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WO2018012595A1 - Pest repellent composition, and method for repelling pests - Google Patents

Pest repellent composition, and method for repelling pests Download PDF

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Publication number
WO2018012595A1
WO2018012595A1 PCT/JP2017/025574 JP2017025574W WO2018012595A1 WO 2018012595 A1 WO2018012595 A1 WO 2018012595A1 JP 2017025574 W JP2017025574 W JP 2017025574W WO 2018012595 A1 WO2018012595 A1 WO 2018012595A1
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WO
WIPO (PCT)
Prior art keywords
component
pest repellent
repellent composition
mass
group
Prior art date
Application number
PCT/JP2017/025574
Other languages
French (fr)
Japanese (ja)
Inventor
昇子 中嶋
耕平 松本
達也 亀澤
Original Assignee
ライオン株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ライオン株式会社 filed Critical ライオン株式会社
Priority to KR1020187026884A priority Critical patent/KR102387616B1/en
Priority to MYPI2018003014A priority patent/MY199207A/en
Priority to CN201780031755.XA priority patent/CN109310079A/en
Priority to JP2018527665A priority patent/JP6971983B2/en
Publication of WO2018012595A1 publication Critical patent/WO2018012595A1/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M29/00—Scaring or repelling devices, e.g. bird-scaring apparatus
    • A01M29/12—Scaring or repelling devices, e.g. bird-scaring apparatus using odoriferous substances, e.g. aromas, pheromones or chemical agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/24—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients to enhance the sticking of the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring

Definitions

  • the present invention relates to a pest repellent composition and a pest repellent method.
  • This application claims priority on July 15, 2016 based on Japanese Patent Application No. 2016-140794 for which it applied to Japan, and uses the content here.
  • Patent Document 1 proposes a pest repellent composition containing an antibacterial compound and a repellent active ingredient. According to the invention described in Patent Document 1, the repellent efficacy of the repellent active ingredient is enhanced by the antibacterial compound.
  • An object of the present invention is to provide a pest repellent composition having an excellent pest repellent effect and a pest repellent method using the same.
  • a pest repellent composition comprising (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component,
  • the component (A) is a repellent active ingredient
  • the component (B) is an antioxidant component
  • the component (C) is a chelating agent
  • the pest repellent composition wherein the component (D) is at least one polymer compound selected from the group consisting of polyvinyl pyrrolidone and a vinyl acetate / vinyl pyrrolidone copolymer.
  • a pest repellent composition having an excellent pest repellent effect and a pest repellent method using the same can be provided.
  • connection cage used in the Example.
  • the pest repellent composition of the present invention includes (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component.
  • the component (A) is a component having a pest repellent effect.
  • the component (A) is not particularly limited, and examples thereof include icaridin (1-methylpropyl 2- (2-hydroxyethyl) -1-piperidinecarboxylate), diet (N, N-diethyl-3-methylbenzamide), 3 -(Nn-butyl-N-acetyl) aminopropionic acid ethyl ester (IR3535), p-menthane-3,8-diol, lemon eucalyptus oil, citronella oil and the like.
  • icaridin is preferable in terms of skin feel and odor when applied to the skin.
  • a component may be used individually by 1 type and may be used in combination of 2 or more type.
  • the content of the component (A) is preferably 1 to 80% by mass, more preferably 5 to 30% by mass with respect to the total mass of the pest repellent composition.
  • it is preferably 1 to 30% by mass, more preferably 5 to 20% by mass, based on the total mass of the pest repellent composition.
  • it is preferably 5 to 50% by mass, more preferably 10 to 30% by mass, based on the total mass of the pest repellent composition.
  • antioxidant component is an antioxidant component and enhances the repellent effect.
  • Antioxidant components include sugars or sugar alcohols such as trehalose, xylitol, sorbitol, maltitol, xylose, mannitol; vitamins such as vitamin A, vitamin E, vitamin C and their derivatives; amino acids such as tyrosine, tryptophan, methionine, histidine And peptides. Among these, trehalose, sorbitol, and maltitol are preferable.
  • a component may be used individually by 1 type and may be used in combination of 2 or more type.
  • the content of the component (B) is preferably 0.1 to 10% by mass with respect to the total mass of the pest repellent composition, and 0.5 to 5%. More preferably, it is more preferably 1 to 3% by mass.
  • content of a component is below the said upper limit, there is no stickiness and a usability
  • the mass ratio represented by the component (A) / the component (B) (hereinafter also referred to as A / B ratio) is preferably 0.1 to 800. 0.1 to 100 is more preferable, and 0.5 to 30 is more preferable. If the A / B ratio is within the above range, the repellent effect is easily exhibited.
  • the component (C) is a chelating component and enhances the repellent effect.
  • an ethylenediamine acetic acid chelating agent, an organic acid chelating agent, and a phosphoric acid chelating agent are preferable.
  • the ethylenediamineacetic acid type chelating agent include ethylenediamineacetic acid derivatives or salts thereof.
  • edetic acid ethylenediaminetetraacetic acid, EDTA
  • EDDA ethylenediaminediacetic acid
  • DTPA diethylenetriaminepentaacetic acid
  • HEDTA N- (2-hydroxyethyl) ethylenediaminetriacetic acid
  • physiologically acceptable salt for example, sodium salt such as sodium ethylenediaminetetraacetate, potassium salt, magnesium salt, calcium salt, etc.
  • ethylenediaminetetraacetic acid or a salt thereof is preferable, and specific examples include disodium ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetic acid dihydrate (hereinafter also referred to as sodium edetate), and the like.
  • the organic acid type chelating agent include maleic acid, tartaric acid, citric acid, succinic acid, gluconic acid and the like, and may be used as a pharmacologically or physiologically acceptable salt.
  • the phosphoric acid chelating agent include phosphoric acid, sodium polyphosphate, metaphosphoric acid and the like, and may be used as a pharmacologically or physiologically acceptable salt. Of these, citric acid and sodium citrate are preferable.
  • a component may be used individually by 1 type and may be used in combination of 2 or more type.
  • the component (C) is a counter ion salt (monosodium salt, trisodium salt, tripotassium salt, etc.) or a hydrate (monohydrate etc.), the mass fluctuation becomes large. Therefore, in this application, it describes with the content converted into “anhydrate” (henceforth "acid conversion") in the state of the "acid” which is not neutralized.
  • the content of the component (C) is “acid conversion” and is 0.01 to 3% by mass with respect to the total mass of the pest repellent composition. Preferably, 0.05 to 2% by mass is more preferable. It is easy to suppress that (C) component precipitates or skin irritation arises as content of (C) component is below the above-mentioned upper limit. When it is at least the lower limit, the effect of component (C) can be easily obtained.
  • the content of citric acid or sodium citrate is “acid equivalent” and is 0.01 to about the total mass of the pest repellent composition. 3% by mass is preferred, 0.1-2% by mass is more preferred, and 0.2-1% by mass is even more preferred. It can suppress that citric acid or sodium citrate precipitates, and skin irritation arises that content of a citric acid or sodium citrate is below the said upper limit. When it is at least the above lower limit value, the repelling effect is easily exhibited.
  • the content of EDTA or a salt thereof is “acid conversion” and is 0.03 to 0.5 mass relative to the total mass of the pest repellent composition. % Is preferable, and 0.05 to 0.3% by mass is more preferable. It can suppress that EDTA or its salt precipitates, or skin irritation arises that EDTA or its salt is below the said upper limit. When it is at least the above lower limit value, the repelling effect is easily enhanced.
  • the component (C) is “acid-converted” and the mass ratio represented by the component (A) / component (C) (hereinafter referred to as A / C ratio). Is also preferably from 0.1 to 8000, more preferably from 1 to 1000, and even more preferably from 5 to 200. If the A / C ratio is within the above range, the repellent effect is easily exhibited.
  • the (C) component is “acid-converted” and the mass ratio represented by (B) component / (C) component (
  • the ratio (hereinafter also referred to as B / C ratio) is preferably 0.01 to 1000, more preferably 0.1 to 200, and further preferably 1 to 50. If the B / C ratio is within the above range, the repellent effect is easily exhibited.
  • ⁇ (D) component at least one polymer compound selected from the group consisting of polyvinylpyrrolidone and vinyl acetate / vinylpyrrolidone copolymer>
  • the component (D) include at least one polymer compound selected from the group consisting of polyvinyl pyrrolidone and vinyl acetate / vinyl pyrrolidone copolymers.
  • polyvinylpyrrolidone those having a weight average molecular weight of 8,000 to 3,000,000 can be used. Particularly, those having a weight average molecular weight of 2,000,000 or less are soluble, feel in use, and have a long-lasting deodorizing effect. Is preferable.
  • the weight average molecular weight is obtained by converting the K value defined in the United States Pharmacopeia USP into the weight average molecular weight measured by the light scattering method.
  • Rubiscol K17 weight average molecular weight: about 9,000
  • Rubiscol K30 weight average molecular weight: about 45,000
  • Rubiscol K90 weight average molecular weight: about 1,600,000
  • BASF BASF
  • PVPK-15 weight average molecular weight: 8,000
  • PVPK-30 weight average molecular weight: 60,000
  • PVPK-60 weight average molecular weight: 400,000
  • PVPK-90 weight average) Molecular weight: 1,300,000
  • PVPK-120 weight average molecular weight: 3,000,000
  • the copolymerization molar ratio (VP / VA) of vinyl pyrrolidone and vinyl acetate in the vinyl acetate / vinyl pyrrolidone copolymer is preferably in the range of 7/3 to 3/7.
  • those having a copolymerization molar ratio (VP / VA) of 7/3 or 6/4 are preferable from the viewpoints of solubility, feeling of use, and sustainability of the deodorizing effect.
  • Commercially available products include PVP / VA S-630 (VP / VA molar ratio 6/4), PVP / VA E-735 (VP / VA molar ratio 7/3), PVP / VA E-535 (VP / VA molar ratio).
  • a component may be used individually by 1 type and may be used in combination of 2 or more type.
  • the weight average molecular weight of the vinyl acetate / vinyl pyrrolidone copolymer is preferably 200 to 80,000, and more preferably 40,000 to 70,000.
  • the weight average molecular weight is obtained by converting the K value defined in the United States Pharmacopeia USP into the weight average molecular weight measured by the light scattering method.
  • the content of the component (D) is preferably 0.1 to 3% by mass with respect to the total mass of the pest repellent composition, 0.2 to 1 The mass% is more preferable.
  • the content of the component (D) is within the above range, the repellent effect is highly durable and there is no stickiness and the feeling of use is good.
  • the mass ratio represented by the component (A) / (D) component is preferably 0.1 to 800. 1 to 200 is more preferable, and 5 to 50 is more preferable. If the A / D ratio is within the above range, the repellent effect is easily exhibited.
  • the mass ratio represented by the component (B) / (D) component (hereinafter also referred to as B / D ratio) is 0. 0.01 to 200 is preferable, 1 to 100 is more preferable, and 1 to 30 is more preferable. If the B / D ratio is within the above range, the repellent effect is easily exhibited.
  • the (C) component is “acid-converted” and the mass ratio represented by (C) component / (D) component (
  • the C / D ratio is preferably 0.001 to 50, more preferably 0.005 to 30, and still more preferably 0.1 to 10. If the C / D ratio is within the above range, the repellent effect is easily exhibited.
