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WO2006042034A2 - Sel et ses formes cristallines d'un medicament - Google Patents

Sel et ses formes cristallines d'un medicament Download PDF

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Publication number
WO2006042034A2
WO2006042034A2 PCT/US2005/036024 US2005036024W WO2006042034A2 WO 2006042034 A2 WO2006042034 A2 WO 2006042034A2 US 2005036024 W US2005036024 W US 2005036024W WO 2006042034 A2 WO2006042034 A2 WO 2006042034A2
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WO
WIPO (PCT)
Prior art keywords
salt
oxo
fluoro
glucitol
deoxy
Prior art date
Application number
PCT/US2005/036024
Other languages
English (en)
Other versions
WO2006042034A8 (fr
WO2006042034A3 (fr
Inventor
Geoff G. Zhang
Michael F. Bradley
David M. Barnes
Rodger Henry
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Priority to EP15199355.7A priority Critical patent/EP3056492B1/fr
Priority to PL15199355T priority patent/PL3056492T3/pl
Priority to EP21196428.3A priority patent/EP3957632A1/fr
Priority to EP05825344A priority patent/EP1802607A2/fr
Priority to MX2007004111A priority patent/MX2007004111A/es
Priority to CA2582954A priority patent/CA2582954C/fr
Priority to JP2007535819A priority patent/JP5294633B6/ja
Publication of WO2006042034A2 publication Critical patent/WO2006042034A2/fr
Publication of WO2006042034A3 publication Critical patent/WO2006042034A3/fr
Publication of WO2006042034A8 publication Critical patent/WO2006042034A8/fr
Priority to CY20211101121T priority patent/CY1125048T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/26—Hexahydroxylic alcohols

Definitions

  • This invention pertains to a salt and crystalline forms thereof of a drug, ways to make it, compositions containing it and methods of treatment using it.
  • Crystallinity of drugs effects, among other physical and mechanical properties, their solubility, dissolution rate, hardness, compressability and melting point. Because these properties may, in turn, effect a drug's manufacture and their utility, there is an existing need in the chemical and therapeutic arts for identification of crystalline forms of drugs and ways of reproducibly making them.
  • FIG. 1 shows a powder X-ray diffraction pattern of crystalline D-glucitol, 1-deoxy-l- (methylamino)-, l-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3- hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate (salt).
  • FIG. 2 shows a powder X-ray diffraction pattern of crystalline D-glucitol, 1-deoxy-l- (methylamino)-, l-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3- hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate trihydrate (salt).
  • One embodiment of this invention pertains to D-glucitol, l-deoxy-l-(methylamino)-, l-(6-ammo-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3-hydroxyazetidin-l- yl)-4-oxo-3-quinolinecarboxylate (salt).
  • Another embodiment pertains to D-glucitol, l-deoxy-l-(methylamino)-, l-(6-amino-
  • Still another embodiment pertains to crystalline D-glucitol, l-deoxy-l-(methylamino)- , 1 -(6-amino-3 ,5-difluoropyridin-2-yl)-8-chloro-6-fluoro- 1 ,4-dihydro-7-(3 -hydroxyazetidin- 1 - yl)-4-oxo-3-quinolinecarboxylate (salt) characterized, when measured at about 25 0 C with Cu-Ka radiation, by the powder diffraction pattern shown in FIGURE 1.
  • Still another embodiment pertains to crystalline D-glucitol, 1-deoxy-l- (methylamino)-, l-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3- hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate (salt) characterized, in the monoclinic crystal system and P 21/C or P 21/M space group, when measured with Mo-Ka radiation at about 25 0 C, by respective lattice parameters a, b and c of about 16.4460A, 21.4010A and 5.3050A and ⁇ of about 109°.
  • Still another embodiment pertains to crystalline D-glucitol, 1-deoxy-l- (methylamino)-, l-(6-ammo-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3- hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate (salt) having substantial crystalline purity and characterized, when measured at about 25 0 C with Cu-Ka radiation, by the powder diffraction pattern shown in FIGURE 1.
