WO2024130853A1

WO2024130853A1 - Shock wave balloon catheter device

Info

Publication number: WO2024130853A1
Application number: PCT/CN2023/080123
Authority: WO
Inventors: 江挺益; 刘广志
Original assignee: 苏州润迈德智能科技发展有限公司
Priority date: 2022-12-20
Filing date: 2023-03-07
Publication date: 2024-06-27
Also published as: CN118252573A

Abstract

Provided is a shock wave balloon catheter device, which comprises a catheter (1), a balloon (2) surrounding the periphery of the catheter (1) in a sealed manner, and at least one electrode pair (3) arranged in the balloon (2). Each electrode pair (3) comprises a first electrode (301) and a second electrode (302), and the first electrode (301) and the second electrode (302) are arranged at intervals along the circumference of the catheter (1). The device further comprises a positioning sheath (4) wrapping an insulating material on the periphery of the electrode pair (3). The positioning sheath (4) enables a part of an outer peripheral wall or an axial end surface of the first electrode (301) and the second electrode (302) to be exposed and thereby to be able to make contact with liquid in the balloon (2). When a voltage is applied between the first electrode (301) and the second electrode (302), the exposed part of the first electrode (301) and the exposed part of the second electrode (302) generate a discharge arc in the liquid. Only a single layer of electrodes and the positioning sheath (4) are arranged on the periphery of the catheter (1) of the shock wave balloon catheter device, such that the catheter (1) can proceed well in a vessel.

Description

Shock wave balloon catheter device

Technical Field

The present application relates to the technical field of medical devices, and in particular to a shock wave balloon catheter device.

Background technique

As heart disease patients age and the disease progresses, plaques in peripheral blood vessels and coronary arteries gradually calcify. This bone-like structure can cause narrowing of the vessels, reduce blood flow in the vessels, and may eventually lead to complete occlusion of the vessels.

A shock wave balloon catheter device is provided for vascular calcification lesions; during treatment, the balloon on the catheter is pushed into the vascular calcification area; the balloon is then inflated and pressurized with fluid; high-voltage pulses are applied to the electrode pairs in the balloon, causing the electrode pairs to discharge and generate shock waves in the fluid; the shock waves hit the balloon wall, causing the calcified plaque to rupture; after the calcified plaque ruptures, the balloon can be further inflated to open the blood vessel.

In the above shock wave balloon catheter device, the balloon is carried by the catheter to move in the blood vessel, so the catheter needs to have good passability in the blood vessel.

Summary of the invention

The embodiments of the present application provide a shock wave balloon catheter device having good permeability in blood vessels.

In one embodiment, a shock wave balloon catheter device is provided, comprising a catheter, a balloon sealed around the outer circumference of the catheter, and at least one electrode pair arranged in the balloon; each of the electrode pairs comprises a first electrode and a second electrode; the first electrode and the second electrode are arranged at intervals along the circumference of the catheter; the first electrode comprises a first end located at one circumferential end of the catheter, and a second end located at the other circumferential end of the catheter; the second electrode comprises a third end located at one circumferential end of the catheter, and a fourth end located at the other circumferential end of the catheter; the first end is adjacent to the fourth end and has a first gap; the second end is adjacent to the third end and has a second gap;

The device also includes a positioning sheath of insulating material wrapped around the periphery of the electrode;

The positioning sheath exposes part of the outer peripheral wall or the axial end surface of the first end portion so as to contact the liquid in the balloon; and the positioning sheath exposes part of the outer peripheral wall or the axial end surface of the fourth end portion so as to contact the liquid in the balloon; when a voltage is applied between the first electrode and the second electrode, the exposed part of the first end portion and the exposed part of the fourth end portion can generate a discharge arc in the liquid;

and / or,

The positioning sheath exposes part of the peripheral wall or the axial end surface of the second end portion so as to contact the liquid in the balloon; and the positioning sheath exposes part of the peripheral wall or the axial end surface of the third end portion so as to contact the liquid in the balloon. when a voltage is applied between the first electrode and the second electrode, the exposed portion of the second end portion and the exposed portion of the third end portion may generate a discharge arc in the liquid.

In the embodiment provided by the present application, the first electrode and the second electrode are arranged at intervals along the circumference of the catheter, and a positioning sheath made of an insulating material is wrapped around the circumference of the electrode. The positioning sheath exposes part of the first electrode and the second electrode to form a discharge shock wave. Therefore, only a single layer of electrodes and positioning sheaths are arranged on the circumference of the catheter, so that the catheter has good permeability in the blood vessels.

BRIEF DESCRIPTION OF THE DRAWINGS

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For those skilled in the art, other drawings can be obtained based on these drawings without paying any creative labor.

FIG1 is a schematic structural diagram of a shock wave balloon catheter device provided by one embodiment of the present application;

FIG2 is a schematic diagram of the structure of a cross section of an electrode pair provided by an embodiment of the present application;

FIG3 is a partial front view of an electrode pair of a shock wave balloon catheter device provided by another embodiment of the present application;

FIG4 is a longitudinal cross-sectional view of FIG3 of the present application;

FIG5 is a partial longitudinal cross-sectional view of an electrode pair of a shock wave balloon catheter device provided by another embodiment of the present application;

FIG6 is a schematic diagram of the structure of a catheter, an electrode pair and a positioning sheath provided in one embodiment of the present application;

FIG7 is a schematic structural diagram of a catheter, an electrode pair and a positioning sheath provided in another embodiment of the present application;

FIG8 is a schematic diagram of the connection between a pulse voltage generator and an electrode pair provided in one embodiment of the present application;

FIG9 is a schematic diagram of the connection structure of the electrode pair and the wire provided in an embodiment of the present application in which the distal electrode pair and the proximal electrode pair are respectively electrically connected to the pulse voltage generator through a power supply circuit;

Fig. 10 is a schematic diagram of the cross-sectional structure of A-A in Fig. 9;

FIG11 is a schematic diagram of the connection structure of electrode pairs and wires provided in another embodiment of the present application in which the distal electrode pair and the proximal electrode pair are respectively electrically connected to the pulse voltage generator through a power supply circuit;

FIG12 is a schematic diagram of the connection structure of the electrode pair and the wire provided in the embodiment in which the distal electrode pair and the proximal electrode pair of the present application are connected in series to the pulse voltage generator;

FIG13 is a schematic diagram of the connection structure of the electrode pair and the wire provided in another embodiment of the present application in which the distal electrode pair and the proximal electrode pair are connected in series to the pulse voltage generator;

FIG14 is a schematic diagram of a cross-sectional structure of an electrode pair, an insulating medium and a wire provided in one embodiment of the present application;

FIG15 is a schematic diagram of the cross-sectional structure of an electrode pair, an insulating medium and a conductor provided in another embodiment of the present application.