  • the other components excluding the components (A) to (D) include, for example, an antibacterial compound (hereinafter also referred to as the (E) component), a surfactant (hereinafter also referred to as the (F) component), a solvent, and a moisturizing agent. And additives such as agents, thickeners, dyes, pH adjusters, fragrances, ultraviolet absorbers, and ultraviolet scattering agents.
  • the phenolic antibacterial component include isopropylmethylphenol (3-methyl-4-isopropylphenol), ortho-phenylphenol, and the like.
  • the quaternary ammonium salt antibacterial component include benzalkonium chloride and benzethonium chloride.
  • Examples of the biguanide antibacterial component include chlorhexidine hydrochloride and polyhexamethylene biguanide hydrochloride.
  • Organic nitrogen sulfur antibacterial components include 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 2-mercaptobenzothiazole, 2-n-octyl-4- Examples thereof include isothiazoline-3-one and 1,2-benzisothiazolin-3-one.
  • other component (E) include triclosan, diclosan, 2-bromo-2-nitropropane-1,3-diol, lichlorocarbanilide, piroctone olamine, and clara extract.
  • a phenolic antibacterial component and a quaternary ammonium salt antibacterial component are preferable, and isopropylmethylphenol and benzalkonium chloride are more preferable.
  • the antibacterial compound may be used alone or in combination of two or more, and it is preferable to use a phenolic antibacterial component and a quaternary ammonium salt antibacterial component in combination. More preferably, phenol and benzalkonium chloride are used in combination.
  • the content of the component (E) is preferably 0.001 to 1% by mass with respect to the total mass of the pest repellent composition, and 0.01 to 0 More preferable is 5% by mass. If content of (E) component exists in the said range, a repelling effect will be easy to be exhibited.
  • the mass ratio represented by the component (B) / (E) component (hereinafter also referred to as B / E ratio) is 0. 0.01 to 1000 is preferable, 1 to 500 is more preferable, and 5 to 200 is more preferable. If the B / E ratio is within the above range, the repellent effect is easily exhibited.
  • the (C) component is “acid-converted” and the mass ratio represented by (C) component / (E) component (
  • the C / E ratio is preferably 0.005 to 300, and more preferably 0.1 to 100.
  • the mass ratio represented by the component (D) / (E) component (hereinafter also referred to as D / E ratio) is 0. .05 to 100 is preferable, and 0.5 to 10 is preferable.
  • D / E ratio is within the above range, the repelling effect is easily exhibited.
  • anionic surfactants examples include fatty acid soap, alkylbenzene sulfonate, linear alkylbenzene sulfonate, alkyl sulfate, alpha olefin sulfonate, alkyl phosphate ester salt, polyoxyethylene alkyl ether sulfate, polyoxyethylene
  • examples thereof include alkyl ether carboxylates, polyoxyethylene alkyl phenyl ether sulfates, polyoxyethylene alkyl ether phosphates, alkyl sulfosuccinates, polyoxyethylene alkyl sulfosuccinates, and the like.
  • Nonionic surfactants include, for example, polyoxyalkylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene higher fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, Examples include coconut oil fatty acid diethanolamide, fatty acid alkanolamide, and amine oxide.
  • amphoteric surfactants include alkyl carbobetaines, alkylamide carbobetaines, alkylsulfobetaines, alkylhydroxysulfobetaines, alkylamide sulfobetaines, alkylamide hydroxysulfobetaines, and the like.
  • Nonionic surfactants are preferable from the viewpoint of irritation to the skin and stability improvement at low temperatures, and polyoxyethylene hydrogenated castor oil is more preferable.
  • the average oxyethylene group of the nonionic surfactant is preferably an addition product of 10 to 100 moles from the viewpoint of stability at low temperatures.
  • a component may be used individually by 1 type and may be used in combination of 2 or more type.
  • the content of the component (F) is preferably 0.1 to 10% by mass with respect to the total mass of the pest repellent composition, and 0.1 to 5%. More preferred is mass%.
  • the content of the component (F) is within the above range, stickiness due to the component (F) is suppressed, and stability at a low temperature is improved.
  • Solvents include alcohol solvents such as ethanol, hydrocarbon solvents such as n-paraffin and isoparaffin, glycols such as propylene glycol, 1,3-butylene glycol, dipropylene glycol and diethylene glycol monobutyl ether, glycol ethers, ketones
  • a system solvent, an ester system solvent, water, etc. can be mix
  • a solvent may be used individually by 1 type and may be used in combination of 2 or more type. Ethanol is preferred from the viewpoint of irritation to the skin, odor, feeling of use (easy to dry) and repellent effect.
  • the ethanol content is preferably 0 to 90% by mass with respect to the total mass of the pest repellent composition, and 30 to 50% by mass is a feeling of use (easy to dry). ), More preferable from the viewpoint of skin irritation. If the content of ethanol is within the above range, the repellent effect is easily exhibited.
  • the pest repellent composition of the present invention can be appropriately mixed with water.
  • the thickener (excluding the component (D)) is not particularly limited as long as it is used in cosmetics, quasi-drugs and pharmaceuticals, natural water-soluble polymers, semi-synthetic water-soluble polymers, Examples include synthetic water-soluble polymers and inorganic water-soluble polymers.
  • natural water-soluble polymers include plant polymers such as gum arabic, gum tragacanth, galactan, guar gum, xanthan gum, carob gum, locust bean gum, caraya gum, carrageenan, pectin, agar, quince seed, alge colloid, starch, and dextran.
  • microbial polymers such as dextrin, succinoglucan and pullulan
  • animal polymers such as collagen, casein, albumin and gelatin.
  • semi-synthetic water-soluble polymers include starch polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxy Examples thereof include cellulose polymers such as sodium methylcellulose (CMC), crystalline cellulose and cellulose powder, and alginic acid polymers such as sodium alginate and propylene glycol alginate.
  • CMC sodium methylcellulose
  • crystalline cellulose and cellulose powder alginic acid polymers
  • Examples of the synthetic water-soluble polymer include vinyl polymers such as polyvinyl alcohol, polyvinyl methyl ether, and carboxyvinyl polymer (carbomer), polyoxyethylene polymers such as polyethylene glycol (molecular weight 1500, 4000, 6000, etc.), Examples thereof include polyoxyethylene polyoxypropylene copolymer polymers, acrylic polymers such as sodium polyacrylate and polyethyl acrylate, polyethyleneimine, and cationic polymers.
  • Examples of the inorganic water-soluble polymer include bentonite, AlMg silicate, laponite, hectorite, and silicic anhydride.
  • a thickener may be used individually by 1 type and may be used in combination of 2 or more type.
  • Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute Natural fragrance ingredients such as peppermint, absoluteton rose and orange flower; processed fragrance ingredients of these natural fragrance ingredients; menthol, carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 2-diol, pinene, Chi le aldehyde, citral, pulegone, Cal beer acetate, separately perfume ingredients such as anisalde
  • flavor may be used individually by 1 type and may be used in combination of 2 or more type.
  • the total content of the component (A) and at least one component selected from the group consisting of the component (B), the component (C), and the component (D) is 100. Does not exceed mass%.
  • the pH at 25 ° C. of the pest repellent composition of the present invention is preferably from 3 to 9, more preferably from 5 to 8, from the viewpoint of repellent effect and low irritation to the skin.
  • the pH can be measured by a usual method using a pH meter (manufactured by Toa Denpa Kogyo Co., Ltd., HM-30G).
  • the pest repellent composition of the present invention comprises (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component,
  • the component is at least one selected from the group consisting of icaridin and diet, and the component (B) is at least one selected from the group consisting of trehalose, sorbitol, and maltitol, and the component (C) is It is at least one selected from the group consisting of citric acid and sodium citrate, and the component (D) is at least one selected from the group consisting of polyvinyl pyrrolidone and vinyl acetate / vinyl pyrrolidone copolymer. Is preferred.
  • the pest repellent composition of the present invention comprises (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component,
  • the component is at least one selected from the group consisting of icaridin and diet, and the component (B) is at least one selected from the group consisting of trehalose, sorbitol, and maltitol, and the component (C) is It is at least one selected from the group consisting of citric acid and sodium citrate, and the component (D) is at least one selected from the group consisting of polyvinyl pyrrolidone and vinyl acetate / vinyl pyrrolidone copolymer,
  • the content of the component (A) is 1 to 80% by mass with respect to the total mass of the pest repellent composition, and the content of the component (B) is 0.1 to 10% by mass,
  • Serial and (C) content is "acid conversion" components is from 0.01 to 3 wt%, the content of component (D) is
  • the pest repellent composition of the present invention comprises (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component,
  • the component is at least one selected from the group consisting of icaridin and diet, the component (B) is trehalose, and the component (C) is at least one selected from the group consisting of citric acid and sodium citrate.
  • the component (D) is a vinyl acetate / vinyl pyrrolidone copolymer.
  • the pest repellent composition of the present invention comprises (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component,
  • the component is at least one selected from the group consisting of icaridin and diet, the component (B) is trehalose, and the component (C) is at least one selected from the group consisting of citric acid and sodium citrate.
  • the component (D) is a vinyl acetate / vinyl pyrrolidone copolymer, and the content of the component (A) is 1 to 80% by mass relative to the total mass of the pest repellent composition, B) content of component is 0.1 to 10% by mass, content of said (C) component is 0.01 to 3% by mass in terms of “acid conversion”, content of said (D) component The amount is preferably 0.1 to 3% by mass.
  • the pest repellent composition of the present invention comprises (A) component, at least one component selected from the group consisting of (B) component, (C) component, and (D) component, and (E) component.
  • the component (A) is at least one selected from the group consisting of icaridin and diet, the component (B) is trehalose, and the component (C) is from the group consisting of citric acid and sodium citrate.
  • the pest repellent composition of the present invention comprises (A) component, at least one component selected from the group consisting of (B) component, (C) component, and (D) component, and (E) component.
  • the component (A) is at least one selected from the group consisting of icaridin and diet, the component (B) is trehalose, and the component (C) is from the group consisting of citric acid and sodium citrate.
  • the amount of the component (A) is 1 to 80% by mass and the content of the component (B) is 0.1 to 10% by mass with respect to the total mass of the pest repellent composition.
  • the content of the component (C) is 0.01 to 3% by mass in terms of acid
  • the content of the component (D) is 0.1 to 3% by mass
  • the component (E) The content is preferably 0.001 to 1% by mass.
  • the method for preparing the pest repellent composition of the present invention includes a method of mixing the component (A) with at least one selected from the group consisting of the component (B), the component (C), and the component (D). It is done. Further, a method of dissolving in a solvent at least one selected from the group consisting of the component (A), the component (B), the component (C), and the component (D) and, if necessary, other components Is mentioned.
  • the pest repellent composition of the present invention can be used in a dosage form such as an emulsion, cream, gel, or spray (solution).
  • a dosage form such as an emulsion, cream, gel, or spray (solution).
  • the content of the pest repellent composition of the present invention in an emulsion, cream or gel is preferably 1 to 100% by mass with respect to the total mass of the emulsion, cream or gel.
  • the content of the pest repellent composition of the present invention in the solution is preferably 1 to 100% by mass relative to the total mass of the solution.
  • the pest repellent composition of the present invention exerts a repellent effect on pests when applied to the skin, for example.
