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WO2018086634A1 - 包含噻苯隆和极细链格孢激活蛋白的组合物 - Google Patents

包含噻苯隆和极细链格孢激活蛋白的组合物 Download PDF

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Publication number
WO2018086634A1
WO2018086634A1 PCT/CN2017/115838 CN2017115838W WO2018086634A1 WO 2018086634 A1 WO2018086634 A1 WO 2018086634A1 CN 2017115838 W CN2017115838 W CN 2017115838W WO 2018086634 A1 WO2018086634 A1 WO 2018086634A1
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composition
active component
composition according
active
thiabendazole
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PCT/CN2017/115838
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English (en)
French (fr)
Inventor
仲汉根
季自华
季红进
花伟
季定根
韦建峰
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江苏辉丰生物农业股份有限公司
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Publication of WO2018086634A1 publication Critical patent/WO2018086634A1/zh

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/30—Microbial fungi; Substances produced thereby or obtained therefrom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture

Definitions

  • the invention belongs to the field of agricultural plant protection, in particular to a pesticidal composition with improved properties, in particular to a pesticidal composition comprising thiabendazole and very fine chain spore activation protein.
  • Pyraclostrobin is a new type of high-efficiency plant growth regulator. When it is absorbed by plants, it can promote the separation of petioles and stems and form natural shedding. It can be widely used in pesticides and fertilizers. It has strong biological activity, and its ability to induce plant cell division and callus formation is many times higher than that of general cytokinins. Improve crop absorptive capacity and increase photosynthesis, so as to increase production and enhance the purpose. It can be used in various kinds of melons, fruits, vegetables, seedlings, flowers, food, tobacco and other crops, and can also be used for tissue culture, genetic engineering, etc. In production, it can significantly improve crop yield, improve quality and use less, has no pollution to the ecological environment, and is non-toxic to humans, animals, birds, bees and natural enemies.
  • Alternaria alternata is a novel protein that has been screened, isolated and purified from Alternaria alternata, which activates the plant's immune system by activating the molecular immune system in plants; by stimulating a series of metabolic regulation in plants. It promotes the growth of roots, stems and leaves of plants, increases chlorophyll content, increases crop yield, and has high control effect on various plant diseases.
  • the inventors have found that both thidiazuron and Alternaria alternata activator have significant synergistic effects in regulating or promoting plant growth.
  • Another object of the present invention is to provide an application comprising a combination of two active ingredients A and B plant growth regulators for regulating and promoting crop growth in the agricultural field.
  • the object of the invention can be achieved by the following measures:
  • a synergistic pesticidal composition comprising two active components A and B, wherein active component A is thiabendone and active component B is very fine chain spore activation protein, two components
  • the weight ratio between the active ingredient A and the active ingredient B is 1:0.01 to 100.
  • the weight ratio of active component A to active component B The ratio of 1:0.0125 to 80 is more preferably 1:0.02 to 50 in order to make the effect more apparent. It is still more preferably 1:0.04 to 40.
  • the weight ratio between the two components of A and B can be arbitrarily adjusted within the range of the following ratios: 100:1, 95:1, 90:1, 85:1, 80: 1, 75:1, 70:1, 65:1, 60:1, 55:1, 50:1, 45:1, 40:1, 35:1, 30:1, 29:1, 28:1 27:1, 26:1, 25:1, 24:1, 23:1, 22:1, 21:1, 20:1, 19:1, 18:1, 17:1, 16:1, 15 : 1, 14: 1, 13: 1, 12: 1, 11: 1, 10: 1, 9: 1, 8: 1, 7: 1, 6: 1, 5: 1, 4: 1, 3: 1 , 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:15, 1 :20, 1:25, 1:30, 1:31, 1:32, 1:33, 1:34, 1:35, 1:36, 1:37, 1:38, 1:39, 1:40 1, 1:41, 1:42, 1:
  • composition of the present invention can better regulate the growth of crops, promote the health effects of crops, and increase crop yield.
  • the present invention provides the use of a composition comprising component A (thiabendazole) and component B (very fine chain spore-acting protein) for regulating crop growth in the agricultural field, in particular for regulating crops in rice, wheat or fruit trees. Use for growth and other aspects of disease resistance.
  • component A thiabendazole
  • component B very fine chain spore-acting protein
  • composition of the present invention can also be used in combination with other pesticides (such as fungicides, insecticides, herbicides, plant growth regulators), fertilizers, etc., and these are mixed with Commonly used pesticides or fertilizers disclosed in the art.
  • pesticides such as fungicides, insecticides, herbicides, plant growth regulators
  • fertilizers etc.
  • composition of the present invention can be made into a pesticide-acceptable dosage form from the active ingredient and the pesticide adjuvant.
  • the active ingredient is present in the composition in an amount of from 0.2 to 80% by mass. More preferably, it is 0.5-50%.
  • the pesticide adjuvant may be selected from one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, etc., and may be mixed during the application. Additives.
  • Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizers. .
  • the method of application of the compositions of the invention comprises the use of the compositions of the invention for aerial parts of plants, in particular leaves or foliage. You can choose to soak or apply to the surface of the control object.
  • the frequency of administration and the amount of application depend on the biology of the pathogen And climate survival conditions.
  • the plant growth site such as rice fields, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant. In vivo (systemic action).
  • compositions may be applied only with the active ingredient or may be mixed with an additive (agrochemical adjuvant).
  • composition of the present invention can be prepared into a pesticide-acceptable dosage form such as a liquid, a suspension, a soluble liquid, an oil suspension, a water-dispersible granule, a microemulsion, a wettable powder and the like.
  • a pesticide-acceptable dosage form such as a liquid, a suspension, a soluble liquid, an oil suspension, a water-dispersible granule, a microemulsion, a wettable powder and the like.
  • the compositions may be applied by spraying, misting, dusting, spreading or pouring, and the like.
  • composition of the present invention can be prepared into various dosage forms by a known method, and the active ingredient and the auxiliary agent, such as a solvent, a solid carrier, and, if necessary, can be uniformly mixed and ground together with the surfactant to prepare a desired preparation. Dosage form.
