WO2013018884A1

WO2013018884A1 - Keratotic plug regrowth inhibition agent, keratotic plug regrowth inhibition method, and keratotic plug regrowth inhibition kit

Info

Publication number: WO2013018884A1
Application number: PCT/JP2012/069823
Authority: WO
Inventors: 茂麦倉; 飯田　年以; 隆之小野; 勝末継
Original assignee: 株式会社資生堂
Priority date: 2011-08-03
Filing date: 2012-08-03
Publication date: 2013-02-07
Also published as: TWI481417B; CN103857378B; CN103857378A; TW201311286A; HK1197582A1; KR101508168B1; KR20140054145A

Abstract

[Problem] To provide a keratotic plug regrowth inhibition agent, keratotic plug regrowth inhibition method, and keratotic plug regrowth inhibition kit whereby the regrowth of a keratotic plug can be effectively inhibited without causing skin irritation. [Solution] A keratotic plug regrowth inhibition agent, characterized in containing: (a) a specific acid (for example, lactic acid, succinic acid, citric acid, or the like) or a salt thereof; (b) a specific surfactant (for example, fatty acid soap, higher alkyl sulfate ester salt, polyoxyalkylene phytosterol, or the like); and (c) a specific skin irritation mitigation agent (for example, POE/POP dimethyl ether, tranexamic acid, pantothenyl ethyl ether, trimethyl glycine, glycylglycine, or the like). A keratotic plug regrowth inhibition method, in which a skin cleanser including a POE fatty acid ester is applied to the skin and thereafter a keratotic plug regrowth inhibition agent including a specific acid (for example, lactic acid, succinic acid, citric acid, or the like) or a salt thereof is applied to the skin; also, a keratotic plug regrowth inhibition kit comprising the skin cleanser and keratotic plug regrowth inhibition agent.

Description

Square plug regeneration inhibitor, method for inhibiting regeneration of corner plug, and kit for inhibiting regeneration of corner plug

The present invention relates to a horn plug regeneration inhibitor, a horn plug regeneration suppression method, and a horn plug regeneration suppression kit. More specifically, the present invention relates to a horn plug regeneration inhibitor, a horn plug regeneration suppression method, and a horn plug regeneration suppression kit that can effectively suppress the regeneration of horn plugs without causing rough skin.

¡Thorn plug trouble is one of the top items among female skin troubles. A horn plug is a mixture of sebum, exfoliated horny layer, etc. clogged in pores (pores) (see Non-Patent Document 1). If it is further included, it becomes a pimple that is clogged with black pores, both of which become noticeable and have a rough appearance as well as an unpleasant touch. It is also said that leaving this untreated leads to skin problems. As countermeasures against such already formed square plugs, it is common to remove them with a cleaning material or a pack, and a large number of products are sold. There are many prior art documents related to horn plug removal, for example, those containing N-acylamino acid salts (Patent Document 1), those containing lauroyl sarcosine (Patent Document 2), room temperature liquid oil and N, N, N ′, N Combination of '-tetrakis (2-hydroxypropyl) ethylenediamine, nonionic surfactant, etc. (Patent Document 3), dimer acid diester and mono fatty acid polyglyceryl combination (Patent Document 4), dimer acid diester and polyoxyethylene fatty acid glyceryl (Patent Document 5), dibasic acid diesters having 6 to 20 carbon atoms (Patent Document 6), and the like. However, the removal efficiency is not so high, and even if it is removed, it may be regenerated in about one week, and the skin often becomes rough by repeating the processing with the pack. However, the removal efficiency is not so high, and even after removal, it may be regenerated in about one week. Moreover, the skin was often roughened by repeating the processing in the pack.

So far, it has been known that organic acids such as tannic acid, lactic acid, citric acid, tartaric acid, glutamic acid and salts thereof are effective in inhibiting regeneration of horn plugs (see Patent Documents 7 to 8). However, the effect is quite difficult to realize, and even in the market there are products that tighten pores, such as astringent lotion, but there are no products that claim to make it difficult to regenerate horn plugs. . In addition, organic acids alone may cause rough skin and sensory irritation, and it is difficult to use them generally as cosmetics.

Japanese Patent No. 3857182 Japanese Patent No. 4058399 Japanese Patent No. 4285699 JP 2007-119393 A JP 2007-119394 A JP 2007-230929 A JP-A-4-360834 JP-A-4-360830

The present invention has been made in view of the above circumstances, and provides a horn plug regeneration inhibitor, a horn plug regeneration suppression method, and a horn plug regeneration suppression kit capable of effectively suppressing regeneration of horn plugs without causing rough skin. The purpose is to provide.

As a result of repeated researches to solve the above problems, the present inventors effectively combined the combination of a specific organic acid, a specific surfactant, and a specific anti-skin roughening component without causing rough skin. It was found that regeneration of horn plugs can be suppressed, and the horn plug regeneration inhibitor of the present invention was completed.

The present inventors have also found that by using a specific skin cleansing agent and a specific horn plug regeneration inhibitor, the effect of suppressing the regeneration of horn plugs is greatly enhanced without causing rough skin. The plug regeneration suppression method and the horn plug regeneration suppression kit have been completed.

That is, the present invention comprises (a) one or more selected from lactic acid, succinic acid, citric acid, malic acid, salicylic acid, pyrrolidone carboxylic acid, glycolic acid, and salts thereof, and (b) fatty acid soap. One or more surfactants selected from among higher alkyl sulfates, N-acyl glutamates, N-acyl lower alkyl taurates, betaine surfactants, and polyoxyalkylene phytosterols; c) Polyoxyethylene / polyoxypropylene dimethyl ether, tranexamic acid, pantothenyl ethyl ether, hypericum, serine, trimethylglycine, alanine, glycylglycine, vitamin E acetate, vitamin E nicotinate, 1-piperidinepropionic acid, and salts thereof Chosen from Contain one or two or more related keratotic plug reproduction suppressing agent characterized.

Further, the present invention may be selected from lactic acid, succinic acid, citric acid, malic acid, salicylic acid, pyrrolidone carboxylic acid, glycolic acid, and salts thereof after applying a skin cleanser containing polyoxyethylene fatty acid ester to the skin. The present invention relates to a method for inhibiting regeneration of horn plugs, which comprises applying to the skin a horn plug regeneration inhibitor containing one or more of the above.