  • Still another embodiment pertains to crystalline D-glucitol, 1-deoxy-l- (methylamino)-, l-(6-ammo-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3- hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate (salt) having substantial crystalline purity and characterized, in the monoclinic crystal system and P 21/C or P 21/M space group, when measured with Mo-Ka radiation at about 25 0 C, by respective lattice parameters a, b and c of about 16.4460A, 21.4010A and 5.3050A and ⁇ of about 109°. Still another embodiment pertains to crystalline D-glucitol, l-deoxy-l-(methylamino)-
  • Still another embodiment pertains to a composition
  • a composition comprising an excipient and a therapeutically acceptable amount of crystalline D-glucitol, 1-deoxy-l -(methylamino)-, l-(6- amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3-hydroxyazetidin-l-yl)-4- oxo-3-quinolinecarboxylate (salt) characterized, when measured at about 25 0 C with Cu-Ka radiation, by the powder diffraction pattern shown in FIGURE 1.
  • Still another embodiment pertains to a composition
  • a composition comprising an excipient and a therapeutically acceptable amount of crystalline D-glucitol, l-deoxy-l-(methylamino)-, l-(6- amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3-hydroxyazetidin-l-yl)-4- oxo-3-quinolinecarboxylate (salt) characterized, in the monoclinic crystal system and P 21/C or P 21/M space group, when measured with Mo-Ka radiation at about 25 0 C, by respective lattice parameters a, b and c of about 16.4460A, 21.4010A and 5.3050A and ⁇ of about 109°.
  • Still another embodiment pertains to a method for treating bacterial infections in a fish or a mammal comprising administering thereto a therapeutically effective amount of crystalline D-glucitol, l-deoxy-l-(methylamino)-, l-(6-amino-3,5-difluoropyridin-2-yl)-8- chloro-6-fluoro-l,4-dihydro-7-(3-hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate (salt) characterized, when measured at about 25 0 C with Cu-Ka radiation, by a powder diffraction pattern shown in FIGURE 1.
  • Still another embodiment pertains to a method for treating bacterial infections in a fish or a mammal comprising administering thereto a therapeutically effective amount of crystalline D-glucitol, l-deoxy-l-(methylamino)-, l-(6-amino-3,5-difluoropyridin-2-yi)-8- chloro-6-fluoro- 1 ,4-dihydro-7-(3 -hydroxyazetidin- 1 -yl)-4-oxo-3 -quinolinecarboxylate (salt) characterized, in the monoclinic crystal system and P 21/C or P 21/M space group, when measured with Mo-Ka radiation at about 25 0 C, by respective lattice parameters a, b and c of about 16.4460A, 21.4010A and 5.3050A and ⁇ of about 109°.
  • Still another embodiment pertains to crystalline D-glucitol, l-deoxy-l-(methylamino)- , 1 -(6-amino-3 ,5-difluoropyridin-2-yl)-8-chloro-6-fluoro- 1 ,4-dihydro-7-(3 -hydroxyazetidin- 1 - yl)-4-oxo-3-quinolinecarboxylate trihydrate (salt) characterized, when measured at about 25 0 C with Cu-Ka radiation, by the powder diffraction pattern shown in FIGURE 2.
  • Still another embodiment pertains to crystalline D-glucitol, 1-deoxy-l- (methylamino)-, l-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3- hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate trihydrate (salt) characterized, in the monoclinic crystal system and P 21/C or P 21/M space group, when measured with Mo-Ka radiation at about 25 0 C, by respective lattice parameters a, b and c bf about 8.2490A, 29.9840A and 12.5070A and ⁇ of about 105°.
  • Still another embodiment pertains to a crystalline D-glucitol, 1-deoxy-l- (methylamino)-, l-(6-amino-3,5-difluoropyridm-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3- hydroxyazetidin-l-yl)-4-oxo-3-qumolinecarboxylate trihydrate (salt) having substantial crystalline purity and characterized, when measured at about 25 0 C with Cu-Ka radiation, by the powder diffraction pattern shown in FIGURE 2.
  • Still another embodiment pertains to a crystalline D-glucitol, 1-deoxy-l- (methylamino)-, l-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3- hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate trihydrate (salt) having substantial crystalline purity and characterized, in the monoclinic crystal system and P 21/C or P 21/M space group, when measured with Mo-Ka radiation at about 25 0 C, by respective lattice parameters a, b and c of about 8.2490A, 29.9840A and 12.5070A and ⁇ of about 105°.