  • the above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
  • aromatic hydrocarbons preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
  • Alkenes or paraffins, alcohols and glycols and their ethers and esters such as ethanol, ethylene glycol, ethylene glycol monomethyl
  • ketones such as cyclohexanone
  • highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide
  • vegetable or vegetable oils such as soybean oil.
  • the above solid carriers are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay.
  • a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand.
  • a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.
  • Suitable surfactants are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene poly
  • Plants in the present invention include, but are not limited to, corn, wheat, rice, and the like.
  • compositions of the present invention exhibit synergistic effects, the activity of which is more pronounced than the expected sum of activity using a single compound, and the individual activity of a single compound.
  • Other characteristics exhibited by the compositions of the present invention Mainly as follows: 1.
  • the composition of the present invention has obvious synergistic effect; 2. Because the chemical composition of the two single agents of the composition is very different, the mechanism of action is completely different, and there is no cross-resistance. The problem of resistance caused by the two single agents being used alone is delayed; 3.
  • the composition of the invention can well regulate crop growth, improve disease resistance and stress resistance, promote crop health effects, and increase crop yield.
  • the active ingredient Alternaria alternata and the thidiazepine, and the components such as dispersant, wetting agent, thickener and water are uniformly mixed according to the formula, after sanding and/or high-speed shearing, A semi-finished product is obtained, and after analysis, the water is mixed and uniformly filtered to obtain a finished product.
  • Example 1 2.025% thiabendazole ⁇ Alternaria alternata activator suspension
  • Example 3 10.2% thiabendazole ⁇ Alternaria alternata activator suspension
  • Example 4 20.25% thiabendazole ⁇ Alternaria alternata activator suspension
  • the active ingredient active group A and the active component B, and the auxiliary agent and the filler are uniformly mixed according to the formula, and the air flow powder is mixed. It is broken into a wettable powder, and then added with a certain amount of water to be mixed and granulated, and sieved by drying to obtain a water-dispersible granule product.
  • Example 5 3.06% thiabendazole ⁇ Alternaria alternata activator protein water dispersible granules
  • Example 6 24% thiabendazole ⁇ Alternaria alternata activator protein water dispersible granules
  • Example 7 13% thiabendazole ⁇ Alternaria alternata activator protein water dispersible granules
  • the active ingredient thiazolone and the ultrafine Alternaria activator active ingredient are mixed with various adjuvants and fillers in proportion, and are pulverized by an ultrafine pulverizer to obtain a wettable powder.
  • Example 8 1.01% thiabendazole ⁇ Alternaria alternata activator protein wettable powder
  • Example 9 5.2% thiabendazole ⁇ Alternaria alternata activator protein wettable powder
  • Example 10 11% thiabendazole ⁇ Alternaria alternata activator protein wettable powder
  • Thiabendron 1% very fine chain spore activation protein 10%, sodium sulfonate 4%, sodium lignosulfonate 5%, diatomaceous earth 4%, kaolin to 100%.
  • Example 11 25.25% thiabendazole ⁇ Alternaria alternata activator protein wettable powder
  • the thiabendazole and the very fine chain spore-acting protein were diluted with acetone at a certain concentration, and the crops were sprayed with stems and leaves.
  • the effects of various concentrations on the growth of the crops were determined in the field, including the plant height, the number of spikes, the seed setting rate, Disease resistance and yield Comprehensive evaluation of the situation, etc.
  • Plant height control rate (clear water control plant height - treated plant height) / clear water control plant height * 100%
  • Increase rate of panicle (number of panicles after treatment - number of spikes of clear water control plants) / number of spikes of clear water control plants * 100%
  • Seed setting rate number of grains per panicle / total number of kernels per pan * 100%
  • Table 1 Summary of combined determination of thiabendazole and Alternaria alternata activator protein in rice growth regulation
  • thio is an abbreviation for “thiablon” and "polar” is an abbreviation for "very fine chain spore-acting protein”.
  • Application period during the flowering stage, rice plants did not occur or began to develop rice smut in this stage.
  • the application frequency 2 times, the application interval is 7 days; the application method: stem and leaf spray; the investigation period: the late rice filling stage; in this experiment, the plant height, the number of panicles, the incidence index, the number of solids and other indicators are treated separately. average value.
  • the invention can effectively reduce the plant height of rice, enhance the nutrient transfer capacity of the plant, and can improve the lodging resistance of rice growth by reducing the plant height;
  • Thiabendazole has certain anti-disease and anti-reverse effects on plant growth when used as a single agent, while Alternaria alternata has a certain immunity to crop diseases, between Alternaria alternata and thiabendazole.
  • Co-administration has a good synergistic effect. From the above analysis, it can be seen that the synergistic effect between thiablon and Alternaria alternata on the rice blast disease is better than that of single dose and water control.
  • the preventive effect; 3 due to the synergistic effect of thiazolone and Alternaria alternata in the early stage of rice growth, promoted the nutrient transmission, disease resistance and resistance of rice plants, and significant yield per unit of mu in rice maturity
  • the promotion effect is as high as 16.5%.
  • the corn flowering stage is prone to diseases such as large spot disease.
  • thio is an abbreviation for “thiablon” and "polar” is an abbreviation for "very fine chain spore-acting protein".
  • the dwarf corn plants can be dwarfed, the corn control can be effectively controlled, the stem diameter of the corn can be promoted to promote nutrient conduction, and the corn can be prevented from lodging.
  • the thidiazepine can promote the growth of corn, and Alternaria alternata has a certain resistance to disease and stress, and it has a synergistic effect after mixing.
  • the composition of the invention has a significant effect on the unit yield of corn. The yield per unit of mu can increase by 16.6%.