In the method for inhibiting the regeneration of horn plugs, in the horn plug regeneration inhibitor, fatty acid soap, higher alkyl sulfate ester salt, N-acyl glutamate, N-acyl lower alkyl taurine salt, betaine surfactant, and polyoxyalkylene One or two or more surfactants selected from phytosterols may be included. Furthermore, an anti-skin roughening agent may be included.

The present invention also provides a skin cleanser comprising a polyoxyethylene fatty acid ester and one or two selected from lactic acid, succinic acid, citric acid, malic acid, salicylic acid, pyrrolidone carboxylic acid, glycolic acid, and salts thereof. The present invention relates to a horn plug regeneration suppression kit comprising a horn plug regeneration inhibitor containing at least species.

According to the present invention, there are provided a horn plug regeneration inhibitor, a horn plug regeneration suppression method, and a horn plug regeneration suppression kit capable of effectively suppressing horn plug regeneration without causing rough skin.

3 is a graph showing the influence on the moisture content of the stratum corneum by continuous application of Formulation 3 in Example 2.

Hereinafter, the present invention will be described in detail. In the following, POE represents polyoxyethylene, POP represents polyoxypropylene, and PEG represents polyethylene glycol.

A. Square plug regeneration inhibitor:
The horn plug regeneration inhibitor which is one embodiment of the present invention contains the following components (a) to (c).

[(A) component]
The component (a) used in the present invention is an organic acid selected from lactic acid, succinic acid, citric acid, malic acid, salicylic acid, pyrrolidone carboxylic acid and glycolic acid, or a salt thereof. The salt is not particularly limited as long as it can be generally used in cosmetics. For example, alkali metal salts (sodium salt, potassium salt, lithium salt, etc.), alkaline earth metal salts (calcium salt, magnesium salt) Etc.), ammonium salts, organic amine salts (monoethanolamine salts, diethanolamine salts, triethanolamine salts, etc.). Of these, lactic acid, succinic acid, salicylic acid, pyrrolidone carboxylic acid, or salts thereof are preferred. (A) A component can use 1 type (s) or 2 or more types.

The blending amount of the component (a) is preferably 0.001 to 20% by mass, more preferably 0.05 to 5% by mass in the horn plug regeneration inhibitor of the present invention. If it is less than 0.001% by mass, the effect as the component (a) cannot be sufficiently exhibited. On the other hand, even if it exceeds 20% by mass, an increase in the effect commensurate with the compounding amount cannot be expected.

[Component (b)]
Component (b) is one or more selected from fatty acid soaps, higher alkyl sulfates, N-acyl glutamates, N-acyl lower alkyl taurates, betaine surfactants, and polyoxyalkylene phytosterols. It is a surfactant.

Examples of fatty acid soaps include sodium laurate, potassium laurate, sodium palmitate, potassium palmitate and the like.

Examples of higher alkyl sulfates include sodium lauryl sulfate and potassium lauryl sulfate.

Examples of N-acylglutamate include sodium N-lauroylglutamate, potassium N-lauroylglutamate, disodium N-cocoylglutamate, dipotassium N-cocoylglutamate, sodium N-myristoyl-L-glutamate, N-myristoyl-L-glutamate mono Potassium etc. are mentioned.

The N-acyl lower alkyl taurine salt is particularly preferably an N-acyl methyl taurine salt. Specific examples include N-coconut oil fatty acid-sodium N-methyltaurine, N-coconut oil fatty acid-N-methyltaurine triethanolamine, N-coconut oil fatty acid-N-methyl taurine magnesium and the like.

Examples of betaine surfactants include 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminobutyric acid betaine, alkylbetaines (eg, laurylbetaine), amide betaines, sulfobetaines, and the like. It is done. Moreover, those salts are mentioned. Examples of the salt include sodium salt and potassium salt, but are not limited to these examples.

Polyoxyethylene phytosterol is preferably used as the polyoxyalkylene phytosterol. Particularly preferred is polyoxyethylene phytosterol added with 5 to 50 mol, more preferably 20 to 50 mol of oxyethylene. Specific examples include POE (5) phytosterol, POE (10) phytosterol, POE (20) phytosterol, POE (30) phytosterol and the like, and commercially available products include NIKKOL BPS-5, NIKKOL BPS-10, NIKKOL BPS- 20, NIKKOL BPS-30 (all of which are manufactured by Nippon Surfactant Co., Ltd.).

As the component (b), POE phytosterol, potassium laurate, lauryl betaine and the like are particularly preferable.

The blending amount of the component (b) is preferably 0.001 to 20% by mass, more preferably 0.05 to 5% by mass in the horn plug regeneration inhibitor of the present invention. If the amount is less than 0.001% by mass, the effect as the component (b) cannot be sufficiently exerted. On the other hand, even if the amount exceeds 20% by mass, an increase in the effect commensurate with the amount cannot be expected.

[Component (c)]
The component (c) is a component having an anti-skin roughening effect that can be generally used for a topical skin preparation. Examples thereof include tranexamic acid derivatives such as tranexamic acid and tranexamic acid methylamide, 1-piperidinepropionic acid, vitamin E acetate and vitamin E nicotinate. Examples include vitamin E derivatives such as erythritol, polyoxyethylene / polyoxypropylene dimethyl ether (= POE / POP dimethyl ether), pantothenyl ethyl ether, serine, trimethylglycine, alanine, glycylglycine and the like. Component (c) may be used in the form of a salt (sodium salt, potassium salt, etc.). In addition to the above, plant extracts such as hypericum, chamomile, clara, and peony are also included.

In the present invention, among others, POE / POP dimethyl ether, tranexamic acid, pantothenyl ethyl ether, hypericum, serine, trimethylglycine, alanine, glycylglycine, vitamin E acetate, vitamin E nicotinate, 1-piperidinepropionic acid, and salts thereof Preferably used.

POE / POP dimethyl ether having a molar ratio of POE to POP of about 1: 2 to 5: 1 is preferably used. Further, those having an oxyethylene addition mole number of 1 to 70 are preferred, those having 2 to 20 are more preferred, those having an oxypropylene addition mole number of 1 to 70 are preferred, and those having 2 to 20 are more preferred. (C) A component can use 1 type (s) or 2 or more types.

The blending amount of the component (c) is preferably 0.001 to 20% by mass, more preferably 0.05 to 5% by mass in the horn plug regeneration inhibitor of the present invention. If the amount is less than 0.001% by mass, the effect as the component (c) cannot be sufficiently exhibited. On the other hand, even if the amount exceeds 20% by mass, an increase in the effect commensurate with the amount added cannot be expected.

