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YU154682A - Process for preparing new bicyclic derivatives of pyrimidine-5-one - Google Patents

Process for preparing new bicyclic derivatives of pyrimidine-5-one

Info

Publication number
YU154682A
YU154682A YU01546/82A YU154682A YU154682A YU 154682 A YU154682 A YU 154682A YU 01546/82 A YU01546/82 A YU 01546/82A YU 154682 A YU154682 A YU 154682A YU 154682 A YU154682 A YU 154682A
Authority
YU
Yugoslavia
Prior art keywords
pyrimidine
preparing new
bicyclic derivatives
new bicyclic
derivatives
Prior art date
Application number
YU01546/82A
Other languages
English (en)
Inventor
L E J Kennis
J C Mertens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of YU154682A publication Critical patent/YU154682A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
YU01546/82A 1981-07-15 1982-07-15 Process for preparing new bicyclic derivatives of pyrimidine-5-one YU154682A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28359081A 1981-07-15 1981-07-15
US06/370,653 US4443451A (en) 1981-07-15 1982-04-21 Bicyclic pyrimidin-5-one derivatives

Publications (1)

Publication Number Publication Date
YU154682A true YU154682A (en) 1985-03-20

Family

ID=26962133

Family Applications (1)

Application Number Title Priority Date Filing Date
YU01546/82A YU154682A (en) 1981-07-15 1982-07-15 Process for preparing new bicyclic derivatives of pyrimidine-5-one

Country Status (22)

Country Link
US (1) US4443451A (pt)
EP (1) EP0070053B1 (pt)
KR (1) KR870000868B1 (pt)
AU (1) AU547967B2 (pt)
CA (1) CA1207765A (pt)
CS (1) CS227690B2 (pt)
DD (1) DD215553A5 (pt)
DE (1) DE3270589D1 (pt)
DK (1) DK160314C (pt)
ES (1) ES8308327A1 (pt)
FI (1) FI75828C (pt)
GR (1) GR76006B (pt)
HU (1) HU186952B (pt)
IE (1) IE53400B1 (pt)
MA (1) MA19536A1 (pt)
NO (1) NO166327C (pt)
NZ (1) NZ201266A (pt)
PH (1) PH18120A (pt)
PL (1) PL136680B1 (pt)
PT (1) PT75247B (pt)
SU (1) SU1138032A3 (pt)
YU (1) YU154682A (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535081A (en) * 1979-11-23 1985-08-13 Pfizer Inc. Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides and intermediates therefor
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4533665A (en) * 1983-07-27 1985-08-06 Janssen Pharmaceutica [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
FR2581993B1 (fr) * 1985-05-14 1988-03-18 Synthelabo Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
ATE146077T1 (de) * 1986-09-22 1996-12-15 Janssen Pharmaceutica Nv Serotonin-antagonisten zur behandlung von wunden
DE3634532A1 (de) * 1986-10-10 1988-04-14 Basf Ag Verfahren zur herstellung von thiazolo-(2,3-b)chinazolonen
US4921854A (en) * 1986-12-30 1990-05-01 Egis Gyogyszergyar Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
US5140029A (en) * 1989-01-09 1992-08-18 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
US5256659A (en) * 1989-01-09 1993-10-26 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
FR2644786B1 (fr) * 1989-03-21 1993-12-31 Adir Cie Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
AU8506791A (en) * 1990-10-01 1992-04-28 Janssen Pharmaceutica N.V. Novel 4-piperidinylcarbonyl derivatives
DE4243287A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
CA2137673C (en) 1992-07-13 2005-09-06 Jan Vandenberk Novel 4-[3-benzofuranyl]piperidinyl and 4-[3-benzothienyl]piperidinyl derivatives
DE4338396A1 (de) * 1993-11-10 1995-05-11 Basf Ag N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
DK0729357T3 (da) * 1993-11-19 2005-06-06 Janssen Pharmaceutica Nv Mikroindkapslede 1,2-benzazoler
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
ES2097093B1 (es) * 1995-05-26 1998-01-16 Ferrer Int Nuevos compuestos derivados de 5h-tiazolo (3,2-a) pirimidin-5-ona.
US5962473A (en) * 1996-08-16 1999-10-05 Eli Lilly And Company Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F
US6380201B1 (en) 1997-08-05 2002-04-30 Eli Lilly And Company Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists
CA2395075A1 (en) * 1999-12-16 2001-06-21 Miles P. Smith 1,3,4-substituted piperidine analogs and uses thereof in treating addictions
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP1615924A1 (en) * 2003-04-22 2006-01-18 Synthon B.V. Water soluble salts of risperidone
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
US7572249B2 (en) * 2006-12-01 2009-08-11 The Procter & Gamble Company Merchandise display systems for baby care articles
US7582075B2 (en) * 2006-08-24 2009-09-01 The Procter & Gamble Company Disposable absorbent article products with improved stages of development identification
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
PL2354124T3 (pl) * 2006-12-19 2013-07-31 Hoffmann La Roche Pochodne heteroarylopirolidynylo- i piperydynyloketonów
JP2011524396A (ja) * 2008-06-18 2011-09-01 エフ．ホフマン−ラ ロシュ アーゲー Ｍｒｉとしてのアリールケトン
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
MY163048A (en) 2009-05-06 2017-08-15 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1306558A (en) * 1970-08-14 1973-02-14 Seperic Derivatives of thiazolino-pyrimidin-5-ones their preparation and applications
GB1374281A (en) * 1971-08-24 1974-11-20 Seperic Thiazolino-pyrimidin-5-one derivatives process for their pre paration and applications thereof
JPS51146497A (en) * 1975-06-12 1976-12-16 Sankyo Co Ltd Process for preparing pyrido (1,2-a)pyrimidinone derivatives
US4041163A (en) * 1976-03-29 1977-08-09 Pfizer Inc. N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents
GB1582744A (en) * 1976-06-04 1981-01-14 Gruenenthal Gmbh 7h-thiazolo (and 1,3,4-thiadiazolo-)(3,2-a) pyrimidin-7-one-5-carboxylic acids derivatives and medicaments therof
US4471117A (en) * 1979-06-21 1984-09-11 Janssen Pharmaceutica N.V. 3,4-Dihydro-2H-pyrimido(2,1-b)benzothiazoles
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives

Also Published As

Publication number Publication date
DE3270589D1 (de) 1986-05-22
PT75247B (en) 1985-01-07
EP0070053B1 (en) 1986-04-16
FI822511A0 (fi) 1982-07-14
PL237492A1 (en) 1984-02-27
DK316582A (da) 1983-01-16
CA1207765A (en) 1986-07-15
FI75828C (fi) 1988-08-08
FI75828B (fi) 1988-04-29
DK160314C (da) 1991-07-29
ES513976A0 (es) 1983-08-16
AU8575982A (en) 1983-01-20
FI822511L (fi) 1983-01-16
DK160314B (da) 1991-02-25
GR76006B (pt) 1984-08-03
DD215553A5 (de) 1984-11-14
CS227690B2 (en) 1984-05-14
IE53400B1 (en) 1988-11-09
EP0070053A2 (en) 1983-01-19
NO166327C (no) 1991-07-10
NZ201266A (en) 1985-01-31
SU1138032A3 (ru) 1985-01-30
HU186952B (en) 1985-10-28
IE821689L (en) 1983-01-15
NO822439L (no) 1983-01-17
MA19536A1 (fr) 1983-04-01
PH18120A (en) 1985-03-22
ES8308327A1 (es) 1983-08-16
PT75247A (en) 1982-08-01
NO166327B (no) 1991-03-25
US4443451A (en) 1984-04-17
EP0070053A3 (en) 1984-03-21
AU547967B2 (en) 1985-11-14
KR870000868B1 (ko) 1987-04-30
KR840000568A (ko) 1984-02-25
PL136680B1 (en) 1986-03-31

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