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Abstract

提供了一种具有增效作用的农药组合物，其有效成分包含A和B，其中活性组分A为噻苯隆，活性组分B为极细链格孢激活蛋白，其重量比为1：0.01～100。还提供了该组合物的制备方法及用途。试验结果表明，该组合物可很好的调节作物生长，提高抗病抗逆性，促进作物健康作用，提高作物产量。

Description

包含噻苯隆和极细链格孢激活蛋白的组合物 技术领域
本发明属于农业植物保护领域，特别是涉及一种具有改进性能的农药组合物，具体地说是涉及一种包含噻苯隆和极细链格孢激活蛋白的农药组合物。
背景技术
噻苯隆(pyraclostrobin)是新型高效植物生长调节剂，噻苯隆被植物吸收后，可促进叶柄与茎之间的分离组织，形成自然脱落，在农药、肥料中可被广泛应用。它具有极强的生物活性，其诱导植物细胞分裂、愈伤组织形成的能力比一般细胞分裂素高许多倍。提高作物吸收能力，增加光合作用，从而达到增产、增优目的。可用于各类瓜、果、蔬菜、苗木、花卉、粮食、烟草等作物，还可用于组织培养、基因工程等。在生产上能显著提高作物产量、改善品质且有用量少、对生态环境无污染，对人、畜、鸟、蜜蜂、天敌无毒等特点。
极细链格孢激活蛋白是从交链孢菌中筛选、分离、纯化出的一类新型蛋白，主要通过激活植物体内分子免疫系统，提高植物自身免疫力；通过激发植物体内的一系列代谢调控，促进植物根、茎、叶生长和提高叶绿素含量，提高作物产量，对多种植物病害有较高的防效。
实际的农药经验已经表明，重复且专一施用一种活性化合物来防治有害真菌在很多情况下将导致真菌菌株的快速选择性，为降低抗性真菌菌株选择性的危险性，目前通常使用不同活性化合物的混合物来防治有害真菌。通过将具有不同作用机理的活性化合物进行组合，可延缓抗性产生，降低施用量，减少防治成本。
发明内容
本发明的目的是提供一种具有增效作用的农药组合物，以促进作物生长，提高作物的抗病和作物产量。发明人发现，噻苯隆与极细链格孢激活蛋白两者在调节或促进植物生长方面具有显著的协同增效作用。
本发明的另一个目的是提供包含两种有效成分A和B植物生长调节剂组合物在农业领域调节和促进农作物生长中的应用。
本发明的目的可以通过以下措施达到：
一种具有增效作用的农药组合物，该组合物包含A和B两种活性组分，其中活性组分A为噻苯隆，活性组分B为极细链格孢激活蛋白，两组分之间的重量比为活性组分A和活性组分B的重量比为1:0.01～100。在一种优选方案中，活性组分A和活性组分B的重量比 为为1：0.0125～80，为使作用效果更明显两者重量比可进一步优选1：0.02～50。更进一步优选为为1：0.04～40。
在一种优选的方案中，A和B两组分之间的重量比可以任意地在下述配比的范围内进行调整：100:1、95:1、90:1、85:1、80:1、75:1、70:1、65:1、60:1、55：1、50:1、45:1、40:1、35：1、30:1、29:1、28:1、27:1、26:1、25:1、24:1、23:1、22:1、21:1、、20:1、19:1、18:1、17:1、16:1、15:1、14:1、13:1、12:1、11:1、10:1、9:1、8:1、7:1、6:1、5:1、4:1、3:1、2:1、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：15、1：20、1：25、1：30、1:31、1:32、1:33、1:34、1:35、1:36、1:37、1:38、1:39、1:40、1:41、1:42、1:43、1:44、1:45、1:46、1:47、1:48、1:49、1:50、1:51、1:52、1:53、1:54、1:55、1:56、1:57、1:58、159:、1:60、1:61、1:62、1:63、1:64、1:65、1:66、1:67、1:68、1:69、1:70、1:71、1:72、1:73、1:74、1:75、1:76、1:77、1:78、1:79、1:80、1:81、1:82、1:83、1:84、1:85、1:86、1:87、1:88、1:89、1:90、1:91、1:92、1:93、1:94、1:95、1:96、1:97、1:98、1:99、1:100，也可以在以上任意两个配比所组成的范围内进行选择，这些比例可以理解为重量比，也可以包括摩尔比。
发明人通过试验发现，本发明的组合物可以更好的调节作物的生长，促进作物的健康作用，提高作物的产量。
本发明提供了包含组分A(噻苯隆)和组分B(极细链格孢激活蛋白)的组合物在农业领域调节农作物生长中的用途，特别是在水稻、小麦或果树方面调节作物生长提高抗病效果等方面的用途。
为充分发挥本发明的优势效果，本发明的组合物还可以与其他农药(如杀菌剂、杀虫剂、除草剂、植物生长调节剂)、肥料等混合使用，这些与之混用的均为现有技术公开的常用的农药或肥料。
本发明的组合物可以由活性成分和农药助剂制成农药上允许的剂型。所述活性成分在组合物中的质量含量为0.2～80％。进一步优选为0.5～50％。
所述的农药助剂可以选自载体、溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂、表面活性剂等中的一种或几种，在施用的过程中可以混合常用的助剂。
合适的助剂可以是固体或液体，它们通常是剂型加工过程中常用的物质，例如天然的或再生的矿物质，溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂或肥料。
本发明组合物的施用方法包括将本发明的组合物用于植物生长的地上部分，特别是叶部或叶面。可以选择浸种或涂抹于防治对象表面。施用的频率和施用量取决于病原体的生物学 和气候生存条件。可以将植物的生长场所，如稻田，用组合物的液体制剂浸湿，或者将组合物以固体形式施用于土壤中，如以颗粒形式(土壤施用)，组合物可以由土壤经植物根部进入植物体内(内吸作用)。
这些组合物可以仅仅包含活性成分进行施用，也可以与添加剂(农药助剂)一起混合使用。
本发明的组合物可以制备成农药上可接受的剂型，例如水剂、悬浮剂、可溶性液剂、油悬浮剂、水分散粒剂、微乳剂、可湿性粉剂等。根据这些组合物的性质以及施用组合物所要达到的目的和环境情况，可以选择将组合物以喷雾、弥雾、喷粉、撒播或泼浇等之类的方法施用。
可用已知的方法可以将本发明的组合物制备成各种剂型，可以将有效成分与助剂，如溶剂、固体载体，需要时可以与表面活性剂一起均匀混合、研磨，制备成所需要的剂型。
上述的溶剂可选自芳香烃，优选含8-12个碳原子，如二甲苯混合物或取代的苯，酞酸酯类，如酞酸二丁酯或酞酸二辛酸，脂肪烃类，如环已烷或石蜡，醇和乙二醇和它们的醚和酯，如乙醇，乙二醇，乙二醇单甲基；酮类，如环已酮，强极性的溶剂，如N-甲基-2-吡咯烷酮，二甲基亚砜或二甲基甲酰胺，和植物油或植物油，如大豆油。
上述的固体载体，如用于可湿性粉剂和可分散剂的通常是天然矿物填料，例如滑石、高岭土，蒙脱石或活性白土。为了管理组合物的物理性能，也可以加入高分散性硅酸或高分散性吸附聚合物载体，例如粒状吸附载体或非吸附载体，合适的粒状吸附载体是多孔型的，如浮石、皂土或膨润土；合适的非吸附载体如方解石或砂。另外，可以使用大量的无机性质或有机性质的预制成粒状的材料作为载体，特别是白云石。
