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WO2007090822A3 - Pharmazeutische formulierung für aerosole mit zwei oder mehr wirkstoffen und mindestens einer oberflächenaktiven substanz - Google Patents

Pharmazeutische formulierung für aerosole mit zwei oder mehr wirkstoffen und mindestens einer oberflächenaktiven substanz Download PDF

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Publication number
WO2007090822A3
WO2007090822A3 PCT/EP2007/051095 EP2007051095W WO2007090822A3 WO 2007090822 A3 WO2007090822 A3 WO 2007090822A3 EP 2007051095 W EP2007051095 W EP 2007051095W WO 2007090822 A3 WO2007090822 A3 WO 2007090822A3
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WO
WIPO (PCT)
Prior art keywords
surfactant
aerosols
active agents
pharmaceutical formulation
active agent
Prior art date
Application number
PCT/EP2007/051095
Other languages
English (en)
French (fr)
Other versions
WO2007090822A2 (de
Inventor
Erhard Berkel
Hubert Hoelz
Friedrich Schmidt
Original Assignee
Boehringer Ingelheim Pharma
Erhard Berkel
Hubert Hoelz
Friedrich Schmidt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38266105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007090822(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU2007213819A priority Critical patent/AU2007213819B2/en
Priority to NZ571016A priority patent/NZ571016A/en
Priority to CA002641883A priority patent/CA2641883A1/en
Priority to JP2008553744A priority patent/JP2009526012A/ja
Priority to EA200801767A priority patent/EA014776B1/ru
Application filed by Boehringer Ingelheim Pharma, Erhard Berkel, Hubert Hoelz, Friedrich Schmidt filed Critical Boehringer Ingelheim Pharma
Priority to EP07704378A priority patent/EP1988874A2/de
Priority to BRPI0707594-4A priority patent/BRPI0707594A2/pt
Publication of WO2007090822A2 publication Critical patent/WO2007090822A2/de
Publication of WO2007090822A3 publication Critical patent/WO2007090822A3/de
Priority to NO20083375A priority patent/NO20083375L/no
Priority to IL193274A priority patent/IL193274A0/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die vorliegende Erfindung betrifft neue pharmazeutische Formulierungen für Aerosole mit mindestens zwei oder mehr Wirkstoffen zusammen mit mindestens einer oberflächenaktiven Substanz für die inhalative oder nasale Anwendung. Im Einzelnen betrifft die Erfindung pharmazeutische Zubereitungen für treibmittelbetriebene Dosieraerosole mit einem Fluorkohlenwasserstoff (HFA) als Treibmittel, die eine Wirkstoffkombination aus zwei oder mehr Wirkstoffen enthalten, wobei mindestens ein Wirkstoff in gelöster Form neben mindestens einem weiteren Wirkstoff in Form suspendierter Teilchen zusammen mit mindestens einer oberflächenaktiven Substanz vorliegt.
PCT/EP2007/051095 2006-02-09 2007-02-06 Pharmazeutische formulierung für aerosole mit zwei oder mehr wirkstoffen und mindestens einer oberflächenaktiven substanz WO2007090822A2 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BRPI0707594-4A BRPI0707594A2 (pt) 2006-02-09 2007-02-06 composÇço farmacÊutica para aerossàis com duas ou mais substÂncias ativas e pelo menos um tensoativo
NZ571016A NZ571016A (en) 2006-02-09 2007-02-06 Pharmaceutical formulation for aerosols, comprising two or more active agents and at least one surfactant
CA002641883A CA2641883A1 (en) 2006-02-09 2007-02-06 Pharmaceutical formulation for aerosols, comprising two or more active agents and at least one surfactant
JP2008553744A JP2009526012A (ja) 2006-02-09 2007-02-06 ２以上の活性物質及び少なくとも一つの界面活性剤を有するエアロゾル用の医薬組成物
EA200801767A EA014776B1 (ru) 2006-02-09 2007-02-06 Фармацевтическая композиция для аэрозольного распыления с двумя действующими веществами и по меньшей мере одним поверхностно-активным веществом
AU2007213819A AU2007213819B2 (en) 2006-02-09 2007-02-06 Pharmaceutical formulation for aerosols, comprising two or more active agents and at least one surfactant
EP07704378A EP1988874A2 (de) 2006-02-09 2007-02-06 Pharmazeutische formulierung für aerosole mit zwei oder mehr wirkstoffen und mindestens einer oberflächenaktiven substanz
NO20083375A NO20083375L (no) 2006-02-09 2008-08-04 Farmasoytisk formulering for aerosoler, omfattende to eller aktive midler og minst et overflate aktivt middel
IL193274A IL193274A0 (en) 2006-02-09 2008-08-06 Pharmaceutical formulation for aerosols, comprising two or more active agents and at least one surfactant