Description of reference numerals:
1. Catheter;
2. Balloon;
3. Electrode pair; 3a. Distal electrode pair; 3b. Proximal electrode pair; 301. First electrode; 302. Second electrode; 3011.
first end; 3012, second end; 3021, third end; 3022, fourth end; 303, first gap; 304, second gap;
4. Positioning sheath; 401. First discharge hole; 402. Second discharge hole; 403. Third discharge hole; 404. Fourth discharge hole;
5. Insulating medium; 501. First insulating strip; 502. Second insulating strip;
6. Pulse voltage generator;
7. Development ring;
801, first conductor; 801a, first distal overlapping segment; 801b, first proximal overlapping segment; 802, second conductor; 803,
A third conductor; 804, a fourth conductor; 804a, a fourth distal overlapping segment; 804b, a fourth proximal overlapping segment.

Detailed ways

The technical solution of the present invention will be described in detail below in conjunction with the accompanying drawings and specific implementation methods. It should be understood that these implementation methods are only used to illustrate the present invention and are not used to limit the scope. After reading the present invention, various equivalent forms of modifications to the present invention by those skilled in the art all fall within the scope defined by the present application.

It should be noted that when an element is referred to as being "disposed on" another element, it may be directly on the other element or there may be an intermediate element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be an intermediate element at the same time.

The shock wave balloon catheter device of the embodiment of the present specification will be explained and described below in conjunction with Figures 1 to 15. It should be noted that in the embodiments of the present invention, the same reference numerals represent the same components. For the sake of brevity, detailed descriptions of the same components are omitted in different embodiments, and the descriptions of the same components can be referenced and quoted to each other.

The shock wave balloon catheter device is indicated for interventional treatment of vascular calcification. The shock wave balloon catheter device comprises a catheter, a balloon sealed around the outer circumference of the catheter, and at least one electrode pair disposed in the balloon; the balloon can be filled with fluid; each of the electrode pairs comprises a first electrode and a second electrode; when a voltage is applied between the first electrode and the second electrode, a plasma arc is formed between the first electrode and the second electrode in the fluid in the balloon, thereby generating a plasma arc in the fluid. The balloon forms bubbles which expand and collapse, in turn creating mechanical shock waves in the balloon which are mechanically transmitted through the fluid and balloon to apply mechanical force or pressure to break apart any calcified plaque on or in the vascular system wall.

When the device is used clinically, the balloon in a decompressed state should first be delivered to the calcified lesion site, and the balloon should be pressurized to ensure close contact with the blood vessel wall; then a voltage is applied between the first electrode and the second electrode, and the fluid in the balloon between the first electrode and the second electrode forms a discharge shock wave. The shock wave impacts and destroys the calcified lesion, causing the calcification of the intima and the media to break. The modification effect of the calcified lesion can be judged by evaluating the symmetrical expansion of the balloon.

The shock wave balloon catheter device efficiently and safely destroys superficial and deep calcifications, thereby significantly improving vascular compliance. The device is effective not only for superficial and deep calcifications, but also for eccentric and non-eccentric lesions, reducing the risk of complications such as dissection and perforation.

In the above-mentioned shock wave balloon catheter device, the balloon is carried by the catheter to move in the blood vessels. In some cases, the blood vessels have already suffered from severe stenosis or even complete occlusion. Therefore, it is necessary to reduce the cross-sectional area of the catheter as much as possible and improve the flexibility of the catheter so that it has good permeability in the blood vessels.

In an optional embodiment, the first electrode and the second electrode are radially stacked and installed on the catheter, and in order to prevent the first electrode and the second electrode from being connected and short-circuited, a layer of insulating medium needs to be stacked between the first electrode and the second electrode. In this structure, two layers of electrodes and a layer of insulating medium are stacked on the outer wall of the catheter, so that the cross-sectional area of the electrode pair is large, the flexibility is poor, and it is difficult to pass through the blood vessels with severe stenosis or completely occluded lesions, and the passability is poor.

An optional embodiment of the shock wave balloon catheter device provided by the present application is shown in FIG1 , wherein the shock wave balloon catheter device comprises a catheter 1, a balloon 2 sealed around the outer periphery of the catheter 1, and at least one electrode pair 3 disposed in the balloon 2; the balloon 2 can be filled with fluid, wherein the fluid includes but is not limited to water, saline, contrast agent and a mixture thereof.

Optionally, in this embodiment, the number of the electrode pairs 3 is at least 2, and at least 2 electrode pairs 3 are arranged at intervals along the axial direction of the catheter 1, so that discharge shock waves are generated at multiple positions in the balloon 2, thereby more efficiently destroying the calcified area.

As shown in Fig. 2, each of the electrode pairs 3 includes a first electrode 301 and a second electrode 302, and the first electrode 301 and the second electrode 302 are arranged at intervals along the circumference of the catheter 1. Optionally, the cross-sectional shapes of the first electrode 301 and the second electrode 302 are both arc-shaped, and the inner wall of the first electrode 301 and the inner wall of the second electrode 302 are respectively attached to the outer wall of the catheter 1, so that the connection is more stable and the cross-sectional size is reduced.

The first electrode 301 includes a first end 3011 located at one end of the catheter 1 in the circumferential direction, and a second end 3012 located at the other end of the catheter 1 in the circumferential direction; the second electrode 302 includes a third end located at one end of the catheter 1 in the circumferential direction. 3021, and a fourth end 3022 located at the other circumferential end of the conduit 1; the first end 3011 is adjacent to the fourth end 3022 and defines a first gap 303; the second end 3012 is adjacent to the third end 3021 and defines a second gap 304.

The arc angles of the arc-shaped first electrode 301 and the second electrode 302 may be the same or different. For example, the arc angles of the first electrode 301 and the second electrode 302 are both 175°; or the arc angle of the first electrode 301 is 120°, and the arc angle of the second electrode 302 is 100°.

The lengths of the first electrode 301 and the second electrode 302 along the axial direction of the catheter 1 may be the same or different; they only need to be at least partially located in the same interval in the axial direction.

When a pulse voltage is applied between the first electrode 301 and the second electrode 302, a potential difference is formed between the first electrode 301 and the second electrode 302, and a discharge shock wave is formed in at least one of the first gap 303 and the second gap 304. When a pulse voltage is applied between the first electrode 301 and the second electrode 302, the balloon 2 needs to be filled with a fluid.

