CN108355130A - It is a kind of to treat psoriasic temperature sensitive type collagen composite antiphlogistic gel spray and preparation method thereof - Google Patents
It is a kind of to treat psoriasic temperature sensitive type collagen composite antiphlogistic gel spray and preparation method thereof Download PDFInfo
- Publication number
- CN108355130A CN108355130A CN201810496842.9A CN201810496842A CN108355130A CN 108355130 A CN108355130 A CN 108355130A CN 201810496842 A CN201810496842 A CN 201810496842A CN 108355130 A CN108355130 A CN 108355130A
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- Prior art keywords
- temperature sensitive
- collagen
- sensitive type
- psoriasic
- antiphlogistic
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Classifications
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Abstract
Psoriasic temperature sensitive type collagen composite antiphlogistic gel spray is treated the invention discloses a kind of, by weight, including following raw material：Temperature sensitive type collagen base composite antibiotic antiphlogistic gel 45~65, haemostatic medicament 15~20, dandelion 12~18, Fructus Forsythiae 3~5, Radix Salviae Miltiorrhizae 2~4, Rhizoma Chuanxiong 1~3, lopseed 4~8, glycerine 8~12, Rosemary Oil 2~3, lauric monoglyceride 1.5~3.5, water 10~20.There is the achievement in research that skin lacks collagen according to psoriatic more in the present invention, antibacterial anti-inflammatory ingredient is added on the basis of original effect of temperature sensitive type collagen-based compound hemostatic gel, by the method for taking collagen direct subsidy to combine with bactericidal antiphlogistic tonic again that develops simultaneously to psoriasis disease sites, realize to psoriasic treating both manifestation and root cause of disease.Product of the present invention uses spray mode, easy to use, has extraordinary application prospect.
Description
Technical field
The present invention relates to preventing and treating skin diseases field, relate in particular to a kind for the treatment of psoriasic temperature sensitive type collagen composite and disappear
Scorching gel spray and preparation method thereof.
Background technology
Psoriasis is a kind of common chronic inflammatory dermatoses for being easy to recurrence with characteristic skin lesion, from the beginning of for inflammation
Property red papules, about grain grain is gradually expanded or merge later to mung bean size as brownish red patch, and clear border around has
Inflammatory blush, substrate infiltration is apparent, and surface covers the canescence or the silvery white scales of skin that peel off of multilayer drying.Psoriasis is a kind of difficult so far
With the refractory skin of healing.
It is well known that collagen (Collagen) is prevalent in each histoorgan of human body, as bone, cartilage, ligament,
The positions such as skin, cornea, various inner membrances, fascia have, and are mainly used as the bonding of connective tissue.Since there are about 70% in skin
Be made of collagen, thus collagen be grasp skin whether consolidation be flexible, human appearance whether young weight
Want crucial.Collagen in skin, is present in skin corium, as soon as the supporter netted with elastic fibers resultant force framework,
Seem that steelframe is general, provides skin corium stable and strong support.Moisture can also be retained in skin corium by it, maintain connective group
The humidity knitted and elasticity, keep skin smooth, soft, it appears that glittering and translucent, glossy.
Inventor studies for many years finds that psoriasis is unable to regular regeneration with collagen in patient's corium and there is positive pass,
Autumn and winter dry season human skin can usually dry chap, if collagen generates in time in human body corium, content is abundant, that
Skin just has the apparent ability for repairing chap, and suitably moistening skin care can restore normal.If in opposite human body corium
Collagen generative capacity is insufficient, leads to skin collagen complementary capabilities existing defects, can not be carried out to chapped skin timely
It repairs, chap position easily by some bacteriums, fungi intrusion infection, causes redness to fester, forms inflammatory dermatoses, here it is normal
The psoriasis seen.If not solving the problems, such as skin collagen scarcity, though psoriasis, through antiphlogistic and bactericidal, symptom is controlled alleviation,
But skin cannot be fundamentally repaired, the window of bacterial invasion is still remained, thus research is it can be seen that psoriasis is a kind of skin
Skin collagen deficiency disease, pathogenesis is not in bacterium infection, and it is insufficient to be that skin collagen generates, and skin is caused to lack
Injury repair ability, so doctor trained in Western medicine Chinese medicine is not symptomatic treatment using various conventional antiphlogistic and bactericidals and clearing heat and detoxicating method,
So effect is bad always.
