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WO2023128884A1 - Thermoreversible gel formulation with herbal active materials in order to calm and accelarate the healing of burnt skin - Google Patents

Thermoreversible gel formulation with herbal active materials in order to calm and accelarate the healing of burnt skin Download PDF

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Publication number
WO2023128884A1
WO2023128884A1 PCT/TR2021/051539 TR2021051539W WO2023128884A1 WO 2023128884 A1 WO2023128884 A1 WO 2023128884A1 TR 2021051539 W TR2021051539 W TR 2021051539W WO 2023128884 A1 WO2023128884 A1 WO 2023128884A1
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Prior art keywords
gel formulation
healing
calm
skin
extract
Prior art date
Application number
PCT/TR2021/051539
Other languages
French (fr)
Inventor
Abdullah Levent ALPARSLAN
Original Assignee
İsti̇nye Üni̇versi̇tesi̇
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Filing date
Publication date
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Priority to PCT/TR2021/051539 priority Critical patent/WO2023128884A1/en
Publication of WO2023128884A1 publication Critical patent/WO2023128884A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on

Definitions

  • Thermoreversible gel formulation with herbal active materials in order to calm and accelarate the healing of burnt skin
  • the present invention relates to thermoreversible gel formulation with herbal active materials to calm and accelerate the healing of burnt skin and production method.
  • Burns are graded according to the severity of the traumas in the relevant technical field.
  • first-degree burn said burn is soothed by applying a product to the skin according to the aforementioned grading.
  • it is difficult to apply the same by contact since the skin sensitivity increases in second and third degree burns.
  • Moisturizing creams, ointments and gels are applied for sunburns and first degree burns.
  • Anesthetic agents, silver-containing creams, antimicrobial ointments and antiseptic effective solutions are used in second-degree burns and traumas. Applications are made to calm the region since the upper layer of the skin is burned. The burn area is deep and wide in griping and severely traumatized third-degree burns. Tissue loss is high and the risk of infection is high. The wounds of these patients are dressed under anesthesia. Debridement treatments are applied in order to accelerate tissue healing. Antiseptic solutions, dressings and antimicrobial ointments are applied. Necrotic tissues are cleaned and blood circulation of the tissues is supported. In particular, burns and dryness of the skin are experienced in cancer patients who have undergone radiation therapy. This region requires moistening and calming.
  • TR2017/22907 application numbered patent application In the treatment of wounds caused by the burn, in the elimination of previously burned scars, and also to help remove calluses found in the body, a drug that acts as an antibiotic, contains the extract of the mentha piperita (mint) plant with antiseptic properties, arnebia Vietnameseroma plant extract, turpentine oil, egg yolk, castor oil and wax.
  • mint mentha piperita
  • TR2021/009075 relates to an ointment developed to provide treatment for two, three and four degree burns and to speed up the healing process.
  • the ointment in question contains fish oil and Vaseline.
  • TR2019/03364 application numbered patent application for use against heat, electricity, chemicals and/or flame-induced skin destruction, it relates to a topically viable pharmaceutical composition containing olive oil (olea europa fruit oil and /or olive oil), egg oil (ovum oil), wheat oil (triticium vulgrai oil), retinyl palmitate (vitamin A), alpha tocoferol (vitamin E).
  • olive oil olea europa fruit oil and /or olive oil
  • egg oil ovum oil
  • wheat oil triticium vulgrai oil
  • vitamin A retinyl palmitate
  • vitamin E alpha tocoferol
  • a product that consists of natural ingredients, used to have smooth skin that eliminates all kinds of burns on the skin and completely eliminates the pain and aesthetic problems caused by the burn is disclosed in the patent application with application number TR 2017/00569.
  • the Chinese patent application with publication number CN103610869 A relates to a burn cream containing safflower, sanguisorba officinalis, cacumen biotae, pseudoginseng, resina draconis and chrysanthemum indicum.
  • the current invention relates to the herbal and thermoreversible gel formulation (thermojel) and the production method of the gel formulation in question, which meets the aforementioned requirements, eliminates all disadvantages and brings some additional advantages, allows the burned skin to calm down and accelerates its healing.
  • the invention is inspired by current situations and aims to solve the above-mentioned negativity.
  • the main aim of the invention is; to obtain a gel formulation that provides innovation to the technical field with the application of both herbal and thermoreversible gels.
  • herbal extracts that provide calming and accelerate healing in accordance with the sensitivity of the burn area are used.
  • one of the important characterizing aspects of the invention is sprayable liquid gels, gelling with body temperature without any additional contact and application to the burnt area. Sprayed and squeezed, the final product acts as a support for moisturizing, soothing and healing of the skin by clinging to living surfaces by gelling with body temperature.