  • the method of using the pest repellent composition of the present invention includes a step of attaching an effective amount of the pest repellent composition of the present invention to the skin or clothing of a subject in need of pest repellent.
  • effective amount and is preferably 0.1 ⁇ 10mg / cm 2, more preferably 0.5 ⁇ 5mg / cm 2.
  • subjects that need to avoid pests include humans and animals.
  • the attaching method include coating and spraying.
  • the pests to be repelled by the pest repellent composition of the present invention include mosquitoes, gnats, sand flies, house dust mites, bed bugs, ticks, and tsutsugamushi. Of these, mosquitoes are preferred.
  • Repellency rate (%) ⁇ 1 ⁇ (number of entries at application ⁇ number of correction entries) / (number of entries without application ⁇ number of correction entries) ⁇ ⁇ 100
  • the number of corrected entries is the number of mosquito entries under the condition that the arm is not inserted. When the number of entries became negative after correction, it was evaluated as 0. (Evaluation criteria)
  • ⁇ : Repelling rate is 50% or more and less than 70.
  • X Repelling rate is less than 50%.
  • Table 3 shows formulation examples of the pest repellent composition of the present invention other than Examples 1 to 8.
  • a pest repellent composition having an excellent pest repellent effect and a pest repellent method using the same can be provided.

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Abstract

A pest repellent composition comprising a component (A) and at last one component selected from the group consisting of components (B), (C) and (D), wherein the component (A) is a component capable of repelling effectively, the component (B) is an antioxidant component, the component (C) is a chelating agent, and the component (D) is at least one polymeric compound selected from the group consisting of polyvinyl pyrrolidone and (vinyl acetate)-(vinyl pyrrolidone) copolymer.

Description

害虫忌避組成物、及び害虫忌避方法Pest repellent composition and pest repellent method
　本発明は、害虫忌避組成物、及び害虫忌避方法に関する。
　本願は、２０１６年７月１５日に、日本に出願された特願２０１６－１４０７９４号に基づき優先権を主張し、その内容をここに援用する。 The present invention relates to a pest repellent composition and a pest repellent method.
This application claims priority on July 15, 2016 based on Japanese Patent Application No. 2016-140794 for which it applied to Japan, and uses the content here.
　従来、蚊等の害虫に対する忌避剤を肌に適用することで、害虫を忌避することが行われている。
　特許文献１には、抗菌性化合物、忌避有効成分を含む害虫忌避組成物について提案されている。特許文献１に記載された発明によれば、抗菌性化合物によって忌避有効成分の忌避効力の増強が図られている。 Conventionally, repellents against insects such as mosquitoes are applied to the skin to repel them.
Patent Document 1 proposes a pest repellent composition containing an antibacterial compound and a repellent active ingredient. According to the invention described in Patent Document 1, the repellent efficacy of the repellent active ingredient is enhanced by the antibacterial compound.
特開２０１６－１０２０９２号公報JP 2016-102092 A
　しかしながら、２０１４年に「デング熱」が発生するなど、国内で蚊媒介性感染症への感染リスクが高まっており、害虫忌避組成物には、害虫忌避効果のさらなる向上が求められている。また、害虫忌避組成物を使用する夏場においては、発汗などにより皮膚に適用した忌避組成物が落ちやすく、害虫忌避効果や害虫忌避持続効果が十分でない。
　本発明は、害虫忌避効果に優れた害虫忌避組成物、及びこれを用いた害虫忌避方法を目的とする。 However, the risk of infection with mosquito-borne infections has increased in Japan, such as the occurrence of “dengue fever” in 2014, and pest repellent compositions are required to further improve the pest repellent effect. Moreover, in the summertime when a pest repellent composition is used, the repellent composition applied to the skin is likely to fall due to sweating and the pest repellent effect and pest repellent sustaining effect are not sufficient.
An object of the present invention is to provide a pest repellent composition having an excellent pest repellent effect and a pest repellent method using the same.
　本発明は、以下の態様を有する。
［１］（Ａ）成分と、（Ｂ）成分、（Ｃ）成分、及び（Ｄ）成分からなる群から選択される少なくとも１種の成分とを含む害虫忌避組成物であって、
　前記（Ａ）成分が忌避有効成分であり、
　前記（Ｂ）成分が抗酸化成分であり、
　前記（Ｃ）成分がキレート剤であり、
　前記（Ｄ）成分がポリビニルピロリドン、及び酢酸ビニル・ビニルピロリドン共重合体からなる群から選択される少なくとも１種の高分子化合物である、害虫忌避組成物。
［２］前記（Ａ）成分がイカリジンである［１］に記載の害虫忌避組成物。
［３］前記（Ｂ）成分、及び前記（Ｃ）成分を含む［１］又は［２］に記載の害虫忌避組成物。
［４］前記（Ｂ）成分、前記（Ｃ）成分、及び前記（Ｄ）成分を含む［１］又は［２］に記載の害虫忌避組成物。
［５］さらに、（Ｅ）成分：抗菌性化合物を含む［１］～［４］のいずれか一項に記載の害虫忌避組成物。
［６］［１］～［５］のいずれか一項に記載の害虫忌避組成物を用いることを特徴とする害虫忌避方法。 The present invention has the following aspects.
[1] A pest repellent composition comprising (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component,
The component (A) is a repellent active ingredient,
The component (B) is an antioxidant component,
The component (C) is a chelating agent,
The pest repellent composition, wherein the component (D) is at least one polymer compound selected from the group consisting of polyvinyl pyrrolidone and a vinyl acetate / vinyl pyrrolidone copolymer.
[2] The pest repellent composition according to [1], wherein the component (A) is icaridin.
[3] The pest repellent composition according to [1] or [2], comprising the component (B) and the component (C).
[4] The pest repellent composition according to [1] or [2], comprising the component (B), the component (C), and the component (D).
[5] The pest repellent composition according to any one of [1] to [4], further comprising (E) component: an antibacterial compound.
[6] A pest repellent method comprising using the pest repellent composition according to any one of [1] to [5].
　本発明によれば、害虫忌避効果に優れた害虫忌避組成物、及びこれを用いた害虫忌避方法を提供できる。 According to the present invention, a pest repellent composition having an excellent pest repellent effect and a pest repellent method using the same can be provided.
実施例において使用した連結ケージの斜視図である。It is a perspective view of the connection cage used in the Example.
≪害虫忌避組成物≫
　本発明の害虫忌避組成物は、（Ａ）成分と、（Ｂ）成分、（Ｃ）成分、及び（Ｄ）成分からなる群から選択される少なくとも１種の成分とを含む。 ≪Pest repellent composition≫
The pest repellent composition of the present invention includes (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component.
＜（Ａ）成分：忌避有効成分＞
　（Ａ）成分は、害虫の忌避効果を有する成分である。
　（Ａ）成分としては、特に限定されず、例えばイカリジン（１－メチルプロピル　２－（２－ヒドロキシエチル）－１－ピペリジンカルボキシレート）、ディート（Ｎ，Ｎ－ジエチル－３－メチルベンズアミド）、３－（Ｎ－ｎ－ブチル－Ｎ－アセチル）アミノプロピオン酸エチルエステル（ＩＲ３５３５）、ｐ－メンタン－３，８－ジオール、レモンユーカリオイル、シトロネラ油等が挙げられる。これらの中でも、肌へ塗布した際のスキンフィール性やにおいの点で、イカリジンが好ましい。
　（Ａ）成分は、１種単独で用いられてもよいし、２種以上が組み合わされて用いられてもよい。 <(A) component: repellent active ingredient>
The component (A) is a component having a pest repellent effect.
The component (A) is not particularly limited, and examples thereof include icaridin (1-methylpropyl 2- (2-hydroxyethyl) -1-piperidinecarboxylate), diet (N, N-diethyl-3-methylbenzamide), 3 -(Nn-butyl-N-acetyl) aminopropionic acid ethyl ester (IR3535), p-menthane-3,8-diol, lemon eucalyptus oil, citronella oil and the like. Among these, icaridin is preferable in terms of skin feel and odor when applied to the skin.
(A) A component may be used individually by 1 type and may be used in combination of 2 or more type.
　（Ａ）成分の含有量は、害虫忌避組成物の総質量に対して１～８０質量％が好ましく、５～３０質量％がさらに好ましい。特にイカリジンの場合は害虫忌避組成物の総質量に対して１～３０質量％が好ましく、５～２０質量％がより好ましい。ディートの場合は害虫忌避組成物の総質量に対して５～５０質量％が好ましく、１０～３０質量％がより好ましい。（Ａ）成分の含有量が上記上限値以下であると、べたつきがなく使用感が良好である。上記下限値以上であると、忌避効果が発揮されやすい。 The content of the component (A) is preferably 1 to 80% by mass, more preferably 5 to 30% by mass with respect to the total mass of the pest repellent composition. In particular, in the case of icaridin, it is preferably 1 to 30% by mass, more preferably 5 to 20% by mass, based on the total mass of the pest repellent composition. In the case of a diet, it is preferably 5 to 50% by mass, more preferably 10 to 30% by mass, based on the total mass of the pest repellent composition. When the content of the component (A) is less than or equal to the above upper limit, there is no stickiness and the usability is good. When it is at least the above lower limit value, the repelling effect is easily exhibited.
＜（Ｂ）成分：抗酸化成分＞
　（Ｂ）成分は、抗酸化作用のある成分であり、忌避効果を増強する。
　抗酸化成分としては、トレハロース、キシリトール、ソルビトール、マルチトール、キシロース、マンニトール等の糖または糖アルコール；ビタミンＡ、ビタミンＥ、ビタミンＣ等のビタミン及びその誘導体；チロシン、トリプトファン、メチオニン、ヒスチジン等のアミノ酸及びペプチド等が挙げられる。これらの中でも、トレハロース、ソルビトール、マルチトールが好ましい。
　（Ｂ）成分は、１種単独で用いられてもよいし、２種以上が組み合わされて用いられてもよい。 <(B) component: antioxidant component>
Component (B) is an antioxidant component and enhances the repellent effect.
Antioxidant components include sugars or sugar alcohols such as trehalose, xylitol, sorbitol, maltitol, xylose, mannitol; vitamins such as vitamin A, vitamin E, vitamin C and their derivatives; amino acids such as tyrosine, tryptophan, methionine, histidine And peptides. Among these, trehalose, sorbitol, and maltitol are preferable.
(B) A component may be used individually by 1 type and may be used in combination of 2 or more type.
　本発明の害虫忌避組成物が（Ｂ）成分を含む場合、（Ｂ）成分の含有量は、害虫忌避組成物の総質量に対して０．１～１０質量％が好ましく、０．５～５質量％がより好ましく、１～３質量％がさらに好ましい。（Ｂ）成分の含有量が上記上限値以下であると、べたつきがなく使用感が良好である。上記下限値以上であると、（Ｂ）成分の効果が得られやすい。 When the pest repellent composition of the present invention contains the component (B), the content of the component (B) is preferably 0.1 to 10% by mass with respect to the total mass of the pest repellent composition, and 0.5 to 5%. More preferably, it is more preferably 1 to 3% by mass. (B) When content of a component is below the said upper limit, there is no stickiness and a usability | use_condition is favorable. When it is at least the lower limit, the effect of component (B) can be easily obtained.