根据本发明的组合物中的有效成分的化学性质，合适的表面活性剂为木质素磺酸、萘磺酸、苯酚磺酸、碱土金属盐或胺盐，烷基芳基磺酸盐，烷基硫酸盐，烷基磺酸盐，脂肪醇硫酸盐，脂肪酸和硫酸化脂肪醇乙二醇醚，还有磺化萘和萘衍生物与甲醛的缩合物，萘或萘磺酸与苯酚和甲醛的缩合物，聚氧乙烯辛基苯基醚，乙氧基化异辛基酚，辛基酚，壬基酚，烷基芳基聚乙二醇醚，三丁基苯聚乙二醇醚，三硬脂基苯基聚乙二醇醚，烷基芳基聚醚醇，乙氧基化蓖麻油，聚氧乙烯烷基醚，氧化乙烯缩合物、乙氧基化聚氧丙烯，月桂酸聚乙二醇醚缩醛，山梨醇酯，木质素亚硫酸盐废液和甲基纤维素。
本发明中的植物包括但不限于玉米、小麦或水稻等。
本发明的组合物中两种有效成分表现为增效效果，该组合物的活性比使用单个化合物的活性预期总和，以及单个化合物的单独活性更为显著。本发明的组合物的表现出的其它特点 主要表现为：1、本发明的组合物混配具有明显的协同增效作用；2、由于本组合物的两个单剂化学结构差异很大，作用机理完全不同，不存在交互抗性，可延缓两单剂单独使用所产生的抗性问题；3、本发明的组合物可很好的调节作物生长，提高抗病抗逆性，促进作物健康作用，提高作物产量。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅用以解释本发明，并不用于限定本发明，凡在本发明的精神和原则之内所做的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。
以下实施例所有配方中百分比均为重量百分比(折百)。本发明组合物各种制剂的加工工艺均为现有技术，根据不同情况可以有所变化。
一、剂型制备实施例
(一)悬浮剂的加工及实施例
将活性成分极细链格孢激活蛋白与噻苯隆，与分散剂、润湿剂、增稠剂和水等各组分按配方的比例混合均匀，经砂磨和/或高速剪切后，得到半成品，分析后补加水混合均匀过滤即得成品。
实施例1：2.025％噻苯隆·极细链格孢激活蛋白悬浮剂
噻苯隆2％，极细链格孢激活蛋白0.025％，十二烷基苯磺酸钠2％，丙二醇3％，硅藻土2％，硫酸铵1％，烷基酚聚氧乙烯醚2％,水补足至100％。
实施例2：6.6％噻苯隆·极细链格孢激活蛋白悬浮剂
噻苯隆6％，极细链格孢激活蛋白0.6％，脂肪酸聚乙二醇酯4％，乙二醇3％，高岭土2％，硅酸镁铝3％，甲基萘磺酸钠甲醛缩合物4％，水补足至100％。
实施例3：10.2％噻苯隆·极细链格孢激活蛋白悬浮剂
噻苯隆0.2％，极细链格孢激活蛋白10％，十二烷基硫酸钠8％，丙三醇4％，膨润土3％，硅酸镁铝4％，脂肪醇聚氧乙烯醚3％，水补足至100％。
实施例4：20.25％噻苯隆·极细链格孢激活蛋白悬浮剂
噻苯隆0.25％，极细链格孢激活蛋白20％，木质素萘磺酸钠盐6％，乙二醇4％，凹凸棒土4％，碳酸氢钠5％，拉开粉5％，水补足至100％。
(二)水分散粒剂的加工及实施例
将活性成分活性分组A与活性组分B，与助剂和填料按配方的比例混合均匀，经气流粉 碎成可湿性粉剂，再加入一定量的水混合挤压造粒，经干燥筛分后制得水分散粒剂产品。
实施例5：3.06％噻苯隆·极细链格孢激活蛋白水分散粒剂
噻苯隆3％，极细链格孢激活蛋白0.06％，硫酸铵2％，烷基磺酸盐3％，膨润土2％，高岭土补足至100％
实施例6:24％噻苯隆·极细链格孢激活蛋白水分散粒剂
噻苯隆12％，极细链格孢激活蛋白12％，硫酸铵6％，十二烷基硫酸钠5％，硅藻土5％，白炭黑补足至100％
实施例7:13％噻苯隆·极细链格孢激活蛋白水分散粒剂
噻苯隆0.5％，极细链格孢激活蛋白12.5％，碳氢酸钠5％，烷基苯磺酸钠4％，白炭黑5％，轻质碳酸钙补足至100％
(三)可湿性粉剂的加工及实施例
将活性成分噻苯隆与极细链格孢激活蛋白活性成分与各种助剂及填料等按比例充分混合，经超细粉碎机粉碎后制得可湿性粉剂。
实施例8:1.01％噻苯隆·极细链格孢激活蛋白可湿性粉剂
噻苯隆1％，极细链格孢激活蛋白0.01％，皂角粉2％，木质素磺酸钠3％，膨润土4％，白炭黑补足至100％。
