[go: up one dir, main page]

WO2007003599A2 - Systeme emulsifiant, emulsion et leur utilisation - Google Patents

Systeme emulsifiant, emulsion et leur utilisation Download PDF

Info

Publication number
WO2007003599A2
WO2007003599A2 PCT/EP2006/063740 EP2006063740W WO2007003599A2 WO 2007003599 A2 WO2007003599 A2 WO 2007003599A2 EP 2006063740 W EP2006063740 W EP 2006063740W WO 2007003599 A2 WO2007003599 A2 WO 2007003599A2
Authority
WO
WIPO (PCT)
Prior art keywords
emulsion
fat
emulsifier system
soluble substance
emulsion according
Prior art date
Application number
PCT/EP2006/063740
Other languages
German (de)
English (en)
Other versions
WO2007003599A3 (fr
Inventor
Jesper Feldthusen Jensen
Christian KÖPSEL
Heike P. Schuchmann
Robert Engel
Henelyta Santos Ribeiro
Helmar Schubert
Karin Ax
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Priority to JP2008518859A priority Critical patent/JP2009500151A/ja
Priority to EP06763993A priority patent/EP1901837A2/fr
Priority to MX2008000033A priority patent/MX2008000033A/es
Publication of WO2007003599A2 publication Critical patent/WO2007003599A2/fr
Publication of WO2007003599A3 publication Critical patent/WO2007003599A3/fr
Priority to NO20080026A priority patent/NO20080026L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/017—Mixtures of compounds

