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WO2025045370A1 - Dispositif de pipetage, robot de pipetage et procédé d'utilisation du dispositif de pipetage - Google Patents

Dispositif de pipetage, robot de pipetage et procédé d'utilisation du dispositif de pipetage Download PDF

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Publication number
WO2025045370A1
WO2025045370A1 PCT/EP2023/073969 EP2023073969W WO2025045370A1 WO 2025045370 A1 WO2025045370 A1 WO 2025045370A1 EP 2023073969 W EP2023073969 W EP 2023073969W WO 2025045370 A1 WO2025045370 A1 WO 2025045370A1
Authority
WO
WIPO (PCT)
Prior art keywords
pump
valve
pipetting device
chamber
pressure
Prior art date
Application number
PCT/EP2023/073969
Other languages
German (de)
English (en)
Inventor
Hans-Jürgen TIEDTKE
Original Assignee
Hombrechtikon Systems Engineering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hombrechtikon Systems Engineering Ag filed Critical Hombrechtikon Systems Engineering Ag
Priority to PCT/EP2023/073969 priority Critical patent/WO2025045370A1/fr
Publication of WO2025045370A1 publication Critical patent/WO2025045370A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F04B43/043—Micropumps
    • F04B43/046—Micropumps with piezoelectric drive
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0615—Loss of fluid by dripping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/146—Employing pressure sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/023—Sending and receiving of information, e.g. using bluetooth
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves

Definitions

  • the invention relates to a pipetting device for dosing a liquid, a pipetting robot and a method for using the pipetting device according to the preamble of the independent claims.
  • Pipettes are used to dose liquids. Pipettes are mostly used in the medical field, with pipette tips being used as disposable plastic items to avoid contamination. For small volumes, so-called micropipettes are used, whereby small volumes of around 100 nanoliters and more can be pipetted. For repetitive work, there are electronically controlled pipettes, which are also used in particular in laboratory machines and robots.
  • Some pipettes work according to the displacement principle, whereby a moving piston displaces or draws in air, causing a liquid to flow out of or into the pipette tip.
  • a corresponding pipetting device is known, for example, from DE10237770A1.
  • an air column separates the liquid sucked up in the pipette tip and an interior of the pipette.
  • the movement of a pump element of the pump creates a vacuum in the pipette tip, which causes the liquid to rise into the tip.
  • the air moved by the pump element Air column provides a fluid flow, which causes the liquid to move into or out of the pipette tip.
  • Resonant acoustic pumps are known from WO 2022023703 A1, in which the volume of a pump chamber is reduced in order to move a fluid out of the pump chamber.
  • a piezoelectric pump is used for a pipetting device.
  • the pump is a disk-shaped micropump with a pump chamber and a piezoelectric membrane actuating element, which can be moved by applying a voltage in such a way that the volume of the pump chamber can change.
  • the micropump comprises two valves with piezoelectric elements.
  • the devices described above have a complex structure and do not allow for precise, rapid and accurate intake and dispensing of liquids.
  • the object of the invention is therefore to provide a pipetting device for dosing liquids, a pipetting robot and a method for using the pipetting device, which Avoid the adverse effects known from the technology, in particular enable precise and rapid processing of liquids and have a simple structure.
  • the object is achieved by a pipetting device, a pipetting robot and by a method for using the pipetting device having the features of the independent claims.
  • a pipetting device for dosing a liquid by means of a fluid stream which comprises a pump, a valve and a connecting element.
  • the pump has a pump chamber for generating the fluid flow, wherein a pump element is arranged in the pump chamber, by which the pump chamber is divided into a pressure chamber and a suction chamber.
  • the pump element is movable in the pump chamber in such a way that the fluid flow can be generated by a change in the volume of the pressure chamber and the suction chamber.
  • the valve is used to control the fluid flow generated by the pump, wherein the valve is fluidly connected to the pressure chamber via a first inlet and is fluidly connected to the suction chamber via a second inlet.
  • the connecting element has a fluid inlet which is fluidly connected to an outlet of the valve in such a way that the fluid flow generated by the pump can act on the liquid for dosing via the connecting element.
  • valve and pump provides a system for precise fluid transfer, which works in particular according to the air displacement principle.
  • the fluid flow can be used in particular as Gas or air flow can be understood, whereby the pump chamber is a space filled with air/gas (which can in particular be disc-shaped) which is enclosed by a housing.
  • the pump element separates the pressure chamber and the suction chamber from each other, preferably in a gas-tight manner.
  • the valve with multiple inlets By arranging the valve with multiple inlets to the various pump chambers, the liquid dispensing and liquid intake can be precisely controlled. This arrangement also allows for quick switching. Neither multiple pumps nor other chambers are required. In addition, the use of the pump with the two chambers enables a large pipetting volume range.
  • the pump is a micropump, in particular a piezoelectric micropump.
  • a micropump can be understood as a pump of small size, which is therefore particularly suitable for pipetting devices and can use an oscillating membrane as a pump element.
  • the pump element can be a piezoelectric disk or the pump element can comprise a membrane and a piezoelectric actuating element for moving (oscillating) the membrane.
  • Piezoelectric pumps are known as so-called resonant acoustic pumps from W02022023703. In this respect, reference is therefore made to the application W02022023703, the content of which is hereby incorporated into this application.
  • the piezoelectric micropump can use an acoustic resonance with a high amplitude in disk-shaped cavities (with a high aspect ratio, ie the ratio of the radius of the cavity to the height of the cavity) in which radial pressure oscillations are excited.
  • the pumping chamber can comprise a first and a second end wall which are connected to a peripheral side wall, the first and second end walls each comprising an opening (pressure opening and suction opening) which contain the one-way valves.
  • the pumping element is located between the first and second end walls and is connected to the peripheral side wall by an insulator (holding element) to define first and second cavities for receiving the fluid (i.e. pressure chamber and suction chamber), each of the cavities being substantially cylindrical and having a characteristic height and a characteristic radius. The ratio of the radius to the height can be greater than about 1.2.
  • the pumping element is configured to oscillate in an axial direction to generate radial pressure oscillations of the fluid in the first and second cavities.
  • the first inlet of the valve can be fluidically connected to a pressure opening of the pressure chamber via a pressure line.
  • a one-way valve can be arranged at the pressure opening (i.e., only able to flow in one direction, in particular a check valve), which is aligned in such a way that the fluid flow can only take place in the direction of the first inlet or the valve.
  • Pressure chamber generates excess pressure, which leads to fluid flow towards the valve (i.e. out of the pressure chamber).
  • the second inlet can be fluidically connected to a suction opening of the suction chamber via a suction line.
  • a one-way valve can also be arranged at the suction opening, but it is aligned in such a way that the fluid flow can only occur from the direction of the second inlet or the valve.
  • the suction chamber creates a negative pressure, which leads to the fluid flow from the direction of the valve (i.e. into the suction chamber).