　本発明の害虫忌避組成物が（Ｂ）成分を含む場合、（Ａ）成分／（Ｂ）成分で表される質量比（以下、Ａ／Ｂ比ともいう）は、０．１～８００が好ましく、０．１～１００がより好ましく、０．５～３０がさらに好ましい。Ａ／Ｂ比が上記範囲内であれば、忌避効果が発揮されやすい。 When the pest repellent composition of the present invention contains the component (B), the mass ratio represented by the component (A) / the component (B) (hereinafter also referred to as A / B ratio) is preferably 0.1 to 800. 0.1 to 100 is more preferable, and 0.5 to 30 is more preferable. If the A / B ratio is within the above range, the repellent effect is easily exhibited.
＜（Ｃ）成分：キレート剤＞
　（Ｃ）成分は、キレート作用のある成分であり、忌避効果を増強する。
　（Ｃ）成分としては、エチレンジアミン酢酸型キレート剤、有機酸型キレート剤、リン酸型キレート剤が好ましい。エチレンジアミン酢酸型キレート剤としてはエチレンジアミン酢酸誘導体又はその塩が挙げられる。例えば、エデト酸（エチレンジアミン四酢酸，ＥＤＴＡ）、エチレンジアミン二酢酸（ＥＤＤＡ）、ジエチレントリアミン五酢酸（ＤＴＰＡ）、Ｎ－（２－ヒドロキシエチル）エチレンジアミン三酢酸（ＨＥＤＴＡ）等が挙げられ、薬理学的に又は生理学的に許容される塩（例えば、エチレンジアミン四酢酸ナトリウム等のナトリウム塩、カリウム塩、マグネシウム塩、カルシウム塩等）として使用してもよい。なかでも、エチレンジアミン四酢酸又はその塩が好ましく、具体的には、エチレンジアミン四酢酸二ナトリウム、エチレンジアミン四酢酸二ナトリウム・二水和物（以下、エデト酸ナトリウムともいう。）等が挙げられる。有機酸型キレート剤としては、マレイン酸、酒石酸、クエン酸、コハク酸、グルコン酸等が挙げられ、薬理学的に又は生理学的に許容される塩として使用してもよい。リン酸型キレート剤としては、リン酸、ポリリン酸ナトリウム、メタリン酸等が挙げられ、薬理学的に又は生理学的に許容される塩として使用しても良い。なかでもクエン酸、クエン酸ナトリウムが好ましい。
　（Ｃ）成分は、１種単独で用いられてもよいし、２種以上が組み合わされて用いられてもよい。 <(C) component: chelating agent>
The component (C) is a chelating component and enhances the repellent effect.
As the component (C), an ethylenediamine acetic acid chelating agent, an organic acid chelating agent, and a phosphoric acid chelating agent are preferable. Examples of the ethylenediamineacetic acid type chelating agent include ethylenediamineacetic acid derivatives or salts thereof. Examples include edetic acid (ethylenediaminetetraacetic acid, EDTA), ethylenediaminediacetic acid (EDDA), diethylenetriaminepentaacetic acid (DTPA), N- (2-hydroxyethyl) ethylenediaminetriacetic acid (HEDTA), and the like pharmacologically or It may be used as a physiologically acceptable salt (for example, sodium salt such as sodium ethylenediaminetetraacetate, potassium salt, magnesium salt, calcium salt, etc.). Of these, ethylenediaminetetraacetic acid or a salt thereof is preferable, and specific examples include disodium ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetic acid dihydrate (hereinafter also referred to as sodium edetate), and the like. Examples of the organic acid type chelating agent include maleic acid, tartaric acid, citric acid, succinic acid, gluconic acid and the like, and may be used as a pharmacologically or physiologically acceptable salt. Examples of the phosphoric acid chelating agent include phosphoric acid, sodium polyphosphate, metaphosphoric acid and the like, and may be used as a pharmacologically or physiologically acceptable salt. Of these, citric acid and sodium citrate are preferable.
(C) A component may be used individually by 1 type and may be used in combination of 2 or more type.
　（Ｃ）成分が対イオン（一ナトリウム塩、三ナトリウム塩、三カリウム塩等）の塩あるいは水和物(一水和物等)となる場合、質量変動が大きくなる。そのため、本願では、中和されていない「酸」の状態で且つ、「無水和物」に換算（以下、「酸換算」ともいう）した含有量で記載する。
　本発明の害虫忌避組成物が（Ｃ）成分を含む場合、（Ｃ）成分の含有量は、「酸換算」して、害虫忌避組成物の総質量に対して０．０１～３質量％が好ましく、０．０５～２質量％がより好ましい。（Ｃ）成分の含有量が上記上限値以下であると、（Ｃ）成分が析出したり皮膚刺激が生じることを抑制しやすい。上記下限値以上であると、（Ｃ）成分の効果が得られやすい。 When the component (C) is a counter ion salt (monosodium salt, trisodium salt, tripotassium salt, etc.) or a hydrate (monohydrate etc.), the mass fluctuation becomes large. Therefore, in this application, it describes with the content converted into "anhydrate" (henceforth "acid conversion") in the state of the "acid" which is not neutralized.
When the pest repellent composition of the present invention contains the component (C), the content of the component (C) is “acid conversion” and is 0.01 to 3% by mass with respect to the total mass of the pest repellent composition. Preferably, 0.05 to 2% by mass is more preferable. It is easy to suppress that (C) component precipitates or skin irritation arises as content of (C) component is below the above-mentioned upper limit. When it is at least the lower limit, the effect of component (C) can be easily obtained.
　本発明の害虫忌避組成物がクエン酸又はクエン酸ナトリウムを含む場合、クエン酸又はクエン酸ナトリウムの含有量は、「酸換算」して、害虫忌避組成物の総質量に対して０．０１～３質量％が好ましく、０．１～２質量％がより好ましく、０．２～１質量％がさらに好ましい。クエン酸又はクエン酸ナトリウムの含有量が上記上限値以下であると、クエン酸又はクエン酸ナトリウムが析出したり、皮膚刺激が生じることを抑制できる。上記下限値以上であると、忌避効果が発揮されやすい。
　本発明の害虫忌避組成物がＥＤＴＡ又はその塩を含む場合、ＥＤＴＡ又はその塩の含有量は、「酸換算」して、害虫忌避組成物の総質量に対して０．０３～０．５質量％が好ましく、０．０５～０．３質量％がより好ましい。ＥＤＴＡ又はその塩が上記上限値以下であると、ＥＤＴＡ又はその塩が析出したり、皮膚刺激が生じることを抑制できる。上記下限値以上であると、忌避効果が増強されやすい。 When the pest repellent composition of the present invention contains citric acid or sodium citrate, the content of citric acid or sodium citrate is “acid equivalent” and is 0.01 to about the total mass of the pest repellent composition. 3% by mass is preferred, 0.1-2% by mass is more preferred, and 0.2-1% by mass is even more preferred. It can suppress that citric acid or sodium citrate precipitates, and skin irritation arises that content of a citric acid or sodium citrate is below the said upper limit. When it is at least the above lower limit value, the repelling effect is easily exhibited.
When the pest repellent composition of the present invention contains EDTA or a salt thereof, the content of EDTA or a salt thereof is “acid conversion” and is 0.03 to 0.5 mass relative to the total mass of the pest repellent composition. % Is preferable, and 0.05 to 0.3% by mass is more preferable. It can suppress that EDTA or its salt precipitates, or skin irritation arises that EDTA or its salt is below the said upper limit. When it is at least the above lower limit value, the repelling effect is easily enhanced.
　本発明の害虫忌避組成物が（Ｃ）成分を含む場合、（Ｃ）成分を「酸換算」して、（Ａ）成分／（Ｃ）成分で表される質量比（以下、Ａ／Ｃ比ともいう）は、０．１～８０００が好ましく、１～１０００がより好ましく、さらに５～２００が好ましい。Ａ／Ｃ比が上記範囲内であれば、忌避効果が発揮されやすい。 When the pest repellent composition of the present invention contains the component (C), the component (C) is “acid-converted” and the mass ratio represented by the component (A) / component (C) (hereinafter referred to as A / C ratio). Is also preferably from 0.1 to 8000, more preferably from 1 to 1000, and even more preferably from 5 to 200. If the A / C ratio is within the above range, the repellent effect is easily exhibited.
　本発明の害虫忌避組成物が（Ｂ）成分、及び（Ｃ）成分を含む場合、（Ｃ）成分を「酸換算」して、（Ｂ）成分／（Ｃ）成分で表される質量比（以下、Ｂ／Ｃ比ともいう）は、０．０１～１０００が好ましく、０．１～２００がより好ましく、さらに１～５０が好ましい。Ｂ／Ｃ比が上記範囲内であれば、忌避効果が発揮されやすい。 When the pest repellent composition of the present invention includes the component (B) and the component (C), the (C) component is “acid-converted” and the mass ratio represented by (B) component / (C) component ( The ratio (hereinafter also referred to as B / C ratio) is preferably 0.01 to 1000, more preferably 0.1 to 200, and further preferably 1 to 50. If the B / C ratio is within the above range, the repellent effect is easily exhibited.
＜（Ｄ）成分：ポリビニルピロリドン、及び酢酸ビニル・ビニルピロリドン共重合体からなる群から選択される少なくとも１種の高分子化合物＞
　（Ｄ）成分としては、ポリビニルピロリドン、及び酢酸ビニル・ビニルピロリドン共重合体からなる群から選択される少なくとも１種の高分子化合物が挙げられる。（Ｄ）成分を配合することで忌避効果の持続性を向上させることができる。 <(D) component: at least one polymer compound selected from the group consisting of polyvinylpyrrolidone and vinyl acetate / vinylpyrrolidone copolymer>
Examples of the component (D) include at least one polymer compound selected from the group consisting of polyvinyl pyrrolidone and vinyl acetate / vinyl pyrrolidone copolymers. By blending the component (D), the sustainability of the repellent effect can be improved.
　ポリビニルピロリドンとしては、重量平均分子量が８，０００～３，０００，０００のものを使用でき、特に重量平均分子量２，０００，０００以下のものが溶解性、使用感触、防臭効果の持続性の点で好ましい。なお、重量平均分子量は、米国薬局方ＵＳＰにおいて規定されたＫ値を光散乱法により測定された重量平均分子量に換算したものである。
　市販品では、ルビスコールＫ１７（重量平均分子量：約９，０００）、ルビスコールＫ３０（重量平均分子量：約４５，０００）、ルビスコールＫ９０（重量平均分子量：約１，６００，０００）（以上、ＢＡＳＦ社製）、ＰＶＰＫ－１５（重量平均分子量：８，０００）、ＰＶＰＫ－３０（重量平均分子量：６０，０００）、ＰＶＰＫ－６０（重量平均分子量：４００，０００）、ＰＶＰＫ－９０（重量平均分子量：１，３００，０００）、ＰＶＰＫ－１２０（重量平均分子量：３，０００，０００）（以上、ＩＳＰ社製）で、好ましくは、防臭効果の持続性の点から、ルビスコールＫ３０（重量平均分子量：約４５，０００）、ルビスコールＫ９０（重量平均分子量：約１，６００，０００）である。 As the polyvinylpyrrolidone, those having a weight average molecular weight of 8,000 to 3,000,000 can be used. Particularly, those having a weight average molecular weight of 2,000,000 or less are soluble, feel in use, and have a long-lasting deodorizing effect. Is preferable. The weight average molecular weight is obtained by converting the K value defined in the United States Pharmacopeia USP into the weight average molecular weight measured by the light scattering method.