  • the invention concerns the herbal and thermoreversible gel formulation (thermojel) that calms the burnt skin and accelerates its healing, and the production method of the gel formulation in question.
  • the gel formulation in question basically, contains herbal content, polymer and excipients.
  • the components contained in the gel formulation in question and the preferred and available percentage usage rates of these components are given in the table below.
  • St. John's Wort extract is obtained from the whole or cut, dried flowering tops of Hypericum perforatum L. harvested during the flowering period.
  • St. John's Wort known botanically as Hypericum perforatum, is a spreading, leafy herb that grows in open, disturbed areas in most of the world's temperate regions. The use of this species as a herbal medicine to treat various internal and external ailments dates back to the time of the ancient Greeks.
  • H. perforatum consists of freely branching bush plants, typically 40 to 80 cm in height. Stems and branches are intensively covered with rectangular, smooth-edged leaves 1 to 3 cm long and 0.3 to 1.0 cm wide. It contains hypericin and hyperforin. It is used externally in the healing of wounds and burns. They cause changes in dopamine and serotonin levels in the body when taken internally.
  • Olive leaf extract is obtained from Olea europaea, a plant belonging to the Oleaceae family.
  • the olive tree is an evergreen tree that grows to a height of about 6 - 9 meters. It is endemic to the entire Mediterranean region, up to Southern European countries and Iran and beyond the Caucasus. Leaves are 7.5 cm long, opposite narrow, in the form of lance or linear, entire margins are pointed, silvery-green (graygreen) above, lighter underside, has fine white, flake-like hairs. Leaves can be collected throughout the year.
  • the main components of olive leaves are oleuropein, ligstroside, I methyloleuropein and oleoside, and flavonoids (apigenin, kaempferol, luteolin, chrysoeriol) and phenolic compounds (caffeic acid, tyrosol, hydroxytrozole). In addition to antioxidant activity, it shows antiviral effect. It increases blood circulation.
  • Thymus vulgaris that belongs to the Lamiaceae family. It is native to the Mediterranean. It grows up to 15 - 30 cm high and 40 cm wide. It is a bushy, evergreen shrub-type plant with purple or pink flowers and highly aromatic gray-green leaves. While it contains high levels of thymol, p-cymene and y-terpinene, it also contains carvacrol, borneol, 1 ,8-cineole, q- cimene, linalool, a-pinene, camphor and myrcene. It has a protective and germicidal effect against bacteria and fungi.
  • the polymer is soluble in deionized water at +4 t C.
  • the temperature of the water can be brought to +4 ‘C by cooling the water that is making the speed in the boiler walls industrially.
  • the alternative way is to heat it.
  • working in the cold positively affects stability, as the substances that will provide treatment support to the content will be disturbed by temperature.
  • Another way is to break down the polymers with the help of powerful homogenizers. In the process, pilot trials continue through which method is more suitable for industrial production. After the polymers are dissolved, the cooling process of the boiler is terminated and other formulation contents are mixed by incorporating them into the system. After filling, packaging is made.
  • aerosols are to be made, aluminum containers and bagged valve systems are filled under pressure and ventiles are installed. After the preparation of the gel formulation, optimization and characterization are performed with quality control parameters. In the next step, packaging selection is made for effective spraying. Shelf life calculation is carried out with stability.
  • the inventive gel formulation in question is prepared as a solution and filled into spray bottles with trigger head, where spraying will be effective.
  • the gel formulation in question When the gel formulation in question is pulverized, it should be a head that easily sprays its viscosity, which has not yet increased.
  • the large pulvarization during spraying is important for its easy spread to the pulverized surface.
  • the diameter of the spray's elevation pipe is slightly wider than normal spray pipes, allowing for a higher amount of product. Since there is no propellant, it is valuable for the monitoring and standardization of applications that the spray head of the ventil system is sprayed with a gun type when the liquid is fluid and does a single dosing and pulvarizes the same amount each time.
  • the inventive gel formulation can also be applied as a propellant aerosol.
  • the gas that does not come into contact with the product is filled into the container for pushing purposes only in the bag system called bag in valve.
  • An effective spray is ensured as long as the aerosol activator is pressed.
  • the trigger system is more convenient for laboratory studies and small quantities.
  • the inventive gel formulation is suitable for industry with its use as a product in places where medical devices and medicines are produced. Mass production is possible. It must be sterile as it will be applied to burnt and injured tissue surfaces. Gamma sterilization can be applied if there is no sterilization at the production site.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to the herbal and thermoreversible gel formulation (thermojel) that calms the burnt skin and accelerates its healing, and the method of production of the gel formulation in question.

