YU46578B - Postupak za dobijanje heterociklične oksoftalazinil sirćetne kiseline - Google Patents
Postupak za dobijanje heterociklične oksoftalazinil sirćetne kiselineInfo
- Publication number
- YU46578B YU46578B YU230788A YU230788A YU46578B YU 46578 B YU46578 B YU 46578B YU 230788 A YU230788 A YU 230788A YU 230788 A YU230788 A YU 230788A YU 46578 B YU46578 B YU 46578B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- fluoro
- heterocyclic
- trifluoromethyl
- sulfur
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
POSTUPAK ZA DOBIJANJE HETEROCIKLICNE OKSOFTALAZINIL SIRCETNE KISELINE, formule I u kojoj je X kiseonik ili sumpor, Z je kovalentna veza O, S, NH ili CH2 ili CHR5Z je vinilen, R1 je hidroksi ili prolek grupa R2 je heterociklicni petoclani prsten koji ima jedan azot, kiseonik ili sumpor, dva azota od kojih jedan moze biti zamenjen sa kiseonikom ili sumporom, ili tri azota od kojih jedan moze biti zamenjen sa kiseonikom ili sumporom, pomenuti heterociklilcni petoclani prsten supstituisan sa jednom ili dve fenil grupe, ili je kondenzovan sa benzo, pomenuti fenil ili benzo je supstituisan sa jednom cijano, nitro, perfluoroetil, trifluoroacetil, ili (C1-C4) alkanoil grupom, jednom ili dve hidroksi ili trifluorometoksi grupe, ili jednim ili dva trifluoro metil sa jednom hidroksi ili jednom (C1-C4)akoksi ili tri fluoro; pomenuti benzo-kondenzovan heterociklicni petoclani prsten opciono supstituisan u heterociklicnom petocalnom prstenu sa jednim fluoro, hlorom bromo, metoksi, ili trifluorometil grupom; imidazolopiridin supstituisan sa jednim trifluorometil, trifluorometiltio, bromo, ili (C1-C4) alkoksi, ili dva fluoro ili hloro; triazolopiridin opciono supstituisan sa jednim trifluorometil, trifluorometiltio, bromo, ili (C1-C4) alkoksi, ili dva fluoro ili hloro; tienotiofen ili tienofuran opciono supstituisan sa jednim fluoro, hloro ili tri-fluorometil; tienotriazol opciono supstituisan sa jednim hloro ili trifluorometil; tienopiridil; ili tienoizotiazol; R3 i R4 su isti ili razliciti i predstavljaju vodonik, fluoro, hloro, bromo, trifluorometil, (C1-C4)alkil, (C1-C4)-alkoksyi, (C1-C4)alkiltio, (C1-C4)alkilsulfinil, (C1-C4)alkilsulfonil, ili nitro, ili R3 i R4 uzeti zajedno su (C1-C4)alkilendioksi; i R5 je vodonik, metil ili trifluorometil; ili farmaceutski prihvatljiva adiciona so sa bazom jedinjenja formule I u kojoj je hidroksi, ili adiciona so sa kiselinom jedinjenja formule I u kojoj R1 je di (C1-C4)alkilamino ili (C1-C4)alkoksi supstituisan sa N-morfolino ili di(C1-C4)alkilamino; pod uslovom sto kada CHR5Z jevinilen, R2 je heterociklicni petoclani prsten koji ima jedan azot, kiseonik ili sumpor, dva azota od kojih jedan moze biti zamenjen sa kiseonikom ili sumporom, ili tri azota od kojih jedan moze biti zamenjen sa kiseonikom ili sumporom, pomenuti heterociklicni petoclani prsten je supstituisan sa jednim ili dva fluoro, hloro, bromo, hidroksi, (C1-C4)alkil, (C1-C4)alkoksi, (C1-C4)alkiltio, trifluorometoksi, tri-fluorometiltio, (C1-C4)alkilsulfinil, (C1-C4)alkilsulfonil, ili trifluor-metil, ili dva fluoro ili dva trifluorometil sa jednom hidroksi ili jednim (C1-C4) alkoksi, ili tri fluoro; pomenuti piridil, furil ili tienil opciono je supstituisan u polozaju -3 sa fluoro, hloro, bromo, (C1-C4)alkil ili (C1-C4)alkoksi; heterociklicni sestoclani prsten koji ima jedan do tri atoma azota, ili k jean ili dva atoma azota i jedan kiseonik ili sumpor, pomenuti heterociklicni sestoclani prsten je supstituisan sa jednim ili dva (C1-C4)alkil ili fenil grupom,
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HRP-2307/88A HRP931304A2 (en) | 1987-12-21 | 1993-10-19 | Process for the preparation of heterocyclic oxoohtalazinyl acetic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13617987A | 1987-12-21 | 1987-12-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU230788A YU230788A (en) | 1990-10-31 |
| YU46578B true YU46578B (sh) | 1993-11-16 |
Family
ID=22471693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU230788A YU46578B (sh) | 1987-12-21 | 1988-12-20 | Postupak za dobijanje heterociklične oksoftalazinil sirćetne kiseline |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0322153A3 (sh) |
| JP (1) | JPH0692402B2 (sh) |
| KR (1) | KR910000438B1 (sh) |