Commercially available products include Rubiscol K17 (weight average molecular weight: about 9,000), Rubiscol K30 (weight average molecular weight: about 45,000), Rubiscol K90 (weight average molecular weight: about 1,600,000) (above, BASF), PVPK-15 (weight average molecular weight: 8,000), PVPK-30 (weight average molecular weight: 60,000), PVPK-60 (weight average molecular weight: 400,000), PVPK-90 (weight average) Molecular weight: 1,300,000), PVPK-120 (weight average molecular weight: 3,000,000) (above, manufactured by ISP), preferably from the viewpoint of durability of deodorizing effect, Rubiscor K30 (weight average) Molecular weight: about 45,000) and rubiscol K90 (weight average molecular weight: about 1,600,000).
　また、酢酸ビニル・ビニルピロリドン共重合体のビニルピロリドンと酢酸ビニルの共重合モル比（ＶＰ／ＶＡ）は７／３～３／７の範囲が好適である。このうち、共重合モル比（ＶＰ／ＶＡ）が７／３又は６／４のものが、溶解性、使用感触、防臭効果の持続性の点で好ましい。市販品では、ＰＶＰ／ＶＡ　Ｓ‐６３０（ＶＰ／ＶＡモル比６／４）、ＰＶＰ／ＶＡ　Ｅ－７３５（ＶＰ／ＶＡモル比７／３）、ＰＶＰ／ＶＡ　Ｅ－５３５（ＶＰ／ＶＡモル比５／５）、ＰＶＰ／ＶＡ　Ｅ－３３５（ＶＰ／ＶＡモル比３／７）（以上、ＩＳＰ社製）、ルビスコールＶＡ３７Ｅ（ＶＰ／ＶＡモル比３／７）、ルビスコールＶＡ５５Ｉ（ＶＰ／ＶＡモル比５／５）、ルビスコールＶＡ６４Ｐ（ＶＰ／ＶＡモル比６／４）、ルビスコールＶＡ７３Ｗ（ＶＰ／ＶＡモル比７／３）（以上、ＢＡＳＦ社製）などがあげられ、中でも、ＰＶＰ／ＶＡ　Ｓ－６３０、ＰＶＰ／ＶＡ　Ｅ－７３５が好ましい。
　（Ｄ）成分は、１種単独で用いられてもよいし、２種以上が組み合わされて用いられてもよい。 The copolymerization molar ratio (VP / VA) of vinyl pyrrolidone and vinyl acetate in the vinyl acetate / vinyl pyrrolidone copolymer is preferably in the range of 7/3 to 3/7. Among these, those having a copolymerization molar ratio (VP / VA) of 7/3 or 6/4 are preferable from the viewpoints of solubility, feeling of use, and sustainability of the deodorizing effect. Commercially available products include PVP / VA S-630 (VP / VA molar ratio 6/4), PVP / VA E-735 (VP / VA molar ratio 7/3), PVP / VA E-535 (VP / VA molar ratio). 5/5), PVP / VA E-335 (VP / VA molar ratio 3/7) (manufactured by ISP), Rubiscol VA37E (VP / VA molar ratio 3/7), Rubiscol VA55I (VP / VA) Mole ratio 5/5), Rubiscol VA64P (VP / VA mole ratio 6/4), Rubiscol VA73W (VP / VA mole ratio 7/3) (above, manufactured by BASF), etc. VA S-630 and PVP / VA E-735 are preferred.
(D) A component may be used individually by 1 type and may be used in combination of 2 or more type.
　酢酸ビニル・ビニルピロリドン共重合体の重量平均分子量は、２００～８０，０００が好ましく、４０，０００～７０，０００がより好ましい。なお、重量平均分子量は、米国薬局方ＵＳＰにおいて規定されたＫ値を光散乱法により測定された重量平均分子量に換算したものである。 The weight average molecular weight of the vinyl acetate / vinyl pyrrolidone copolymer is preferably 200 to 80,000, and more preferably 40,000 to 70,000. The weight average molecular weight is obtained by converting the K value defined in the United States Pharmacopeia USP into the weight average molecular weight measured by the light scattering method.
　本発明の害虫忌避組成物が（Ｄ）成分を含む場合、（Ｄ）成分の含有量は、害虫忌避組成物の総質量に対して０．１～３質量％が好ましく、０．２～１質量％がより好ましい。
　（Ｄ）成分の含有量が上記範囲内であれば、忌避効果の持続性が高く、べたつきがなく使用感が良好である。 When the pest repellent composition of the present invention contains the component (D), the content of the component (D) is preferably 0.1 to 3% by mass with respect to the total mass of the pest repellent composition, 0.2 to 1 The mass% is more preferable.
When the content of the component (D) is within the above range, the repellent effect is highly durable and there is no stickiness and the feeling of use is good.
　本発明の害虫忌避組成物が（Ｄ）成分を含む場合、（Ａ）成分／（Ｄ）成分で表される質量比（以下、Ａ／Ｄ比ともいう）は、０．１～８００が好ましく、１～２００がより好ましく、５～５０がさらに好ましい。Ａ／Ｄ比が上記範囲内であれば、忌避効果が発揮されやすい。 When the pest repellent composition of the present invention contains the component (D), the mass ratio represented by the component (A) / (D) component (hereinafter also referred to as A / D ratio) is preferably 0.1 to 800. 1 to 200 is more preferable, and 5 to 50 is more preferable. If the A / D ratio is within the above range, the repellent effect is easily exhibited.
　本発明の害虫忌避組成物が（Ｂ）成分、及び（Ｄ）成分を含む場合、（Ｂ）成分／（Ｄ）成分で表される質量比（以下、Ｂ／Ｄ比ともいう）は、０．０１～２００が好ましく、１～１００がより好ましく、１～３０がさらに好ましい。Ｂ／Ｄ比が上記範囲内であれば、忌避効果が発揮されやすい。 When the pest repellent composition of the present invention includes the component (B) and the component (D), the mass ratio represented by the component (B) / (D) component (hereinafter also referred to as B / D ratio) is 0. 0.01 to 200 is preferable, 1 to 100 is more preferable, and 1 to 30 is more preferable. If the B / D ratio is within the above range, the repellent effect is easily exhibited.
　本発明の害虫忌避組成物が（Ｃ）成分、及び（Ｄ）成分を含む場合、（Ｃ）成分を「酸換算」して、（Ｃ）成分／（Ｄ）成分で表される質量比（以下、Ｃ／Ｄ比ともいう）は、０．００１～５０が好ましく、０．００５～３０がより好ましく、０．１～１０がさらに好ましい。Ｃ／Ｄ比が上記範囲内であれば、忌避効果が発揮されやすい。 When the pest repellent composition of the present invention contains the (C) component and the (D) component, the (C) component is “acid-converted” and the mass ratio represented by (C) component / (D) component ( Hereinafter, the C / D ratio is preferably 0.001 to 50, more preferably 0.005 to 30, and still more preferably 0.1 to 10. If the C / D ratio is within the above range, the repellent effect is easily exhibited.
＜他の成分＞
　（Ａ）～（Ｄ）成分を除く、他の成分としては、例えば、抗菌性化合物（以下、（Ｅ）成分ともいう）、界面活性剤（以下、（Ｆ）成分ともいう）、溶剤、保湿剤、増粘剤、色素、ｐＨ調整剤、香料、紫外線吸収剤、紫外線散乱剤等の添加剤等が挙げられる。 <Other ingredients>
The other components excluding the components (A) to (D) include, for example, an antibacterial compound (hereinafter also referred to as the (E) component), a surfactant (hereinafter also referred to as the (F) component), a solvent, and a moisturizing agent. And additives such as agents, thickeners, dyes, pH adjusters, fragrances, ultraviolet absorbers, and ultraviolet scattering agents.
　（Ｅ）成分としては、フェノール系抗菌成分、四級アンモニウム塩系の抗菌成分、ビグアナイド系抗菌成分、有機窒素硫黄系抗菌成分、など各種の化合物が挙げられる。フェノール系抗菌成分としては、イソプロピルメチルフェノール（３－メチル－４－イソプロピルフェノール）、オルト－フェニルフェノールなどが挙げられる。四級アンモニウム塩系抗菌成分としてはベンザルコニウム塩化物、塩化ベンゼトニウム等が挙げられる。ビグアナイド系抗菌成分としては塩酸クロルヘキシジン、ポリヘキサメチレンビグアニド塩酸塩等などが挙げられる。有機窒素硫黄系抗菌成分としては５－クロロ－２－メチル－４－イソチアゾリン－３－オン、２－メチル－４－イソチアゾリン－３－オン、２－メルカプトベンゾチアゾール、２－ｎ－オクチル－４－イソチアゾリン－３－オン、１，２－ベンゾイソチアゾリン－３－オン等が挙げられる。その他の（Ｅ）成分としては、トリクロサン、ジクロサン、２－ブロモ－２－ニトロプロパン－１，３－ジオール、リクロロカルバニリド、ピロクトンオラミン、クララエキスなどが挙げられる。
　これらの中でもフェノール系抗菌成分、四級アンモニウム塩系抗菌成分が好ましく、イソプロピルメチルフェノール、ベンザルコニウム塩化物がより好ましい。
　抗菌性化合物は、１種単独で用いられてもよいし、２種以上が組み合わされて用いられてもよく、フェノール系抗菌成分と四級アンモニウム塩系抗菌成分を併用することが好ましく、イソプロピルメチルフェノールとベンザルコニウム塩化物を併用する事がより好ましい。 (E) As a component, various compounds, such as a phenol type antibacterial component, a quaternary ammonium salt type antibacterial component, a biguanide type antibacterial component, an organic nitrogen sulfur type antibacterial component, are mentioned. Examples of the phenolic antibacterial component include isopropylmethylphenol (3-methyl-4-isopropylphenol), ortho-phenylphenol, and the like. Examples of the quaternary ammonium salt antibacterial component include benzalkonium chloride and benzethonium chloride. Examples of the biguanide antibacterial component include chlorhexidine hydrochloride and polyhexamethylene biguanide hydrochloride. Organic nitrogen sulfur antibacterial components include 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 2-mercaptobenzothiazole, 2-n-octyl-4- Examples thereof include isothiazoline-3-one and 1,2-benzisothiazolin-3-one. Examples of other component (E) include triclosan, diclosan, 2-bromo-2-nitropropane-1,3-diol, lichlorocarbanilide, piroctone olamine, and clara extract.
Among these, a phenolic antibacterial component and a quaternary ammonium salt antibacterial component are preferable, and isopropylmethylphenol and benzalkonium chloride are more preferable.
The antibacterial compound may be used alone or in combination of two or more, and it is preferable to use a phenolic antibacterial component and a quaternary ammonium salt antibacterial component in combination. More preferably, phenol and benzalkonium chloride are used in combination.