Definitions

  • Emulsifier system Emulsifier system, emulsion and their use
  • the present invention relates to an emulsifier system comprising a) a whey protein and / or a whey protein hydrolyzate and b) a sucrose fatty acid ester having an HLB value in the range from 10 to 18.
  • the present invention furthermore relates to an emulsion which contains ⁇ ) a disperse phase containing at least one fat-soluble substance, ⁇ ) water as the continuous phase and ⁇ ) the emulsifier system according to the invention.
  • the present invention relates to a process for the preparation of the emulsion according to the invention and its use in human nutrition, in animal nutrition, in cosmetics or in the pharmaceutical industry. Further embodiments of the present invention can be taken from the claims, the description and the examples. It is understood that the features mentioned above and those yet to be explained of the subject matter according to the invention can be used not only in the particular combination given, but also in other combinations, without departing from the scope of the invention.
  • German Patent DE 2 363 534 describes the preparation of sugar-containing liquid vitamin and carotenoid preparations.
  • Physiologically acceptable emulsifiers such as lecithin or ascorbyl palmitate, are used for emulsification.
  • a disadvantage of such products is the crystallization tendency of the sugar or sugar alcohol, e.g. during storage of the product at low temperatures. This crystallization tendency leads to undesirable inhomogeneities.
  • the European Patent EP 551 638 has the stabilization of liquid preparations of fat-soluble substances over as long as possible storage period (> 6 months) to the object.
  • the esters of ascorbic acid with long-chain fatty acids are proposed for this purpose as an emulsifier.
  • the emulsions must be stored refrigerated. This can increase transport costs and make handling difficult.
  • Japanese Patent Publication JP 2000 212 066 discloses the use of polyoxyethylene sorbitan fatty acid esters and of sugar fatty acid esters as emulsifier for emulsions of fat-soluble substances.
  • Japanese Patent Publication JP 08 120 187 discloses the use of sorbitan fatty acid esters and sucrose fatty acid esters as emulsifier for carotenoid emulsions.
  • Korean Patent KR 20 020 018 518 discloses the use of sucrose fatty acid esters and sorbitan fatty acid esters as an emulsifier for a rotarotide emulsion. Ss-carotene concentrations of up to 3% are achieved.
  • European Patent EP 1 095 986 deals with the task of preventing coagulation of the disperse phase. This object is achieved by providing a method for stabilizing liquid, aqueous preparations of fat-soluble substances.
  • a protective colloid-free oil-in-water emulsion is mixed with a lipid-soluble substance with a protective colloid.
  • This preparation is mixed with an aqueous phase.
  • the protective colloid is a high molecular weight stabilizer.
  • European Patent EP 361 928 shows an extremely finely divided emulsion with a glycerol / water mixture as dispersing agent and a fat-soluble excipient as disperse phase.
  • Nonionic stabilizers having a molecular weight of 1,000 or more are used as stabilizers.
  • the mean particle size of the disperse phase is in this case between 10 and 70 nm.
  • the emulsions mentioned in the examples already show changes after 3 months.
  • One of the objects of the present invention was to provide an emulsifier system which should be as versatile as possible.
  • the emulsifier system should be useful for the preparation of emulsions which are physiologically compatible.
  • the emulsifier system should in particular lead to emulsions in which the active ingredients have a high bioavailability.
  • Emulsifiers are auxiliaries for the preparation and stabilization of emulsions.
  • Emulsions are understood to mean a disperse system of two or more immiscible liquids.
  • Stabilization is understood to mean the prevention of the separation of a disperse phase ⁇ ) and of a dispersant ⁇ ) into the thermodynamically stable final state.
  • Disperse phase is related to the present invention for the finely divided phase of the emulsion.
  • the continuous phase of the emulsion is referred to as a dispersant in the context of the present invention.
  • the dispersant used is the emulsifier system according to the invention.
  • the emulsifier system according to the invention contains as component a) a whey protein and / or a whey protein hydrolyzate.
  • the whey protein used is preferably a spray-dried whey protein isolate having a protein content of at least 80%, more preferably having a protein content of at least 95%.
  • whey protein hydrolysates preference is given to using purified, enzymatically degraded whey proteins having a degree of hydrolysis of from 3 to 20, particularly preferably having a degree of hydrolysis of from 4 to 16 (determined by the OPA method).
  • Sucrose fatty acid esters as component b) having an HLB in the range of 10 to 18 include sucrose stearate, sucrose palmitate, sucrose myristate, sucrose laurate and sucrose oleate.
  • the proportion of monoester - for example, sucrose monostearate is greater than 55%, preferably in the range of 70 to 85%.