Description

Thermoreversible gel formulation with herbal active materials in order to calm and accelarate the healing of burnt skin
Field of the Invention
The present invention relates to thermoreversible gel formulation with herbal active materials to calm and accelerate the healing of burnt skin and production method.
State of the Art
Burns are graded according to the severity of the traumas in the relevant technical field. In the case of sunburn known as first-degree burn, said burn is soothed by applying a product to the skin according to the aforementioned grading. However, it is difficult to apply the same by contact since the skin sensitivity increases in second and third degree burns. In case of application by contact, it is painful to patient and the comfort in applications is low. Moisturizing creams, ointments and gels are applied for sunburns and first degree burns.
Anesthetic agents, silver-containing creams, antimicrobial ointments and antiseptic effective solutions are used in second-degree burns and traumas. Applications are made to calm the region since the upper layer of the skin is burned. The burn area is deep and wide in griping and severely traumatized third-degree burns. Tissue loss is high and the risk of infection is high. The wounds of these patients are dressed under anesthesia. Debridement treatments are applied in order to accelerate tissue healing. Antiseptic solutions, dressings and antimicrobial ointments are applied. Necrotic tissues are cleaned and blood circulation of the tissues is supported. In particular, burns and dryness of the skin are experienced in cancer patients who have undergone radiation therapy. This region requires moistening and calming. In more serious cases, applications are required to accelerate tissue healing, prevent infection, and provide moisturizing in the skin integrity lost by applying anesthesia. In this case, pain may continue even under anesthesia. In brief, the most important technical problem encountered frequently in the technical field is sensitivity in the inflammatory region in burn applications. Applications made by contacting obstruct patient compliance. According to the burn severity, it may be necessary to use consecutive products such as moisturizer, soothing and anti-infection products. In this case; there is a case of exposure to more than one drug. Wound healing process and scarring is also an important problem. The healing process and performance vary according to the condition of trauma and the condition of the case, the skill of the medical personnel who will evaluate the burn treatment and the medical supplies available. Patients who are treated with rays and have burns on their skin try to remove dermatitis and redness on the skin by using expensive products.
In this technical field, numerous alternative methods and studies have been tried as a solution to burn and wound applications. The documents identified in the patent and literature research on the known status of the technique are summarized below.
TR2017/22907 application numbered patent application, In the treatment of wounds caused by the burn, in the elimination of previously burned scars, and also to help remove calluses found in the body, a drug that acts as an antibiotic, contains the extract of the mentha piperita (mint) plant with antiseptic properties, arnebia euchroma plant extract, turpentine oil, egg yolk, castor oil and wax.
The patent application numbered TR2021/009075 relates to an ointment developed to provide treatment for two, three and four degree burns and to speed up the healing process. In the application, it is stated that the ointment in question contains fish oil and Vaseline.
TR2019/03364 application numbered patent application, for use against heat, electricity, chemicals and/or flame-induced skin destruction, it relates to a topically viable pharmaceutical composition containing olive oil (olea europa fruit oil and /or olive oil), egg oil (ovum oil), wheat oil (triticium vulgrai oil), retinyl palmitate (vitamin A), alpha tocoferol (vitamin E).
A product that consists of natural ingredients, used to have smooth skin that eliminates all kinds of burns on the skin and completely eliminates the pain and aesthetic problems caused by the burn is disclosed in the patent application with application number TR 2017/00569.
Publication CN101856366 A Chinese patent application describes a burn cream containing 500 -1000 g of albolen, 20 - 30 g of borax, 1 - 4 g of borneol and 1 - 4 g of phenol according to its weight ratio. The document states that the aforementioned burn cream, compared to the previous technique, has the effects of relieving pain, promoting tissue, reducing inflammation and performing antibiotics, reducing scar hyperplasia and preventing the wound surface from becoming infected.
The Chinese patent application with publication number CN103610869 A relates to a burn cream containing safflower, sanguisorba officinalis, cacumen biotae, pseudoginseng, resina draconis and chrysanthemum indicum.
As a result due to the abovementioned disadvantages and the insufficiency of the current solutions regarding the subject matter, a development is required to be made in the relevant technical field.
Brief Description of the Invention
The current invention relates to the herbal and thermoreversible gel formulation (thermojel) and the production method of the gel formulation in question, which meets the aforementioned requirements, eliminates all disadvantages and brings some additional advantages, allows the burned skin to calm down and accelerates its healing.
The invention is inspired by current situations and aims to solve the above-mentioned negativity.
The main aim of the invention is; to obtain a gel formulation that provides innovation to the technical field with the application of both herbal and thermoreversible gels. In the invention, herbal extracts that provide calming and accelerate healing in accordance with the sensitivity of the burn area are used. At the same time, one of the important characterizing aspects of the invention is sprayable liquid gels, gelling with body temperature without any additional contact and application to the burnt area. Sprayed and squeezed, the final product acts as a support for moisturizing, soothing and healing of the skin by clinging to living surfaces by gelling with body temperature.