The horn plug regeneration inhibitor of the present invention in which the above components (a) to (c) are combined does not cause rough skin, and is excellent in the effect of inhibiting horn plug regeneration and feeling of effect. In addition, “suppression of regeneration of horn plugs” refers to preventing the horn plugs from being formed again in the pores after the horn plugs are once removed from the pores.

The horn plug regeneration inhibitor of the present invention is not limited to the effects of the present invention, and other optional additives usually used for external preparations for skin, such as cosmetics and pharmaceuticals, such as fats and oils, waxes, hydrocarbon oils. , Higher fatty acids, higher alcohols, synthetic ester oils, silicone oils, water-soluble polymers, chelating agents, lower alcohols, polyhydric alcohols, pH adjusters, antioxidants, powder components, perfumes, water, etc. as needed Can be blended. However, it is not limited to these examples.

The dosage form of the horn plug regeneration inhibitor of the present invention is not particularly limited, and can be used as a liquid preparation, a gel-like preparation, a cream, a sheet-impregnated preparation, etc., but a liquid preparation is particularly preferable. The horn plug regeneration inhibitor of the present invention preferably has a pH of about 3.0 to 8.0.

B. Square plug regeneration suppression method and square plug regeneration suppression kit:
A method for inhibiting corneal plug regeneration, which is another aspect of the present invention, includes a step of applying the following specific skin cleansing agent to the skin, and, after the step, applying the specific keratin plug regeneration inhibitor shown below to the skin. The process of carrying out is included.

Further, the horn plug regeneration suppression kit which is still another embodiment of the present invention comprises the following specific skin cleansing material and the following specific horn plug regeneration inhibitor.

<Skin cleansing agent>
The skin cleansing agent used in the method for inhibiting the regeneration of horn plugs of the present invention contains a polyoxyethylene fatty acid ester as an active ingredient. POE fatty acid esters include one or more fatty acid residues selected from oleic acid residues, isostearic acid residues and lauric acid residues, POE sorbitan fatty acid esters, POE fatty acid esters, POE glycerin fatty acid esters, POE propylene glycol Examples include fatty acid esters, POE hydrogenated castor oil surfactants, and sorbitan surfactants. However, it is not limited to these examples. POE fatty acid ester can use 1 type (s) or 2 or more types.

The blending amount of the POE fatty acid ester in the skin cleansing agent is preferably 1 to 60% by mass, more preferably 5 to 40% by mass. By setting it as the said compounding quantity range, in the combined use with a horn plug regeneration inhibitor, a very excellent horn plug regeneration inhibitory effect can be obtained. If the blending amount is less than 1% by mass, the effect as a component cannot be sufficiently exhibited. On the other hand, even if blending exceeds 60% by mass, an increase in the effect commensurate with the blending amount cannot be expected.

The skin cleansing material may be any base such as an oil type, a foam type, or a liquid type. In the present invention, an oil type liquid preparation (cleansing oil or the like) is particularly preferably used. In the case of an oil-type cleaning material (oil-based cleaning material), in addition to the above essential components, a liquid oil component at room temperature is blended as a main component. Examples of such liquid oils include hydrocarbon oils such as liquid paraffin (mineral oil), squalane, olefin oligomers, light isoparaffins; 2-ethylhexanoic acid triglyceride, 2-ethylhexanoic acid cetyl, 2-ethylhexanoic acid pentane Erythritol, triethylolpropane 2-ethylhexanoate, 2-ethylhexyl palmitate, isocetyl isononanoate, isopropyl myristate, etc .; jojoba oil, olive oil, macadamia nut oil, cottonseed oil, teaseed oil, safflower oil, rice bran oil Natural vegetable oils such as decamethylpentacyclosiloxane, octamethyltetracyclosiloxane, dimethylsiloxane, and methylphenylsiloxane.

When liquid oil is blended, it is preferably blended in the skin cleansing agent in the range of 50 to 95% by mass, more preferably 60 to 80% by mass. If the blending amount is 50% by mass, the effect as a component cannot be sufficiently exhibited. On the other hand, even if blending exceeds 95% by mass, an increase in the effect commensurate with the blending amount cannot be expected.

Moreover, as components that can be blended in addition to these liquid oils, various components that are usually blended in the field of cosmetics and pharmaceuticals can be added within a range that does not impair the effects of the present invention. Examples of such components include lower alcohols such as ethanol and isopropyl alcohol, and polyhydric alcohols such as glycerin, 1,3-butylene glycol, isoprene glycol, 1,3-butanediol, dipropylene glycol, and propylene glycol. , Anionic surfactants, amphoteric surfactants such as N-alkyl-N, N-dimethylaminoacetic acid betaine, alkyldimethylamine oxide, cationic surfactants, nonionic surfactants, bactericides, UV absorbers , Antioxidants, fragrances, water and the like.

<Square plug regeneration inhibitor>
[Organic acids]
The horn plug regeneration inhibitor used in the corn plug regeneration suppression method of the present invention contains organic acids, and these organic acids are the same as the component (a) in the above-mentioned “A. horn plug regeneration inhibitor”. It is done. The same applies to the preferred examples. These organic acids can be used alone or in combination of two or more.

The blending amount of the organic acids is preferably 0.001 to 20% by mass, more preferably 0.05 to 5% by mass in the horn plug regeneration inhibitor used in the present invention. If the amount is less than 0.001% by mass, the effect as the component (a) cannot be sufficiently exhibited. On the other hand, even if the amount exceeds 20% by mass, an increase in the effect commensurate with the amount cannot be expected.

[Surfactant]
The horn plug regeneration inhibitor used in the method of inhibiting horn plug regeneration according to the present invention includes fatty acid soap, higher alkyl sulfate, N-acyl glutamate, N-acyl lower alkyl taurine, betaine in addition to the above organic acids. It is preferable to contain a surfactant selected from a system surfactant and a polyoxyalkylene phytosterol. Specific examples and preferred examples of these surfactants include those similar to the component (b) in the above-mentioned “A. Square plug regeneration inhibitor”. Surfactant can use 1 type (s) or 2 or more types.

The blending amount of these surfactants is preferably 0.001 to 20% by mass, more preferably 0.05 to 5% by mass in the horn plug regeneration inhibitor. If it is less than 0.001% by mass, the effect as a blending component cannot be sufficiently exhibited. On the other hand, even if it exceeds 20% by mass, an increase in the effect commensurate with the blending amount cannot be expected.

