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WO2012018635A3 - Arylsulfonamide derivatives, compositions, and methods of use - Google Patents

Arylsulfonamide derivatives, compositions, and methods of use Download PDF

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Publication number
WO2012018635A3
WO2012018635A3 PCT/US2011/045390 US2011045390W WO2012018635A3 WO 2012018635 A3 WO2012018635 A3 WO 2012018635A3 US 2011045390 W US2011045390 W US 2011045390W WO 2012018635 A3 WO2012018635 A3 WO 2012018635A3
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WIPO (PCT)
Prior art keywords
disorders
pain
migraine
disease
aura
Prior art date
Application number
PCT/US2011/045390
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French (fr)
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WO2012018635A2 (en
Inventor
Stephen Wanaski
Stephen Collins
John Kincaid
Original Assignee
Neurotherapeutics Pharma, Inc.
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Publication date
Application filed by Neurotherapeutics Pharma, Inc. filed Critical Neurotherapeutics Pharma, Inc.
Priority to EP11815079.6A priority Critical patent/EP2598478A2/en
Priority to CA2806664A priority patent/CA2806664A1/en
Priority to JP2013521910A priority patent/JP2013536178A/en
Publication of WO2012018635A2 publication Critical patent/WO2012018635A2/en
Publication of WO2012018635A3 publication Critical patent/WO2012018635A3/en

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    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
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    • C07C311/40—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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Abstract

The present invention provides acylsulfonamides including bumetanide derivatives and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these compounds and methods for their use. All of these analogs are particularly useful for the treatment and/or prophylaxis of conditions that involve the Na+K+Cl- co-transporter or GABAA receptor including but not limited to addictive disorders, Alzheimer's Disease, anxiety disorders, ascites, attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (autism), bipolar disorder, cancer, the improvement of cognitive function, cognitive impairment, cognitive dysfunction, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma, Huntington's Disease, inflammatory pain, insomnia, ischemia, migraine, migraine with aura, migraine without aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, Parkinson's disease, periodic limb movement disorder (PLMD), personality disorders, postherpetic neuralgia, psychosis, restless legs syndrome (RLS), schizophrenia, seizure disorders, spasticity, tinnitus, and withdrawal syndromes.
PCT/US2011/045390 2010-07-26 2011-07-26 Arylsulfonamide derivatives, compositions, and methods of use WO2012018635A2 (en)

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