　本発明の害虫忌避組成物が（Ｅ）成分を含む場合、（Ｅ）成分の含有量は、害虫忌避組成物の総質量に対して０．００１～１質量％が好ましく、０．０１～０．５質量％がより好ましい。（Ｅ）成分の含有量が上記範囲内であれば、忌避効果が発揮されやすい。 When the pest repellent composition of the present invention includes the component (E), the content of the component (E) is preferably 0.001 to 1% by mass with respect to the total mass of the pest repellent composition, and 0.01 to 0 More preferable is 5% by mass. If content of (E) component exists in the said range, a repelling effect will be easy to be exhibited.
　本発明の害虫忌避組成物が（Ｂ）成分、及び（Ｅ）成分を含む場合、（Ｂ）成分／（Ｅ）成分で表される質量比（以下、Ｂ／Ｅ比ともいう）は、０．０１～１０００が好ましく、１～５００がより好ましく、さらに５～２００が好ましい。Ｂ／Ｅ比が上記範囲内であれば、忌避効果が発揮されやすい。 When the pest repellent composition of the present invention includes the component (B) and the component (E), the mass ratio represented by the component (B) / (E) component (hereinafter also referred to as B / E ratio) is 0. 0.01 to 1000 is preferable, 1 to 500 is more preferable, and 5 to 200 is more preferable. If the B / E ratio is within the above range, the repellent effect is easily exhibited.
　本発明の害虫忌避組成物が（Ｃ）成分、及び（Ｅ）成分を含む場合、（Ｃ）成分を「酸換算」して、（Ｃ）成分／（Ｅ）成分で表される質量比（以下、Ｃ／Ｅ比ともいう）は、０．００５～３００が好ましく、０．１～１００が好ましい。Ｃ／Ｅ比が上記範囲内であると、忌避効果が発揮されやすい。 When the pest repellent composition of the present invention contains the (C) component and the (E) component, the (C) component is “acid-converted” and the mass ratio represented by (C) component / (E) component ( Hereinafter, the C / E ratio) is preferably 0.005 to 300, and more preferably 0.1 to 100. When the C / E ratio is within the above range, the repelling effect is easily exhibited.
　本発明の害虫忌避組成物が（Ｄ）成分、及び（Ｅ）成分を含む場合、（Ｄ）成分／（Ｅ）成分で表される質量比（以下、Ｄ／Ｅ比ともいう）は、０．０５～１００が好ましく、０．５～１０が好ましい。Ｄ／Ｅ比が上記範囲内であると、忌避効果が発揮されやすい。 When the pest repellent composition of the present invention contains the component (D) and the component (E), the mass ratio represented by the component (D) / (E) component (hereinafter also referred to as D / E ratio) is 0. .05 to 100 is preferable, and 0.5 to 10 is preferable. When the D / E ratio is within the above range, the repelling effect is easily exhibited.
　（Ｆ）成分としては、アニオン界面活性剤、非イオン界面活性剤、両性界面活性剤が使用できる。アニオン界面活性剤としては、例えば脂肪酸石けん、アルキルベンゼンスルホン酸塩、直鎖アルキルベンゼンスルホン酸塩、アルキル硫酸塩、アルファオレフィンスルホン酸塩、アルキルリン酸エステル塩、ポリオキシエチレンアルキルエーテル硫酸塩、ポリオキシエチレンアルキルエーテルカルボン酸塩、ポリオキシエチレンアルキルフェニルエーテル硫酸塩、ポリオキシエチレンアルキルエーテルリン酸塩、アルキルスルホコハク酸塩、ポリオキシエチレンアルキルスルホコハク酸塩などが挙げられる。非イオン界面活性剤としては、例えばポリオキシアルキレンアルキルエーテル、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレン高級脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ヤシ油脂肪酸ジエタノールアミド、脂肪酸アルカノールアミド、アミンオキシドなどが挙げられる。両性界面活性剤としてはアルキルカルボベタイン、アルキルアミドカルボベタイン、アルキルスルホベタイン、アルキルヒドロキシスルホベタイン、アルキルアミドスルホベタイン、アルキルアミドヒドロキシスルホベタイン等が挙げられる。
　皮膚への刺激性、低温に置ける安定性向上の観点から非イオン界面活性剤が好ましく、ポリオキシエチレン硬化ヒマシ油がより好ましい。非イオン界面活性剤のオキシエチレン基は低温における安定性の観点から平均１０～１００モル付加品が好ましい。
　（Ｆ）成分は、１種単独で用いられてもよいし、２種以上が組み合わされて用いられてもよい。 As the component (F), anionic surfactants, nonionic surfactants, and amphoteric surfactants can be used. Examples of the anionic surfactant include fatty acid soap, alkylbenzene sulfonate, linear alkylbenzene sulfonate, alkyl sulfate, alpha olefin sulfonate, alkyl phosphate ester salt, polyoxyethylene alkyl ether sulfate, polyoxyethylene Examples thereof include alkyl ether carboxylates, polyoxyethylene alkyl phenyl ether sulfates, polyoxyethylene alkyl ether phosphates, alkyl sulfosuccinates, polyoxyethylene alkyl sulfosuccinates, and the like. Nonionic surfactants include, for example, polyoxyalkylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene higher fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, Examples include coconut oil fatty acid diethanolamide, fatty acid alkanolamide, and amine oxide. Examples of amphoteric surfactants include alkyl carbobetaines, alkylamide carbobetaines, alkylsulfobetaines, alkylhydroxysulfobetaines, alkylamide sulfobetaines, alkylamide hydroxysulfobetaines, and the like.
Nonionic surfactants are preferable from the viewpoint of irritation to the skin and stability improvement at low temperatures, and polyoxyethylene hydrogenated castor oil is more preferable. The average oxyethylene group of the nonionic surfactant is preferably an addition product of 10 to 100 moles from the viewpoint of stability at low temperatures.
(F) A component may be used individually by 1 type and may be used in combination of 2 or more type.
　本発明の害虫忌避組成物が（Ｆ）成分を含む場合、（Ｆ）成分の含有量は、害虫忌避組成物の総質量に対して０．１～１０質量％が好ましく、０．１～５質量％がさらに好ましい。（Ｆ）成分の含有量が前記範囲内であると（Ｆ）成分によるベタツキを抑え、低温での安定性を向上する。 When the pest repellent composition of the present invention contains the component (F), the content of the component (F) is preferably 0.1 to 10% by mass with respect to the total mass of the pest repellent composition, and 0.1 to 5%. More preferred is mass%. When the content of the component (F) is within the above range, stickiness due to the component (F) is suppressed, and stability at a low temperature is improved.
　溶剤としては、エタノール等のアルコール系溶剤、ｎ－パラフィン、イソパラフィン等の炭化水素系溶剤、プロピレングリコール、１，３－ブチレングリコール、ジプロピレングリコール、ジエチレングリコールモノブチルエーテル等のグリコール類やグリコールエーテル類、ケトン系溶剤、エステル系溶剤、水等を配合することができる。
　溶剤は、１種単独で用いられてもよいし、２種以上が組み合わされて用いられてもよい。
　皮膚への刺激性や臭気、使用感（乾きやすさ）および忌避効果の観点からエタノールが好ましい。 Solvents include alcohol solvents such as ethanol, hydrocarbon solvents such as n-paraffin and isoparaffin, glycols such as propylene glycol, 1,3-butylene glycol, dipropylene glycol and diethylene glycol monobutyl ether, glycol ethers, ketones A system solvent, an ester system solvent, water, etc. can be mix | blended.
A solvent may be used individually by 1 type and may be used in combination of 2 or more type.
Ethanol is preferred from the viewpoint of irritation to the skin, odor, feeling of use (easy to dry) and repellent effect.
　本発明の害虫忌避組成物がエタノールを含む場合、エタノールの含有量は、害虫忌避組成物の総質量に対して０～９０質量％が好ましく、３０～５０質量％が、使用感触（乾きやすさ）、肌刺激性の点からより好ましい。エタノールの含有量が上記範囲内であれば、忌避効果が発揮されやすい。 When the pest repellent composition of the present invention contains ethanol, the ethanol content is preferably 0 to 90% by mass with respect to the total mass of the pest repellent composition, and 30 to 50% by mass is a feeling of use (easy to dry). ), More preferable from the viewpoint of skin irritation. If the content of ethanol is within the above range, the repellent effect is easily exhibited.
　本発明の害虫忌避組成物には適宜水を配合することができる。 The pest repellent composition of the present invention can be appropriately mixed with water.
　増粘剤（（Ｄ）成分を除く）としては、化粧品・医薬部外品・医薬品に使用されるものであれば特に限定されず、天然の水溶性高分子、半合成の水溶性高分子、合成の水溶性高分子、無機の水溶性高分子等が挙げられる。天然の水溶性高分子としては、例えばアラビアガム、トラガカントガム、ガラクタン、グアーガム、キサンタンガム、キャロブガム、ローカストビーンガム、カラヤガム、カラギーナン、ペクチン、寒天、クインスシード、アルゲコロイド、デンプン等の植物系高分子、デキストラン、デキストリン、サクシノグルカン、プルラン等の微生物系高分子、コラーゲン、カゼイン、アルブミン、ゼラチン等の動物系高分子等が挙げられる。半合成の水溶性高分子としては、例えばカルボキシメチルデンプン、メチルヒドロキシプロピルデンプン等のデンプン系高分子、メチルセルロース、ニトロセルロース、エチルセルロース、メチルヒドロキシプロピルセルロース、ヒドロキシエチルセルロース、セルロース硫酸ナトリウム、ヒドロキシプロピルセルロース、カルボキシメチルセルロースナトリウム（ＣＭＣ）、結晶セルロース、セルロース末等のセルロース系高分子、アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル等のアルギン酸系高分子等が挙げられる。合成の水溶性高分子としては、例えばポリビニルアルコール、ポリビニルメチルエーテル、カルボキシビニルポリマー（カルボマー）等のビニル系高分子、ポリエチレングリコール（分子量１５００、４０００、６０００等）等のポリオキシエチレン系高分子、ポリオキシエチレンポリオキシプロピレン共重合系高分子、ポリアクリル酸ナトリウム、ポリエチルアクリレート等のアクリル系高分子、ポリエチレンイミン、カチオンポリマー等が挙げられる。無機の水溶性高分子としては、例えばベントナイト、ケイ酸ＡｌＭｇ、ラポナイト、ヘクトライト、無水ケイ酸等が挙げられる。
　増粘剤は、１種単独で用いられてもよいし、２種以上が組み合わされて用いられてもよい。 The thickener (excluding the component (D)) is not particularly limited as long as it is used in cosmetics, quasi-drugs and pharmaceuticals, natural water-soluble polymers, semi-synthetic water-soluble polymers, Examples include synthetic water-soluble polymers and inorganic water-soluble polymers. Examples of natural water-soluble polymers include plant polymers such as gum arabic, gum tragacanth, galactan, guar gum, xanthan gum, carob gum, locust bean gum, caraya gum, carrageenan, pectin, agar, quince seed, alge colloid, starch, and dextran. And microbial polymers such as dextrin, succinoglucan and pullulan, and animal polymers such as collagen, casein, albumin and gelatin. Examples of semi-synthetic water-soluble polymers include starch polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxy Examples thereof include cellulose polymers such as sodium methylcellulose (CMC), crystalline cellulose and cellulose powder, and alginic acid polymers such as sodium alginate and propylene glycol alginate. Examples of the synthetic water-soluble polymer include vinyl polymers such as polyvinyl alcohol, polyvinyl methyl ether, and carboxyvinyl polymer (carbomer), polyoxyethylene polymers such as polyethylene glycol (molecular weight 1500, 4000, 6000, etc.), Examples thereof include polyoxyethylene polyoxypropylene copolymer polymers, acrylic polymers such as sodium polyacrylate and polyethyl acrylate, polyethyleneimine, and cationic polymers. Examples of the inorganic water-soluble polymer include bentonite, AlMg silicate, laponite, hectorite, and silicic anhydride.
