YU43576B - PROCESS FOR PREPARATION OF 7-PIPERIDINO-1,2,3,5-TETRA-HYDRO-IMIDAZO(2,1-b) QUINAZOLINE-2-ONES - Google Patents

PROCESS FOR PREPARATION OF 7-PIPERIDINO-1,2,3,5-TETRA-HYDRO-IMIDAZO(2,1-b) QUINAZOLINE-2-ONES

Info

Publication number: YU43576B
Authority: YU; Yugoslavia
Prior art keywords: piperidino; quinazoline; imidazo; hydro; tetra
Prior art date: 1983-06-21

Application number

YU1078/84A

Other languages

English (en)

Other versions

YU107884A (en

Inventor

F Ishikawa

S Ashida

Original Assignee

Daiichi Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-06-21

Filing date

1984-06-20

Publication date

1989-08-31

1984-06-20 Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co

1986-10-31 Publication of YU107884A publication Critical patent/YU107884A/xx

1989-08-31 Publication of YU43576B publication Critical patent/YU43576B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Lubricants (AREA)
Saccharide Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Furan Compounds (AREA)

YU1078/84A 1983-06-21 1984-06-20 PROCESS FOR PREPARATION OF 7-PIPERIDINO-1,2,3,5-TETRA-HYDRO-IMIDAZO(2,1-b) QUINAZOLINE-2-ONES YU43576B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP58111498A JPS604186A (ja)	1983-06-21	1983-06-21	イミダゾキナゾリン化合物

Publications (2)

Publication Number	Publication Date
YU107884A YU107884A (en)	1986-10-31
YU43576B true YU43576B (en)	1989-08-31

Family

ID=14562811

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
YU1078/84A YU43576B (en)	1983-06-21	1984-06-20	PROCESS FOR PREPARATION OF 7-PIPERIDINO-1,2,3,5-TETRA-HYDRO-IMIDAZO(2,1-b) QUINAZOLINE-2-ONES

Country Status (19)

Country	Link
US (1)	US4596806A (xx)
EP (1)	EP0129258B1 (xx)
JP (1)	JPS604186A (xx)
KR (1)	KR910003153B1 (xx)
AT (1)	ATE29884T1 (xx)
AU (1)	AU558124B2 (xx)
CA (1)	CA1231946A (xx)
DE (1)	DE3466392D1 (xx)
DK (1)	DK162999C (xx)
ES (1)	ES533609A0 (xx)
FI (1)	FI77864C (xx)
GR (1)	GR81629B (xx)
IE (1)	IE57736B1 (xx)
IL (1)	IL72188A (xx)
NO (1)	NO161220C (xx)
PH (1)	PH19413A (xx)
PT (1)	PT78775A (xx)
YU (1)	YU43576B (xx)
ZA (1)	ZA844437B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4663320A (en) *	1983-02-16	1987-05-05	Syntex (U.S.A.) Inc.	(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
JPS6028979A (ja) *	1983-07-14	1985-02-14	Dai Ichi Seiyaku Co Ltd	イミダゾキナゾリン類化合物
HU191316B (en) *	1984-02-15	1987-02-27	Syntex Usa Inc.,Us	Process for producing (2-oxo-1,2,3,5-tetrahydro-imidazo /2,1-b/ quinazoline)-oxy-lakyl-amides and pharmacutical compositions containing them
US4783467A (en) *	1985-06-05	1988-11-08	Pfizer Inc.	Tetrahydroimidazoquinazolinone inotropic agents
US4837239A (en) *	1985-08-23	1989-06-06	Syntex (U.S.A.) Inc.	Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4670434A (en) *	1985-11-14	1987-06-02	Syntex (U.S.A.) Inc.	(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US4766126A (en) *	1986-01-10	1988-08-23	Daiichi Seiyaku Co., Ltd.	Process for treatment of nephritis with imidazoquinazolines
US4775674A (en) *	1986-05-23	1988-10-04	Bristol-Myers Company	Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) *	1986-07-08	1987-10-20	Bristol-Myers Company	7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4761416A (en) *	1986-07-25	1988-08-02	Syntex (U.S.A.) Inc.	N-N-disubstituted-ω-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides and related compounds
US6818613B2 (en) *	2001-11-07	2004-11-16	Ortho-Mcneil Pharmaceutical, Inc.	Aqueous sustained-release formulations of proteins