[Anti-skin roughening agent]
It is preferable that an anti-skin roughening agent is further blended in the horn plug regeneration inhibitor used in the horn plug regeneration inhibiting method of the present invention. Specific examples and preferred examples of these anti-skin roughening agents include those similar to the component (c) in the “A. The anti-skin roughening agent can use 1 type (s) or 2 or more types.

The compounding amount of the anti-skin roughening agent is preferably 0.001 to 20% by mass, more preferably 0.05 to 5% by mass in the horn plug regeneration inhibitor. If it is less than 0.001% by mass, the effect as an anti-skin rough component cannot be sufficiently exhibited. On the other hand, even if it exceeds 20% by mass, an increase in the effect commensurate with the compounding amount cannot be expected.

The horn plug regeneration inhibitor used in the method of inhibiting horn plug regeneration according to the present invention is, as long as the effects of the present invention are not impaired, usually other optional components used in skin external preparations such as cosmetics and pharmaceuticals, such as fats and oils. Waxes, hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, silicone oils, water-soluble polymers, chelating agents, lower alcohols, polyhydric alcohols, pH adjusters, antioxidants, powder ingredients, perfumes, water Etc. can be appropriately blended as necessary. However, it is not limited to these examples.

The dosage form of the horn plug regeneration inhibitor used in the method of inhibiting horn plug regeneration according to the present invention is not particularly limited and can be used as a liquid preparation, a gel preparation, a cream, a sheet-impregnated preparation, etc. A formulation is preferred. It is preferable that the horn plug regeneration inhibitor has a pH of about 3.0 to 8.0.

<Method and kit for inhibiting regeneration of horn plug of the present invention>
In this invention, after washing | cleaning skin using the said skin washing | cleaning material, the square plug regeneration inhibitor can be suppressed very effectively by applying the said square plug regeneration inhibitor to skin. The method of application to the skin can be appropriately performed depending on the dosage form, such as impregnation with cotton or the like, application by spraying, or the like.

In addition, it can be used easily by selling as a cosmetic kit that includes the above-mentioned cleaning agent and horn plug regeneration inhibitor as a set.

Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited thereto. Unless otherwise specified, all the amounts are mass%.

A. Square plug regeneration inhibitor:
(Example 1: Comparison of inhibitory effect on horn plug regeneration by human test)
1. Samples Formulations 1 and 2 shown below were used. The preparation 1 is a comparative preparation containing the component (a) and the component (c). Formulation 2 is a sample obtained by adding POE (30) phytosterol to Formulation 1, and is a preparation of the present invention in which (a) component, (b) component, and (c) component are blended.

(Formulation 1: Comparative preparation, pH 4.1)
Succinic acid 0.5 (mass%)
Lactic acid 1
Tranexamic acid 1
Ethanol 5
Glycerin 5
Dipropylene glycol 5
POE (14), POP (7) dimethyl ether 1
Potassium hydroxide 0.135
Glycine 0.1
Ion exchange water

(Formulation 2: Product formulation of the present invention, pH 4.1)
Succinic acid 0.5 (mass%)
Lactic acid 1
Tranexamic acid 1
Ethanol 5
Glycerin 5
Dipropylene glycol 5
POE (14), POP (7) dimethyl ether 1
Potassium hydroxide 0.135
Glycine 0.1
POE (30) phytosterol 2
Ion exchange water

2. Evaluation test method Regeneration inhibition test of horn plugs was conducted by four males in their 30s to 50s who were relatively conspicuous. The square plug was observed by attaching a frame paper to an appropriate area of the top of the nose and observing with a video microscope (VMS, “Keyence VHX-100”). After dropping several drops of adhesive (“Aron Alpha A”; Sankyo) on a slide glass (with matsunami APS coat, s8444), the adhesive application surface side was brought into close contact with the above region. After 10 minutes, the slide glass was slowly peeled off to remove the square plug. The pores from which the horn plugs were completely removed were identified by VMS observation again, and the progress of regeneration of the horn plugs was observed for these identified pores. Here, the progress of the regeneration of the horn plug when the preparation was not used (control) was compared with the progress of the regeneration of the horn plug when the preparation (preparation 1, 2) was applied continuously.

Preparation 1: Take 2 mL of cotton (Shiseido Beauty Up Cotton) twice a day, and apply to the entire face centered on the nose and cheek including the top of the nose, which is the VMS observation site, for 3 weeks.

Formulation 2: The same application as in the case of Formulation 1 described above was performed by four identical subjects. However, formulation 2 was applied to the half-face including the nasal apex, which is the VMS observation site, and used continuously for 3 weeks.

The growth of horn plugs with the same pores over time was compared, and the growth of horn plugs (= clogged pores) when the preparation was applied was slower compared to the growth of horn plugs without using the preparation (control). “Draw” when the growth of the plug is almost the same between the control and the application of the formulation. “Draw”, compared to the growth of the plug without the formulation (control), = The pores were clogged) was fast, and the comparison was made for 4 people. The results are shown in Table 1.

In addition, since the number of pores (= number of pores to be subjected to test evaluation) that were able to completely remove the horn plugs initially differs for each evaluation test, the number of pores evaluated for Formulation 1 and Formulation 2 is Is different. A total of 4 subjects, who were 12 wins and 8 losses 9 divisions in the test using formulation 1, were 16 wins, 2 losses and 7 divisions in the test using formulation 2. Table 2 below shows the result of calculating the rate of “win” only. In the test using Formulation 2, the “win” rate was clearly increased. That is, it was confirmed that the preparation 2 obtained by adding the component (b) to the preparation 1 has a higher inhibitory effect on the regeneration of the horn plug than the preparation 1 containing the components (a) and (c).

(Example 2: Effect of skin plug regeneration inhibitor on skin condition)
1. Sample The following formulation 3 (= a formulation obtained by adding pantothenyl ethyl ether to the above-described formulation 2; a formulation of the present invention) was used.

