[go: up one dir, main page]

WO2007132026A1 - Substance de régénération osseuse composée de sulfate calcique semi-hydraté et de phosphate calcique - Google Patents

Substance de régénération osseuse composée de sulfate calcique semi-hydraté et de phosphate calcique Download PDF

Info

Publication number
WO2007132026A1
WO2007132026A1 PCT/ES2006/000240 ES2006000240W WO2007132026A1 WO 2007132026 A1 WO2007132026 A1 WO 2007132026A1 ES 2006000240 W ES2006000240 W ES 2006000240W WO 2007132026 A1 WO2007132026 A1 WO 2007132026A1
Authority
WO
WIPO (PCT)
Prior art keywords
bone
calcium phosphate
semi
calcium
substance composed
Prior art date
Application number
PCT/ES2006/000240
Other languages
English (en)
Spanish (es)
Inventor
Christobal Martin-Nieto Camacho
Francisco Javier Poblete Martin
Original Assignee
Martin-Nieto Camacho Christoba
Poblete Martin Francisco Javie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Martin-Nieto Camacho Christoba, Poblete Martin Francisco Javie filed Critical Martin-Nieto Camacho Christoba
Priority to PCT/ES2006/000240 priority Critical patent/WO2007132026A1/fr
Publication of WO2007132026A1 publication Critical patent/WO2007132026A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite

Definitions

  • the present invention relates to a substance, composed of calcium sulfate hemihydrate and calcium phosphate.
  • the substance, to which the present invention refers, acts as a bone regenerator, both for its application in stomatology, traumatology and in any other medical specialty that requires bone regeneration, traumatology for its development.
  • the bone regeneration process involves the following stages: 1.- Activation of osteogenic precursor cells. 2.- Active bone absorption, resorption. 3.- Rest period and 4.- New bone formation.
  • osteoblasts bone-producing cells
  • the osteoclastic absorption lagoons are repopulated by a contingent of osteoblasts that make osteoid (young bone), which calcifies, the bone being restored.
  • For osteogenesis to exist it is necessary that the tissue from which the bone is formed is very vascularized, so that vessels can grow inside blood.
  • the products that are used for bone regeneration can be classified into two large groups: Organic or inorganic or synthetic.
  • the oldest of the synthetic products used is calcium phosphate, since the body transforms that product into bone tissue.
  • the proportion of reabsorption varies and depends on the chemical structure of the material, its porosity and size of the par- title It is osteoconductive.
  • B) Calcium sulfate It is soluble in water, a condition lacking calcium phosphate and is, like this one, osteoconductive and, in addition, of great osteoinductive capacity.
  • Dr. Dreesman used calcium sulfate as a filler for cavitary defects due to its osteoconductive quality. Resorbable in bone in a shorter time than calcium phosphate (2-3 months).
  • the substance in question here composed of calcium sulfate hemihydrate and calcium phosphate, using potassium sulfate as a catalyst, combines the advantages of calcium sulfate hemihydrate and calcium phosphate, that is: it is a porous material, and by therefore of great vascular capacity, of easy reabsorption, containing the phosphate anion and calcium cation necessary for bone neoformation. It is antiseptic and easy to use, not presenting rejection by being inorganic with increased osteoconductivity.
  • potassium sulfate in catalytic amounts, to 4%, to accelerate the setting process.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention une substance de régénération osseuse composée de sulfate calcique semi-hydraté et de phosphate calcique, utilisée en stomatologie, traumatologie ou n'importe quelle autre spécialité médicale nécessitant pour son développement une régénération osseuse. L'invention concerne un composé inorganique qui, conjuguant les avantages du sulfate calcique semi-hydraté et du phosphate calcique, constitue un composé de régénération osseuse idéal, ostéoinducteur, ostéoconducteur, réabsorbable, antiseptique, non toxique et facile à manipuler, et également peu coûteux.
PCT/ES2006/000240 2006-05-12 2006-05-12 Substance de régénération osseuse composée de sulfate calcique semi-hydraté et de phosphate calcique WO2007132026A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/ES2006/000240 WO2007132026A1 (fr) 2006-05-12 2006-05-12 Substance de régénération osseuse composée de sulfate calcique semi-hydraté et de phosphate calcique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/ES2006/000240 WO2007132026A1 (fr) 2006-05-12 2006-05-12 Substance de régénération osseuse composée de sulfate calcique semi-hydraté et de phosphate calcique

Publications (1)

Publication Number Publication Date
WO2007132026A1 true WO2007132026A1 (fr) 2007-11-22

Family

ID=38693568

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2006/000240 WO2007132026A1 (fr) 2006-05-12 2006-05-12 Substance de régénération osseuse composée de sulfate calcique semi-hydraté et de phosphate calcique

Country Status (1)