  • Still another embodiment pertains to crystalline D-glucitol, l-deoxy-l-(methylamino)- , l-(6-amino-3,5-difluoropyridm-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3-hydroxyazetidin-l- yl)-4-oxo-3-quinolinecarboxylate trihydrate (salt) having substantial crystalline purity and substantial chemical purity and characterized, when measured at about 25 0 C with Cu-Ka radiation, by the powder diffraction pattern shown in FIGURE 2.
  • Still another embodiment pertains to crystalline D-glucitol, l-deoxy-l-(methylamino)- , l-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3-hydroxyazetidin-l- yl)-4-oxo-3-quinolinecarboxylate trihydrate (salt) having substantial crystalline purity and substantial chemical purity and characterized, in the monoclinic crystal system and P 21/C or P 21/M space group, when measured with Mo-Ka radiation at about 25 0 C, by respective lattice parameters a, b and c of about 8.2490A, 29.9840A and 12.5070A and ⁇ of about 105°.
  • Still another embodiment pertains to a composition
  • a composition comprising an excipient and a therapeutically acceptable amount of crystalline D-glucitol, l-deoxy-l-(methylamino)-, l-(6- amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3-hydroxyazetidin-l-yl)-4- oxo-3-quinolinecarboxylate trihydrate (salt) characterized, when measured at about 25 0 C with Cu-Ka radiation, by the powder diffraction pattern shown in FIGURE 2.
  • Still another embodiment pertains to a composition
  • a composition comprising an excipient and a therapeutically acceptable amount of crystalline D-glucitol, l-deoxy-l-(methylamino)-, l-(6- amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3-hydroxyazetidin-l-yl)-4- oxo-3-quinolinecarboxylate trihydrate (salt) characterized, in the monoclinic crystal system and P 21/C or P 21/M space group, when measured with Mo-Ka radiation at about 25 0 C, by respective lattice parameters a, b and c of about 8.2490A, 29.9840A and 12.5070A and ⁇ of about 105°.
  • Still another embodiment pertains to a method for treating bacterial infections in a fish or a mammal comprising administering thereto a therapeutically effective amount of crystalline D-glucitol, l-deoxy-l-(methylamino)-, l-(6-amino-3,5-difluoropyridin-2-yl)-8- chloro-6-fluoro- 1 ,4-dihydro-7-(3 -hydroxyazetidin- 1 -yl)-4-oxo-3-quinolinecarboxylate trihydrate (salt) characterized, when measured at about 25 0 C with Cu-Ka radiation, by a powder diffraction pattern shown in FIGURE 2.
  • Still another embodiment pertains to a method for treating bacterial infections in a fish or a mammal comprising administering thereto a therapeutically effective amount of crystalline D-glucitol, l-deoxy-l-(methylamino)-, l-(6-ammo-3,5-difluoropyridin-2-yl)-8- chloro-6-fluoro-l,4-dihydro-7-(3-hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate trihydrate (salt) characterized, in the monoclinic crystal system and P 21/C or P 21/M space group, when measured with Mo-Ka radiation at about 25 0 C, by respective lattice parameters a, b and c of about 8.2490A, 29.9840A and 12.5070A and ⁇ of about 105°.
  • Still another embodiment pertains to a process for making D-glucitol, 1-deoxy-l- (methylamino)-, l-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3- hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate (salt) comprising dehydrating D-glucitol, 1 -deoxy-1 -(methylamino)-, 1 -(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro- 1 ,4- dihydro-7-(3 -hydroxyazetidin- 1 -yl)-4-oxo-3 -quinolinecarboxylate trihydrate (salt) .
  • Still another embodiment pertains to D-glucitol, 1 -deoxy-1 -(methylamino)-, l-(6- amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3-hydroxyazetidin-l-yl)-4- oxo-3 -quinolinecarboxylate (salt) prepared as described in the preceding embodiment.