The structural and characteristic features of the present invention will be understood clearly by the following detailed description and therefore the evaluation shall be made by taking the detailed description into consideration.
Detailed Description of the Invention
In this detailed description, the preferred embodiments of the inventive gel formulation are described by means of examples only for clarifying the subject matter.
The invention concerns the herbal and thermoreversible gel formulation (thermojel) that calms the burnt skin and accelerates its healing, and the production method of the gel formulation in question. The gel formulation in question, basically, contains herbal content, polymer and excipients. The components contained in the gel formulation in question and the preferred and available percentage usage rates of these components are given in the table below.
Figure imgf000005_0001
St. John's Wort extract is obtained from the whole or cut, dried flowering tops of Hypericum perforatum L. harvested during the flowering period. St. John's Wort (SJW), known botanically as Hypericum perforatum, is a spreading, leafy herb that grows in open, disturbed areas in most of the world's temperate regions. The use of this species as a herbal medicine to treat various internal and external ailments dates back to the time of the ancient Greeks. H. perforatum consists of freely branching bush plants, typically 40 to 80 cm in height. Stems and branches are intensively covered with rectangular, smooth-edged leaves 1 to 3 cm long and 0.3 to 1.0 cm wide. It contains hypericin and hyperforin. It is used externally in the healing of wounds and burns. They cause changes in dopamine and serotonin levels in the body when taken internally.
Olive leaf extract is obtained from Olea europaea, a plant belonging to the Oleaceae family. The olive tree is an evergreen tree that grows to a height of about 6 - 9 meters. It is endemic to the entire Mediterranean region, up to Southern European countries and Iran and beyond the Caucasus. Leaves are 7.5 cm long, opposite narrow, in the form of lance or linear, entire margins are pointed, silvery-green (graygreen) above, lighter underside, has fine white, flake-like hairs. Leaves can be collected throughout the year. The main components of olive leaves are oleuropein, ligstroside, I methyloleuropein and oleoside, and flavonoids (apigenin, kaempferol, luteolin, chrysoeriol) and phenolic compounds (caffeic acid, tyrosol, hydroxytrozole). In addition to antioxidant activity, it shows antiviral effect. It increases blood circulation.
There are 35 types of thyme in our country. The species we will use is Thymus vulgaris that belongs to the Lamiaceae family. It is native to the Mediterranean. It grows up to 15 - 30 cm high and 40 cm wide. It is a bushy, evergreen shrub-type plant with purple or pink flowers and highly aromatic gray-green leaves. While it contains high levels of thymol, p-cymene and y-terpinene, it also contains carvacrol, borneol, 1 ,8-cineole, q- cimene, linalool, a-pinene, camphor and myrcene. It has a protective and germicidal effect against bacteria and fungi.
In the production method of the gel formulation in question, the polymer is soluble in deionized water at +4 tC. The temperature of the water can be brought to +4 ‘C by cooling the water that is making the speed in the boiler walls industrially. The alternative way is to heat it. However, working in the cold positively affects stability, as the substances that will provide treatment support to the content will be disturbed by temperature. Another way is to break down the polymers with the help of powerful homogenizers. In the process, pilot trials continue through which method is more suitable for industrial production. After the polymers are dissolved, the cooling process of the boiler is terminated and other formulation contents are mixed by incorporating them into the system. After filling, packaging is made. If aerosols are to be made, aluminum containers and bagged valve systems are filled under pressure and ventiles are installed. After the preparation of the gel formulation, optimization and characterization are performed with quality control parameters. In the next step, packaging selection is made for effective spraying. Shelf life calculation is carried out with stability.
The inventive gel formulation in question is prepared as a solution and filled into spray bottles with trigger head, where spraying will be effective. When the gel formulation in question is pulverized, it should be a head that easily sprays its viscosity, which has not yet increased. The large pulvarization during spraying is important for its easy spread to the pulverized surface. The diameter of the spray's elevation pipe is slightly wider than normal spray pipes, allowing for a higher amount of product. Since there is no propellant, it is valuable for the monitoring and standardization of applications that the spray head of the ventil system is sprayed with a gun type when the liquid is fluid and does a single dosing and pulvarizes the same amount each time.
The inventive gel formulation can also be applied as a propellant aerosol. The gas that does not come into contact with the product is filled into the container for pushing purposes only in the bag system called bag in valve. An effective spray is ensured as long as the aerosol activator is pressed. The trigger system is more convenient for laboratory studies and small quantities.
The inventive gel formulation is suitable for industry with its use as a product in places where medical devices and medicines are produced. Mass production is possible. It must be sterile as it will be applied to burnt and injured tissue surfaces. Gamma sterilization can be applied if there is no sterilization at the production site.