Invention content
Technical problem to be solved by the invention is to provide a kind of easy to use, long action time, curative effect is reliably treated
Psoriasic temperature sensitive type collagen composite antiphlogistic gel spray and preparation method thereof.
In order to solve the above-mentioned technical problem, the present invention adopts the following technical scheme that：It is a kind of to treat psoriasic temperature sensitive type glue
Former compound antiphlogistic gel spray, by weight, including following raw material：Temperature sensitive type collagen base composite antibiotic antiphlogistic gel 45~65,
Haemostatic medicament 15~20, dandelion 12~18, Fructus Forsythiae 3~5, Radix Salviae Miltiorrhizae 2~4, Rhizoma Chuanxiong 1~3, lopseed 4~8, glycerine 8~12,
Rosemary Oil 2~3, lauric monoglyceride 1.5~3.5, water 10~20.
Dandelion, bitter but sweet flavor is cold in nature, has broad-spectrum antiseptic anti-inflammatory, can be clearing heat and detoxicating, diuresis dissipating bind.Control acute mammary gland
Inflammation, adenolymphitis, scrofula, boil poisonous soreness, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis,
Hepatitis, cholecystitis, urinary tract infections etc..
Fructus Forsythiae, bitter is cool in nature, has the effect of heat-clearing, removing toxic substances, dissipating bind, detumescence.Control warm, erysipelas, macula, large carbuncle is swollen
Poison, scrofula, urine leaching closes etc..
Radix Salviae Miltiorrhizae, bitter, cold nature.Major function stasis-dispelling and pain-killing, invigorate blood circulation, relieving restlessness that clears away heart-fire.For irregular menstruation, Amenorrhea
Dysmenorrhoea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, dysphoria and insomnia；Hepatosplenomegaly, angina pectoris.
Rhizoma Chuanxiong, acrid flavour are warm-natured.Major function blood-activating and qi-promoting, wind-expelling pain-stopping.For irregular menstruation, closed dysmenorrhea, abdominal mass abdomen
Bitterly, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.
Lopseed, alias phoenix celestial being stalk, bitter, pungent, warm-natured, major function wind-damp dispelling；Promoting blood circulation；Removing toxic substances.Main arthralgia pain due to rheumatism；Fall
Play swelling and pain；Amenorrhoea；Dysmenorrhoea；Carbuncle swells；Erysipelas；The fungal infection of the hand；Snakebite and bugbite.
Glycerine, can be miscible with water, ethyl alcohol, has hygroscopicity, has extraordinary moistening effect to skin.
Rosemary Oil commonly uses heal-care essential oil, can not only moisturizing, and sharp liver and gall, toxin expelling, purification work(
Effect.
Lauric monoglyceride, lipophilic nonionic surface active agent have hydrophilic and lipophilic group, in the present invention
It is middle to be used as emulsifier, and the antibiotic property with high-efficiency broad spectrum, it can bactericidal antiphlogistic.
Further, the haemostatic medicament be dencichine, aminomethylbenzoic acid, tranexamic acid, adrenobazonum, in aminocaproic acid extremely
Few one kind (ratio is unlimited).
