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WO2015162559A1 - Composition de maille pour la réparation ou régénération de tissus et ses procédés - Google Patents

Composition de maille pour la réparation ou régénération de tissus et ses procédés Download PDF

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Publication number
WO2015162559A1
WO2015162559A1 PCT/IB2015/052913 IB2015052913W WO2015162559A1 WO 2015162559 A1 WO2015162559 A1 WO 2015162559A1 IB 2015052913 W IB2015052913 W IB 2015052913W WO 2015162559 A1 WO2015162559 A1 WO 2015162559A1
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WO
WIPO (PCT)
Prior art keywords
collagen
mesh
previous
composition according
mesh composition
Prior art date
Application number
PCT/IB2015/052913
Other languages
English (en)
Inventor
Fernando Jorge MONTEIRO
Susana Maria RIBEIRO E SOUSA MENDES DE FREITAS
Nilza Maria LOPES RIBEIRO
Lorenzo Moroni
Original Assignee
Ineb - Instituto Nacional De Engenharia Biomédica
Universidade Do Porto
Isep - Instituto Superior De Engenharia Do Porto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ineb - Instituto Nacional De Engenharia Biomédica, Universidade Do Porto, Isep - Instituto Superior De Engenharia Do Porto filed Critical Ineb - Instituto Nacional De Engenharia Biomédica
Publication of WO2015162559A1 publication Critical patent/WO2015162559A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D01F1/10—Other agents for modifying properties
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F4/00—Monocomponent artificial filaments or the like of proteins; Manufacture thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/21—Acids
    • A61L2300/214—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Definitions

  • the mesh composition of the present invention may further comprise a crosslinking agent selected from the following list: N-(3- dimethylaminopropyl)-N'-ethylcarbodiimide, N-hydroxysuccinimide, transglutaminase enzymes tyrosinase enzymes and lysyl oxidase enzymes or their mixtures.
  • a crosslinking agent selected from the following list: N-(3- dimethylaminopropyl)-N'-ethylcarbodiimide, N-hydroxysuccinimide, transglutaminase enzymes tyrosinase enzymes and lysyl oxidase enzymes or their mixtures.
  • the mesh composition of the present invention may have a thickness between 100 - 5000 ⁇ .
  • the mesh composition/biocomposite material is functionalized with an active agent selected from growth factors, amino acids, proteins, protein fragments, or peptides.
  • the structured mesh/biocomposite material may be use as a model matrix for the research of regeneration and reconstruction of tissues and cell adhesion, growth, proliferation and differentiation.
  • the fibres in order to obtain the collagen fibres with calcium phosphate in better conditions, the fibres may be produced by

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Textile Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Inorganic Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne une matrice ou une composition de maille comportant des nanofibres de collagène et des agglomérats de phosphate de calcium pour la réparation et/ou la régénération de tissus et pour le traitement de maladies osseuses, de l'arthrose ou de maladies cutanées. La composition de maille selon l'invention concerne, de façon surprenante, une combinaison et une structure d'élément qui rend une composition de maille plus efficace et appropriée pour imiter un tissu, en particulier un tissu osseux, ladite composition peut également être absorbée par l'organisme après la reconstitution du tissu, et cette nouvelle composition de maille permet une régénération tissulaire améliorée et efficace (os, peau, cartilage).
PCT/IB2015/052913 2014-04-21 2015-04-21 Composition de maille pour la réparation ou régénération de tissus et ses procédés WO2015162559A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT107598 2014-04-21
PT10759814 2014-04-21

Publications (1)

Publication Number Publication Date
WO2015162559A1 true WO2015162559A1 (fr) 2015-10-29

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Country Status (1)