Claims

CLAIMS 1. A herbal and thermoreversible gel formulation that allows the burnt skin to calm and accelerate its healing to be applied by spraying, characterized by comprising; St. John's Wort extract, olive leaf extract, thyme extract, polymer and excipient. 2. The gel formulation according to claim 1 , characterized by comprising; St. John's Wort extract, olive leaf extract, thyme extract, Poloxamer 407, Polyethylene glycol 1500, pH regulator, preservative and deionized water. 3. The gel formulation according to claim 2, characterized by comprising; St. John's Wort extract in the range of 0.1 - 5% by weight, Olive leaf extract in the range of 0.1 - 5%, thyme extract in the range of 0.1 - 5%, Poloxamer 407 in the range of 0.1 - 20%, Polyethylene glycol 1500, pH regulator in the range of 0.1 -
5%, preservative in the range of 0.01 - 1% and deionized water in the range of 49 - 99.39%.
PCT/TR2021/051539 2021-12-28 2021-12-28 Thermoreversible gel formulation with herbal active materials in order to calm and accelarate the healing of burnt skin WO2023128884A1 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117959479A (en) * 2024-02-01 2024-05-03 中国中医科学院中医基础理论研究所 Preparation method of three-dimensional traditional Chinese medicine dressing for treating pressure sores and three-dimensional traditional Chinese medicine dressing prepared by preparation method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP19981089B (en) * 1996-05-10 1998-06-09 Nino Shikhashvili Green Ointment
EP2829276A1 (en) * 2012-03-22 2015-01-28 Garcia Gilabert, Juan Miguel Composition for preventing and/or treating dermatosis and method for obtaining same
CN108355130A (en) * 2018-05-22 2018-08-03 界首市菁华科技信息咨询服务有限公司 It is a kind of to treat psoriasic temperature sensitive type collagen composite antiphlogistic gel spray and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP19981089B (en) * 1996-05-10 1998-06-09 Nino Shikhashvili Green Ointment
EP2829276A1 (en) * 2012-03-22 2015-01-28 Garcia Gilabert, Juan Miguel Composition for preventing and/or treating dermatosis and method for obtaining same
CN108355130A (en) * 2018-05-22 2018-08-03 界首市菁华科技信息咨询服务有限公司 It is a kind of to treat psoriasic temperature sensitive type collagen composite antiphlogistic gel spray and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117959479A (en) * 2024-02-01 2024-05-03 中国中医科学院中医基础理论研究所 Preparation method of three-dimensional traditional Chinese medicine dressing for treating pressure sores and three-dimensional traditional Chinese medicine dressing prepared by preparation method

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