The preparation method of the above-mentioned psoriasic temperature sensitive type collagen composite antiphlogistic gel spray for the treatment of, includes the following steps：
(1) preparation of temperature sensitive type collagen base composite antibiotic antiphlogistic gel
The Type I collagen of 1~5 parts by weight is taken, the 10mM hydrochloric acid for being dissolved in 100~500 parts by volume is stirred at 4~10 DEG C
In solution, after collagen is completely dissolved, it is slowly added to hydrochloric acid solution equal volume containing 30~50mM Tris, 0.1~
The Tris-NaCl buffer solutions that the pH value of 0.2M NaCl composition is 8.0 stir at 4~10 DEG C, regeneration collagen are made
Fiber buffer stoste；Then above-mentioned regeneration Buffer stock is statically placed in 25~37 DEG C of constant incubator, cultivates 0.5~5h,
Regenerated collagen fiber solution is made；A concentration of 50U/g~150U/g glutamine transaminages are finally added to above-mentioned reclaimed rubber
In fibrinogen solution, it is sufficiently stirred 10 at 4~10 DEG C~for 24 hours, hydroxylation regenerated collagen fiber solution is prepared；
The polyvinylpyrrolidone of the poloxamer188 of 0.5~5 parts by weight and 0.5~5 parts by weight is added to above-mentioned hydroxyl
Change in regenerated collagen fiber solution, is sufficiently stirred 5~12h at 4~10 DEG C, temperature sensitive type collagen base composite antibiotic is prepared and disappears
Scorching gel；
(2) preparation of Chinese medical extract
Ground into end after dandelion, Fructus Forsythiae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong and lopseed are mixed, addition ethanol water, immersion 12~
36 hours, filtration treatment later, then by gained filtrate is concentrated successively and freeze-drying process, obtain Chinese medical extract；
(3) preparation of spray
Temperature sensitive type glue is added in haemostatic medicament, Chinese medical extract, glycerine, Rosemary Oil, lauric monoglyceride and water
In former base composite antibacterial antiphlogistic gel, it is sufficiently stirred 0.5~2h at 4~10 DEG C, the psoriasic temperature sensitive Collagen Type VI that obtains medical treatment is multiple
Close antiphlogistic gel spray.
Psoriasic temperature sensitive type collagen composite antiphlogistic gel spray is treated through gamma-rays sterilization, with cleaning spraying bottle packet
Dress Cord blood is spare, and Key Performance Indicator is as follows：
Appearance：Gel, surface is smooth, the impurity being visible by naked eyes；
Mass fraction shared by moisture：≤ 10%；
Gel strength：100~500g/cm 2；
Content of beary metal：≤10μg/g；
Cytotoxicity：Cell-cytotoxic reaction is not more than 1 grade；
Sterility test：It is sterile；
Sensitization test (STT)：Without delayed type hypersensitivity, DTH；
Intradermal reaction is tested：Primary stimulus index PII<0.4；
Gel time：5~20s.
Further, a concentration of 38~45vt% of the ethanol water.In implementing the present invention, it may, inventor
It was found that the active ingredient of each Chinese medicine material has soluble easily in water, some is soluble in ethyl alcohol, using the ethanol water of above-mentioned concentration
It can ensure that the active ingredient in each raw material is fully precipitated and is extracted, to ensure to treat psoriasic effect.
Further, the Type I collagen is from pigskin, pig tendon, ox-hide, beef tendon, donkey hide, donkey tendon, horse skin, horse tendon, mouse skin
Or (ratio is unlimited) that any one of rat-tail tendon prepares.
Further, the hydroxylation regenerated collagen fiber is the regenerated collagen fiber of 30%~65% proline hydroxylation.
Inventor has found that application No. is 201510229099.7 Chinese invention patent institutes during studying psoriasic
Disclosed temperature sensitive type collagen-based compound hemostatic gel, it not only has hemostasia effect, but also has well with human tissue cell
Compatibility can be well skin replenishing collagen, promote the reparation of damaged skin, especially this medical new material institute
The low temperature that has is presented liquid and can form the characteristic of gel under body temperature, is suitable for the protection of the closing to psoriasis sore face, non-
Often be conducive to the reparation and treatment of damaged skin.
The present invention lacks the achievement in research of collagen according to psoriatic's skin, in temperature sensitive type collagen-based compound hemostatic
Antibacterial anti-inflammatory ingredient is added on the basis of original effect of gel, creatively provides that a kind of to treat psoriasic temperature sensitive Collagen Type VI multiple
Antimicrobial inflammation-relieving gel spray prescription and its therapy are closed, is that prescription science is credible through ens morbi identification, clinical verification curative effect can
It leans on.
Prescription of the present invention takes collagen direct subsidy to develop simultaneously with antibacterial anti-inflammatory psoriasis disease sites to combine tonic again
Method realizes that application method is as follows to psoriasic treating both manifestation and root cause of disease：
1, first psoriatic lesion is cleaned with clean warm water；Stored refrigerated spray is taken advantage of the machine that low temperature liquid can flow by 2 to be sprayed
It is coated in affected part；3 wait a moment (about 1 minute) covers affected part with absorbent cotton thin slice, then covers one layer of barrier paper (moisturizing) again；4
The wrapping of terminal disinfection gauze is fixed.Replace within 3-5 days primary, replacing 3-4 times can fully recover, and then regular tonic collagen consolidates
Gu curative effect.