  • Still another embodiment pertains to a process for making D-glucitol, 1 -deoxy-1 - (methylamino)-, l-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3- hydroxyazetidin-l-yl)-4-oxo-3 -quinolinecarboxylate trihydrate (salt) by crystallization of D- glucitol, 1 -deoxy-1 -(methylamino)-, l-(6-amino-3,5-difluoro2-pyridinyl)-8-chloro-6-fluoro- l,4-dihydro-7-(3-hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate (salt) from water, with or without alcohol.
  • Still another embodiment pertains to D-glucitol, 1 -deoxy-1 -(methylamino)-, l-(6- amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-l,4-dihydro-7-(3-hydroxyazetidin-l-yl)-4- oxo-3 -quinolinecarboxylate trihydrate (salt) prepared as described in the preceding embodiment.
  • alcolol means a compound having formula R OH, wherein R 1 is Ci-alkyl, C 2 -alkyl, C 3 -alkyl, C 4 -alkyl, C 5 -alkyl or C 6 -alkyl.
  • Ci-alkyl means methyl.
  • C 2 -alkyl means ethyl.
  • C 3 -alkyl means prop-1-yl and prop-2-yl (isopropyl).
  • C 4 -alkyl means but-l-yl, but-2-yl, 2-methylprop-l-yl and 2-methylprop-2-yl (tert-butyl).
  • Cs-alkyl means 2,2-dimethyl ⁇ rop-l-yl (neo-pentyl), 2- methylbut-1-yl, 2-methylbut-2-yl, 3-methylbut-l-yl, 3-methylbut-2-yl, pent-1-yl, pent-2-yl and pent-3-yl.
  • Cg-alkyl means 2,2-dimethylbut-l-yl, 2,3-dimethylbut-l- yl, 2,3-dimethylbut-2-yl, 3,3-dimethylbut-l-yl, 3,3-dimethylbut-2-yl, 2-ethylbut-l-yl, hex-1- yl, hex-2-yl, hex-3-yl, 2-methylpent-l-yl, 2-methylpent-2-yl, 2-methylpent-3-yl, 3-methylpent-l-yl, 3-methylpent-2-yl, 3-methyl ⁇ ent-3-yl, 4-methylpent-l-yl and A- methylpent-2-yl.
  • crystalline means having a regularly repeating arrangement of molecules or external face planes.
  • substantially crystalline purity means at least about 95% crystalline purity, preferably about 97% crystalline purity, more preferably about 99% crystalline purity, and most preferably about 100% crystalline purity.
  • crystalline purity means percentage of a crystalline compound in a sample which may contain an amorphous form of the same compound, at least one other crystalline form of the compound or a mixture thereof.
  • substantially chemical purity means about 95% chemical purity, preferably about 97% chemical purity, more preferably about 98% chemical purity, and most preferably about 100% chemical purity.
  • amorphous means essentially without regularly repeating arrangement of molecules or external face planes.
  • mixture means a combination of at least two substances, in which one substance may be completely soluble, partially soluble or essentially insoluble in the other substance.
  • solvent means a substance, preferably a liquid or a miscible, partially miscible or immiscible mixture of two or more liquids, which is capable of completely dissolving, partially dissolving, dispersing or partially dispersing another substance, preferably a solid or a mixture of solids.
  • anti-solvent means a solvent in which a compound is essentially insoluble. It is meant to be understood that, because many solvents and anti-solvents contain impurities, the level of impurities in solvents and anti-solvents for the practice of this invention, if present, are at a low enough concentration that they do not interfere with the intended use of the solvent in which they are present.
  • peak heights in a powder x-ray diffraction pattern may vary and will be dependent on variables such as the temperature, crystal size, crystal habit, sample preparation or sample height in the analysis well of the Scintagx2 Diffraction Pattern System.
  • peak positions may vary when measured with different radiation sources.
  • Cu-Ka ⁇ , Mo-Ka, Co-Ka and Fe-Ka radiation having wavelengths of 1.54060 A, 0.7107 A, 1.7902 A and 1.9373 A, respectively, may provide peak positions which differ from those measured with Cu-Ka radiation.
  • compositions made with or comprising a crystalline compound of this invention may be administered, for example, bucally, ophthalmically, orally, osmotically, parenterally (intramuscularly, intrasternally, intravenously, subcutaneously), rectally, topically, transdermally or vaginally.
