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YU46570B - Postupak za dobivanje derivata hinolin karboksilne kiseline - Google Patents

Postupak za dobivanje derivata hinolin karboksilne kiseline

Info

Publication number
YU46570B
YU46570B YU121788A YU121788A YU46570B YU 46570 B YU46570 B YU 46570B YU 121788 A YU121788 A YU 121788A YU 121788 A YU121788 A YU 121788A YU 46570 B YU46570 B YU 46570B
Authority
YU
Yugoslavia
Prior art keywords
general formula
compound
hydrogen
halogen
preparation
Prior art date
Application number
YU121788A
Other languages
English (en)
Other versions
YU121788A (en
Inventor
J. Hermecz
G. Kereszturi
A. Vasvari
M. Balogh
P. Ritli
J. Sipos
A. Pajor
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU285887A external-priority patent/HU200175B/hu
Priority claimed from HU873146A external-priority patent/HU199822B/hu
Application filed by Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Publication of YU121788A publication Critical patent/YU121788A/xx
Publication of YU46570B publication Critical patent/YU46570B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

POSTUPAK ZA DOBIVANJE DERIVATA HINOLIN KARBOKSILNE KISELINE, opšte formule I gde je R1 fenil grupa po izboru supstituisana sa 1 ili 2 atoma halogena ili grupa opšte formule CH2CR6R7R8 (gde R6, R7 i R8 su vodonik ili halogen): R2 piperazinil ili 4-metil-piperazinil; R3 vodonik ili fluor; i farmaceutski prihvatljivih njihovih soli, naznačen time, što reaguje jedinjenje opšte formule II: gde je R halogen ili alifatična acikloksi grupa koja sadrži 2-6 atoma ugljenika ili acikloksi aromatična grupa koja sadrži 7-11 atoma ugljenika: R4 fluor ili hlor: a R3 i R1 imaju značenje kao gore, sa piperazinskim derivatom opšte formule III: gde je R5 vodonik ili metil, ili sa njegovom solju u prisustvu organskog rastvarača, poželjno amida kiseline, sulfoksida, ketona, alkohola, etra ili estra i u prisustvu sredstva za vezivanje kiseline, poželjno amina ili viška jedinjenja opšte formule III, na temperaturi 100-110В°C, i tako dobiveno jedinjenje opšte formule IV: gde R, R1, R2 i R3 su kao što je definisano napred, se podvrgava hidrolizi u kiseloj ili alkalnoj sredini na temperaturi refluksa, posle ili bez izolovanja, i ako se želi temperaturi refluksa, posle ili bez izolovanja, i ako se želi dobiveno jedinjenje opšte formule I se prevodi u svoju farmaceutski prihvatljivu so ili se oslobadja iz svoje soli. Prijava sadrži još 1 nezavisan i 7 zavisnih patentnih zatheva.
YU121788A 1987-06-24 1988-06-23 Postupak za dobivanje derivata hinolin karboksilne kiseline YU46570B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU285887A HU200175B (en) 1987-06-24 1987-06-24 Process for producing quinolinecarboxylic acid derivatives
HU873146A HU199822B (en) 1987-07-10 1987-07-10 Process for production of derivatives of quinoline carbonic acid

Publications (2)

Publication Number Publication Date
YU121788A YU121788A (en) 1989-12-31
YU46570B true YU46570B (sh) 1993-11-16

Family

ID=26317564

Family Applications (1)

Application Number Title Priority Date Filing Date
YU121788A YU46570B (sh) 1987-06-24 1988-06-23 Postupak za dobivanje derivata hinolin karboksilne kiseline

Country Status (11)

Country Link
EP (1) EP0329719A1 (sh)
JP (1) JP2693988B2 (sh)
KR (1) KR970005911B1 (sh)
CN (1) CN1025028C (sh)
CA (1) CA1325010C (sh)
CS (1) CS274677B2 (sh)
DK (1) DK84089A (sh)
ES (1) ES2006994A6 (sh)
FI (1) FI91400C (sh)
WO (1) WO1988010253A1 (sh)
YU (1) YU46570B (sh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562852A (en) * 1984-08-20 1986-01-07 Britt Franklin J Safety valve
US4606367A (en) * 1985-04-04 1986-08-19 Britt Franklin J Apparatus and method for relieving pressure within a high pressure tank
HU198709B (en) * 1987-04-08 1989-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing quinoline-carboxylic acid derivatives
EP0548224B1 (en) * 1990-09-11 1994-11-23 Schering Corporation Process for preparing albuterol, acetal, hemi-acetal, and hydrates of arylglyoxal intermediates thereof
JP3165742B2 (ja) * 1991-07-16 2001-05-14 中外製薬株式会社 キノロンカルボン酸誘導体の製造方法
US5869661A (en) * 1991-07-16 1999-02-09 Chugai Seiyaku Kabushiki Kaisha Method of producing a quinolonecarboxylic acid derivative
ES2049636B1 (es) * 1992-04-15 1994-12-16 Genesis Para La Investigacion Procedimiento para la preparacion de derivados de acidos quinolincarboxilicos.
ES2077490B1 (es) * 1992-11-18 1996-10-16 Marga Investigacion Esteres trimetilsililicos y solvatos de quelatos de acidos quinolin-3-carboxilicos. preparacion y aplicacion al proceso de quinolonas.
ES2092963B1 (es) * 1995-04-12 1997-12-16 Sint Quimica Sa Procedimiento para la preparacion del acido 1-ciclopropil-6-fluoro-1, 4-dihidro-7-(1s,4s)-5-metil-2,5-diazabiciclo(2.2.1) hept-2-il)-4-oxo-3-quinolincarboxilico y sus sales.
ES2095809B1 (es) * 1995-07-27 1997-12-16 Sint Quimica Sa Procedimiento para la preparacion de acidos naftiridin carboxilicos y sus sales.
FR2916446B1 (fr) 2007-05-24 2009-08-21 Biocodex Sa Nouveau procede de synthese de fluoroquinolones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59122470A (ja) * 1982-12-27 1984-07-14 Dai Ichi Seiyaku Co Ltd キノリン−３−カルボン酸誘導体の製造法
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such

Also Published As

Publication number Publication date
KR890701564A (ko) 1989-12-21
FI91400B (fi) 1994-03-15
JP2693988B2 (ja) 1997-12-24
FI91400C (fi) 1994-06-27
FI890723A (fi) 1989-02-15
CA1325010C (en) 1993-12-07
KR970005911B1 (ko) 1997-04-22
WO1988010253A1 (en) 1988-12-29
CN1032166A (zh) 1989-04-05
DK84089D0 (da) 1989-02-23
YU121788A (en) 1989-12-31
CN1025028C (zh) 1994-06-15
DK84089A (da) 1989-02-23
ES2006994A6 (es) 1989-05-16
CS274677B2 (en) 1991-09-15
JPH02500366A (ja) 1990-02-08
FI890723A0 (fi) 1989-02-15
CS412388A2 (en) 1990-11-14
EP0329719A1 (en) 1989-08-30

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