Optionally, the first gap 303 between the first electrode 301 and the second electrode 302 is relatively small, and a discharge shock wave can be formed; while the second gap 304 is relatively large, and a discharge shock wave cannot be formed. For example, the arc angle of the first electrode 301 is 120°, and the arc angle of the second electrode 302 is 100°, and the central angle between the first end 3011 and the fourth end 3022 is configured to be 5°, and the first gap 303 is small enough to form a discharge shock wave; then the central angle between the second end 3012 and the third end 3021 is 135°, and since the distance between the second end 3012 and the third end 3021 is relatively far, the second gap 304 does not form a discharge shock wave.

In this embodiment, the first gap 303 and the second gap 304 are both small enough, and when a voltage is applied between the first electrode 301 and the second electrode 302, a discharge shock wave can be formed in the first gap 303 and the second gap 304. For example, the arc angles of the first electrode 301 and the second electrode 302 are both 175°, and the two are arranged symmetrically, then the central angle between the first end 3011 and the fourth end 3022 is 5°, and the central angle between the second end 3012 and the third end 3021 is also 5°, and the first gap 303 and the second gap 304 can both form a discharge shock wave.

Optionally, in two adjacent electrode pairs 3, the gap that can form a discharge shock wave of one electrode pair 3 and the gap that can form a discharge shock wave of the other electrode pair 3 are arranged circumferentially of the catheter 1. Such a configuration makes the shock wave applied to the lesion more dispersed, which is conducive to the fragmentation of calcified plaques.

During the process of the electrode pair 3 following the catheter 1 in the human body's blood vessels and the discharge process, the electrode pair 3 will follow the catheter 1 to bend and be subjected to the resistance and mechanical vibration applied by the blood vessels, which may cause the electrode pair 3 to be displaced relative to the catheter 1 or even fall off the catheter 1. Therefore, in an optional embodiment of the present application, the shock wave balloon catheter device also includes a fixed The positioning sheath 4 is used to maintain the relative position between the electrode pair 3 and the catheter 1. Optionally, the positioning sheath 4 is formed by thermoplastic molding.

As shown in FIG4 , the first electrode 301 and the second electrode 302 are wrapped and fixed on the catheter 1 by the thermoplastically formed positioning sheath 4, which can effectively prevent the first electrode 301 or the second electrode 302 from falling off from the catheter 1 due to various factors during the operation, and the first electrode 301 or the second electrode 302 from being displaced relative to the catheter 1, thereby improving the safety and reliability of the device.

The positioning sheath 4 exposes part of the outer wall or the axial end face of the first end 3011 to contact the liquid in the balloon 2; and the positioning sheath 4 exposes part of the outer wall or the axial end face of the fourth end 3022 to contact the liquid in the balloon 2; when a voltage is applied between the first electrode 301 and the second electrode 302, the exposed part of the first end 3011 and the exposed part of the fourth end 3022 can generate a discharge arc in the liquid;

and / or,

The positioning sheath 4 exposes part of the outer wall or axial end face of the second end 3012 so as to contact the liquid in the balloon 2; and the positioning sheath 4 exposes part of the outer wall or axial end face of the third end 3021 so as to contact the liquid in the balloon 2; when a voltage is applied between the first electrode 301 and the second electrode 302, the exposed part of the second end 3012 and the exposed part of the third end 3021 can generate a discharge arc in the liquid.

As shown in FIG. 3 , in an optional embodiment, the positioning sleeve 4 is provided with a first discharge hole 401 , a second discharge hole 402 , a third discharge hole 403 , and a fourth discharge hole 404 .

The first discharge hole 401 exposes a portion of the outer peripheral wall of the first end 3011 to form a first discharge area; the fourth discharge hole 404 exposes a portion of the outer peripheral wall of the fourth end 3022 to form a fourth discharge area; when a voltage is applied between the first electrode 301 and the second electrode 302, the first discharge area and the fourth discharge area are configured to form a discharge arc;

The second discharge hole 402 exposes a portion of the outer peripheral wall of the second end 3012 to form a second discharge area; the third discharge hole 403 exposes a portion of the outer peripheral wall of the third end 3021 to form a third discharge area; when a voltage is applied between the first electrode 301 and the second electrode 302, the second discharge area and the third discharge area are configured to form a discharge arc.

In an optional implementation of this embodiment, the proximal end faces and the distal end faces of the first electrode 301 and the second electrode 302 are both covered by the positioning sheath 4 .

As shown in FIG5 , in another optional implementation of this embodiment, the axial end face of the positioning sheath 4 is substantially flush with the axial end face of the first electrode 301; the axial end face of the positioning sheath 4 is substantially flush with the axial end face of the second electrode 302; wherein the axial end face refers to at least one of the proximal end face and the distal end face. To prevent the axial end faces of the first electrode 301 and the second electrode 302 from contacting the liquid in the balloon 2, the axial end faces of the first electrode 301 and the second electrode 302 are respectively covered with an insulating layer; the insulating layer may be an insulating coating, an adhesive insulating film or other alternatives.

Optionally, the first discharge zone is connected to the axial end surface of the first electrode 301; the fourth discharge zone is connected to the axial end surface of the second electrode 302; the second discharge zone is connected to the axial end surface of the first electrode 301; the fourth discharge zone is connected to the axial end surface of the second electrode 302; that is, the first discharge hole 401, the second discharge hole 402, the third discharge hole 403, and the fourth discharge hole 404 are all opened at the axial edge of the positioning sleeve 4. This solution makes the hole opening process of the positioning sleeve 4 simpler.

In this embodiment, as shown in FIG. 3 and FIG. 4 , the first discharge hole 401 and the second discharge hole 402 may be connected, or the first discharge hole 401 and the second discharge hole 402 may be discrete; similarly, the third discharge hole 403 and the fourth discharge hole 404 may be connected, or the third discharge hole 403 and the fourth discharge hole 404 may be discrete.

In the optional schemes shown in Figures 3 and 4, the first discharge area and the fourth discharge area are arranged alternately along the axial direction; the second discharge area and the third discharge area are arranged alternately along the axial direction; or in another optional scheme, the first discharge area and the fourth discharge area are located in the same conduit cross-section; the second discharge area and the third discharge area are located in the same conduit cross-section.

In another optional embodiment, the axial end face of the positioning sleeve 4 is substantially flush with the axial end face of the first electrode 301; the axial end face of the positioning sleeve 4 is substantially flush with the axial end face of the second electrode 302; wherein the axial end face refers to at least one of the proximal end face and the distal end face.