  • the preferred sucrose fatty acid ester is sucrose laurate with a sucrose monolaurate content of 75 to 85% and an HLB value of 16.
  • a preferred embodiment of the emulsifier system according to the invention is characterized in that the weight ratio of component a) to component b) in the range of 0.01 to 1 to 100 to 1, preferably in the range of 0.1 to 1 to 10 to 1, more preferably in the range of 0.9 to 1 to 1.1: 1.
  • the emulsifier system in addition to the sucrose fatty acid ester additionally one or more low molecular weight emulsifiers in a concentration of 0.01 to 70 wt .-%, preferably 0.1 to 50 wt .-%, particularly preferably 0.5 to 20 wt. %, based on the total amount of the emulsifier system.
  • Particularly suitable as such are amphiphilic compounds or mixtures of such compounds. In principle, all surfactants with an HLB value of 5 to 20 come into consideration.
  • esters of long chain fatty acids such as C 0 - C 2 o alkyl ester with ascorbic acid, mono- and diglycerides of fatty acids and their ethoxylation products, esters of monofatty acid glycerides with acetic acid, citric acid, lactic acid or diacetyltartaric acid, polyglycerol fatty acid esters such as the monostearate of triglycerol, sorbitan fatty acid esters, propylene glycol fatty acid esters and lecithin. Ascorbyl palmitate is preferably used.
  • the emulsifier system according to the invention is distinguished, in particular, by the fact that emulsions of liposoluble active substances prepared therewith exhibit a bioavailability-increasing effect.
  • the invention also provides an emulsion comprising ⁇ ) a disperse phase of at least one fat-soluble substance ⁇ i), ⁇ ) water as the continuous phase and ⁇ ) an emulsifier system according to the invention. But it may also contain other components. All components of an emulsion according to the invention together give 100% by weight, based on the emulsion.
  • a fat-soluble substance od) contained in the emulsion according to the invention may in principle be any fat-soluble substance.
  • a fat-soluble substance ⁇ i) is physiologically compatible, ie it is compatible with respect to human and animal physiology. But it is also a plant-physiological compatibility possible.
  • Suitable examples are the fat-soluble vitamins A, D, E or K or their derivatives, for example vitamin A and vitamin E esters such as retinyl acetate or tocopherol acetate, tocotrienol, vitamin Ki, vitamin K 2 , and carotenoids such as .beta.-carotene, canthaxanthin , Astaxanthin and ester derivatives, zeaxanthin and ester derivatives, lutein and ester derivatives, lycopene and apocarotenal.
  • Carotenoids are widely used in nature color pigments, which are contained in many foods in finely divided form and give the food a characteristic color.
  • carotenoids are therefore also of interest as dyes for the food, animal feed and pharmaceutical industries.
  • the colorations achieved by higher-percentage carotenoid emulsions usually cover the range from orange to red.
  • higher-percentage ⁇ -carotene-containing emulsions according to the present invention are distinguished by a brilliant yellow shade, as desired for many foods, and a high color strength.
  • carotenoids are often used as skin protection.
  • fat-soluble substances ⁇ i) which can be used in the context of the present invention are polyunsaturated fatty acids, such as e.g. Arachidonic acid, docosahexaenoic acid, eicosapentaenoic acid, linoleic acid, linolenic acid, both in free form and as triglyceride, and aroma oils such as orange oil, peppermint oil or citrus oils.
  • polyunsaturated fatty acids such as e.g. Arachidonic acid, docosahexaenoic acid, eicosapentaenoic acid, linoleic acid, linolenic acid, both in free form and as triglyceride
  • aroma oils such as orange oil, peppermint oil or citrus oils.
  • glycerides of polyunsaturated fatty acids such as wheat oil, sunflower oil, corn oil or medium chain triglycerides or mixtures of said oils into consideration.
  • any fat-soluble substances od) are suitable as a component of the emulsion, which play a physiological role in the human or animal organism and are processed due to their insolubility in water usually emulsions.
  • Preferred fat-soluble substances od) in the context of the present invention are in particular the abovementioned fat-soluble vitamins, for example vitamin A, D, E and K and their derivatives, carotenoids selected from the group consisting of asthma.
  • xanthine, lycopene, ß-carotene and lutein as well as the polyunsaturated fatty acids.
  • Particularly preferred are astaxanthin, lycopene, beta-carotene and lutein.
  • Carotenoids as fat-soluble substance od are generally dissolved in oil.
  • the carotenoid dissolved in oil is generally used together with the oil as a disperse phase.
  • Suitable oils include, for example, all physiologically acceptable oils, in particular peanut oil, coconut oil, sunflower oil, olive oil or other triacylglycerides. The amount of oil used depends on the solubility of the particular carotenoid in the corresponding oil.
  • the dissolution of the carotenoid in the oil is generally carried out at temperatures in the range of 120 0 C to 220 0 C, preferably in the range of 160 0 C to 200 0 C.