Beneficial effects of the present invention are embodied in：
1. the present invention treat psoriasic temperature sensitive type collagen composite antiphlogistic gel spray can stop blooding, replenishing collagen,
Repair damaged skin, low temperaturePresent liquid andBut gel can be formed under body temperature, and it is anti-to be very suitable for the closing to psoriasis sore face
Shield is conducive to many characteristics of reparation and the treatment of damaged skin, and there is skin according to psoriatic lacks collagen more
Achievement in research, on the basis of original effect of temperature sensitive type collagen-based compound hemostatic gel add antibacterial anti-inflammatory ingredient, by right
Psoriasis disease sites develop simultaneously the method for taking collagen direct subsidy to combine tonic again with bactericidal antiphlogistic, realize to psoriasic mark
Originally simultaneous to control.Product of the present invention uses spray mode, easy to use, has extraordinary application prospect.
2. the present invention treats psoriasic temperature sensitive type collagen composite antiphlogistic gel spray with temperature sensitive type collagen-based compound hemostatic
Gel is base material, therefore also has Thermo-sensitive, and when cryopreservation is in a liquid state, and affected part can be sprayed on by taking out use, and connect
After contacting human body, due to the influence of body temperature, temperature is got higher, and can be formed gel and is attached on skin, not only be formed to skin
Protective film prevents moisture evaporation, and contained medicinal ingredient is not volatile, long action time, has extraordinary treatment effect
Fruit.
3. the present invention treats psoriasic temperature sensitive type collagen composite antiphlogistic gel spray with temperature sensitive type collagen-based compound hemostatic
Gel is base material, and assistant has psoriasis with anti-inflammation components, removing toxic substances ingredient, ingredient promoting blood circulation and removing blood stasis, moisturizing ingredient, moisturizing ingredient etc.
There is extraordinary therapeutic effect, refers to specific implementation part table 1.
4. the psoriasic temperature sensitive type collagen composite antiphlogistic gel spray preparation method of present invention treatment is simple, it is easy to implement,
It is edible very convenient, there is extraordinary application prospect.
Specific implementation mode
With reference to embodiment, the invention will be further described：
Various raw materials, are such as not specifically noted used in following embodiment, are commercial product well known in the art.
Embodiment 1
Treat the preparation of psoriasic temperature sensitive type collagen composite antiphlogistic gel spray
The present embodiment treats psoriasic temperature sensitive type collagen composite antiphlogistic gel spray, by weight, by following raw material system
At：It is temperature sensitive type collagen base composite antibiotic antiphlogistic gel 55, haemostatic medicament 18, dandelion 15, Fructus Forsythiae 4, Radix Salviae Miltiorrhizae 3, Rhizoma Chuanxiong 2, deep
Grass 6, glycerine 10, Rosemary Oil 2.5, lauric monoglyceride 2.5, water 15；Preparation method includes the following steps：
(1) preparation of temperature sensitive type collagen base composite antibiotic antiphlogistic gel
The Type I collagen of 3 parts by weight is taken, stirs and is dissolved in the 10mM hydrochloric acid solutions of 300 parts by volume at 7 DEG C, wait for glue
After original is completely dissolved, be slowly added to be with pH value of the hydrochloric acid solution equal volume containing 40mM Tris, 0.15M NaCl compositions
8.0 Tris-NaCl buffer solutions stir at 7 DEG C, and regenerated collagen fiber Buffer stock is made；Then by it is above-mentioned again
Raw Buffer stock is statically placed in 31 DEG C of constant incubator, cultivates 3h, and regenerated collagen fiber solution is made；It finally will be a concentration of
100U/g glutamine transaminages are added in above-mentioned regenerated collagen fiber solution, are sufficiently stirred 17h at 7 DEG C, hydroxyl is prepared
Change regenerated collagen fiber solution；
The polyvinylpyrrolidone of the poloxamer188 of 3 parts by weight and 3 parts by weight is added to above-mentioned hydroxylation regeneration collagen
In fiber solution, it is sufficiently stirred 8h at 7 DEG C, temperature sensitive type collagen base composite antibiotic antiphlogistic gel is prepared；
(2) preparation of Chinese medical extract
Ground into end after dandelion, Fructus Forsythiae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong and lopseed are mixed, is added the ethyl alcohol of a concentration of 41vt%
Aqueous solution (did not had raw material, similarly hereinafter), immersion 24 hours, later filtration treatment, then gained filtrate is concentrated and cold successively
Freeze and be dried, obtains Chinese medical extract；
(3) preparation of spray
Temperature sensitive type glue is added in haemostatic medicament, Chinese medical extract, glycerine, Rosemary Oil, lauric monoglyceride and water
In former base composite antibacterial antiphlogistic gel, it is sufficiently stirred 1.2h at 7 DEG C, the psoriasic temperature sensitive type collagen composite anti-inflammatory that obtains medical treatment is solidifying
Glue spray.