The axial end surface of the first electrode 301 is exposed to contact the liquid in the balloon 2; the axial end surface of the second electrode 302 is exposed to contact the liquid in the balloon 2. When a voltage is applied between the first electrode 301 and the second electrode 302, the exposed axial end surface of the first end 3011 and the exposed axial end surface of the fourth end 3022 can generate a discharge arc in the liquid; the exposed axial end surface of the second end 3012 and the exposed axial end surface of the third end 3021 can generate a discharge arc in the liquid.

In the above embodiment, when the number of the electrode pairs 3 is at least 2, optionally, as shown in FIG6 , one positioning sheath 4 is correspondingly covered on the outside of each electrode pair 3; or, as shown in FIG7 , one positioning sheath 4 covers the outside of at least two electrode pairs 3; further, one positioning sheath 4 is made by thermoplastic molding so as to cover the outside of all the electrode pairs 3 on the catheter 1.

In the above embodiment, the cross section at the location of the electrode pair 3 includes the catheter 1, the electrode pair 3 sleeved on the outer periphery of the catheter 1, and the positioning sheath 4 sleeved on the outer periphery of the electrode pair 3. The diameter of the cross section at this location (i.e., the outer wall of the positioning sheath 4) is The diameter) can be less than 1.2mm, and has good permeability in blood vessels; the thickness of the positioning sheath 4 formed by thermoplastic molding can be as low as 0.01mm, so the positioning sheath 4 can effectively fix the electrode pair 3 while having little effect on the cross-sectional size of the catheter 1.

In the above embodiment, the first end 3011 is adjacent to the fourth end 3022 and defines a first gap 303, and the second end 3012 is adjacent to the third end 3021 and defines a second gap 304; the first gap 303 and the second gap 304 separate the first electrode 301 from the second electrode 302; the positioning sheath is used to maintain the relative position between the electrode pair 3 and the catheter 1, that is, the first electrode 301 and the second electrode 302 can be kept separated. Therefore, it is not necessary to set an insulating medium at the first gap 303 and the second gap 304.

However, in order to facilitate the generation of discharge, the distance between the first gap 303 or the second gap 304 is small. In extreme cases, the first electrode 301 or the second electrode 302 may be loosely fixed, or the catheter 1 may be bent, so that the relative position of the first electrode 301 and the second electrode 302 changes, resulting in the first electrode 301 and the second electrode 302 contacting and short-circuiting. This situation needs to be avoided. Therefore, in an optional embodiment, an insulating medium 5 is provided in the first gap 303 and the second gap 304 at least at the gap where the discharge shock wave can be formed, so as to prevent the first electrode 301 from contacting the second electrode 302 and improve the reliability of the device.

In this embodiment, both the first gap 303 and the second gap 304 can form a discharge shock wave, so the first gap 303 and the second gap 304 are both provided with an insulating medium 5 .

Optionally, the insulating medium 5 at the first gap 303 is fixedly connected to the first end 3011. The present application does not limit the fixing method therebetween, and fixing structures such as bonding, screws, and mortise and tenon joints may be used. The same applies below; the insulating medium 5 at the first gap 303 is fixedly connected to the fourth end 3022; in this embodiment, the first electrode 301 and the second electrode 302 are fixedly connected via the insulating medium 5 at the first gap 303, so that the positions of the first electrode 301 and the second electrode 302 on the catheter 1 are more firmly and stably positioned. Furthermore, the insulating medium 5 at the second gap 304 is fixedly connected to the second end 3012; the insulating medium 5 at the second gap 304 is connected to the third end 3021; the first electrode 301, the second electrode 302, the first gap 303 and the insulating medium 5 at the second gap 304 are fixedly connected together to form a ring structure which is sleeved on the catheter 1, so that the positions of the first electrode 301 and the second electrode 302 on the catheter 1 are more firmly and stably positioned, and the first electrode 301 and the second electrode 302 can be effectively prevented from falling off from the catheter 1.

In an optional embodiment, a developing ring 7 is sleeved on the outside of the catheter 1. The developing ring 7 is located in the balloon 2 and is used to mark the position of the balloon 2 in the human body through an imaging system. Preferably, the developing ring 7 is located in an area outside the electrode pair 3, and is not placed overlapping with the electrode pair 3, so as to prevent the local cross-sectional size of the catheter 1 from being too large.

In an optional embodiment, the device further comprises a pulse voltage generator 6 for providing a pulse voltage to the electrode pair 3; the pulse voltage generator 6 is electrically connected to the electrode pair 3 via a wire.

In an optional embodiment, the number of the electrode pairs 3 is at least two, and the at least two electrode pairs 3 include a distal electrode pair 3a and a proximal electrode pair 3b; the proximal electrode pair 3b is located between the pulse voltage generator 6 and the distal electrode pair 3a. The distal electrode pair 3a and the proximal electrode pair 3b are used to distinguish the two electrode pairs 3 by the relative position relationship between the two electrode pairs 3. When the number of the electrode pairs 3 is greater than two, the distal electrode pair 3a and the proximal electrode pair 3b do not specifically refer to a certain electrode pair 3, and any two of the electrode pairs 3 can be called the distal electrode pair 3a and the proximal electrode pair 3b.

The conductor includes a first conductor 801 connected between the pulse voltage generator 6 and the distal electrode pair 3a; the first conductor 801 is laid along the extension direction of the catheter 1, and must pass through the section where the proximal electrode is located along the axial direction of the catheter 1, and the portion of the first conductor 801 located in the section where the proximal electrode is located along the axial direction of the catheter 1 is defined as the first proximal overlapping section 801b.

Optionally, the first proximal overlapping section 801b is overlapped on the outer wall of the proximal electrode pair 3b. In this embodiment, the first wire 801 will increase the cross-sectional area of the outer contour at the proximal electrode pair 3b, reducing the passability and compliance of the catheter 1.

In another optional embodiment, the first proximal overlapping section 801b is arranged in the first gap 303 or the second gap 304 of the proximal electrode pair 3b. In this embodiment, the first wire 801 is prevented from occupying space at the proximal electrode pair 3b, resulting in an increase in the cross-sectional area of the outer contour at the proximal electrode pair 3b. Compared with the previous embodiment, the catheter 1 has better passability in the blood vessel. In addition, the first proximal overlapping section 801b is arranged in the first gap 303 or the second gap 304, which can be used to maintain insulation isolation between the first electrode 301 and the second electrode 302 of the proximal electrode pair 3b.