  • the weight ratio of oil to carotenoid in the case of astaxanthin can be in the range from 50 to 1000, preferably from 100 to 500, particularly preferably from 200 to 400. For other carotenoids, this weight ratio may be greater than 1000 depending on the solubility of the carotenoid used.
  • a fat-soluble substance od Under a fat-soluble substance od is first to understand a single fat-soluble substance. However, it is also possible to combine various fat-soluble substances, for example two or three fat-soluble substances od). It is preferred to use only one fat-soluble substance od).
  • a fat-soluble substance od) according to the invention is generally present in amounts of from 0.01 to 50% by weight, based on the total weight of the emulsion. In a preferred embodiment, the proportion of a fat-soluble substance is od) 2 to
  • wt .-% particularly preferably 2 to 20 wt .-%, most preferably 5 to 15 wt .-%, based on the total weight of the emulsion.
  • carotenoids as fat-soluble substance od
  • they are usually in concentrations of 0.01 to 5 wt .-%, preferably from 0.01 to 2 wt .-%, particularly preferably from 0.05 to 1 part by weight. %, most preferably from 0.1 to 0.5 wt .-%, based on the total weight of the emulsion before.
  • the mean particle size of the disperse phase ⁇ ) of the emulsion according to the invention is generally 900 nm or below. In a further embodiment of the invention, the mean particle size of the disperse phase ⁇ ) is from 50 nm to 850 nm. In a preferred embodiment of the invention, the particle size of the disperse phase ⁇ ) is from 150 nm to 500 nm.
  • the average particle size of an emulsion according to the invention can In this case, for example, a mass-based weight distribution can be determined using a photon correlation spectrometer with a wavelength of 632.8 nm.
  • the emulsifier system ⁇ ) is 0.2 to 20 wt .-%, preferably 0.5 to 10 wt .-%, more preferably 0.5 to 5 wt .-%, most preferably 1 to 3 wt .-%, based on the total weight of the emulsion.
  • the components ⁇ ), ⁇ ), ⁇ ) and the optionally possible components give a total of 100 wt .-% based on the emulsion.
  • the emulsions according to the invention may additionally comprise at least one further protective colloid.
  • Suitable additional colloids are advantageously water-soluble or wasserquell bare protective colloids such as bovine, porcine or fish gelatin, especially acidic or basic degraded gelatin with Bloom numbers in the range of 0 to 250, most preferably gelatin A 100, A 200, B 100th and B 200 and low molecular weight, enzymatically degraded gelatin types with the Bloom number 0 and molecular weights of 15000 to 25000 D such as Collagel A and Gelitasol P (Stoess, Eberbach) and mixtures of these gelatin varieties and starch, dextrin, pectin, gum arabic , Lignin sulfonates, chitosan, polystyrenesulfonate, alginates, casein, caseinate, such as sodium caseinate, methylcellulose, carboxymethylcellulose, hydroxypropylcellulose, modified starch, such as sodium octenylsuccinate starch (Capsul, National Starch), plant proteins such as soybean, rice and
  • Preferred protective colloids are modified starch, casein and / or sodium caseinate, soy protein and gelatin, particularly preferred are casein and / or sodium caseinate
  • the amount of additionally used protective colloid is from 0.1 to 50 wt .-%, preferably 1 to 30 wt .-%, particularly preferably 2 to 20 wt .-%, most preferably from 3 to 10 wt .-%, based on the dry matter of the emulsion.
  • the additional protective colloids are preferably used when the emulsion according to the invention is added to beverages or other aqueous solutions in order to stabilize the disperse phase in addition to the emulsifier system according to the invention.
  • the preferably high molecular weight stabilizers are thus added, in particular when the emulsion according to the invention is used, for example by adding the emulsion according to the invention to the formulations in the food and animal feed sector.
  • the emulsions may also contain at least one low molecular weight stabilizer such as antioxidants and / or preservatives to protect the active ingredients.
  • Suitable antioxidants or preservatives are, for example, ascorbic acid, ascorbyl palmitate, tert-butyl-hydroxytoluene, tert-butylhydroxyanisole, lecithin, ethoxyquin, methylparaben, propylparaben, sorbic acid or sodium benzoate.
  • the antioxidants or preservatives may be used in amounts of 0.01 to 50 wt .-%, preferably 0.1 to 30 wt .-%, particularly preferably 0.5 to 20 wt .-%, most preferably 1 to 10 wt. -%, based on the dry matter of the emulsion, are used.
  • the antioxidative effect of the ascorbyl palmitate can be increased further by adding to the disperse phase ⁇ ) additionally tocopherol.
  • the proportion of tocopherol is preferably 0.01 wt .-% to 4 wt .-%, preferably 0.05 to 0.5 wt .-%, based on the total amount of the emulsion according to the invention.
  • the emulsion according to the invention exhibits an improved bioavailability of the fat-soluble active substance present in the emulsion as a disperse phase.
  • the emulsion of the invention also displays a high color strength.
  • the relative color strength also referred to as the E 1/1 value