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102006006207 2006-02-09
DE102006006207.8 2006-02-09
DE102006053374.7 2006-11-10
DE102006053374A DE102006053374A1 (de) 2006-02-09 2006-11-10 Pharmazeutische Formulierung für Aerosole mit zwei oder mehr Wirkstoffen und mindestens einer oberflächenaktiven Substanz

Publications (2)

Publication Number Publication Date
WO2007090822A2 WO2007090822A2 (de) 2007-08-16
WO2007090822A3 true WO2007090822A3 (de) 2007-11-08

Family

ID=38266105

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/051095 WO2007090822A2 (de) 2006-02-09 2007-02-06 Pharmazeutische formulierung für aerosole mit zwei oder mehr wirkstoffen und mindestens einer oberflächenaktiven substanz

Country Status (19)

Country Link
US (1) US20070183982A1 (de)
EP (1) EP1988874A2 (de)
JP (1) JP2009526012A (de)
KR (1) KR20080098656A (de)
CN (1) CN102861339A (de)
AR (1) AR059350A1 (de)
AU (1) AU2007213819B2 (de)
BR (1) BRPI0707594A2 (de)
CA (1) CA2641883A1 (de)
DE (1) DE102006053374A1 (de)
EA (1) EA014776B1 (de)
EC (1) ECSP088653A (de)
IL (1) IL193274A0 (de)
NO (1) NO20083375L (de)
NZ (1) NZ571016A (de)
PE (2) PE20070951A1 (de)
TW (1) TW200800294A (de)
UY (1) UY30139A1 (de)
WO (1) WO2007090822A2 (de)

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EP2077132A1 (de) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Abgabevorrichtung, Aufbewahrungsvorrichtung und Verfahren zur Abgabe einer Formulierung
WO2010112358A2 (de) 2009-03-31 2010-10-07 Boehringer Ingelheim International Gmbh Verfahren zur beschichtung einer oberfläche eines bauteils
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JP5715640B2 (ja) 2009-11-25 2015-05-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
JP5658268B2 (ja) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
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EP2694220B1 (de) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
GB201306984D0 (en) * 2013-04-17 2013-05-29 Mexichem Amanco Holding Sa Composition
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
EP3030298B1 (de) 2013-08-09 2017-10-11 Boehringer Ingelheim International GmbH Vernebler
RU2536253C1 (ru) * 2013-10-09 2014-12-20 Шолекс Девелопмент Гмбх Комбинированный аэрозольный препарат для лечения болезней органов дыхания
IL247927B (en) 2014-05-07 2022-09-01 Boehringer Ingelheim Int Container, nebulizer and use
EP3139984B1 (de) 2014-05-07 2021-04-28 Boehringer Ingelheim International GmbH Zerstäuber
NZ724724A (en) 2014-05-07 2022-01-28 Boehringer Ingelheim Int Container, indicator device, and nebulizer
EP2985019B1 (de) 2014-08-16 2021-10-20 Church & Dwight Co., Inc. Nasale Zusammensetzung mit antiviralen Eigenschaften
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GB2332372A (en) * 1997-12-08 1999-06-23 Minnesota Mining & Mfg Pharmaceutical aerosol compositions containing a plurality of active ingredients
WO1999065464A1 (en) * 1998-06-18 1999-12-23 Boehringer Ingelheim Pharmaceuticals, Inc. Pharmaceutical formulations for aerosols with two or more active substances
WO2004019985A1 (en) * 2002-08-29 2004-03-11 Cipla Ltd Pharmaceutical products and compositions comprising specific anticholinergic agents, beta-2 agonists and corticosteroids

Also Published As

Publication number Publication date
AU2007213819A1 (en) 2007-08-16
NO20083375L (no) 2008-10-30
JP2009526012A (ja) 2009-07-16
AU2007213819B2 (en) 2012-11-15
ECSP088653A (es) 2008-10-31
WO2007090822A2 (de) 2007-08-16
KR20080098656A (ko) 2008-11-11
NZ571016A (en) 2012-01-12
DE102006053374A1 (de) 2007-08-16
EA200801767A1 (ru) 2009-02-27
EA014776B1 (ru) 2011-02-28
US20070183982A1 (en) 2007-08-09
PE20070951A1 (es) 2007-09-24
BRPI0707594A2 (pt) 2011-05-10
AR059350A1 (es) 2008-03-26
CN102861339A (zh) 2013-01-09
UY30139A1 (es) 2007-09-28
EP1988874A2 (de) 2008-11-12
TW200800294A (en) 2008-01-01
CA2641883A1 (en) 2007-08-16
PE20120023A1 (es) 2012-02-13
IL193274A0 (en) 2009-08-03

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