Country Link
WO (1) WO2015162559A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107299456A (zh) * 2017-06-27 2017-10-27 江南大学 一种复合纳米纤维膜及其制备方法和应用
WO2018024700A1 (fr) * 2016-08-02 2018-02-08 Aesculap Ag Implant, de préférence pour le traitement d'un défaut de l'acetabulum
EP3311854A1 (fr) * 2016-10-20 2018-04-25 Ústav Struktury A Mechaniky Hornin AV CR, V.V.I. Couche nanocomposite à base de nanofibres de collagène et son procédé de préparation
CN108042854A (zh) * 2017-12-16 2018-05-18 诺迈尔（苏州）医学科技有限公司 用于牙种植手术的明胶纤维引导组织再生膜的生产工艺
WO2018187407A1 (fr) * 2017-04-04 2018-10-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Échafaudages hybrides polymère/ecm renforcés par un treillis en alliage de mg pour la régénération des défauts osseux de taille critique
CN109908405A (zh) * 2019-03-10 2019-06-21 西北大学 一种多孔骨修复支架材料及其制备方法
US10940042B2 (en) 2015-10-23 2021-03-09 The Trustees Of Columbia University In The City Of New York Laser induced collagen crosslinking in tissue
CN113645944A (zh) * 2019-03-28 2021-11-12 国家研究院 包含从渔业和水产养殖废物中获得的羟基磷灰石或改性羟基磷灰石的物理防晒剂、其生产方法和包含其的光保护组合物
CN113893388A (zh) * 2021-09-23 2022-01-07 上海市第六人民医院 一种模块化组织工程骨-韧带-骨移植物及其制备方法
US11497403B2 (en) 2016-06-10 2022-11-15 The Trustees Of Columbia University In The City Of New York Devices, methods, and systems for detection of collagen tissue features
CN116161950A (zh) * 2023-03-08 2023-05-26 中国科学技术大学 一种基于纳米尺度梯度结构优化的仿生陶瓷基材料及其制备方法
US11666481B1 (en) 2017-12-01 2023-06-06 The Trustees Of Columbia University In The City Of New York Diagnosis and treatment of collagen-containing tissues
CN116271182A (zh) * 2022-12-15 2023-06-23 四川大学 静电纺丝重组人源化ⅲ型胶原蛋白伤口敷料及其制备方法
WO2024075118A1 (fr) * 2022-10-03 2024-04-11 Corneat Vision Ltd. Implants dentaires et sous-périostés avec greffe biocompatible

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Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10940042B2 (en) 2015-10-23 2021-03-09 The Trustees Of Columbia University In The City Of New York Laser induced collagen crosslinking in tissue
US11559433B2 (en) 2015-10-23 2023-01-24 The Trustees Of Columbia University In The City Of New York Laser induced collagen crosslinking in tissue
US11957622B2 (en) 2015-10-23 2024-04-16 The Trustees Of Columbia University In The City Of New York Laser induced collagen crosslinking in tissue
US11497403B2 (en) 2016-06-10 2022-11-15 The Trustees Of Columbia University In The City Of New York Devices, methods, and systems for detection of collagen tissue features
WO2018024700A1 (fr) * 2016-08-02 2018-02-08 Aesculap Ag Implant, de préférence pour le traitement d'un défaut de l'acetabulum
US11918707B2 (en) 2016-08-02 2024-03-05 Aesculap Ag Implant, preferably for the treatment of an acetabular defect
US11110208B2 (en) 2016-08-02 2021-09-07 Aesculap Ag Implant, preferably for the treatment of an acetabular defect
RU2756164C2 (ru) * 2016-10-20 2021-09-28 Устав структуры а механики горнин АВ ЧР, в.в.и. Нанокомпозитный слой на основе коллагеновых нановолокон и способ его изготовления
EP3311854A1 (fr) * 2016-10-20 2018-04-25 Ústav Struktury A Mechaniky Hornin AV CR, V.V.I. Couche nanocomposite à base de nanofibres de collagène et son procédé de préparation
WO2018187407A1 (fr) * 2017-04-04 2018-10-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Échafaudages hybrides polymère/ecm renforcés par un treillis en alliage de mg pour la régénération des défauts osseux de taille critique
CN107299456A (zh) * 2017-06-27 2017-10-27 江南大学 一种复合纳米纤维膜及其制备方法和应用
US11666481B1 (en) 2017-12-01 2023-06-06 The Trustees Of Columbia University In The City Of New York Diagnosis and treatment of collagen-containing tissues
CN108042854A (zh) * 2017-12-16 2018-05-18 诺迈尔（苏州）医学科技有限公司 用于牙种植手术的明胶纤维引导组织再生膜的生产工艺
CN109908405A (zh) * 2019-03-10 2019-06-21 西北大学 一种多孔骨修复支架材料及其制备方法
CN109908405B (zh) * 2019-03-10 2020-07-03 西北大学 一种多孔骨修复支架材料及其制备方法
CN113645944A (zh) * 2019-03-28 2021-11-12 国家研究院 包含从渔业和水产养殖废物中获得的羟基磷灰石或改性羟基磷灰石的物理防晒剂、其生产方法和包含其的光保护组合物
CN113893388A (zh) * 2021-09-23 2022-01-07 上海市第六人民医院 一种模块化组织工程骨-韧带-骨移植物及其制备方法
WO2024075118A1 (fr) * 2022-10-03 2024-04-11 Corneat Vision Ltd. Implants dentaires et sous-périostés avec greffe biocompatible
CN116271182A (zh) * 2022-12-15 2023-06-23 四川大学 静电纺丝重组人源化ⅲ型胶原蛋白伤口敷料及其制备方法
CN116161950A (zh) * 2023-03-08 2023-05-26 中国科学技术大学 一种基于纳米尺度梯度结构优化的仿生陶瓷基材料及其制备方法
CN116161950B (zh) * 2023-03-08 2024-03-29 中国科学技术大学 一种基于纳米尺度梯度结构优化的仿生陶瓷基材料及其制备方法

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