  • the E1 / 1 value defines the specific extinction of a 1.0% aqueous emulsion in a 1 cm cuvette at the absorption maximum.
  • a high color intensity is understood in particular to mean a relative color intensity of 100 or more.
  • the relative color strength of the emulsion according to the invention is usually from 100 to 200.
  • the emulsion according to the invention has a favorable low turbidity, which is desired, for example, in certain foods.
  • the turbidity of an emulsion is generally determined according to ISO 7027 / DIN EN 27027.
  • An emulsion according to the invention generally has a turbidity of from 50 NTU to 1000 NTU, depending on its specific composition.
  • Low haze is generally present at from 50 NTU to 400 NTU, and more preferably from 50 NTU to 200 NTU.
  • a slight haze can be achieved with the emulsion according to the invention even at the abovementioned high proportions of a fat-soluble substance od), in particular in the embodiment of the ß-carotene.
  • the emulsion according to the invention is distinguished in another embodiment by its good applicability in the food sector (in the beverage industry) as well as in the animal feed sector, ie the presently described positive properties can be achieved in each case or in different combinations, in particular in applications, for example in the beverage industry.
  • a concentration of about 5 ppm to 100 ppm carotenoid is desired.
  • High electrolyte contents may be present. High electrolyte contents are achieved especially in critical systems such as concentrates or isotonic drinks, which have a considerable proportion of different salts.
  • a low pH when using the emulsion in the beverage industry, generally a low pH may be present.
  • a low pH means in particular a pH of 6 or below, for example a pH of 2 to 5 and in particular a pH of 2 to 3.
  • the emulsion according to the invention is distinguished in a further embodiment of the present invention by its bacteriostatic effect. This refers to the prevention of bacterial growth and proliferation without killing the bacteria.
  • the mixing of the components of the emulsion according to the invention can take place immediately before the addition of the emulsion to a foodstuff, to a beverage, to a feed, to a cosmetic or to a pharmaceutical.
  • the emulsion according to the invention can also initially be filled and stored after it has been prepared in order to provide it, as needed, with a foodstuff, with a drink, with a feedstuff, with a cosmetic or with a pharmaceutical.
  • an emulsion according to the invention comprises from 0.1 to 0.5% by weight of a fat-soluble substance od) in the embodiment of astaxanthin, from 1.0 to 3.0% by weight of an emulsifier system according to the invention in the Embodiment with a whey protein a) and sucrose laurate b) with an HLB value of 16.
  • the person skilled in the art is familiar with processes for the preparation of the emulsion according to the invention.
  • the emulsion according to the invention may e.g. be made in two steps:
  • Another method of preemulsion may be by means of a membrane method.
  • the fine emulsification may be carried out by one or more times, e.g. pass two or three times the crude emulsion, for example by a high-pressure homogenizer.
  • the homogenization is generally carried out at a pressure of 200 bar up to 1200 bar, preferably from 600 bar to 1000 bar.
  • the emulsion according to the invention can be used for a variety of purposes, in particular for coloring, for vitaminization, in particular provitamin A or as an antioxidant in human nutrition, in particular in beverages, particularly preferably in soft drinks, vitamin juices or sports drinks. Furthermore, a use in animal nutrition, in the cosmetics or in the pharmaceutical industry is possible.
  • the emulsion according to the invention is outstandingly suitable for simple and exact metering for the addition of e.g. from vitamins to liquid food or feed or, in the case of the .beta.-carotene, to the coloring of beverages e.g. of sodas.
  • the present invention also provides a food, a feed, a cosmetic or a pharmaceutical containing an emulsifier system according to the invention or an emulsion according to the invention.
  • composition of the O / W emulsion (per kg of emulsion)
  • sucrose laurate L-1695, Fa. Mitsubishi-Kagaku Foods Corp.
  • whey protein BiPRO ®, Fa. Davisco, USA
  • the emulsion was prepared as follows:
  • Crystalline astaxanthin was suspended in the medium-chain triglyceride and ground by a vibratory mill to particle sizes of about 20 microns. Subsequently, the finely ground suspension was pumped through a heated coil and briefly heated to a temperature of 160 0 C to 200 0 C, the astaxanthin went into solution. Then, the disperse phase ⁇ ) was mixed with the emulsifier system ⁇ ) and mixed together in the dispersant ß) and homogenized using an Ultra Turrax with a diameter D of 12 mm at 10,000 revolutions per minute for about 15 seconds. The temperature of the emulsion was about 70 0 C.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Colloid Chemistry (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Edible Oils And Fats (AREA)
  • Fodder In General (AREA)