实施例9:5.2％噻苯隆·极细链格孢激活蛋白可湿性粉剂
噻苯隆5％，极细链格孢激活蛋白0.2％，拉开粉BX4％，十二烷基硫酸钠3％，分子筛2％，高岭土补足至100％。
实施例10:11％噻苯隆·极细链格孢激活蛋白可湿性粉剂
噻苯隆1％，极细链格孢激活蛋白10％，磺酸钠4％，木质素磺酸钠5％，硅藻土4％，高岭土补足至100％。
实施例11:25.25％噻苯隆·极细链格孢激活蛋白可湿性粉剂
噻苯隆0.25％，极细链格孢激活蛋白25％，烷基苯磺酸钠8％，十二烷基硫酸钠4％，硅凝胶4％，轻质碳酸钠补足至100％。
二、药效验证试验
(一)生物测定实施例
1、噻苯隆与极细链格孢激活蛋白复配对水稻生长调节综合测定试验
将噻苯隆与极细链格孢激活蛋白用丙酮按照一定浓度稀释，对作物进行茎叶喷雾，在田间测定各个浓度对作物生长的影响，包括对作物的株高、穗数、结实率、抗病情况以及产量 情况等进行综合评价。
株高控制率＝(清水对照株高-处理后的株高)/清水对照株高*100％
穗数提高率＝(处理后的植株穗数-清水对照植株穗数)/清水对照植株穗数*100％
结实率＝每穗实粒数/穗总粒数*100％
预防效果＝(清水对照的发病指数-处理后的发病指数)/清水对照的发病指数*100％
亩产提高率＝(处理后的亩产量-清水对照的亩产量)/清水对照的亩产量*100％
表1.噻苯隆与极细链格孢激活蛋白复配对水稻生长调节综合测定汇总表
Figure PCTCN2017115838-appb-000001
注：表格中“噻”为“噻苯隆”的缩写,“极”为“极细链格孢激活蛋白”缩写。施药时期：扬花期，该阶段水稻植株未发生或开始发生稻曲病。施药次数：2次，施药间隔期7天；施药方式：茎叶喷雾；调查时期：水稻灌浆后期；本试验中，株高、穗数、发病指数、结实数等指标均为各处理的平均值。
通过实验发明人发现，噻苯隆与极细链格孢激活蛋白之间具有很好协同提升作用，噻苯隆与极细链格孢激活蛋白混配在不同配比下，相对噻苯隆、极细链格孢激活蛋白单剂，以及 清水对照，对玉米的生长调节作用明显，主要表现在：1、本发明可有效减少水稻的株高，提升植株上下营养传导能力，而且通过减少株高，可以提高水稻生长的抗倒伏性能；2、噻苯隆在作为单剂使用时对植物生长具有一定的抗病抗逆作用，而极细链格孢激活蛋白对作物病害具有一定免疫力，极细链格孢激活蛋白与噻苯隆之间共同施用具有良好的协同作用，从上表分析可以看出，噻苯隆与极细链格孢激活蛋白之间协同作用对水稻稻曲病的预防效果相对于单剂及清水对照，具有很好的预防效果；3、由于水稻生长前期噻苯隆与极细链格孢激活蛋白的协同作用，促进了水稻植株的营养传导、抗病抗逆，在水稻成熟期，对单位亩产有显著的提升作用，亩产提高率最高达到16.5％。
(二)田间药效验证试验
1、噻苯隆与极细链格孢激活蛋白混配对玉米作物调节生长及抗病增产的田间综合试验
施药时期：玉米喇叭期，玉米扬花期易发生大斑病等病害。
施药次数：2次，每次间隔7天。利用本发明的制剂实施例进行喷施，三个重复，结果取平均值。
表2 噻苯隆与极细链格孢激活蛋白混配对玉米调节生长的田间综合实验
Figure PCTCN2017115838-appb-000002
Figure PCTCN2017115838-appb-000003
注：表格中“噻”为“噻苯隆”的缩写,“极”为“极细链格孢激活蛋白”缩写。从表2实验数据显示，1、可以矮化玉米植株，有效控制玉米控旺徒长，提高玉米茎径促进营养传导，防止玉米倒伏；2、噻苯隆对玉米的生长具有一定的促进作用，而极细链格孢激活蛋白对玉米生长具有一定的抗病抗逆能力，两者混配后具有一定的协同增效作用；3、本发明的组合物对玉米的单位产量具有显著的提升作用，单位亩产量提高率可达16.6％。