| CN (1) | CN1035116A (sh) |
| AU (1) | AU609559B2 (sh) |
| CA (1) | CA1299181C (sh) |
| DK (1) | DK712388A (sh) |
| FI (1) | FI885886A (sh) |
| HU (1) | HU207086B (sh) |
| IL (1) | IL88729A (sh) |
| MX (1) | MX14287A (sh) |
| MY (1) | MY103505A (sh) |
| NZ (1) | NZ227441A (sh) |
| PT (1) | PT89268B (sh) |
| YU (1) | YU46578B (sh) |
| ZA (1) | ZA889519B (sh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4954629A (en) * | 1989-05-11 | 1990-09-04 | Pfizer Inc. | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof |
| US5064830A (en) * | 1990-08-02 | 1991-11-12 | Pfizer Inc. | Lowering of blood uric acid levels |
| FR2682108B1 (fr) * | 1991-10-07 | 1994-01-07 | Lipha | Acide 3,4-dihydro-4-oxo-3(prop-2-enyl)-1-phtalazineacetiques et derives, leurs preparations et medicaments les contenant. |
| US5391551A (en) * | 1993-05-10 | 1995-02-21 | Pfizer Inc. | Method of lowering blood lipid levels |
| US5700819A (en) * | 1994-11-29 | 1997-12-23 | Grelan Pharmaceutical Co., Ltd. | 2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications |
| IL124236A (en) * | 1997-05-05 | 2003-01-12 | Pfizer | Pharmaceutical composition for treating or reversing diabetic cardiomyopathy comprising aldose reductase inhibitor |
| US6878522B2 (en) * | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
| CN101058558B (zh) * | 2007-05-28 | 2013-04-10 | 沈阳药科大学 | 具有醛糖还原酶抑制活性的4-氧代-1(4h)-喹啉羧酸类化合物、组合物及其制备方法 |
| FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0222576B1 (en) * | 1985-11-07 | 1992-03-18 | Pfizer Inc. | Heterocyclic oxophthalazinyl acetic acids |
| CA1299178C (en) * | 1985-11-07 | 1992-04-21 | Banavara Lakshmana Mylari | Heterocyclic oxophtalazinyl acetic acids |
| US4748280A (en) * | 1985-11-07 | 1988-05-31 | Pfizer Inc. | Certain chlorination process for preparing 2-chloro-1,1,1-(C1 -C6) |
| ES2031813T3 (es) * | 1985-11-11 | 1993-01-01 | Asta Pharma Ag | Procedimiento para la preparacion de derivados de 4-bencil-1-(2h)-ftalazinona. |
| JPH0676391B2 (ja) * | 1987-06-09 | 1994-09-28 | フアイザー・インコーポレイテツド | ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法 |
| JPS6419077A (en) * | 1987-07-13 | 1989-01-23 | Yamanouchi Pharma Co Ltd | Thiazolidine derivative |
-
1988
- 1988-12-15 EP EP88311857A patent/EP0322153A3/en not_active Withdrawn
- 1988-12-16 CA CA000586121A patent/CA1299181C/en not_active Expired - Lifetime
- 1988-12-19 IL IL8872988A patent/IL88729A/en not_active IP Right Cessation
- 1988-12-20 HU HU886506A patent/HU207086B/hu not_active IP Right Cessation
- 1988-12-20 KR KR1019880017067A patent/KR910000438B1/ko not_active IP Right Cessation
- 1988-12-20 YU YU230788A patent/YU46578B/sh unknown
- 1988-12-20 MY MYPI88001483A patent/MY103505A/en unknown
- 1988-12-20 FI FI885886A patent/FI885886A/fi not_active Application Discontinuation
- 1988-12-20 PT PT89268A patent/PT89268B/pt not_active IP Right Cessation
- 1988-12-21 ZA ZA889519A patent/ZA889519B/xx unknown
- 1988-12-21 AU AU27337/88A patent/AU609559B2/en not_active Ceased
- 1988-12-21 JP JP63323225A patent/JPH0692402B2/ja not_active Expired - Fee Related
- 1988-12-21 DK DK712388A patent/DK712388A/da not_active Application Discontinuation
- 1988-12-21 CN CN88109263A patent/CN1035116A/zh active Pending
- 1988-12-21 MX MX1428788A patent/MX14287A/es unknown
- 1988-12-21 NZ NZ227441A patent/NZ227441A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK712388D0 (da) | 1988-12-21 |
| MY103505A (en) | 1993-06-30 |
| IL88729A (en) | 1996-07-23 |
| JPH01211585A (ja) | 1989-08-24 |
| KR910000438B1 (ko) | 1991-01-25 |
| KR890009888A (ko) | 1989-08-04 |
| AU609559B2 (en) | 1991-05-02 |
| ZA889519B (en) | 1990-08-29 |
| JPH0692402B2 (ja) | 1994-11-16 |
| HU207086B (en) | 1993-03-01 |
| HUT56552A (en) | 1991-09-30 |
| MX14287A (es) | 1993-06-01 |
| EP0322153A3 (en) | 1990-08-16 |
| FI885886A (fi) | 1989-06-22 |
| IL88729A0 (en) | 1989-07-31 |
| CA1299181C (en) | 1992-04-21 |
| YU230788A (en) | 1990-10-31 |
| PT89268B (pt) | 1993-07-30 |
| CN1035116A (zh) | 1989-08-30 |
| PT89268A (pt) | 1989-12-29 |
| EP0322153A2 (en) | 1989-06-28 |
| DK712388A (da) | 1989-07-31 |
| FI885886A0 (fi) | 1988-12-20 |
| NZ227441A (en) | 1990-12-21 |
| AU2733788A (en) | 1989-06-22 |
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