(Preparation 3: Preparation of the present invention, pH 4.1)
Succinic acid 0.5 (mass%)
Lactic acid 1
Tranexamic acid 1
Ethanol 5
Glycerin 5
Dipropylene glycol 5
POE (14), POP (7) dimethyl ether 1
Potassium hydroxide 0.135
Glycine 0.1
POE (30) phytosterol 2
Pantothenyl ethyl ether 0.05
Ion exchange water

2. Evaluation test method For 5 male subjects, the preparation 3 was continuously applied to the nose and cheeks for 3 and a half faces for comparison with changes in the skin condition on the non-application side. For the nose on the application side and the non-application side, the amount of sebum and the amount of stratum corneum before and after continuous use for three weeks were measured and compared using a multi-probe meter MP5 (Courage + khazaka). Table 3 shows the results of the sebum amount, and FIG. 1 shows the results of the stratum corneum moisture amount. In FIG. 1, the vertical axis indicates the Corneometer measurement value (unit: AU).

As is clear from the results shown in Table 3, the amount of sebum tends to increase on the application side, but the increase tends to be less than that on the non-application side. It was.

As is clear from the results shown in FIG. 1, the amount of stratum corneum moisture also increased as an average value on the application side, and the application side was improved in 3 out of 5 individuals. Thus, it was confirmed that the skin condition became favorable by continuously applying Formulation 3.

(Example 4: Comparison of inhibitory effect of horn plug regeneration by human test)
1. Sample The preparation 2 described in Example 1 (= the preparation of the present invention) and the following preparations 4 and 5 were used.

Formulation 4 is a formulation obtained by removing tranexamic acid and POE (14) / POP (7) dimethyl ether from formulation 2, increasing the amount of glycerin and potassium hydroxide, and adding xylitol. Component (a) and component (b) It is a comparative product formulated.

Formulation 5 is a formulation obtained by removing tranexamic acid from formulation 2, increasing the amount of potassium hydroxide, and adding L-serine, trimethylglycine, and hypericum extract. The components (a), (b), and (c) are mixed. It is a blended product of the present invention.

(Formulation 4: Comparative preparation, pH 4.2)
Succinic acid 0.5 (mass%)
Lactic acid 1
Ethanol 5
Glycerin 9
Xylitol 3
Dipropylene glycol 5
Potassium hydroxide 0.5
Glycine 0.1
POE (30) phytosterol 2
Ion exchange water

(Formulation 5: Product formulation of the present invention, pH 4.2)
Succinic acid 0.5 (mass%)
Lactic acid 1
Ethanol 5
Glycerin 5
L-serine 0.1
Trimethylglycine 2.9
Hypericum extract 0.1
Dipropylene glycol 5
POE (14), POP (7) dimethyl ether 1
Potassium hydroxide 0.5
Glycine 0.1
POE (30) phytosterol 2
Ion exchange water Residual Evaluation test method

• A test for inhibiting the regeneration of horn plugs was conducted by four men who were relatively conspicuous in their 30s and 50s. Of the 4 subjects, 3 were subjects common to Example 1 (Subject Nos. 1, 3, and 4. The same numbers as in Example 1 were assigned). The remaining one person (Subject No. 5) conducted the evaluation test for the first time. The evaluation test of Example 4 was performed on a different day from the evaluation test of Example 1.

The observation of the square plug was performed in the same manner as in Example 1. That is, a frame paper was pasted on an appropriate area at the top of the nose and VMS observation was performed. After dropping a few drops of adhesive (“Aron Alpha A”; Sankyo) on a slide glass (Matsunami with APS coat, s8444), the adhesive application surface side was brought into close contact with the region. After 10 minutes, the slide glass was slowly peeled off to remove the square plug. The pores from which the horn plugs were completely removed were identified by VMS observation again, and the progress of regeneration of the horn plugs was observed for these identified pores. Here, the process of regeneration of horn plugs in a state where the preparation is not used (control), and the regeneration of horn plugs when the preparation (formulations 2, 4, and 5. Only one kind of preparation in one test) is applied continuously. The progress was compared. Each preparation was taken twice a day in 2 mL cotton and applied to the entire face including the nose and cheek including the nasal apex, which was the VMS observation site, for 3 weeks. All were carried out by four identical subjects.

The growth of horn plugs with the same pores was compared over time, and the growth of horn plugs (= clogged pores) when the preparation was applied was slower compared to the growth of horn plugs without using the preparation (control). “Win”, “Draw” when the growth of the plug is almost the same between the control and the formulation application, and compared to the growth of the plug without using the formulation (control), = The pores were clogged) was fast, and the comparison was made for 4 people. The results are shown in Table 4.

In addition, since the number of pores (= number of pores to be subjected to test evaluation) that can completely remove the horn plugs at the first time is different for each evaluation test, the number of each pore evaluated in the preparations 2, 4, and 5 is Is different. Table 5 below shows the result of calculating the rate of “winning” only.

As is clear from the results shown in Table 5, subject No. 3 shows that the preparation 4 has a higher inhibitory effect on the regeneration of horn plugs than the preparations 2 and 5, but when the results in Table 4 are taken together, the ratio of “losing” to the number of pores to be evaluated is The rate of “losing” in formulation 4 is as high as 28.6%, compared with 0% in formulation 2 and 8.7% in formulation 5. In Table 5, the other test subjects (3 persons) have higher inhibitory effect on the regeneration of the horn plugs of the preparations 2 and 5 than the preparation 4. Even when the total of four subjects are seen, the percentage of “winning” is reduced in the application of the preparation 4 as compared with the preparation 2, and the test of the preparation 5 is almost equivalent to the preparation 2. That is, compared with the preparation 4 containing only the components (a) and (b), the preparations 2 and 5 containing all of the components (a), (b), and (c) have a higher effect of inhibiting the regeneration of horn plugs. It was confirmed.

(Example 6: Screening of horn plug regeneration inhibitor)
Using the horn plug obtained according to the method described in Example 1, screening was performed for the effect of inhibiting horn plug regeneration using the evaluation drugs shown in Table 6 below.

That is, after dropping several drops of adhesive (“Aron Alpha A”; Sankyo) on the slide glass, the adhesive application surface side was brought into close contact with a partial region of the subject's nasal apex. After 10 minutes, the slide glass was slowly peeled off to obtain a square plug.