  • Ophthalmically administered dosage forms may be administered as, for example, elixirs, emulsions, microemulsions, oinments, solutions, suspensions or syrups.
  • Orally administered solid dosage forms may be administered as, for example, capsules, dragees, emulsions, granules, pills, powders, solutions, suspensions, tablets, microemulsions, elixirs, syrups or powders for reconstitution.
  • Osmotically and topically administered dosage forms may be administered as, for example, creams, gels, inhalants, lotions, ointments, pastes or powders.
  • Parenterally administered dosage forms may be administered, as, for example, aqueous or oleaginous suspensions.
  • Rectally and vaginally dosage forms may be administered, for example, as creams, gels, lotions, ointments or pastes.
  • the therapeutically acceptable amount of a crystalline compound of this invention depends on recipient of treatment, disorder being treated and severity thereof, composition containing it, time of administration, route of administration, duration of treatment, its potency, its rate of clearance and whether or not another drug is co-administered.
  • the amount of a crystalline compound of this invention used to make a composition to be administered daily to a patient in a single dose or in divided doses is from about 0.03 to about 200 mg/kg body weight.
  • Single dose compositions contain these amounts or a combination of submultiples thereof.
  • a crystalline compound of this invention may be administered with or without an excipient.
  • Excipients include, for example, encapsulating materials or additives such as absorption accelerators, antioxidants, binders, buffers, coating agents, coloring agents, diluents, disintegrating agents, emulsifiers, extenders, fillers, flavoring agents, humectants, lubricants, perfumes, preservatives, propellants, releasing agents, sterilizing agents, sweeteners, solubilizers, wetting agents and mixtures thereof.
  • encapsulating materials or additives such as absorption accelerators, antioxidants, binders, buffers, coating agents, coloring agents, diluents, disintegrating agents, emulsifiers, extenders, fillers, flavoring agents, humectants, lubricants, perfumes, preservatives, propellants, releasing agents, sterilizing agents, sweeteners, solubilizers, wetting agents and mixtures thereof.
  • Excipients for preparation of compositions made with or comprising a crystalline compound of this invention to be administered orally in solid dosage form include, for example, agar, alginic acid, aluminum hydroxide, benzyl alcohol, benzyl benzoate, 1,3-butylene glycol, carbomers, castor oil, cellulose, cellulose acetate, cocoa butter, corn starch, corn oil, cottonseed oil, cross-povidone, diglycerides, ethanol, ethyl cellulose, ethyl laureate, ethyl oleate, fatty acid esters, gelatin, germ oil, glucose, glycerol, groundnut oil, hydroxypropylmethyl celluose, isopropanol, isotonic saline, lactose, magnesium hydroxide, magnesium stearate, malt, mannitol, monoglycerides, olive oil, peanut oil, potassium phosphate salts, potato starch, povidone, prop
  • Excipients for preparation of compositions made with a crystalline compound of this invention to be administered ophthalmically or orally in liquid dosage forms include, for example, 1,3-butylene glycol, castor oil, corn oil, cottonseed oil, ethanol, fatty acid esters of sorbitan, germ oil, groundnut oil, glycerol, isopropanol, olive oil, polyethylene glycols, propylene glycol, sesame oil, water and mixtures thereof.
  • Excipients for preparation of compositions made with a crystalline compound of this invention to be administered osmotically include, for example, chlorofluorohydrocarbons, ethanol, water and mixtures thereof.
  • Excipients for preparation of compositions made with a crystalline compound of this invention to be administered parenterally include, for example, 1,3-butanediol, castor oil, corn oil, cottonseed oil, dextrose, germ oil, groundnut oil, liposomes, oleic acid, olive oil, peanut oil, Ringer's solution, safflower oil, sesame oil, soybean oil, U. S. P. or isotonic sodium chloride solution, water and mixtures thereof.
  • Excipients for preparation of compositions made with or comprising a crystalline compound of this invention to be administered rectally or vaginally include, for example, cocoa butter, polyethylene glycol, wax and mixtures thereof.