Optionally, the first proximal overlapping section 801b is disposed in the first gap 303 of the proximal electrode pair 3b; the first proximal overlapping section 801b is fixedly connected to the first end 3011 of the proximal electrode pair 3b, and the present application does not limit the fixing method therebetween, and a fixing structure such as bonding or snapping may be used; the first proximal overlapping section 801b is fixedly connected to the fourth end 3022 of the proximal electrode pair 3b. In this embodiment, the first electrode 301 and the second electrode 302 of the proximal electrode pair 3b are fixedly connected through the first proximal overlapping section 801b at the first gap 303, so that the positions of the first electrode 301 and the second electrode 302 on the catheter 1 are more firmly and stably arranged.

In this embodiment, when the first gap 303 and the second gap 304 of the proximal electrode pair 3b are both provided with an insulating medium 5; the insulating medium 5 and the first proximal overlapping section 801b are located in the same gap of the proximal electrode pair 3b; when only one of the first gap 303 and the second gap 304 of the proximal electrode pair 3b is An insulating medium 5 is disposed inside, and one of the insulating medium 5 and the first proximal overlapping section 801b is located in the first gap 303 of the proximal electrode pair 3b, and the other is located in the second gap 304 of the proximal electrode pair 3b.

When the insulating medium 5 and the first proximal overlapping section 801b are both located in the first gap 303 of the proximal electrode pair 3b:

In an optional embodiment, as shown in Figure 14, the radial width of the insulating medium 5 along the catheter 1 is smaller than the width of the first end 3011, and the radial width of the insulating medium 5 along the catheter 1 is smaller than the width of the fourth end 3022; and the insulating medium 5 is located between the first proximal overlapping section 801b and the outer wall of the catheter 1.

In another optional embodiment, the axial length of the insulating medium 5 along the catheter 1 is less than the length of the first end 3011, and the axial length of the insulating medium 5 along the catheter 1 is less than the length of the fourth end 3022; and a channel is provided on the insulating medium 5 and passes through the axial direction of the catheter 1; the first proximal overlapping section 801b is provided in the channel.

In another optional embodiment, as shown in Figure 15, the insulating medium 5 includes a first insulating strip 501 and a second insulating strip 502; wherein the first insulating strip 501 and the second insulating strip 502 are radially spaced apart along the catheter 1, and the first proximal overlapping section 801b is located between the first insulating strip 501 and the second insulating strip 502; or the first insulating strip 501 and the second insulating strip 502 are axially spaced apart along the catheter 1, and the first insulating strip 501 and the second insulating strip 502 are respectively provided with a channel passing through the axial direction of the catheter 1; the first proximal overlapping section 801b is provided in the channel between the first insulating strip 501 and the second insulating strip 502.

In another optional embodiment, a protrusion 3011a is provided on the first end 3011; a groove 3022a is provided at a corresponding position of the fourth end 3022; the area on the first end 3011 that contacts the insulating medium 5 is located outside the protrusion 3011a; the area on the fourth end 3022 that contacts the insulating medium 5 is located outside the groove 3022a; and the first proximal overlapping section 801b is located between the protrusion 3011a and the groove 3022a.

The distal electrode pair 3a and the proximal electrode pair 3b can be electrically connected to the pulse voltage generator 6 through an independent power supply circuit respectively;

Alternatively, the distal electrode pair 3a and the proximal electrode pair 3b may share a power supply circuit and be connected in series to the pulse voltage generator 6; that is, the second electrode 302 of the distal electrode pair 3a is electrically connected to the first electrode 301 of the proximal electrode pair 3b. When the pulse voltage generator 6 applies voltage between the first electrode 301 of the distal electrode pair 3a and the second electrode 302 of the proximal electrode pair 3b, the distal electrode pair 3a and the proximal electrode pair 3b are configured to respectively form discharge arcs in the liquid to allow current to pass through the first electrode 301 of the distal electrode pair 3a, the second electrode 302 of the distal electrode pair 3a, the first electrode 301 of the proximal electrode pair 3b and the second electrode 302 of the proximal electrode pair 3b in sequence.

As shown in FIG8 , the distal electrode pair 3a and the proximal electrode pair 3b are each powered by an independent power supply circuit. In the embodiment connected to the pulse voltage generator 6, the wire connected between the pulse voltage generator 6 and the distal electrode pair 3a also includes a second wire 802; the second wire 802 includes a second proximal overlapping segment, and the second proximal overlapping segment is located in the interval where the proximal electrode is located along the axial direction of the catheter 1; the first wire 801 is electrically connected between the pulse voltage generator 6 and the first electrode 301 of the distal electrode pair 3a; the second wire 802 is electrically connected between the pulse voltage generator 6 and the second electrode 302 of the distal electrode pair 3a, and one of the first electrode 301 and the second electrode 302 of the distal electrode pair 3a is electrically connected to the anode of the pulse voltage generator 6, and the other is electrically connected to the cathode of the pulse voltage generator 6.

Correspondingly, one of the first electrode 301 and the second electrode 302 of the proximal electrode pair 3b is electrically connected to the anode of the pulse voltage generator 6 through a wire, and the other is electrically connected to the cathode of the pulse voltage generator 6 through a wire.

In this embodiment, the first proximal overlapping segment 801b and the second proximal overlapping segment are arranged in the following manner:

Optionally, as shown in Fig. 9 and Fig. 10, the first proximal overlapping section 801b is arranged in the first gap 303 of the proximal electrode pair 3b; the second proximal overlapping section is arranged in the second gap 304 of the proximal electrode pair 3b. In this embodiment, the first end 3011 and the fourth end 3022 of the proximal electrode pair 3b are insulated and isolated through the first proximal overlapping section 801b, and the second end 3012 and the third end 3021 of the proximal electrode pair 3b are insulated and isolated through the second proximal overlapping section, and the reliability of the device is higher.

Optionally, the first proximal overlapping section 801b is fixedly connected to the first end 3011 of the proximal electrode pair 3b, the first proximal overlapping section 801b is fixedly connected to the fourth end 3022 of the proximal electrode pair 3b; the second proximal overlapping section is fixedly connected to the second end 3012 of the proximal electrode pair 3b, and the second proximal overlapping section is fixedly connected to the third end 3021 of the proximal electrode pair 3b. In this embodiment, the first electrode 301, the second electrode 302, the first proximal overlapping section 801b and the second proximal overlapping section of the proximal electrode pair 3b are fixedly connected together to form a ring structure that is sleeved on the catheter 1, so that the positions of the first electrode 301 and the second electrode 302 of the proximal electrode pair 3b on the catheter 1 are more firmly and stably maintained, and the first electrode 301 and the second electrode 302 of the proximal electrode pair 3b can be effectively prevented from falling off from the catheter 1.