Embodiment 2
Treat the preparation of psoriasic temperature sensitive type collagen composite antiphlogistic gel spray
The present embodiment treats psoriasic temperature sensitive type collagen composite antiphlogistic gel spray, by weight, by following raw material system
At：It is temperature sensitive type collagen base composite antibiotic antiphlogistic gel 45, haemostatic medicament 15, dandelion 12, Fructus Forsythiae 3, Radix Salviae Miltiorrhizae 2, Rhizoma Chuanxiong 1, deep
Grass 4, glycerine 8, Rosemary Oil 2, lauric monoglyceride 1.5, water 10；Preparation method includes the following steps：
The Type I collagen of 1 parts by weight is taken, stirs and is dissolved in the 10mM hydrochloric acid solutions of 100 parts by volume at 4 DEG C, wait for glue
After original is completely dissolved, be slowly added to be with pH value of the hydrochloric acid solution equal volume containing 30mM Tris, 0.1M NaCl compositions
8.0 Tris-NaCl buffer solutions stir at 4 DEG C, and regenerated collagen fiber Buffer stock is made；Then by it is above-mentioned again
Raw Buffer stock is statically placed in 25 DEG C of constant incubator, cultivates 0.5h, and regenerated collagen fiber solution is made；It finally will be a concentration of
50U/g glutamine transaminages are added in above-mentioned regenerated collagen fiber solution, and 10h is sufficiently stirred at 4 DEG C, and hydroxylation is prepared
Regenerated collagen fiber solution；
The polyvinylpyrrolidone of the poloxamer188 of 0.5 parts by weight and 0.5 parts by weight is added to above-mentioned hydroxylation regeneration
In collagenous fibres solution, it is sufficiently stirred 5h at 4 DEG C, temperature sensitive type collagen base composite antibiotic antiphlogistic gel is prepared；
(2) preparation of Chinese medical extract
Ground into end after dandelion, Fructus Forsythiae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong and lopseed are mixed, is added the ethyl alcohol of a concentration of 45vt%
Aqueous solution (did not had raw material, similarly hereinafter), immersion 12 hours, later filtration treatment, then gained filtrate is concentrated and cold successively
Freeze and be dried, obtains Chinese medical extract；
(3) preparation of spray
Temperature sensitive type glue is added in haemostatic medicament, Chinese medical extract, glycerine, Rosemary Oil, lauric monoglyceride and water
In former base composite antibacterial antiphlogistic gel, it is sufficiently stirred 0.5h at 4 DEG C, the psoriasic temperature sensitive type collagen composite anti-inflammatory that obtains medical treatment is solidifying
Glue spray.