  • Solubilities of 1 -(6-amino-3 ,5-difluoropyridin-2-yl)-8-chloro-6-fluoro- 1 ,4-dihydro-7- (3-hydroxyazetidin-l-yl)-4-oxo-3-quinolmecarboxylic acid in different buffered solutions at 25°C are shown in TABLE 1.
  • EXAMPLE 1 A mixture of 1 -(6-amino-3,5-difluoro2-pyridinyl)-8-chloro-6-fluoro- 1 ,4-dihydro-7-(3- hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate (50Kg) and l-deoxy-l-(methylamino)-D- glucitol (26.1Kg) was diluted with water (75.5Kg) and isopropanol (60.2Kg), stirred at 45 0 C, cooled to 30 ⁇ 5 0 C, treated with isopropanol (175.7Kg) while maintaining the internal temperature at about 3O 0 C and filtered.
  • EXAMPLE 2 A mixture of l-(6-ammo-3,5-difluoro2-pyridinyl)-8-chloro-6-fluoro-l,4-dihydro-7-(3- hydroxyazetidin-l-yl)-4-oxo-3-quinolinecarboxylate (29.6Kg) and l-deoxy-l-(methylamino)- D-glucitol (18.4Kg) was diluted with water (133Kg), stirred at 6O 0 C until all solids dissolved, cooled to 38 0 C and held there until solid formed, cooled to O 0 C and filtered. The filtrant was washed with isopropanol and dried at 5O 0 C.

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Abstract

L'invention concerne une forme cristalline d'un médicament, des manières de la produire et des compositions la contenant, ainsi que des méthodes de traitement de maladies et d'inhibition d'événements physiologiques défavorables, à l'aide de ladite forme cristalline.
PCT/US2005/036024 2004-10-08 2005-10-07 Sel et ses formes cristallines d'un medicament WO2006042034A2 (fr)

Priority Applications (8)

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EP15199355.7A EP3056492B1 (fr) 2004-10-08 2005-10-07 Sel de meglumine et formes cristallines correspondantes d'un médicament (delafloxacin)
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WO2010056872A2 (fr) 2008-11-15 2010-05-20 Rib-X Pharmaceuticals, Inc. Compositions antimicrobiennes
CN105017223A (zh) * 2015-07-08 2015-11-04 扬子江药业集团有限公司 德拉沙星葡甲胺晶型i及其制备方法
CN105017224A (zh) * 2015-07-10 2015-11-04 扬子江药业集团有限公司 一种德拉沙星葡甲胺晶型的制备方法
CN105693695A (zh) * 2014-11-24 2016-06-22 重庆医药工业研究院有限责任公司 一种德拉沙星葡甲胺盐的晶型及其制备方法
EP2964652A4 (fr) * 2013-03-08 2016-10-12 Melinta Therapeutics Inc Formes cristallines de d-glucitol, 1-désoxy-1-(méthylamino)-, 1-(6-amino-3, 5-difluoropyridine-2-yl)-8-chloro-6-fluoro-1, 4-dihydro-7-(3-hydroxyazétidin-1-yl)-4-oxo-3-quinolinecarboxylate
CN106572982A (zh) * 2014-06-20 2017-04-19 梅琳塔治疗公司 具有泡腾剂的抗微生物组合物
CN106916142A (zh) * 2015-12-25 2017-07-04 江苏奥赛康药业股份有限公司 一种制备高纯度德拉沙星的方法
EP3157633A4 (fr) * 2014-06-20 2018-02-21 Melinta Therapeutics, Inc. Méthodes de traitement d'infections
US10471046B2 (en) 2014-11-14 2019-11-12 Melinta Subsidary Corp. Method for treating, preventing, or reducing the risk of skin infection
CN111718331A (zh) * 2019-03-23 2020-09-29 南京海润医药有限公司 德拉沙星的杂质i和ii及产品精制方法
CN111718329A (zh) * 2019-03-23 2020-09-29 南京海润医药有限公司 一种德拉沙星杂质iv及产品精制方法
CN111718330A (zh) * 2019-03-23 2020-09-29 南京海润医药有限公司 一种德拉沙星杂质iii及产品精制方法