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3932407A (en) *	1973-11-19	1976-01-13	Bristol-Myers Company	Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US3983120A (en) *	1974-11-06	1976-09-28	Bristol-Myers Company	Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
US3983119A (en) *	1974-11-06	1976-09-28	Bristol-Myers Company	Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
NL7807507A (nl) *	1977-07-25	1979-01-29	Hoffmann La Roche	Tricyclische verbindingen.
US4208521A (en) *	1978-07-31	1980-06-17	Bristol-Myers Company	Process for the preparation of imidazo[2,1-b]quinazolinones
US4455311A (en) *	1981-08-28	1984-06-19	Hoffmann-La Roche Inc.	Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system

1983
- 1983-06-21 JP JP58111498A patent/JPS604186A/ja active Granted
1984
- 1984-06-12 ZA ZA844437A patent/ZA844437B/xx unknown
- 1984-06-13 CA CA000456454A patent/CA1231946A/en not_active Expired
- 1984-06-13 DK DK290084A patent/DK162999C/da not_active IP Right Cessation
- 1984-06-15 AU AU29432/84A patent/AU558124B2/en not_active Ceased
- 1984-06-20 DE DE8484107130T patent/DE3466392D1/de not_active Expired
- 1984-06-20 ES ES533609A patent/ES533609A0/es active Granted
- 1984-06-20 PT PT78775A patent/PT78775A/pt not_active IP Right Cessation
- 1984-06-20 US US06/622,596 patent/US4596806A/en not_active Expired - Fee Related
- 1984-06-20 PH PH30852A patent/PH19413A/en unknown
- 1984-06-20 IE IE1549/84A patent/IE57736B1/en not_active IP Right Cessation
- 1984-06-20 EP EP84107130A patent/EP0129258B1/en not_active Expired
- 1984-06-20 AT AT84107130T patent/ATE29884T1/de active
- 1984-06-20 YU YU1078/84A patent/YU43576B/xx unknown
- 1984-06-21 IL IL72188A patent/IL72188A/xx unknown
- 1984-06-21 FI FI842532A patent/FI77864C/fi not_active IP Right Cessation
- 1984-06-21 GR GR75075A patent/GR81629B/el unknown
- 1984-06-21 KR KR1019840003512A patent/KR910003153B1/ko not_active IP Right Cessation
- 1984-06-21 NO NO842502A patent/NO161220C/no unknown

Also Published As

Publication number	Publication date
ATE29884T1 (de)	1987-10-15
FI842532A (fi)	1984-12-22
DK162999B (da)	1992-01-06
FI77864B (fi)	1989-01-31
JPS635030B2 (xx)	1988-02-01
FI842532A0 (fi)	1984-06-21
ES8603483A1 (es)	1985-12-16
IL72188A (en)	1987-03-31
KR910003153B1 (ko)	1991-05-20
JPS604186A (ja)	1985-01-10
ES533609A0 (es)	1985-12-16
ZA844437B (en)	1985-01-30
NO161220B (no)	1989-04-10
DE3466392D1 (de)	1987-10-29
CA1231946A (en)	1988-01-26
IE57736B1 (en)	1993-03-24
IL72188A0 (en)	1984-10-31
US4596806A (en)	1986-06-24
DK290084D0 (da)	1984-06-13
DK290084A (da)	1984-12-22
PT78775A (en)	1984-07-01
AU558124B2 (en)	1987-01-22
NO842502L (no)	1984-12-27
PH19413A (en)	1986-04-10
AU2943284A (en)	1985-01-03
NO161220C (no)	1989-07-19
GR81629B (xx)	1984-12-11
EP0129258A1 (en)	1984-12-27
EP0129258B1 (en)	1987-09-23
YU107884A (en)	1986-10-31
KR850000442A (ko)	1985-02-27
FI77864C (fi)	1989-05-10
DK162999C (da)	1992-06-01
IE841549L (en)	1984-12-21