Country Link
WO (1) WO2007132026A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619655A (en) * 1984-01-26 1986-10-28 University Of North Carolina Plaster of Paris as a bioresorbable scaffold in implants for bone repair
WO1991000252A1 (fr) * 1989-06-30 1991-01-10 United States Gypsum Company Composition a base d'hemihydrate de sulfate de calcium utilisable en contact avec le sang
WO1991017722A1 (fr) * 1990-05-11 1991-11-28 Lifecore Medical, Inc. Composition de platre et d'hydroxylapatite a prise rapide
WO2000007639A1 (fr) * 1998-08-07 2000-02-17 Tissue Engineering, Inc. Compositions precurseurs osseuses
WO2000027316A1 (fr) * 1998-11-06 2000-05-18 John Ricci Implantation d'implants chirurgicaux a l'aide de sulfate de calcium
WO2002005861A1 (fr) * 2000-07-17 2002-01-24 Bone Support Ab Composition injectable d'un materiau substitut mineral de l'os

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619655A (en) * 1984-01-26 1986-10-28 University Of North Carolina Plaster of Paris as a bioresorbable scaffold in implants for bone repair
WO1991000252A1 (fr) * 1989-06-30 1991-01-10 United States Gypsum Company Composition a base d'hemihydrate de sulfate de calcium utilisable en contact avec le sang
WO1991017722A1 (fr) * 1990-05-11 1991-11-28 Lifecore Medical, Inc. Composition de platre et d'hydroxylapatite a prise rapide
WO2000007639A1 (fr) * 1998-08-07 2000-02-17 Tissue Engineering, Inc. Compositions precurseurs osseuses
WO2000027316A1 (fr) * 1998-11-06 2000-05-18 John Ricci Implantation d'implants chirurgicaux a l'aide de sulfate de calcium
WO2002005861A1 (fr) * 2000-07-17 2002-01-24 Bone Support Ab Composition injectable d'un materiau substitut mineral de l'os

Similar Documents

Publication Publication Date Title
Combes et al. Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction
Horch et al. Synthetic, pure-phase beta-tricalcium phosphate ceramic granules (Cerasorb®) for bone regeneration in the reconstructive surgery of the jaws
Xiao et al. Preparation of resorbable carbonate-substituted hollow hydroxyapatite microspheres and their evaluation in osseous defects in vivo
Berberi et al. Physicochemical characteristics of bone substitutes used in oral surgery in comparison to autogenous bone
US11628069B2 (en) 3D printing of polymeric bioceramics for the treatment of bone defects
US20090028954A1 (en) Precursor for the preparation of a pasty bone replacement material by admixture of a liquid
EP2421543A1 (fr) Composition de ciment à base de phosphate de calcium biphasique
Masaeli et al. Efficacy of the biomaterials 3 wt%-nanostrontium-hydroxyapatite-enhanced calcium phosphate cement (nanoSr-CPC) and nanoSr-CPC-incorporated simvastatin-loaded poly (lactic-co-glycolic-acid) microspheres in osteogenesis improvement: An explorative multi-phase experimental in vitro/vivo study
US10172977B2 (en) Porous biomaterial
PT1829565E (pt) Novo substituto mineral de osso
Demirel et al. Effect of strontium-containing compounds on bone grafts
Ebrahimi Bone grafting substitutes in dentistry: general criteria for proper selection and successful application
Takechi et al. The in vitro antibiotic release from anti-washout apatite cement using chitosan
Hesaraki et al. Phase evaluation of an effervescent‐added apatitic calcium phosphate bone cement
Saxena et al. Calcium phosphate enriched synthetic tyrosine-derived polycarbonate–dicalcium phosphate dihydrate polymer scaffolds for enhanced bone regeneration
Daculsi Biphasic calcium phosphate granules concept for injectable and mouldable bone substitute
Aqib et al. Metal-Doped brushite cement for bone regeneration
US20130309214A1 (en) Composition containing injectable self-hardened apatite cement
Mamidwar et al. In vitro characterization of a calcium sulfate/PLLA composite for use as a bone graft material
WO2007132026A1 (fr) Substance de régénération osseuse composée de sulfate calcique semi-hydraté et de phosphate calcique
US20060110422A1 (en) Conversion of calcite powders into macro- and microporous calcium phosphate scaffolds for medical applications
BRPI0611774A2 (pt) precursor sólido para a preparação de um material pastoso para substituição óssea pela mistura de um lìquido
ES2373137B2 (es) Cemento de fosfato cálcico-silicato cálcico para aplicaciones biomédicas.
Hallman et al. Bone replacement following dental trauma prior to implant surgery–present status
Straub et al. Calcium Sulfate Bone Substitutes in Clinical Use: History, Material Properties, Application, and Outlook for the Future

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06743479

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06743479

Country of ref document: EP

Kind code of ref document: A1