Claims (10)

  1. 一种具有增效作用的农药组合物，其特征在于该组合物包含A和B两种活性组分，其中活性组分A为噻苯隆，活性组分B为极细链格孢激活蛋白，活性组分A和活性组分B的重量比为1:0.01～100。
  2. 根据权利要求1所述的组合物，其特征在于活性组分A和活性组分B的重量比为1：0.0125～80。
  3. 根据权利要求2所述的组合物，其特征在于活性组分A和活性组分B的重量比为1：0.02～50。
  4. 根据权利要求1所述的组合物，其特征在于该组合物由活性组分和农药助剂制成农药上允许的剂型。
  5. 根据权利要求4所述的组合物，其特征在于所述剂型为可湿性粉剂、水分散粒剂或悬浮剂。
  6. 根据权利要求4所述的组合物，其特征在于所述活性成分在组合物中的质量含量为0.2～80％。
  7. 根据权利要求4所述的组合物，其特征在于所述活性成分在组合物中的质量含量为0.5～50％。
  8. 根据权利要求4所述的组合物，其特征在于所述农药助剂选自载体、溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂、表面活性剂或肥料中的一种或几种。
  9. 权利要求1～8中任意一项所述的农药组合物在农业领域促进或调节植物生长中的用途。
  10. 根据权利要求9所述的用途，其特征在于所述的农药组合物作为植物生长调节剂在玉米、小麦或水稻上的应用。
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CN106962406A (zh) * 2016-11-10 2017-07-21 江苏辉丰农化股份有限公司 包含噻苯隆和极细链格孢激活蛋白的组合物

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CN113229293A (zh) * 2021-05-07 2021-08-10 河北中保绿农作物科技有限公司 一种杀菌组合物及其应用

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