Embodiment 3
Treat the preparation of psoriasic temperature sensitive type collagen composite antiphlogistic gel spray
The present embodiment treats psoriasic temperature sensitive type collagen composite antiphlogistic gel spray, by weight, by following raw material system
At：It is temperature sensitive type collagen base composite antibiotic antiphlogistic gel 65, haemostatic medicament 20, dandelion 18, Fructus Forsythiae 5, Radix Salviae Miltiorrhizae 4, Rhizoma Chuanxiong 3, deep
Grass 8, glycerine 12, Rosemary Oil 3, lauric monoglyceride 3.5, water 20；Preparation method includes the following steps：
The Type I collagen of 5 parts by weight is taken, stirs and is dissolved in the 10mM hydrochloric acid solutions of 500 parts by volume at 10 DEG C, wait for glue
After original is completely dissolved, be slowly added to be with pH value of the hydrochloric acid solution equal volume containing 50mM Tris, 0.2M NaCl compositions
8.0 Tris-NaCl buffer solutions stir at 10 DEG C, and regenerated collagen fiber Buffer stock is made；Then by it is above-mentioned again
Raw Buffer stock is statically placed in 37 DEG C of constant incubator, cultivates 5h, and regenerated collagen fiber solution is made；It finally will be a concentration of
150U/g glutamine transaminages are added in above-mentioned regenerated collagen fiber solution, are sufficiently stirred at 10 DEG C for 24 hours, hydroxyl is prepared
Change regenerated collagen fiber solution；
The polyvinylpyrrolidone of the poloxamer188 of 5 parts by weight and 5 parts by weight is added to above-mentioned hydroxylation regeneration collagen
In fiber solution, it is sufficiently stirred 12h at 10 DEG C, temperature sensitive type collagen base composite antibiotic antiphlogistic gel is prepared；
(2) preparation of Chinese medical extract
Ground into end after dandelion, Fructus Forsythiae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong and lopseed are mixed, is added the ethyl alcohol of a concentration of 38vt%
Aqueous solution (did not had raw material, similarly hereinafter), immersion 36 hours, later filtration treatment, then gained filtrate is concentrated and cold successively
Freeze and be dried, obtains Chinese medical extract；
(3) preparation of spray
Temperature sensitive type glue is added in haemostatic medicament, Chinese medical extract, glycerine, Rosemary Oil, lauric monoglyceride and water
In former base composite antibacterial antiphlogistic gel, it is sufficiently stirred 2h at 10 DEG C, the psoriasic temperature sensitive type collagen composite anti-inflammatory that obtains medical treatment is solidifying
Glue spray.
Embodiment 4
Treat the clinical effect trial of psoriasic temperature sensitive type collagen composite antiphlogistic gel spray
Selected case：Through being diagnosed as psoriasis, with the one or more patient of psoriasis clinical symptoms；
Usage and dosage is：As specification is recorded.
Curative effect situation criterion：1. curing.Malaise symptoms completely disappear；2. effectively.Malaise symptoms mitigate or part disappears
It loses；3. invalid.Malaise symptoms are unchanged.Table 1 is that 300 psoriatics are psoriasic temperature sensitive using the treatment of embodiment 1 to 3
The clinical pharrnacokinetics of the compound antiphlogistic gel spray of Collagen Type VI are reported.
1 clinical effect trial result of table
| Spray group | Number of users | Healing number | Efficiently individual quantity | Invalid number | Cure rate | Total effective rate |
| Embodiment 1 | 100 | 68 | 31 | 1 | 68% | 99% |
| Embodiment 2 | 100 | 63 | 35 | 2 | 63% | 98% |
| Embodiment 3 | 100 | 65 | 34 | 1 | 65% | 99% |
Model case is as follows：
Wu, female, 37 years old, double lower limb played the dotted fash of red grouper, and with the white scales of skin that peel off, slight itch is diagnosed as ox
Psoriasis.After treating psoriasic less than one course for the treatment of of temperature sensitive type collagen composite antiphlogistic gel spray using the present invention, fash is reduced,
Itch mitigates, and is continuing with, and after 4 courses for the treatment of, recovery from illness has no any side effect；Spraying is once prevented daily later, is had no
Recurrence.
Zheng, man, 42 years old, four limbs and trunk gathered the erythema scales of skin that peel off, warts partly occur, serious itch is diagnosed as ox-hide
Tinea.After treating psoriasic two courses for the treatment of of temperature sensitive type collagen composite antiphlogistic gel spray using the present invention, erythema, warts are reduced,
Itch mitigates, and is continuing with, and after 8 courses for the treatment of, recovery from illness has no any side effect；Spraying is once prevented daily later, is had no
Recurrence.