Optionally, the first proximal overlapping section 801b and the second proximal overlapping section are both arranged in the first gap 303 of the proximal electrode pair 3b; or the first proximal overlapping section 801b and the second proximal overlapping section are both arranged in the second gap 304 of the proximal electrode pair 3b. In this embodiment, when the distance between the first end 3011 and the fourth end 3022 of the proximal electrode pair 3b is relatively small, and the distance between the second end 3012 and the third end 3021 of the proximal electrode pair 3b is relatively large, it is possible to firstly determine the space between the first gap 303 and the second gap 304 of the proximal electrode pair 3b:

In one case, the first gap 303 of the proximal electrode pair 3b is too small, resulting in the first proximal If the overlapping section 801b and the second proximal overlapping section cannot be inserted, the first proximal overlapping section 801b and the second proximal overlapping section can only be arranged in the second gap 304 of the proximal electrode pair 3b;

In another case, the size of the first gap 303 of the proximal electrode pair 3b can accommodate the first proximal overlapping segment 801b and the second proximal overlapping segment at the same time. It is also possible to choose to set the first proximal overlapping segment 801b and the second proximal overlapping segment in the first gap 303 of the proximal electrode pair 3b, so that the first end 3011 and the fourth end 3022 of the proximal electrode pair 3b are insulated and isolated by the first proximal overlapping segment 801b; and the distance between the second end 3012 and the third end 3021 of the proximal electrode pair 3b is relatively large, and the change in the insulation state between the second end 3012 and the third end 3021 of the proximal electrode pair 3b can be ignored.

In the above embodiment, optionally, the first wire 801 is electrically connected to the axial end of the first electrode 301 of the distal electrode pair 3a close to the pulse voltage generator 6; the second wire 802 is electrically connected to the axial end of the second electrode 302 of the distal electrode pair 3a close to the pulse voltage generator 6; therefore, the first wire 801 and the second wire 802 have no axial overlapping area with the distal electrode pair 3a, and the first wire 801 and the second wire 802 do not pass through the first gap 303 and the second gap 304 of the distal electrode pair 3a.

When the insulating medium 5 is not provided in the first gap 303 or the second gap 304 of the distal electrode pair 3a, considering the insulation reliability between the first electrode 301 and the second electrode 302 of the distal electrode pair 3a, optionally, the first wire 801 is electrically connected to the axial end of the first electrode 301 of the distal electrode pair 3a away from the pulse voltage generator 6, and/or the second wire 802 is electrically connected to the axial end of the second electrode 302 of the distal electrode pair 3a away from the pulse voltage generator 6.

Optionally, the first conductive wire 801 includes a first distal overlapping section 801a, and the first distal overlapping section 801a is located in the interval where the distal electrode pair 3a is located along the axial direction of the catheter 1; the second conductive wire 802 includes a second distal overlapping section, and the second distal overlapping section is located in the interval where the distal electrode pair 3a is located along the axial direction of the catheter 1;

In this embodiment, the first distal overlapping segment 801a and the second distal overlapping segment are arranged in the following manner:

Optionally, as shown in Fig. 11, the first distal overlapping section 801a is arranged in the first gap 303 of the distal electrode pair 3a; the second distal overlapping section is arranged in the second gap 304 of the distal electrode pair 3a. In this embodiment, the first end 3011 and the fourth end 3022 of the distal electrode pair 3a are insulated and isolated through the first distal overlapping section 801a, and the second end 3012 and the third end 3021 of the distal electrode pair 3a are insulated and isolated through the second distal overlapping section, and the reliability of the device is higher.

Optionally, the first distal overlapping section 801a and the second distal overlapping section are both disposed in the first gap 303 of the distal electrode pair 3a; or the first distal overlapping section 801a and the second distal overlapping section are both disposed in the second gap 304 of the distal electrode pair 3a. When the distance between the end 3011 and the fourth end 3022 is relatively small, and the distance between the second end 3012 and the third end 3021 of the distal electrode pair 3a is relatively large, the distance between the first gap 303 and the second gap 304 of the distal electrode pair 3a can be first determined based on the space between the first gap 303 and the second gap 304:

In one case, the first gap 303 of the distal electrode pair 3a is too small to fit the first distal overlapping section 801a and the second distal overlapping section. Then, the first distal overlapping section 801a and the second distal overlapping section can only be disposed in the second gap 304 of the distal electrode pair 3a.

In another case, the size of the first gap 303 of the distal electrode pair 3a can accommodate the first distal overlapping segment 801a and the second distal overlapping segment at the same time. In this case, the first distal overlapping segment 801a and the second distal overlapping segment can be arranged in the first gap 303 of the distal electrode pair 3a, so that the first end 3011 and the fourth end 3022 of the distal electrode pair 3a are insulated and isolated by the first distal overlapping segment 801a; and the distance between the second end 3012 and the third end 3021 of the distal electrode pair 3a is relatively large, and the change in the insulation state between the second end 3012 and the third end 3021 of the distal electrode pair 3a can be ignored.

In the embodiment where the distal electrode pair 3a and the proximal electrode pair 3b are connected in series to the pulse voltage generator 6, the wire connected between the pulse voltage generator 6 and the proximal electrode pair 3b includes a third wire 803; the second electrode 302 of the proximal electrode pair 3b is electrically connected to the pulse voltage generator 6 via the third wire 803; the first electrode 301 of the proximal electrode pair 3b is electrically connected to the second electrode 302 of the distal electrode pair 3a via a fourth wire 804; the first electrode 301 of the distal electrode pair 3a is electrically connected to the pulse voltage generator 6 via the first wire 801. When one pole of the pulse voltage generator 6 applies a pulse voltage to the second electrode 302 of the proximal electrode pair 3b through the third wire 803, a discharge arc is generated between the second electrode 302 of the proximal electrode pair 3b and the first electrode 301, so that current flows through the proximal electrode pair 3b; the first electrode 301 of the proximal electrode pair 3b is electrically connected to the second electrode 302 of the distal electrode pair 3a through the fourth wire 804; a discharge arc is generated between the second electrode 302 of the distal electrode pair 3a and the first electrode 301, so that current flows through the distal electrode pair 3a; the first electrode 301 of the distal electrode pair 3a is electrically connected to the other pole of the pulse voltage generator 6 through the first wire 801.