  • the suction chamber can generate the negative pressure (suction pressure) in a valve interior/valve chamber of the valve, and the pressure chamber can generate the positive pressure in the valve interior/valve chamber of the valve.
  • suction pressure suction pressure
  • the positive pressure leads to a fluid flow in the direction of the connecting element, whereby liquid can be released from the connecting element
  • the negative pressure leads to a fluid flow from the direction of the connecting element, whereby liquid can be taken up into the connecting element.
  • the outlet of the valve is simply designed as an opening, so that the positive pressure leads to a fluid flow in the direction of the connecting element when the first inlet is opened, whereby liquid can be released from the connecting element, and the negative pressure leads to a fluid flow from the direction of the connecting element when the second inlet is opened, whereby liquid can be taken up into the connecting element.
  • the connecting element is preferably a pipette tip adapter, which comprises a channel that extends from the fluid inlet to a fluid outlet, wherein the fluid outlet is arranged on a receiving element for receiving a pipette tip. The liquid can thus be taken in and dispensed via an exchangeable pipette tip, thereby avoiding cross-contamination.
  • the pressure chamber and the suction chamber can each comprise a compensation opening through which an interior of the pressure chamber and an interior of the suction chamber are fluidically connected to the environment.
  • the compensation opening can therefore be understood in particular as an opening in a housing wall surrounding the chamber through which gas can flow into the chamber or out of the chamber.
  • the suction line and/or the pressure line can include a bypass opening, which is dimensioned in such a way that a predeterminable minimum flow can be set independently of the minimum power of the pump.
  • the minimum flow can be set because the bypass opening causes a pressure drop (in the pressure line) or a pressure increase (in the suction line), both of which depend on the size of the bypass opening.
  • the pipetting device can comprise a control device for controlling the valve and the pump, wherein the control device can comprise a valve control for separately controlling the first inlet and the second inlet (and optionally the outlet).
  • the control device can comprise a pump control for controlling the movement of the pump element.
  • a pressure and/or flow sensor can be provided, which can be connected to the control device and is arranged at the outlet and/or the connecting element for pressure and/or flow determination.
  • the valve can be a three-way valve (3/3), in particular a piezoelectric three-way valve.
  • the valve uses in particular (separate/separately controllable) piezoelectric actuators for the first and second inlets, the movement/deformation of which enables the flow of the fluid stream.
  • the valve control can apply an electrical voltage to the actuators, whereby a piezoelectric material of the actuators is compressed or stretched (depending on the applied voltage). This mechanical deformation creates a movement.
  • the movement of the piezoelectric actuator either presses a corresponding closure element against a valve seat to block the fluid flow, or removes it from it to enable the fluid flow.
  • the valve can be opened or closed within a very short time. This enables precise control of the fluid flow and thus very precise fluid intake and discharge.
  • the first inlet and the second inlet can be controlled separately and reliably, so that the interior of the valve can be connected to either the pressure chamber or the suction chamber. This enables a seamless change between positive, negative and no flow.
  • the pipetting device can be part of a robot system.
  • a pipetting robot can therefore comprise one pipetting device or a plurality of pipetting devices that can be moved and controlled by a movement device.
  • the movement device can be a robot arm. Freely programmable movement sequences make it possible to carry out a wide variety of tasks in a wide range of application areas.
  • the sensors can be used to measure the fluid flow over time and to measure the expansion/contraction of the volume in the pipette tip and the pipette tip adapter to determine the volume of air displaced.
  • the volume of air displaced causes a pressure difference that pulls/pushes the liquid in or out of the pipette tip attached to the pipette tip adapter.
  • the air displacement volume can be determined by a precise measurement of the fluid flow under constant pressure control in order to enable control of the valve and thus the dosing volume.
  • the pipetting device has the following significant advantages over a manual pipette. Fast and precise pipetting is possible without knowledge of the properties of the liquid being moved. An unusually large pipetting volume range is possible (replaces several standard manual pipettes). Since the pipetting mechanism is completely driven by electrical movement, many secondary properties can also be realized, such as autocalibration, drip-free control, multidispensing and Bluetooth connectivity.
  • the pump element 20 is movable in the pump chamber 27 such that the fluid flow can be generated by a volume change of the pressure chamber 21 and the suction chamber 22.
  • the pump 2 is designed as a piezoelectric micropump 2 with a disk-shaped pump chamber 27, wherein the pump element 20 is a membrane with a piezoelectric actuating element, which is controlled by a pump control 43 of the control device 4. A voltage is applied to the piezoelectric actuating element in order to set the membrane in motion.
  • a voltage is applied to the pump element 20 to prevent deformation of the Membrane so that the volume of the suction chamber 22 increases. This creates a negative pressure in the suction chamber 22, whereby air is sucked in from the suction line 34, which flows through the one-way valve 24 into the suction chamber 22.
  • the three-way valve 3 is first actuated in such a way that only the first inlet 31 is open.
  • the three-way valve 3 is actuated by applying an electrical voltage to the piezoelectric actuator 47.
  • Fig. 2 shows a schematic representation of a second embodiment of a pipetting device 1 according to the invention.
  • the structure of the pipetting device 1 corresponds to the structure of the embodiment of Fig. 1, but the pipetting device 1 additionally comprises an ambient pressure sensor 44, which is used to compensate for pipetting errors due to ambient pressure changes.
  • the suction line 34 comprises a bypass opening 36 and a damping volume 39 to enable a slow and wave-free increase in pressure and flow.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Reciprocating Pumps (AREA)