The square plug on the slide glass thus obtained was cut out from the adhesive surface with a cutter or the like and adhered onto a double-sided tape laid on the cover glass. It was put into a 5 mL petri dish, and an aqueous solution (1% aqueous solution) containing an evaluation agent shown in Table 4 was added. The change of the horn plug over time was observed with a stereomicroscope and SEM, and its form was evaluated according to the following four steps according to the degree of collapse of the horn plug. In addition, evaluation evaluated comprehensively the evaluation by a stereoscopic microscope method and a SEM method.
(Evaluation criteria)
Rank 0: No change (no change is observed on the surface of the plug)
Rank 1: Some changes are observed (Slight changes are observed, such as the surface of the square plug being slightly blurred)
Rank 2: There is a change (a clear change is observed on the surface of the plug)
Rank 3: There is considerable change (the unevenness change is remarkable, such as the surface of the square plug is broken)
(Evaluation solution)
As the evaluation solution, an aqueous solution containing 1% of the evaluation agent shown in Table 6 (1% by mass-containing aqueous solution) was used.

The following are examples of the formulation of the present invention.

(Formulation Example 1: Emulsion)
(Mixed component) (mass%)
(1) Stearic acid 2.0
(2) Lauric acid 0.5
(3) Cetyl alcohol 1.5
(4) Vaseline 5.0
(5) Liquid paraffin 10.0
(6) POE (10) monooleate 2.0
(7) Polyethylene glycol (1500) 3.0
(8) Triethanolamine 1.0
(9) Potassium hydroxide 0.05
(10) Carboxyvinyl polymer 0.05
(11) Sodium bisulfite 0.01
(12) Preservative appropriate amount (13) Fragrance proper amount (14) Citric acid 0.05
(15) 1-piperidinepropionic acid 0.05
(16) Residual ion-exchanged water (Production method)
(10) is dissolved in a part of (16) (A phase). (7), (8), (9), (11), (14), and (15) are added to the remaining (16), and the mixture is kept at 70 ° C. by heating and dissolving (aqueous phase). On the other hand, (1) to (6), (12) and (13) are mixed, heated and melted and kept at 70 ° C. (oil phase). Preliminarily emulsify by adding an oil phase to the aqueous phase, add phase A, uniformly emulsify with a homomixer, and cool to 30 ° C. while stirring well after emulsification to obtain an emulsion.

(Formulation Example 2: Latex)
(Mixed component) (mass%)
(1) Microcrystalline wax 1.0
(2) Beeswax 2.0
(3) Lanolin 20.0
(4) Liquid paraffin 10.0
(5) Squalane 5.0
(6) Sorbitan sesquioleate ester 4.0
(7) POE (20) sorbitan monooleate 1.0
(8) Lauryl betaine 0.1
(9) Propylene glycol 7.0
(10) L-arginine hydrochloride 5.0
(11) L-alanine 1.0
(12) Glycerin 3.0
(13) Glycolic acid 0.05
(14) Sodium bisulfite 0.01
(15) Preservative appropriate amount (16) Perfume appropriate amount (17) Ion-exchanged water residue (Production method)
Add (8) to (14) to (17) and heat to maintain at 70 ° C. (aqueous phase). On the other hand, (1) to (7), (15) and (16) are mixed, heated and melted and kept at 70 ° C. (oil phase). The water phase is gradually added while stirring the oil phase, and the mixture is uniformly emulsified with a homomixer, and then cooled to 30 ° C. while stirring well to obtain an emulsion.

(Formulation Example 3: Emulsion (W / O emulsion type))
(Mixed component) (mass%)
(1) Isopropyl alcohol 10.0
(2) Diglyceryl diisostearate 0.5
(3) POE-modified dimethylpolysiloxane 1.0
(4) POE (30) phytosterol 0.5
(5) Octamethylcyclotetrasiloxane 25.0
(6) Decamethylcyclopentasiloxane 15.0
(7) Trimethylsiloxysilicic acid 5.0
(8) Eucalyptus oil 3.0
(9) Fragrance 0.05
(10) Dipropylene glycol 2.0
(11) Phenoxyethanol 0.3
(12) Trisodium edetate 0.1
(13) Residual ion exchange water (14) Potassium chloride 0.5
(15) Tranexamic acid 0.5
(16) Lactic acid 0.05
(Manufacturing method)
(1) to (9) are dissolved by heating (oil phase), (10) to (16) are dissolved (aqueous phase), the aqueous phase is added to the oil phase and emulsified to obtain an emulsion.

(Prescription Example 4: Jelly)
(Mixed component) (mass%)
(Phase A)
95% ethyl alcohol 10.0
POE (20) Octyldodecanol 1.0
Pantothenyl ethyl ether 0.1
Lauryl betaine 0.05
Vitamin E-acetate 0.05
Preservative appropriate amount (phase B)
Potassium hydroxide 0.1
(Phase C)
Glycerin 5.0
Dipropylene glycol 10.0
Sodium bisulfite 0.03
Citric acid 0.05
L-arginine magnesium salt 0.05
Carboxyvinyl polymer 0.2
Ion-exchanged water residue (production method)
A phase and C phase are uniformly dissolved, and A phase is added to C phase to solubilize. Then, after adding phase B, filling is performed to obtain a jelly.

(Formulation example 5: O / W cream)
(Mixed component) (mass%)
A. Oil phase Cetanol 4.0
Vaseline 7.0
Isopropyl myristate 8.0
Squalane 15.0
Stearic acid monoglycerol ester 2.2
POE (20) sorbitan monostearate 2.8
Lauryl betaine 0.05
5-Ethoxysalicylic acid 0.01
Vitamin E Nicotinate 2.0
Fragrance 0.3
Antioxidant appropriate amount Preservative appropriate amount Aqueous phase Glycerin 10.0
Sodium hyaluronate 0.02
Xylitol 1.0
Dipropylene glycol 4.0
POE (14) / POP (7) dimethyl ether 1.0
L-Alanine 3.0
Edetate disodium 0.01
Citric acid 1.0
Purified water residue (production method)
A (oil phase) and B (aqueous phase) were each heated to 70 ° C. and completely dissolved. Next, A was added to B and emulsified with an emulsifier. Further, the emulsion is cooled using a heat exchanger to obtain a cream.

(Formulation example 6: W / O cream)
(Mixed component) (mass%)
(1) Hectorite treated with dimethyl distearyl ammonium chloride 2.0
(2) Polyoxyethylene / methylpolysiloxane polymer 0.1
(3) Lauryl betaine 0.5
(4) Liquid paraffin 10.0
(5) Vaseline 5.0
(6) Cetyl octoate 20.0
(7) Sodium L-glutamate 0.01
(8) Dipropylene glycol 5.0
(9) Methylparaben 0.2
(10) Salicylic acid 1.0
(11) Xylitol 2.0
(12) Glycylglycine 0.5
(13) Remaining amount of ion-exchanged water (production method)
(2), (3), (4), (6) heated to 50 ° C, and then (1) was added to the oil phase part completely dissolved by adding (5) and uniformly dispersed In addition, the aqueous phase parts in which (7) to (12) are dissolved are added to (13) by heating to 50 ° C., uniformly dispersed in HM, then cooled to room temperature, and the W / O cream is added. obtain.