It should be understood that example as described herein and embodiment are not intended to restrict the invention, this field only for explanation
Technical staff can make various modifications or variation according to it, all within the spirits and principles of the present invention, made by it is any modification,
Equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (6)
1. a kind for the treatment of psoriasic temperature sensitive type collagen composite antiphlogistic gel spray, which is characterized in that by weight, including it is following
Raw material：Temperature sensitive type collagen base composite antibiotic antiphlogistic gel 45~65, haemostatic medicament 15~20, dandelion 12~18, Fructus Forsythiae 3~5,
Radix Salviae Miltiorrhizae 2~4, Rhizoma Chuanxiong 1~3, lopseed 4~8, glycerine 8~12, Rosemary Oil 2~3, lauric monoglyceride 1.5~3.5,
Water 10~20.
2. the preparation method of psoriasic temperature sensitive type collagen composite antiphlogistic gel spray is treated as described in claim 1, it is special
Sign is that the haemostatic medicament is at least one of dencichine, aminomethylbenzoic acid, tranexamic acid, adrenobazonum, aminocaproic acid.
3. the preparation method of psoriasic temperature sensitive type collagen composite antiphlogistic gel spray is treated as claimed in claim 1 or 2,
It is characterized in that, includes the following steps：
(1) preparation of temperature sensitive type collagen base composite antibiotic antiphlogistic gel
The Type I collagen of 1~5 parts by weight is taken, the 10mM hydrochloric acid solutions for being dissolved in 100~500 parts by volume are stirred at 4~10 DEG C
In, after collagen is completely dissolved, it is slowly added to contain 30~50mM Tris, 0.1~0.2M with hydrochloric acid solution equal volume
The Tris-NaCl buffer solutions that the pH value of NaCl compositions is 8.0, stir at 4~10 DEG C, and it is slow that regenerated collagen fiber is made
Rush stoste；Then above-mentioned regeneration Buffer stock is statically placed in 25~37 DEG C of constant incubator, cultivates 0.5~5h, be made again
Crude rubber original fiber solution；A concentration of 50U/g~150U/g glutamine transaminages are finally added to above-mentioned regenerated collagen fiber
In solution, it is sufficiently stirred 10 at 4~10 DEG C~for 24 hours, hydroxylation regenerated collagen fiber solution is prepared；
The polyvinylpyrrolidone of the poloxamer188 of 0.5~5 parts by weight and 0.5~5 parts by weight is added to above-mentioned hydroxylation again
In crude rubber original fiber solution, it is sufficiently stirred 5~12h at 4~10 DEG C, it is solidifying that temperature sensitive type collagen base composite antibiotic anti-inflammatory is prepared
Glue；
(2) preparation of Chinese medical extract
Ethanol water is added in ground into end after dandelion, Fructus Forsythiae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong and lopseed are mixed, and it is small to impregnate 12~36
When, filtration treatment later, then by gained filtrate is concentrated successively and freeze-drying process, obtain Chinese medical extract；
(3) preparation of spray
Temperature sensitive type collagen-based is added in haemostatic medicament, Chinese medical extract, glycerine, Rosemary Oil, lauric monoglyceride and water
In composite antibacterial antiphlogistic gel, it is sufficiently stirred 0.5~2h at 4~10 DEG C, the psoriasic temperature sensitive type collagen composite that obtains medical treatment disappears
Scorching gel spray.
4. the preparation method of psoriasic temperature sensitive type collagen composite antiphlogistic gel spray is treated as claimed in claim 3, it is special
Sign is, a concentration of 38~45vt% of the ethanol water.
5. the preparation method of psoriasic temperature sensitive type collagen composite antiphlogistic gel spray is treated as claimed in claim 3, it is special
Sign is that the Type I collagen is from pigskin, pig tendon, ox-hide, beef tendon, donkey hide, donkey tendon, horse skin, horse tendon, mouse skin or rat-tail tendon
Any prepare.
6. the preparation method of psoriasic temperature sensitive type collagen composite antiphlogistic gel spray is treated as claimed in claim 3, it is special
Sign is that the hydroxylation regenerated collagen fiber is the regenerated collagen fiber of 30%~65% proline hydroxylation.
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| WO2023128884A1 (en) * | 2021-12-28 | 2023-07-06 | İsti̇nye Üni̇versi̇tesi̇ | Thermoreversible gel formulation with herbal active materials in order to calm and accelarate the healing of burnt skin |
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