Abstract

L'invention concerne un dispositif de pipetage (1) permettant de doser un liquide (60) au moyen d'un écoulement de fluide. Le dispositif de pipetage (1) comprend une pompe (2) dotée d'une chambre de pompe (27) pour générer l'écoulement de fluide ; dans la chambre de pompe (27), un élément de pompe (20) au moyen duquel la chambre de pompe (27) est divisée en une chambre de pression (21) et une chambre d'aspiration (22) est agencé ; et l'élément de pompe (20) peut être déplacé dans la chambre de pompe (27) de telle sorte que l'écoulement de fluide peut être généré par un changement de volume de la chambre de pression (21) et de la chambre d'aspiration (22). Le dispositif de pipetage (1) comprend en outre une soupape (3) permettant de réguler l'écoulement de fluide ; et la soupape (3) est reliée de façon fluidique par l'intermédiaire d'une première entrée (31) à la chambre de pression (21) et par l'intermédiaire d'une seconde entrée (32) à la chambre d'aspiration (22). Le dispositif de pipetage (1) comprend également un élément de raccordement (6) avec une entrée de fluide (63) qui est en communication fluidique avec une sortie (38) de la soupape (3) de telle sorte que l'écoulement de fluide généré par la pompe (2) peut agir sur le liquide (60) par l'intermédiaire de l'élément de raccordement (6) à des fins de dosage.
PCT/EP2023/073969 2023-08-31 2023-08-31 Dispositif de pipetage, robot de pipetage et procédé d'utilisation du dispositif de pipetage WO2025045370A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2023/073969 WO2025045370A1 (fr) 2023-08-31 2023-08-31 Dispositif de pipetage, robot de pipetage et procédé d'utilisation du dispositif de pipetage

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2023/073969 WO2025045370A1 (fr) 2023-08-31 2023-08-31 Dispositif de pipetage, robot de pipetage et procédé d'utilisation du dispositif de pipetage

Publications (1)

Publication Number Publication Date
WO2025045370A1 true WO2025045370A1 (fr) 2025-03-06

Family

ID=87974342

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2023/073969 WO2025045370A1 (fr) 2023-08-31 2023-08-31 Dispositif de pipetage, robot de pipetage et procédé d'utilisation du dispositif de pipetage

Country Status (1)

Country Link
WO (1) WO2025045370A1 (fr)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0993869A2 (fr) * 1998-10-17 2000-04-19 Hirschmann Laborgeräte GmbH & Co. KG Dispositif de pipettage
EP1150105A2 (fr) * 2000-04-28 2001-10-31 Eppendorf Ag Système microdoseur à coussin de gaz
DE10237770A1 (de) 2002-08-17 2004-03-11 Eppendorf Ag Pipettiervorrichtung
EP1531937A1 (fr) 2002-08-22 2005-05-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Systeme de pipetage et procede pour exploiter un systeme de pipetage
WO2006005923A1 (fr) 2004-07-08 2006-01-19 Norgren Limited Systeme de distribution de liquide
US7303728B2 (en) 2000-10-20 2007-12-04 Seyonic Sa Fluid dispensing device
DE102008016549A1 (de) * 2008-03-27 2009-11-19 Nyársik, Lajos, Dr. Dosiervorrichtung für kontaktfreie Flüssigkeitsabgabe
US20140191058A1 (en) * 2011-08-26 2014-07-10 Basf Se Method for the expulsion of a plant protection composition and spray gun
CH712572B1 (de) * 2007-11-28 2017-12-15 Integra Biosciences Ag Handpipettiergerät.
WO2022023703A1 (fr) 2020-07-31 2022-02-03 Ttp Ventus Ltd. Actionneur pour une pompe acoustique résonante

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0993869A2 (fr) * 1998-10-17 2000-04-19 Hirschmann Laborgeräte GmbH & Co. KG Dispositif de pipettage
EP1150105A2 (fr) * 2000-04-28 2001-10-31 Eppendorf Ag Système microdoseur à coussin de gaz
US7303728B2 (en) 2000-10-20 2007-12-04 Seyonic Sa Fluid dispensing device
DE10237770A1 (de) 2002-08-17 2004-03-11 Eppendorf Ag Pipettiervorrichtung
EP1531937A1 (fr) 2002-08-22 2005-05-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Systeme de pipetage et procede pour exploiter un systeme de pipetage
WO2006005923A1 (fr) 2004-07-08 2006-01-19 Norgren Limited Systeme de distribution de liquide
CH712572B1 (de) * 2007-11-28 2017-12-15 Integra Biosciences Ag Handpipettiergerät.
DE102008016549A1 (de) * 2008-03-27 2009-11-19 Nyársik, Lajos, Dr. Dosiervorrichtung für kontaktfreie Flüssigkeitsabgabe
US20140191058A1 (en) * 2011-08-26 2014-07-10 Basf Se Method for the expulsion of a plant protection composition and spray gun
WO2022023703A1 (fr) 2020-07-31 2022-02-03 Ttp Ventus Ltd. Actionneur pour une pompe acoustique résonante

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