A thickener may be used individually by 1 type and may be used in combination of 2 or more type.
　香料としては、ペパーミント油、スペアミント油、アニス油、ユーカリ油、ウィンターグリーン油、カシア油、クローブ油、タイム油、セージ油、レモン油、オレンジ油、ハッカ油、カルダモン油、コリアンダー油、マンダリン油、ライム油、ラベンダー油、ローズマリー油、ローレル油、カモミル油、キャラウェイ油、マジョラム油、ベイ油、レモングラス油、オリガナム油、パインニードル油、ネロリ油、ローズ油、ジャスミン油、イリスコンクリート、アブソリュートペパーミント、アブソリュートンローズ、オレンジフラワー等の天然香料成分；これらの天然香料成分の加工処理した香料成分；メントール、カルボン、アネトール、シネオール、サリチル酸メチル、シンナミックアルデヒド、オイゲノール、２－ジオール、ピネン、オクチルアルデヒド、シトラール、プレゴン、カルビールアセテート、アニスアルデヒド等の単品香料成分等が挙げられる。
　香料は、１種単独で用いられてもよいし、２種以上が組み合わされて用いられてもよい。
　本発明の害虫忌避組成物において、（Ａ）成分と、（Ｂ）成分、（Ｃ）成分、及び（Ｄ）成分からなる群から選択される少なくとも１種の成分との合計の含有量は１００質量％を超えない。 Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute Natural fragrance ingredients such as peppermint, absoluteton rose and orange flower; processed fragrance ingredients of these natural fragrance ingredients; menthol, carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 2-diol, pinene, Chi le aldehyde, citral, pulegone, Cal beer acetate, separately perfume ingredients such as anisaldehyde the like.
A fragrance | flavor may be used individually by 1 type and may be used in combination of 2 or more type.
In the pest repellent composition of the present invention, the total content of the component (A) and at least one component selected from the group consisting of the component (B), the component (C), and the component (D) is 100. Does not exceed mass%.
　本発明の害虫忌避組成物の２５℃におけるｐＨとしては、忌避効果、及び肌への刺激の少なさの点から、３～９が好ましく、５～８がより好ましい。なお、前記ｐＨは、ｐＨメーター（東亜電波工業株式会社製、ＨＭ－３０Ｇ）を用いて通常の方法にて測定することができる。 The pH at 25 ° C. of the pest repellent composition of the present invention is preferably from 3 to 9, more preferably from 5 to 8, from the viewpoint of repellent effect and low irritation to the skin. The pH can be measured by a usual method using a pH meter (manufactured by Toa Denpa Kogyo Co., Ltd., HM-30G).
　本発明の害虫忌避組成物は、（Ａ）成分と、（Ｂ）成分、（Ｃ）成分、及び（Ｄ）成分からなる群から選択される少なくとも１種の成分とを含み、前記（Ａ）成分がイカリジン及びディートからなる群から選択される少なくとも１種であり、前記（Ｂ）成分がトレハロース、ソルビトール、及びマルチトールからなる群から選択される少なくとも１種であり、前記（Ｃ）成分がクエン酸及びクエン酸ナトリウムからなる群から選択される少なくとも１種であり、前記（Ｄ）成分がポリビニルピロリドン、及び酢酸ビニル・ビニルピロリドン共重合体からなる群から選択される少なくとも１種であることが好ましい。
　本発明の害虫忌避組成物は、（Ａ）成分と、（Ｂ）成分、（Ｃ）成分、及び（Ｄ）成分からなる群から選択される少なくとも１種の成分とを含み、前記（Ａ）成分がイカリジン及びディートからなる群から選択される少なくとも１種であり、前記（Ｂ）成分がトレハロース、ソルビトール、及びマルチトールからなる群から選択される少なくとも１種であり、前記（Ｃ）成分がクエン酸及びクエン酸ナトリウムからなる群から選択される少なくとも１種であり、前記（Ｄ）成分がポリビニルピロリドン、及び酢酸ビニル・ビニルピロリドン共重合体からなる群から選択される少なくとも１種であり、害虫忌避組成物の総質量に対して、前記（Ａ）成分の含有量が１～８０質量％であり、前記（Ｂ）成分の含有量が０．１～１０質量％であり、前記（Ｃ）成分の含有量が「酸換算」して、０．０１～３質量％であり、前記（Ｄ）成分の含有量が０．１～３質量％であることが好ましい。 The pest repellent composition of the present invention comprises (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component, The component is at least one selected from the group consisting of icaridin and diet, and the component (B) is at least one selected from the group consisting of trehalose, sorbitol, and maltitol, and the component (C) is It is at least one selected from the group consisting of citric acid and sodium citrate, and the component (D) is at least one selected from the group consisting of polyvinyl pyrrolidone and vinyl acetate / vinyl pyrrolidone copolymer. Is preferred.
The pest repellent composition of the present invention comprises (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component, The component is at least one selected from the group consisting of icaridin and diet, and the component (B) is at least one selected from the group consisting of trehalose, sorbitol, and maltitol, and the component (C) is It is at least one selected from the group consisting of citric acid and sodium citrate, and the component (D) is at least one selected from the group consisting of polyvinyl pyrrolidone and vinyl acetate / vinyl pyrrolidone copolymer, The content of the component (A) is 1 to 80% by mass with respect to the total mass of the pest repellent composition, and the content of the component (B) is 0.1 to 10% by mass, Serial and (C) content is "acid conversion" components is from 0.01 to 3 wt%, the content of component (D) is preferably 0.1 to 3 wt%.
　本発明の害虫忌避組成物は、（Ａ）成分と、（Ｂ）成分、（Ｃ）成分、及び（Ｄ）成分からなる群から選択される少なくとも１種の成分とを含み、前記（Ａ）成分がイカリジン及びディートからなる群から選択される少なくとも１種であり、前記（Ｂ）成分がトレハロースであり、前記（Ｃ）成分がクエン酸及びクエン酸ナトリウムからなる群から選択される少なくとも１種であり、前記（Ｄ）成分が酢酸ビニル・ビニルピロリドン共重合体であることが好ましい。　本発明の害虫忌避組成物は、（Ａ）成分と、（Ｂ）成分、（Ｃ）成分、及び（Ｄ）成分からなる群から選択される少なくとも１種の成分とを含み、前記（Ａ）成分がイカリジン及びディートからなる群から選択される少なくとも１種であり、前記（Ｂ）成分がトレハロースであり、前記（Ｃ）成分がクエン酸及びクエン酸ナトリウムからなる群から選択される少なくとも１種であり、前記（Ｄ）成分が酢酸ビニル・ビニルピロリドン共重合体であり、害虫忌避組成物の総質量に対して、前記（Ａ）成分の含有量が１～８０質量％であり、前記（Ｂ）成分の含有量が０．１～１０質量％であり、前記（Ｃ）成分の含有量が「酸換算」して、０．０１～３質量％であり、前記（Ｄ）成分の含有量が０．１～３質量％であることが好ましい。 The pest repellent composition of the present invention comprises (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component, The component is at least one selected from the group consisting of icaridin and diet, the component (B) is trehalose, and the component (C) is at least one selected from the group consisting of citric acid and sodium citrate. It is preferable that the component (D) is a vinyl acetate / vinyl pyrrolidone copolymer. The pest repellent composition of the present invention comprises (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component, The component is at least one selected from the group consisting of icaridin and diet, the component (B) is trehalose, and the component (C) is at least one selected from the group consisting of citric acid and sodium citrate. The component (D) is a vinyl acetate / vinyl pyrrolidone copolymer, and the content of the component (A) is 1 to 80% by mass relative to the total mass of the pest repellent composition, B) content of component is 0.1 to 10% by mass, content of said (C) component is 0.01 to 3% by mass in terms of “acid conversion”, content of said (D) component The amount is preferably 0.1 to 3% by mass.
　本発明の害虫忌避組成物は、（Ａ）成分と、（Ｂ）成分、（Ｃ）成分、及び（Ｄ）成分からなる群から選択される少なくとも１種の成分と、（Ｅ）成分とを含み、前記（Ａ）成分がイカリジン及びディートからなる群から選択される少なくとも１種であり、前記（Ｂ）成分がトレハロースであり、前記（Ｃ）成分がクエン酸及びクエン酸ナトリウムからなる群から選択される少なくとも１種であり、前記（Ｄ）成分が酢酸ビニル・ビニルピロリドン共重合体であり、前記（Ｅ）成分がベンザルコニウム塩化物、及びイソプロピルメチルフェノールからなる群から選択される少なくとも１種であることが好ましい。　本発明の害虫忌避組成物は、（Ａ）成分と、（Ｂ）成分、（Ｃ）成分、及び（Ｄ）成分からなる群から選択される少なくとも１種の成分と、（Ｅ）成分とを含み、前記（Ａ）成分がイカリジン及びディートからなる群から選択される少なくとも１種であり、前記（Ｂ）成分がトレハロースであり、前記（Ｃ）成分がクエン酸及びクエン酸ナトリウムからなる群から選択される少なくとも１種であり、前記（Ｄ）成分が酢酸ビニル・ビニルピロリドン共重合体あり、前記（Ｅ）成分がベンザルコニウム塩化物、及びイソプロピルメチルフェノールからなる群から選択される少なくとも１種であり、害虫忌避組成物の総質量に対して、前記（Ａ）成分の含有量が１～８０質量％であり、前記（Ｂ）成分の含有量が０．１～１０質量％であり、前記（Ｃ）成分の含有量が「酸換算」して、０．０１～３質量％であり、前記（Ｄ）成分の含有量が０．１～３質量％であり、前記（Ｅ）成分の含有量が０．００１～１質量％であることが好ましい。 The pest repellent composition of the present invention comprises (A) component, at least one component selected from the group consisting of (B) component, (C) component, and (D) component, and (E) component. The component (A) is at least one selected from the group consisting of icaridin and diet, the component (B) is trehalose, and the component (C) is from the group consisting of citric acid and sodium citrate. At least one selected, wherein the component (D) is a vinyl acetate / vinylpyrrolidone copolymer, and the component (E) is at least selected from the group consisting of benzalkonium chloride and isopropylmethylphenol One type is preferable. The pest repellent composition of the present invention comprises (A) component, at least one component selected from the group consisting of (B) component, (C) component, and (D) component, and (E) component. The component (A) is at least one selected from the group consisting of icaridin and diet, the component (B) is trehalose, and the component (C) is from the group consisting of citric acid and sodium citrate. At least one selected, wherein the component (D) is a vinyl acetate-vinylpyrrolidone copolymer, and the component (E) is at least one selected from the group consisting of benzalkonium chloride and isopropylmethylphenol. The amount of the component (A) is 1 to 80% by mass and the content of the component (B) is 0.1 to 10% by mass with respect to the total mass of the pest repellent composition. ,in front The content of the component (C) is 0.01 to 3% by mass in terms of acid, the content of the component (D) is 0.1 to 3% by mass, and the component (E) The content is preferably 0.001 to 1% by mass.