Abstract

La présente invention concerne un système émulsifiant contenant : a) une protéine de lactosérum et/ou un hydrolysat de protéine de lactosérum ; et b) un ester d'acide gras de saccharose ayant une valeur HLB de 10 à 18, ainsi que des émulsions préparées à partir de ce système émulsifiant.
PCT/EP2006/063740 2005-07-04 2006-06-30 Systeme emulsifiant, emulsion et leur utilisation WO2007003599A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2008518859A JP2009500151A (ja) 2005-07-04 2006-06-30 乳化剤系、エマルジョンおよびその使用
EP06763993A EP1901837A2 (fr) 2005-07-04 2006-06-30 Systeme emulsifiant, emulsion et leur utilisation
MX2008000033A MX2008000033A (es) 2005-07-04 2006-06-30 Sistema emulsionante, emulsion y uso de los mismos.
NO20080026A NO20080026L (no) 2005-07-04 2008-01-03 Emulgatorsystem, emulsjon og anmvendelse derav

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005031467A DE102005031467A1 (de) 2005-07-04 2005-07-04 Emulgatorsystem, Emulsion und deren Verwendung
DE102005031467.8 2005-07-04

Publications (2)

Publication Number Publication Date
WO2007003599A2 true WO2007003599A2 (fr) 2007-01-11
WO2007003599A3 WO2007003599A3 (fr) 2007-04-19

Family

ID=37575364

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/063740 WO2007003599A2 (fr) 2005-07-04 2006-06-30 Systeme emulsifiant, emulsion et leur utilisation

Country Status (8)

Country Link
EP (1) EP1901837A2 (fr)
JP (1) JP2009500151A (fr)
CN (1) CN101227971A (fr)
DE (1) DE102005031467A1 (fr)
MX (1) MX2008000033A (fr)
NO (1) NO20080026L (fr)
TW (1) TW200727973A (fr)
WO (1) WO2007003599A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008260761A (ja) * 2007-03-16 2008-10-30 Up Well:Kk 乳成分加水分解物
US9718044B2 (en) 2014-11-24 2017-08-01 The Procter & Gamble Company Compositions comprising encapsulated actives within droplets and other compartments
EP3117838B1 (fr) 2014-03-10 2020-09-16 Saraya Co., Ltd. Composition contenant un sophorolipide, substance, huile et matière grasse physiologiquement active, et procédé de production de cette composition

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202007003800U1 (de) * 2007-03-14 2008-07-17 Sensient Food Colors Germany Gmbh & Co. Kg Farbstoff-Emulsion
DE102011053829A1 (de) * 2011-09-21 2013-03-21 Otc Gmbh Verfahren zur Herstellung einer Dispersion und Verwendung von Proteinhydrolysaten als Dispergatoren
JP2013107832A (ja) * 2011-11-17 2013-06-06 Tsubaki:Kk 化粧料組成物及びその製造方法
EP2644186A1 (fr) 2012-03-26 2013-10-02 OTC GmbH Composition de conditionnement des cheveux pour des applications de coloration capillaire permanente et semi-permanente
ES2607715B1 (es) * 2015-10-01 2018-01-17 Solutex Na, Lcc Proceso para la preparación y estabilización de emulsiones con omega-3 mediante redes cristalinas isométricas de derivados de celulosa
CN106605672B (zh) * 2015-10-22 2021-08-27 丰益(上海)生物技术研发中心有限公司 乳液组合物及其制备方法以及其用途
CN105662908A (zh) * 2016-01-29 2016-06-15 广州康钰生物科技有限公司 一种配合其他油包水乳液使用的凝露及其制备方法
CN107581357A (zh) * 2017-09-28 2018-01-16 麦仑(漳州)生物科技有限公司 一种饲料用乳化剂及其生产工艺
CN114680325B (zh) * 2022-04-25 2022-11-11 武汉星辰现代生物工程有限公司 一种β-胡萝卜素纳米乳剂及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2609895B2 (ja) * 1988-03-11 1997-05-14 荒川化学工業株式会社 感熱記録体用オーバーコート剤
ATE272946T1 (de) * 1997-11-04 2004-08-15 Kyowa Hakko Kogyo Kk Neue proteinkomplexe
JP4450450B2 (ja) * 1998-09-02 2010-04-14 株式会社Ａｄｅｋａ 水中油型乳化組成物
US6605311B2 (en) * 2000-06-22 2003-08-12 The Procter & Gamble Company Insoluble protein particles
AU2003302675A1 (en) * 2002-11-29 2004-06-23 Unilever Plc Beverage product with modified starch and nitrogen