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WO2022240897A1 (fr) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Composition pharmaceutique comprenant de la délafloxacine destinée à être administrée dans le poumon
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EP3214083A1 (fr) 2008-09-24 2017-09-06 Melinta Therapeutics, Inc. Procédé de préparation de composés de quinolone
EP3766876A1 (fr) 2008-09-24 2021-01-20 Melinta Subsidiary Corp. Formulation pharmaceutique comprenant des composés de quinolone
WO2010036329A2 (fr) 2008-09-24 2010-04-01 Rib-X Pharmaceuticals, Inc. Procédé de préparation de composés de quinolone
USRE46617E1 (en) 2008-09-24 2017-11-28 Melinta Therapeutics, Inc. Process for making quinolone compounds
WO2010056872A2 (fr) 2008-11-15 2010-05-20 Rib-X Pharmaceuticals, Inc. Compositions antimicrobiennes
US12138257B2 (en) 2008-11-15 2024-11-12 Melinta Subsidiary Corp. Antimicrobial compositions
EP2964652A4 (fr) * 2013-03-08 2016-10-12 Melinta Therapeutics Inc Formes cristallines de d-glucitol, 1-désoxy-1-(méthylamino)-, 1-(6-amino-3, 5-difluoropyridine-2-yl)-8-chloro-6-fluoro-1, 4-dihydro-7-(3-hydroxyazétidin-1-yl)-4-oxo-3-quinolinecarboxylate
US12036219B2 (en) 2013-03-15 2024-07-16 Melinta Subsidiary Corp. Methods of treating infections in overweight and obese patients using antibiotics
EP3581180A1 (fr) 2014-06-20 2019-12-18 Melinta Subsidiary Corp. Compositions antimicrobiennes ayant des agents effervescents
CN106572982B (zh) * 2014-06-20 2022-06-03 梅琳塔有限责任公司 具有泡腾剂的抗微生物组合物
EP3157633A4 (fr) * 2014-06-20 2018-02-21 Melinta Therapeutics, Inc. Méthodes de traitement d'infections
CN114831955B (zh) * 2014-06-20 2024-03-12 梅琳塔有限责任公司 药物组合物在制备用于治疗、预防细菌感染，或降低细菌感染的风险的药物中的用途
CN106572982A (zh) * 2014-06-20 2017-04-19 梅琳塔治疗公司 具有泡腾剂的抗微生物组合物
CN114831955A (zh) * 2014-06-20 2022-08-02 梅琳塔有限责任公司 药物组合物在制备用于治疗、预防细菌感染，或降低细菌感染的风险的药物中的用途
CN106572982B9 (zh) * 2014-06-20 2022-07-08 梅琳塔有限责任公司 具有泡腾剂的抗微生物组合物
EP3919057A1 (fr) 2014-06-20 2021-12-08 Melinta Subsidiary Corp. Compositions antimicrobiennes ayant des agents effervescents
US10471046B2 (en) 2014-11-14 2019-11-12 Melinta Subsidary Corp. Method for treating, preventing, or reducing the risk of skin infection
CN105693695A (zh) * 2014-11-24 2016-06-22 重庆医药工业研究院有限责任公司 一种德拉沙星葡甲胺盐的晶型及其制备方法
CN105017223A (zh) * 2015-07-08 2015-11-04 扬子江药业集团有限公司 德拉沙星葡甲胺晶型i及其制备方法
CN105017224A (zh) * 2015-07-10 2015-11-04 扬子江药业集团有限公司 一种德拉沙星葡甲胺晶型的制备方法
CN106916142A (zh) * 2015-12-25 2017-07-04 江苏奥赛康药业股份有限公司 一种制备高纯度德拉沙星的方法
CN111718330A (zh) * 2019-03-23 2020-09-29 南京海润医药有限公司 一种德拉沙星杂质iii及产品精制方法
CN111718329A (zh) * 2019-03-23 2020-09-29 南京海润医药有限公司 一种德拉沙星杂质iv及产品精制方法
CN111718331A (zh) * 2019-03-23 2020-09-29 南京海润医药有限公司 德拉沙星的杂质i和ii及产品精制方法

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US20130060040A1 (en) 2013-03-07
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CA2582954A1 (fr) 2006-04-20
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