Publication	Publication Date	Title
EP0133913A3 (en)	1986-01-22	Process for the preparation of 3,3-dichloro-2-methyl propene
AU587648B2 (en)	1989-08-24	Process for the preparation of (2,2)- paracyclophane
YU43576B (en)	1989-08-31	PROCESS FOR PREPARATION OF 7-PIPERIDINO-1,2,3,5-TETRA-HYDRO-IMIDAZO(2,1-b) QUINAZOLINE-2-ONES
AU3011584A (en)	1984-12-04	PROCESS FOR THE PREPARATION OF 1a, 25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS
EP0237735A3 (en)	1989-05-24	3,7-disubstituted-3-cephem compounds and process for production of the same
NO157099C (no)	1988-01-20	Fremgangsmte for fremstilling av 1,8-dihydroksy-10-acyl-9-antron-derivater.
AU3303484A (en)	1985-03-21	Dibromobenzylcyclohexylamine compounds for the treatment of infections
FR2549039B1 (fr)	1986-12-26	Procede de preparation de 3,3,3-trifluoro-2-trifluoro-mehylpropene
DE3468207D1 (en)	1988-02-04	Process for the preparation of 1,4-butanediol
AR242576A1 (es)	1993-04-30	Proceso para la preparacion de alfa-n-¡(hipoxantin-9-il)-pentiloxicarbonil¿-arginina.
NO842514L (no)	1984-12-27	Fremgangsmaate for fremstilling av bicyklo(3,2,1)oktankarboksylsyre-derivater.
OA08376A (en)	1988-02-29	3,7-disubstituted-3-cephem compounds and processes for production of the same.
DE3267707D1 (en)	1986-01-09	Process for the preparation of 1-formyl-2,6,6-trimethyl-cyclohex-1-ene derivatives
AU557580B2 (en)	1986-12-24	15-cycloaliphatic derivatives of 13,14-didehydro- carboprostacyclins
AU8877482A (en)	1983-05-12	Preparation of satietin
ES518725A0 (es)	1984-06-16	Procedimiento de preparacion de nuevos derivados del azabiciclo (3.2.0) heptano.
AU7652487A (en)	1988-02-11	Process for the preparation of 2,4-diamino-5-benzylpyrimidines
GB2165242B (en)	1988-02-17	Process for the preparation of 1, 2-benzoxathiine derivatives
PT79451A (en)	1984-12-01	Process for the preparation of dust-free quinoxaline 1,4-di-n-oxides
PT81633B (en)	1987-10-13	Process for the preparation of 1,4-dihydropiridine derivatives
DE3363751D1 (en)	1986-07-03	Process for the preparation of 4,4-dimethyl-tetrahydrofuran-2,3 dione
GB2151626B (en)	1987-04-29	Process for the preparation of 3,4,5-trimethoxy-benzonitrile
HRP930888B1 (en)	1996-04-30	Process for the preparation of 7,16-dioxa-2-aza-10-0-cladynozyl-12-0-desozaminyl-4,5-dihydroxy-5-ethyl-3,5,9,11,13,15-hexamethylbicyclo (11.2.1) hexadeca-1(2)-en-8-ones
AU8045587A (en)	1989-05-25	Process for the preparation of n-acyl-n-alkyl-2,6-dialkyl-3- chloroanilines
FI880080A0 (fi)	1988-01-08	Foerfarande foer framstaellning av 1,2,3,4-tetrahydro-5h-(1)bensopyrano-(3,4-c)pyridin-5-on.