In an optional embodiment, as shown in FIG12, the first proximal overlapping section 801b is arranged in the first gap 303 or the second gap 304 of the proximal electrode pair 3b; the first wire 801 is electrically connected to the axial end of the first electrode 301 of the distal electrode pair 3a close to the pulse voltage generator 6; the third wire 803 is electrically connected to the axial end of the second electrode 302 of the proximal electrode pair 3b close to the pulse voltage generator 6; one end of the fourth wire 804 is electrically connected to the axial end of the first electrode 301 of the proximal electrode pair 3b away from the pulse voltage generator 6, and the other end of the fourth wire 804 is electrically connected to the axial end of the distal electrode pair 3a. The second electrode 302 is close to the axial end of the pulse voltage generator 6. Therefore, the first wire 801 and the fourth wire 804 have no axial overlap with the distal electrode pair 3a, and the first wire 801 and the fourth wire 804 do not pass through the first gap 303 and the second gap 304 of the distal electrode pair 3a, and the third wire 803 and the fourth wire 804 have no axial overlap with the proximal electrode pair 3b, and the third wire 803 and the fourth wire 804 do not pass through the first gap 303 and the second gap 304 of the proximal electrode pair 3b.

When the insulating medium 5 is not provided in the first gap 303 and the second gap 304 of the proximal electrode pair 3b, considering the insulation reliability between the first electrode 301 and the second electrode 302 of the proximal electrode pair 3b, when the first gap 303 and the second gap 304 of the proximal electrode pair 3b need to be isolated by wire insulation, optionally:

The third wire 803 is electrically connected to the axial end of the second electrode 302 of the proximal electrode pair 3b away from the pulse voltage generator 6, and the third wire 803 includes a third proximal overlapping section, and the third proximal overlapping section is located in the section where the proximal electrode is located along the axial direction of the catheter 1; the first proximal overlapping section 801b is arranged in the first gap 303 of the proximal electrode pair 3b; the third proximal overlapping section is arranged in the second gap 304 of the proximal electrode pair 3b;

or,

As shown in FIG. 13 , the fourth wire 804 is electrically connected to the axial end of the first electrode 301 of the proximal electrode pair 3b close to the pulse voltage generator 6, and the fourth wire 804 includes a fourth proximal overlapping section 804b, and the fourth proximal overlapping section 804b is located in the section where the proximal electrode is located along the axial direction of the catheter 1;

The first proximal overlapping section 801b is disposed in the first gap 303 of the proximal electrode pair 3b; and the fourth proximal overlapping section 804b is disposed in the second gap 304 of the proximal electrode pair 3b.

When the insulating medium 5 is not provided in the first gap 303 or the second gap 304 of the distal electrode pair 3a, considering the insulation reliability between the first electrode 301 and the second electrode 302 of the distal electrode pair 3a, optionally, the first wire 801 is electrically connected to the axial end of the first electrode 301 of the distal electrode pair 3a away from the pulse voltage generator 6, and/or the fourth wire 804 is electrically connected to the axial end of the second electrode 302 of the distal electrode pair 3a away from the pulse voltage generator 6.

Optionally, as shown in FIG13 , the first conductive wire 801 includes a first distal overlapping segment 801a, and the first distal overlapping segment 801a is located in the interval where the distal electrode pair 3a is located along the axial direction of the catheter 1; the fourth conductive wire 804 includes a fourth distal overlapping segment 804a, and the fourth distal overlapping segment 804a is located in the interval where the distal electrode pair 3a is located along the axial direction of the catheter 1;

In this embodiment, the first distal overlapping segment 801a and the fourth distal overlapping segment 804a are arranged in the following manner:

Optionally, the first distal overlapping section 801a is disposed in the first gap 303 of the distal electrode pair 3a; and the fourth distal overlapping section 804a is disposed in the second gap 304 of the distal electrode pair 3a. In this embodiment, the first end 3011 and the fourth end 3022 of the distal electrode pair 3a are insulated and isolated through the first distal overlapping section 801a, and the second end 3012 and the third end 3021 of the distal electrode pair 3a are insulated and isolated through the fourth distal overlapping section 804a, and the reliability of the device is higher.

Optionally, the first distal overlapping section 801a and the fourth distal overlapping section 804a are both disposed in the first gap 303 of the distal electrode pair 3a; or the first distal overlapping section 801a and the fourth distal overlapping section 804a are both disposed in the second gap 304 of the distal electrode pair 3a. In this embodiment, when the distance between the first end 3011 and the fourth end 3022 of the distal electrode pair 3a is relatively small, and the distance between the second end 3012 and the third end 3021 of the distal electrode pair 3a is relatively large, the first distance between the first gap 303 and the second gap 304 of the distal electrode pair 3a can be:

In one case, the first gap 303 of the distal electrode pair 3a is too small, so that the first distal overlapping section 801a and the fourth distal overlapping section 804a cannot be placed therein, and the first distal overlapping section 801a and the fourth distal overlapping section 804a can only be arranged in the second gap 304 of the distal electrode pair 3a;

In another case, the size of the first gap 303 of the distal electrode pair 3a can accommodate the first distal overlapping segment 801a and the fourth distal overlapping segment 804a at the same time. It is also possible to choose to set the first distal overlapping segment 801a and the fourth distal overlapping segment 804a in the first gap 303 of the distal electrode pair 3a, so that the first end 3011 and the fourth end 3022 of the distal electrode pair 3a are insulated and isolated by the first distal overlapping segment 801a; and the distance between the second end 3012 and the third end 3021 of the distal electrode pair 3a is relatively large, and the change in the insulation state between the second end 3012 and the third end 3021 of the distal electrode pair 3a can be ignored.

The embodiment of the present application also provides another shock wave balloon catheter device, comprising

Catheter 1;

A balloon 2 is sealed around the outer circumference of the catheter 1;

A distal electrode pair 3a and a proximal electrode pair 3b are arranged in the balloon 2; the proximal electrode pair 3b is located between the pulse voltage generator 6 and the distal electrode pair 3a; the proximal electrode pair 3b includes a first electrode 301 and a second electrode 302;

The wire has an outer insulating layer; the distal electrode pair 3a and the proximal electrode pair 3b are respectively electrically connected to a pulse voltage generator 6 through the wire; the pulse voltage generator 6 is used to provide a pulse voltage for the distal electrode pair 3a and the proximal electrode;

The first electrode 301 and the second electrode 302 are arranged at intervals along the circumference of the catheter 1; the first electrode 301 The conduit 1 comprises a first end 3011 located at one circumferential end of the conduit 1, and a second end 3012 located at the other circumferential end of the conduit 1; the second electrode 302 comprises a third end 3021 located at one circumferential end of the conduit 1, and a fourth end 3022 located at the other circumferential end of the conduit 1; the first end 3011 and the fourth end 3022 are adjacent to each other and define a first gap 303; the second end 3012 and the third end 3021 are adjacent to each other and define a second gap 304; when the pulse voltage generator 6 applies a pulse voltage between the first electrode 301 and the second electrode 302, the first electrode 301 and the second electrode 302 are configured to form a discharge shock wave in at least one of the first gap 303 and the second gap 304;

The conductor includes a first conductor connected between the pulse voltage generator 6 and the distal electrode pair 3a; the first conductor includes a first proximal overlapping segment; the first proximal overlapping segment is located in the interval where the proximal electrode is located along the axial direction of the catheter 1; the first proximal overlapping segment is arranged in the first gap 303 or the second gap 304 of the proximal electrode pair 3b.