(Formulation example 7: cloudy lotion)
(Mixed component) (mass%)
(1) α-olefin oligomer 2.0
(2) Isostearyl alcohol 0.5
(3) Isostearic acid 0.8
(4) Sorbitan sesquiisostearate 0.1
(5) POE (14) / POP (7) dimethyl ether 1.0
(6) POE (30) Phytosterol 1.0
(7) DL-α-tocopherol acetate 0.05
(8) Perfume appropriate amount (9) 1,3-butylene glycol 5.0
(10) Ethanol 5.0
(11) Xanthan gum 0.1
(12) Succinic acid 0.5
(13) Dipropylene glycol 5.0
(14) Tranexamic acid 1.0
(15) Sodium hyaluronate 0.01
(16) Sodium pyrosulfite 0.005
(17) Phenoxyethanol 0.5
(18) Sodium metaphosphate 0.05
(19) Lauryldimethylaminoacetic acid betaine 0.2
(20) Potassium hydroxide 0.2
(21) Lactic acid 1.0
(22) Concentrated glycerin 5.0
(23) Remaining amount of purified water (production method)
(1) to (8) are heated and dissolved at 70 ° C., stirred and mixed, and while maintaining the temperature at 70 ° C. while stirring, (23) is gradually added to emulsify and oil-in-water emulsification A composition is obtained. The obtained oil-in-water emulsion composition is further added to an aqueous formulation containing (9) to (22), and uniformly dispersed by stirring to obtain a cloudy lotion.

(Formulation example 8: lotion)
(Mixed component) (mass%)
(1) Succinic acid 0.5
(2) Lactic acid 1.0
(3) Ethanol 5.0
(4) Vitamin E acetate 0.05
(5) Glycerin 5.0
(6) Hypericum extract 0.1
(7) Clara extract 0.1
(8) Dipropylene glycol 5.0
(9) POE (14) / POP (7) Dimethyl ether 1.0
(10) Potassium hydroxide 0.5
(11) Glycine 0.1
(12) POE (30) Phytosterol 1.0
(13) Residual ion exchange water (Production method)
Dissolve (4) and (12) heated and dissolved in (3). Also, (1), (2), (5) to (11) are dissolved in (13), and both are mixed to obtain a skin lotion.

B. Square plug regeneration suppression method and square plug regeneration suppression kit:
(Example 7: Synergistic effect of skin cleanser and horn plug regeneration inhibitor by human test)
1. Sample The skin cleansing agent and the horn plug regeneration inhibitor used in this example are as follows.

≪Skin cleansing oil (cleaning oil) ≫
(mass%)
Mineral oil 67.54
Diphenylsiloxyphenyl trimethicone 2
Ethanol 1
Isostearyl alcohol 1
Cetyl isooctanoate 20
POE (12) diisostearate 5
POE (8) diisostearate 1
POE (10) isostearate 2
Tetrahydroxypropylethylenediamine 0.01
Dibutylhydroxytoluene 0.05
Ion exchange water 0.4

<< Square plug regeneration inhibitor ("Formulation 6"). pH 4.1 >>
(mass%)
Succinic acid 0.5
Lactic acid 1
Tranexamic acid 1
Ethanol 5
Glycerin 5
Dipropylene glycol 5
POE (14), POP (7) dimethyl ether 1
Potassium hydroxide 0.135
POE (30) phytosterol 2
Glycine 0.1
Ion exchange water

2. Evaluation Test Method [Test (1): Use only Formulation 6]
Four males in their 30s to 40s who are relatively conspicuous with plugs were tested for suppression of regeneration of the plugs. The square plug was observed by attaching a frame paper to an appropriate area of the top of the nose and observing with a video microscope (VMS, “Keyence VHX-100”). After dropping several drops of adhesive (“Aron Alpha A”; Sankyo) on a slide glass (with matsunami APS coat, s8444), the adhesive application surface side was brought into close contact with the above region. After 10 minutes, the slide glass was slowly peeled off to remove the square plug. The pores from which the horn plugs were completely removed were identified by VMS observation again, and the progress of regeneration of the horn plugs was observed for these identified pores. Here, the progress of regeneration of the horn plug when the preparation was not used (control) was compared with the progress of regeneration of the horn plug when the preparation was continuously applied.

Preparation 6: Take 2 mL of cotton (Shiseido Beauty Up Cotton) twice a day, and apply to a half face centered on the nose and cheek including the nasal apex, which is a VMS observation site, for 3 weeks.

[Test (2): Combination of skin cleanser and formulation 6]
An experiment in which the test (2) in which the preparation 6 was combined with a skin cleanser was applied in the same manner as in the test (1) was performed by the same four subjects. For the skin cleansing agent, the preparation (1) was applied after the components were sufficiently wiped off.

In addition, about one of four persons, the observation by VMS was not implemented but only continuous application was performed.

<Evaluation>
Comparing the growth of square plugs with the same pore over time, when formulation 6 was applied as compared to the growth of square plugs without using formulation 6 (in combination with skin cleanser in test (2), the same applies hereinafter) Horn plug growth (= clogged pores) was won, and those with the same growth rate were drawn between the control and the formulation 6 application, and the corneal plug in the state where the formulation 6 was not used (control) Compared to the growth, a comparison was made for four patients, assuming that the growth of horn plug (= the pores were clogged) when the preparation 6 was applied was lost. The results are shown in Table 7.

The number of pores evaluated in Test (1) and Test (2) is different because the number of pores that can be completely removed and compared can be different depending on the test. A total of 4 subjects, who were 22 wins and 3 losses in the test (1), became 8 wins in 43 wins and 4 losses when combined with cleaning oil in the test (2). Table 8 shows the result of calculating the win-only rate, which increases from 66.7% to 78.2%. 7 and no. The effect increased at 8.

