-06
CZ284695A3 (en) 1997-07-16
RU2149000C1 (ru) 2000-05-20
IL100450A0 (en) 1992-09-06
CZ121393A3 (en) 1994-02-16
US5686462A (en) 1997-11-11
ATE177948T1 (de) 1999-04-15
HU217819B (hu) 2000-04-28
SI9111975A (en) 1997-06-30
HRP940721B1 (en) 2000-02-29
SK281017B6 (sk) 2000-10-09
IL100450A (en) 1997-01-10
IE20001043A1 (en) 2001-05-30
NO932279L (no) 1993-06-21
ZA9110116B (en) 1992-08-26
TW283145B (sh) 1996-08-11
PL172262B1 (pl) 1997-08-29
RU2115647C1 (ru) 1998-07-20
NO179515C (no) 1996-10-23
KR930702973A (ko) 1993-11-29
ID16001A (id) 1997-08-21
US5665729A (en) 1997-09-09
ES2129040T3 (es) 1999-06-01
KR100227953B1 (ko) 1999-11-01
HU9301820D0 (en) 1993-09-28
SK61793A3 (en) 1994-01-12
DE4041482A1 (de) 1992-06-25
CA2098917A1 (en) 1992-06-23
FI932709A (fi) 1993-06-14
BR1100520A (pt) 2000-06-06
HK1010683A1 (en) 1999-06-25
JPH06504277A (ja) 1994-05-19
DE59109115D1 (de) 1999-04-29
FI105026B (fi) 2000-05-31
YU197591A (sh) 1994-06-24
NZ241140A (en) 1997-06-24
CZ289533B6 (cs) 2002-02-13
JP3283877B2 (ja) 2002-05-20
US6034094A (en) 2000-03-07
IE914486A1 (en) 1992-07-01

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