This embodiment does not impose any limitation on the structure of the distal electrode pair 3a.

It should be noted that, in the description of this specification, the terms "first", "second", etc. are only used for descriptive purposes and to distinguish similar objects. There is no order of precedence between the two, and they cannot be understood as indicating or implying relative importance. In addition, in the description of this specification, unless otherwise specified, the meaning of "plurality" is two or more.

The above embodiments are only for illustrating the technical concept and features of the present application, and their purpose is to enable people familiar with the technology to understand the content of the present application and implement it accordingly, and they cannot be used to limit the protection scope of the present application. Any equivalent changes or modifications made according to the spirit of the present application should be included in the protection scope of the present application.

It should be understood that the above description is for illustration and not for limitation. By reading the above description, many embodiments and many applications beyond the provided examples will be apparent to those skilled in the art. For comprehensive purposes, all articles and references, including the disclosures of patent applications and announcements, are incorporated herein by reference.

Claims

A shock wave balloon catheter device comprises a catheter, a balloon sealed around the outer circumference of the catheter, and at least one electrode pair arranged in the balloon; each of the electrode pairs comprises a first electrode and a second electrode, characterized in that: the first electrode and the second electrode are arranged at intervals along the circumference of the catheter; the first electrode comprises a first end located at one circumferential end of the catheter, and a second end located at the other circumferential end of the catheter; the second electrode comprises a third end located at one circumferential end of the catheter, and a fourth end located at the other circumferential end of the catheter; the first end is adjacent to the fourth end and has a first gap; the second end is adjacent to the third end and has a second gap;

The device also includes a positioning sheath of insulating material wrapped around the periphery of the electrode;

The positioning sheath exposes part of the outer peripheral wall or the axial end surface of the first end portion so as to contact the liquid in the balloon; and the positioning sheath exposes part of the outer peripheral wall or the axial end surface of the fourth end portion so as to contact the liquid in the balloon; when a voltage is applied between the first electrode and the second electrode, the exposed part of the first end portion and the exposed part of the fourth end portion can generate a discharge arc in the liquid;

and / or,

The positioning sheath exposes part of the outer wall or the axial end surface of the second end portion so as to contact the liquid in the balloon; and the positioning sheath exposes part of the outer wall or the axial end surface of the third end portion so as to contact the liquid in the balloon; when a voltage is applied between the first electrode and the second electrode, the exposed part of the second end portion and the exposed part of the third end portion can generate a discharge arc in the liquid.
The device according to claim 1, characterized in that: the positioning sleeve is provided with a first discharge hole, a second discharge hole, a third discharge hole, and a fourth discharge hole;

The first discharge hole exposes a portion of the outer peripheral wall of the first end to form a first discharge area; the fourth discharge hole exposes a portion of the outer peripheral wall of the fourth end to form a fourth discharge area; when a voltage is applied between the first electrode and the second electrode, the first discharge area and the fourth discharge area are configured to form a discharge arc;

The second discharge hole exposes part of the outer peripheral wall of the second end to form a second discharge area; the third discharge hole exposes part of the outer peripheral wall of the third end to form a third discharge area; when a voltage is applied between the first electrode and the second electrode, the second discharge area and the third discharge area are configured to form a discharge arc.
The device according to claim 2 is characterized in that: the first discharge area and the fourth discharge area are arranged alternately along the axial direction; the second discharge area and the third discharge area are arranged alternately along the axial direction.
The device according to claim 2, characterized in that the axial end surface of the positioning sleeve is adjacent to the first electrode The axial end surface of the positioning sleeve is substantially flush with the axial end surface of the second electrode;

The first discharge region is connected to the axial end surface of the first electrode; the fourth discharge region is connected to the axial end surface of the second electrode; the second discharge region is connected to the axial end surface of the first electrode; the third discharge region is connected to the axial end surface of the second electrode;

The axial end surface of the first electrode and the axial end surface of the second electrode are respectively covered with an insulating layer.
The device as claimed in claim 2, characterized in that: the first discharge hole is connected to the second discharge hole; the third discharge hole is connected to the fourth discharge hole.
The device according to claim 1, characterized in that: the axial end surface of the positioning sleeve is substantially flush with the axial end surface of the first electrode; the axial end surface of the positioning sleeve is substantially flush with the axial end surface of the second electrode;

The axial end surface of the first end is exposed and can contact the liquid in the balloon; the axial end surface of the fourth end is exposed and can contact the liquid in the balloon; the axial end surface of the second end is exposed and can contact the liquid in the balloon; the axial end surface of the third end is exposed and can contact the liquid in the balloon.
The device as claimed in claim 1 is characterized in that the outer diameter of the cross-sectional outer contour at the location of the electrode pair is less than 1.2 mm.
The device according to claim 1 is characterized in that: an insulating medium is arranged in the interval between the first end and the fourth end; and an insulating medium is arranged in the interval between the second end and the third end.
The device according to claim 1, characterized in that: the electrode pair comprises a distal electrode pair and a proximal electrode pair; the proximal electrode pair is located between a pulse voltage generator and the distal electrode pair; the pulse voltage generator is used to provide a pulse voltage to the electrode pair;

The guide wire includes a first guide wire connected between the pulse voltage generator and the distal electrode pair; the first guide wire includes a first proximal overlapping segment; the first proximal overlapping segment is located in the interval where the proximal electrode is located along the axial direction of the catheter; the first proximal overlapping segment is arranged in the first gap or the second gap of the proximal electrode pair.
The device as described in claim 9 is characterized in that: the distal electrode pair and the proximal electrode pair are electrically connected to the pulse voltage generator through an independent power supply circuit respectively; or, the distal electrode pair and the proximal electrode pair are connected in series to the pulse voltage generator through a power supply circuit.