≪害虫忌避組成物の調製方法≫
　本発明の害虫忌避組成物の調製方法は、（Ａ）成分と、（Ｂ）成分、（Ｃ）成分、及び（Ｄ）成分からなる群から選択される少なくとも１種とを混合する方法が挙げられる。さらには、（Ａ）成分と、（Ｂ）成分、（Ｃ）成分、及び（Ｄ）成分からなる群から選択される少なくとも１種と、必要に応じて他の成分とを溶剤に溶解させる方法が挙げられる。 ≪Method for preparing pest repellent composition≫
The method for preparing the pest repellent composition of the present invention includes a method of mixing the component (A) with at least one selected from the group consisting of the component (B), the component (C), and the component (D). It is done. Further, a method of dissolving in a solvent at least one selected from the group consisting of the component (A), the component (B), the component (C), and the component (D) and, if necessary, other components Is mentioned.
≪害虫忌避方法≫
　本発明の害虫忌避組成物は、例えば、乳液、クリーム、ジェル、スプレー（液剤）等の剤型で用いることができる。例えば、乳液、クリーム、又はジェルにおける本発明の害虫忌避組成物の含有量は、乳液、クリーム、又はジェルの総質量に対し、１～１００質量％が好ましい。液剤における本発明の害虫忌避組成物の含有量は、液剤の総質量に対し、１～１００質量％が好ましい。
　本発明の害虫忌避組成物は、例えば皮膚に塗布されることで、害虫に対して忌避効果を発揮する。本発明の害虫忌避組成物の使用方法は、本発明の害虫忌避組成物の有効量を、害虫忌避が必要な対象の皮膚又は着衣に付着させる工程を含む。ここで有効量とは、０．１～１０ｍｇ／ｃｍ２が好ましく、０．５～５ｍｇ／ｃｍ２がより好ましい。害虫忌避が必要な対象としては、ヒト、及び動物が挙げられる。付着させる方法としては、塗布、及びスプレー等が挙げられる。
　本発明の害虫忌避組成物によって忌避対象となる害虫としては、例えば蚊、ブヨ、サシバエ、イエダニ、トコジラミ（ナンキンムシ）、マダニ、ツツガムシ等が挙げられる。なかでも蚊が好ましい。 ≪Pest repellent method≫
The pest repellent composition of the present invention can be used in a dosage form such as an emulsion, cream, gel, or spray (solution). For example, the content of the pest repellent composition of the present invention in an emulsion, cream or gel is preferably 1 to 100% by mass with respect to the total mass of the emulsion, cream or gel. The content of the pest repellent composition of the present invention in the solution is preferably 1 to 100% by mass relative to the total mass of the solution.
The pest repellent composition of the present invention exerts a repellent effect on pests when applied to the skin, for example. The method of using the pest repellent composition of the present invention includes a step of attaching an effective amount of the pest repellent composition of the present invention to the skin or clothing of a subject in need of pest repellent. Here effective amount and is preferably 0.1 ~ 10mg / cm 2, more preferably 0.5 ~ 5mg / cm 2. Examples of subjects that need to avoid pests include humans and animals. Examples of the attaching method include coating and spraying.
Examples of the pests to be repelled by the pest repellent composition of the present invention include mosquitoes, gnats, sand flies, house dust mites, bed bugs, ticks, and tsutsugamushi. Of these, mosquitoes are preferred.
　以下に実施例を用いて本発明をさらに詳しく説明するが、本発明はこれら実施例に限定されるものではない。
　本実施例において使用した原料は下記の表１に示す通りである。
　表１中、グレードの欄の「外原規」は医薬部外品原料規格の略である。「日局」は日本薬局方の略である。 Hereinafter, the present invention will be described in more detail using examples, but the present invention is not limited to these examples.
The raw materials used in this example are as shown in Table 1 below.
In Table 1, “Outside original regulations” in the grade column is an abbreviation for raw materials specifications for quasi drugs. “JP” is an abbreviation for Japanese Pharmacopoeia.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
［害虫忌避組成物の調製］
　表２に示す組成（質量％にて記載）に従い、各成分を混合し各例の害虫忌避組成物を調整した。
　得られた害虫忌避組成物について、以下の手順で忌避効果の評価を行った。 [Preparation of pest repellent composition]
According to the composition shown in Table 2 (described in mass%), each component was mixed to prepare the pest repellent composition of each example.
About the obtained pest repellent composition, the repellent effect was evaluated in the following procedures.
［忌避効果の評価］
　図１に示すように、５０ｃｍ×５０ｃｍ×５０ｃｍのアクリルボックスを仕切板４を介して２つ連結し、連結ケージ１０を作成した。連結ケージ１０の右側ケージ２にヒトスジシマカ（メス）５を５０匹放中した。専門パネラー１名の前腕から手の先の範囲に各忌避組成物を約２ｇ塗布し乾燥させた。３０℃条件下で１０分間エアロバイク（登録商標）による運動を行い、強制発汗させた後、ストッキング製の筒３内に腕を入れて、仕切板４開口部を開放し、５分間に左側ケージ１内に侵入する蚊のエントリー数を測定した（発汗直後）。忌避組成物を塗布後発汗してから２時間、及び４時間経過した腕を筒３内に入れて、蚊のエントリー数を測定した。これを塗布時エントリー数とした。
　忌避組成物を塗布していない腕で同様の評価を行い、蚊のエントリー数を測定した。これを無塗布時エントリー数とした。
　得られた塗布時エントリー数と無塗布時エントリー数から、以下の式により忌避率を算出し、下記評価基準により忌避効果を評価した。
　忌避率（％）＝｛１－（塗布時エントリー数－補正エントリー数）／（無塗布時エントリー数－補正エントリー数）｝×１００
　補正エントリー数とは、腕を入れない条件下での蚊のエントリー数である。補正後、エントリー数がマイナスとなった場合、０として評価した。
（評価基準）
　　◎：忌避率が９０％以上～１００％。
　　○：忌避率が７０％以上～９０％未満。
　　△：忌避率が５０％以上～７０未満。
　　×：忌避率が５０％未満。 [Evaluation of repellent effect]
As shown in FIG. 1, two acrylic boxes each having a size of 50 cm × 50 cm × 50 cm were connected via a partition plate 4 to create a connection cage 10. 50 human striped mosquitoes (female) 5 were released into the right cage 2 of the connecting cage 10. About 2 g of each repellent composition was applied to the range from the forearm to the tip of a hand of one specialist panelist and dried. Exercise with an exercise bike (registered trademark) for 10 minutes under the condition of 30 ° C. After forced sweating, put an arm into the tube 3 made of stockings, open the opening of the partition plate 4 and open the left cage for 5 minutes. The number of mosquito entries entering 1 was measured (immediately after sweating). Arms that had passed 2 hours and 4 hours after sweating after applying the repellent composition were placed in the tube 3, and the number of mosquito entries was measured. This was the number of entries at the time of application.
The same evaluation was performed on the arm to which the repellent composition was not applied, and the number of mosquito entries was measured. This was the number of entries without application.
The repelling rate was calculated by the following formula from the number of entries at the time of application and the number of entries at the time of no application, and the repellent effect was evaluated according to the following evaluation criteria.
Repellency rate (%) = {1− (number of entries at application−number of correction entries) / (number of entries without application−number of correction entries)} × 100
The number of corrected entries is the number of mosquito entries under the condition that the arm is not inserted. When the number of entries became negative after correction, it was evaluated as 0.
(Evaluation criteria)
A: Repelling rate is 90% to 100%.
○: Repelling rate is 70% or more and less than 90%.
Δ: Repelling rate is 50% or more and less than 70.
X: Repelling rate is less than 50%.
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
　実施例１～８以外の本発明の害虫忌避組成物の処方例を表３に示す。 Table 3 shows formulation examples of the pest repellent composition of the present invention other than Examples 1 to 8.
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
　本発明を適用した実施例１～８では、高い忌避効果が得られた。一方、（Ｂ）～（Ｄ）成分をいずれも含まない比較例１、２及び３では、忌避効果において劣っていた。
　以上の結果から、本発明の害虫忌避組成物によれば、高い害虫忌避効果が得られることが判った。 In Examples 1 to 8 to which the present invention was applied, a high repellent effect was obtained. On the other hand, Comparative Examples 1, 2 and 3 which did not contain any of the components (B) to (D) were inferior in the repellent effect.
From the above results, it was found that according to the pest repellent composition of the present invention, a high pest repellent effect can be obtained.
　本発明によれば、害虫忌避効果に優れた害虫忌避組成物、及びこれを用いた害虫忌避方法を提供できる。 According to the present invention, a pest repellent composition having an excellent pest repellent effect and a pest repellent method using the same can be provided.
　１０　連結ケージ
　　１　左側ケージ
　　２　右側ケージ
　　３　筒
　　４　仕切板
　　５　ヒトスジシマカ 10 Linkage cage 1 Left cage 2 Right cage 3 Tube 4 Partition plate 5 Hitsujishimaka

Claims (6)

  1. 　（Ａ）成分と、（Ｂ）成分、（Ｃ）成分、及び（Ｄ）成分からなる群から選択される少なくとも１種の成分とを含む害虫忌避組成物であって、
    　前記（Ａ）成分が忌避有効成分であり、
    　前記（Ｂ）成分が抗酸化成分であり、
    　前記（Ｃ）成分がキレート剤であり、
    　前記（Ｄ）成分がポリビニルピロリドン、及び酢酸ビニル・ビニルピロリドン共重合体からなる群から選択される少なくとも１種の高分子化合物である、害虫忌避組成物。     A pest repellent composition comprising (A) component and at least one component selected from the group consisting of (B) component, (C) component, and (D) component,
    The component (A) is a repellent active ingredient,
    The component (B) is an antioxidant component,
    The component (C) is a chelating agent,
    The pest repellent composition, wherein the component (D) is at least one polymer compound selected from the group consisting of polyvinyl pyrrolidone and a vinyl acetate / vinyl pyrrolidone copolymer.
  2. 　前記（Ａ）成分がイカリジンである請求項１に記載の害虫忌避組成物。 The pest repellent composition according to claim 1, wherein the component (A) is icaridin.
  3. 　前記（Ｂ）成分、及び前記（Ｃ）成分を含む請求項１又は請求項２に記載の害虫忌避組成物。 The pest repellent composition according to claim 1 or 2, comprising the component (B) and the component (C).
  4. 　前記（Ｂ）成分、前記（Ｃ）成分、及び前記（Ｄ）成分を含む請求項１又は請求項２に記載の害虫忌避組成物。 The pest repellent composition according to claim 1 or 2, comprising the component (B), the component (C), and the component (D).
  5. 　さらに、（Ｅ）成分：抗菌性化合物を含む請求項１～４のいずれか一項に記載の害虫忌避組成物。 The pest repellent composition according to any one of claims 1 to 4, further comprising (E) component: an antibacterial compound.
  6. 　請求項１～５のいずれか一項に記載の害虫忌避組成物を用いることを特徴とする害虫忌避方法。 A pest repellent method comprising using the pest repellent composition according to any one of claims 1 to 5.
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