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008260761A (ja) * 2007-03-16 2008-10-30 Up Well:Kk 乳成分加水分解物
EP3117838B1 (fr) 2014-03-10 2020-09-16 Saraya Co., Ltd. Composition contenant un sophorolipide, substance, huile et matière grasse physiologiquement active, et procédé de production de cette composition
US9718044B2 (en) 2014-11-24 2017-08-01 The Procter & Gamble Company Compositions comprising encapsulated actives within droplets and other compartments
US9878299B2 (en) 2014-11-24 2018-01-30 The Procter & Gamble Company Methods for encapsulation of actives within droplets and other compartments
US10434485B2 (en) 2014-11-24 2019-10-08 The Procter & Gamble Company Compositions comprising encapsulated actives within droplets and other compartments

Also Published As

Publication number Publication date
TW200727973A (en) 2007-08-01
MX2008000033A (es) 2008-03-19
CN101227971A (zh) 2008-07-23
JP2009500151A (ja) 2009-01-08
WO2007003599A3 (fr) 2007-04-19
DE102005031467A1 (de) 2007-01-25
EP1901837A2 (fr) 2008-03-26
NO20080026L (no) 2008-01-29

Similar Documents

Publication Publication Date Title
EP0551638B1 (fr) Préparations fluides stables de substances solubles dans des matières grasses
EP1901837A2 (fr) Systeme emulsifiant, emulsion et leur utilisation
EP0981969B1 (fr) Composition de caroténoides compenant un mélange de beta-carotène, lycopène et lutéine
EP2413710B1 (fr) Suspension stable, prête à l'emploi, de particules de bêta-carotène partiellement amorphes
EP1901836A1 (fr) Systeme emulsifiant, emulsion et leur utilisation
EP0845503B1 (fr) Compositions de caroténoides liquides miscibles à l'huile
EP2343986B1 (fr) Émulsion stable prête à l'emploi
DE19653410A1 (de) Verwendung von Carotinoid-Solubilisaten zum Färben von Lebensmitteln und pharmazeutischen Zubereitungen
DE69621445T2 (de) Neues verfahren
EP1972206B1 (fr) Emulsion de colorant et composition émulsifiante et leur utilisation
DE69232376T2 (de) Carotinoide zusammensetzung
EP0986963A2 (fr) Formulations de lycopène stable et pulvérulente contenant de lycopène avec un taux de crystallisation de plus de 20%
EP1228705A2 (fr) Procédé de préparation de poudres sèches d' un caroténoide ou plusieurs caroténoides
DE60223569T2 (de) Zeacarotene-farbstoff für lebensmittel oder pharmazeutika
EP2066310B1 (fr) Émulsions contenant de la gomme arabique
WO1999057995A1 (fr) Utilisation de nano-aliments dans des produits finis alimentaires pour l'homme et l'animal
EP2142015A2 (fr) Préconcentrés en émulsion et préparations micellaires contenant de la résine de bois
CH699449A2 (de) Emulsionsvorkonzentrate sowie micellare Formulierungen enthaltend Glycerinfettsäureester.
EP1095986A1 (fr) Procédé pour stabiliser des produits liquides aqueux de substances solubles dans des lipides
DE102017009186A1 (de) Lutein und -derivate enthaltende Zusammensetzung sowie Verfahren zur Herstellung
CH699448A2 (de) Emulsionsvorkonzentrate sowie micellare Formulierungen enthaltend Cyclodextrin.

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 2008518859

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 200680024430.0

Country of ref document: CN

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Ref document number: DE

WWE Wipo information: entry into national phase

Ref document number: MX/a/2008/000033

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2006763993

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 566/CHENP/2008

Country of ref document: IN

WWP Wipo information: published in national office

Ref document number: 2006763993

Country of ref document: EP