In addition, as a result of the interview (total of 5 subjects) including one subject who did not perform VMS observation of the horn plug, the number of people who could feel that the plug was delayed after 3 weeks was Only 1 out of 5 people was applied. On the other hand, when combined with the cleaning agent, the fact that the plugging of the horn plugs was delayed was realized in 2 people in 1 week out of 5 people, 3 in 2 weeks, and 4 in 3 weeks. It turned out that the feeling increased considerably. Regarding the skin condition, there was a voice that the nose and cheeks were smooth and moisturized on the application side, and the skin condition was also improved.

(Example 8: Screening of horn plug regeneration inhibitor)
Also in the invention of the aspect of “B. Method for inhibiting regeneration of horn plug and kit for inhibiting horn plug regeneration”, the evaluation drugs shown in Table 6 above were obtained using the horn plug obtained according to the method described in Example 6 above. Using the same method and evaluation criteria as in Example 6 for screening for the effect of inhibiting the regeneration of horn plugs, the same results as the evaluation results shown in Table 6 were obtained.

Below, the formulation example of this invention is shown further.
<Skin cleansing agent (Prescription Examples 9 to 10)>
(Formulation example 9: skin cleansing agent)
(Mixed component) (mass%)
(1) Liquid paraffin 62.0
(2) Pentaerythritol 2-ethylhexanoate 10.0
(3) POE (8) Oleate 10.0
(4) POE (20) glyceryl triisostearate 10.0
(5) N, N, N ′, N′-tetrakis (2-hydroxypropyl)
Ethylenediamine 3.0
(6) Purified water 5.0

(Formulation example 10: skin cleansing agent)
(Mixed component) (mass%)
(1) Squalane residue (2) 2-methylhexanoic acid trimethylolpropane 10.0
(3) POE (12) oleate 2.0
(4) POE (20) glyceryl triisostearate 8.0
(5) POE (50) hydrogenated castor oil monoisostearate 3.0
(6) N, N, N ′, N′-tetrakis (2-hydroxypropyl)
Ethylenediamine 0.1
(7) Vitamin E 0.05
(8) BHT 0.05
(9) Purified water 2
(Manufacturing method)
A room temperature liquid oil and a surfactant are mixed and stirred at room temperature to be uniform, and then an aqueous component is added and mixed and stirred to prepare a sample.

<Square plug regeneration inhibitor (Prescription Examples 11 to 19)>
(Formulation example 11: lotion)
(Mixed component) (mass%)
A.
Ethanol 5.0
POE (30) Phytosterol 2.0
PPG-13decyltetradeces-24 0.2
2-Ethylhexyl-P-dimethylaminobenzoate 0.18
Fragrance 0.05
B.
1,3-butylene glycol 9.5
Sodium pyrrolidonecarboxylate 0.5
Xylitol 0.5
Nicotinamide 0.3
Glycerin 5.0
Trimethylglycine 5.0
Tranexamic acid 1.0
Lysine 0.05
Succinic acid 0.5
Purified water residue (production method)
The alcohol phase of A is added to the aqueous phase of B and solubilized to obtain a lotion.

(Prescription Example 12: Emulsion)
(Mixed component) (mass%)
A. Oil phase Dimethylpolysiloxane 0.5
Decamethylcyclopentasiloxane 1
Jojoba oil 0.5
POE (30) Phytosterol 0.2
B. Water phase tranexamic acid 1
Carrot extract 0.5
Alkyl-modified carboxyvinyl polymer 0.05
Carboxyvinyl polymer 0.3
Gum arabic 0.05
Ethyl alcohol 8
Edetate trisodium 0.1
Methylparaben 0.1
Phenoxyethanol 0.2
Citric acid 0.05
Ion exchange water Residual C. Neutralization Potassium hydroxide 0.15
(Manufacturing method)
The dissolved (A) phase is added to the dissolved (B) phase, emulsified, and then neutralized with the (C) phase to obtain an emulsion.

(Prescription Example 13) to (Prescription Example 19)
The same prescription examples as the prescription examples 1 to 7 described in the above section “A.

Claims

(A) one or more selected from lactic acid, succinic acid, citric acid, malic acid, salicylic acid, pyrrolidone carboxylic acid, glycolic acid, and salts thereof; and (b) fatty acid soap and higher alkyl sulfate. One or more surfactants selected from among salts, N-acyl glutamates, N-acyl lower alkyl taurine salts, betaine surfactants, and polyoxyalkylene phytosterols; and (c) polyoxyethylene -Selected from polyoxypropylene dimethyl ether, tranexamic acid, pantothenyl ethyl ether, hypericum, serine, trimethylglycine, alanine, glycylglycine, vitamin E acetate, vitamin E nicotinate, 1-piperidinepropionic acid, and salts thereof 1 type or 2 types or more Characterized in that it contains a keratin plug regeneration inhibitors.
The inhibition of regeneration of horn plug according to claim 1, comprising 0.001 to 20% by mass of component (a), 0.001 to 20% by mass of component (b), and 0.001 to 20% by mass of component (c). Agent.
One or two selected from lactic acid, succinic acid, citric acid, malic acid, salicylic acid, pyrrolidone carboxylic acid, glycolic acid, and salts thereof after applying the skin cleanser containing polyoxyethylene fatty acid ester to the skin A method for inhibiting the regeneration of horn plugs, which comprises applying to the skin a horn plug regeneration inhibitor containing more than one species.
One or two selected from fatty acid soap, higher alkyl sulfate ester salt, N-acyl glutamate salt, N-acyl lower alkyl taurine salt, betaine surfactant, and polyoxyalkylene phytosterol in the horn plug inhibitor The method for inhibiting regeneration of horn plugs according to claim 3, comprising at least one kind of surfactant.
5. The method of inhibiting horn plug regeneration according to claim 3 or 4, further comprising an anti-skin roughening agent in the horn plug inhibitor.
Anti-skin roughening agents are polyoxyethylene / polyoxypropylene dimethyl ether, tranexamic acid, pantothenyl ethyl ether, hypericum, serine, trimethylglycine, alanine, glycylglycine, vitamin E acetate, vitamin E nicotinate, 1-piperidine propionic acid, and The method for inhibiting regeneration of horn plugs according to claim 5, wherein the salt is one or more selected from those salts.
Skin cleansing agent containing polyoxyethylene fatty acid ester and horn containing one or more selected from lactic acid, succinic acid, citric acid, malic acid, salicylic acid, pyrrolidone carboxylic acid, glycolic acid, and salts thereof Square plug regeneration suppression kit comprising a plug regeneration inhibitor.