[go: up one dir, main page]

WO2002042328A3 - Method for studying the effects of commensal microflora on mammalian intestine and treatments of gastrointestinal-associated disease based thereon - Google Patents

Method for studying the effects of commensal microflora on mammalian intestine and treatments of gastrointestinal-associated disease based thereon Download PDF

Info

Publication number
WO2002042328A3
WO2002042328A3 PCT/US2001/044332 US0144332W WO0242328A3 WO 2002042328 A3 WO2002042328 A3 WO 2002042328A3 US 0144332 W US0144332 W US 0144332W WO 0242328 A3 WO0242328 A3 WO 0242328A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatments
studying
gastrointestinal
intestine
effects
Prior art date
Application number
PCT/US2001/044332
Other languages
French (fr)
Other versions
WO2002042328A2 (en
Inventor
Jeffrey Ivan Gordon
Lora Virginia Hooper
Thaddeus F Stappenbeck Iv
Per Falk
Lennart Hansson
Original Assignee
Univ Washington
Astrazeneca Ab
Jeffrey Ivan Gordon
Lora Virginia Hooper
Thaddeus F Stappenbeck Iv
Per Falk
Lennart Hansson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington, Astrazeneca Ab, Jeffrey Ivan Gordon, Lora Virginia Hooper, Thaddeus F Stappenbeck Iv, Per Falk, Lennart Hansson filed Critical Univ Washington
Priority to US10/432,819 priority Critical patent/US20040091893A1/en
Priority to JP2002544461A priority patent/JP2004536557A/en
Priority to EP01995938A priority patent/EP1414853A2/en
Priority to AU2002226984A priority patent/AU2002226984A1/en
Publication of WO2002042328A2 publication Critical patent/WO2002042328A2/en
Publication of WO2002042328A3 publication Critical patent/WO2002042328A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

a method of investigating chemical changes resulting from commensal microflora colonisation of mammalian intestine which comprises: a) measuring gene expression in commensal bacterium-colonized and germ-free intestine of at least one gene; and b) identifying a gene from a) that has at least a 2-fold difference in expression level between commensal bacterium-colonized and germ-free intestine. The method selects genes for further evaluation, and gives rise to the development of prophylactic treatments.
PCT/US2001/044332 2000-11-27 2001-11-27 Method for studying the effects of commensal microflora on mammalian intestine and treatments of gastrointestinal-associated disease based thereon WO2002042328A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/432,819 US20040091893A1 (en) 2001-11-27 2001-11-27 Method for studying the effects of commensal microflora on mammalian intestine and treatments of gastrointestinal-associated disease based thereon
JP2002544461A JP2004536557A (en) 2000-11-27 2001-11-27 Method for investigating the effect of symbiotic microflora on mammalian intestine and treatment of gastrointestinal related diseases based on it
EP01995938A EP1414853A2 (en) 2000-11-27 2001-11-27 Method for studying the effects of commensal microflora on mammalian intestine and treatments of gastrointestinal-associated disease based thereon
AU2002226984A AU2002226984A1 (en) 2000-11-27 2001-11-27 Method for studying the effects of commensal microflora on mammalian intestine and treatments of gastrointestinal-associated disease based thereon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25290100P 2000-11-27 2000-11-27
US60/252,901 2000-11-27

Publications (2)

Publication Number Publication Date
WO2002042328A2 WO2002042328A2 (en) 2002-05-30
WO2002042328A3 true WO2002042328A3 (en) 2004-02-19

Family

ID=22958021

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044332 WO2002042328A2 (en) 2000-11-27 2001-11-27 Method for studying the effects of commensal microflora on mammalian intestine and treatments of gastrointestinal-associated disease based thereon

Country Status (4)

Country Link
EP (1) EP1414853A2 (en)
JP (1) JP2004536557A (en)
AU (1) AU2002226984A1 (en)
WO (1) WO2002042328A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005518195A (en) * 2001-11-27 2005-06-23 ワシントン・ユニバーシティ Therapeutic proteins and therapeutic methods
US20050239706A1 (en) * 2003-10-31 2005-10-27 Washington University In St. Louis Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject
DE102005026710A1 (en) * 2005-06-09 2006-12-14 Basf Ag Method for testing substances or substance mixtures, their use and corresponding analysis kits
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
JP6271093B1 (en) 2014-12-23 2018-01-31 フォーディー ファーマ リサーチ リミテッド4D Pharma Research Limited Immunoregulation
ES2668934T3 (en) 2014-12-23 2018-05-23 4D Pharma Research Limited Pirin polypeptide and immune modulation
AU2016278070B2 (en) 2015-06-15 2021-09-09 Cj Bioscience, Inc. Compositions comprising bacterial strains
MA41060B1 (en) 2015-06-15 2019-11-29 4D Pharma Res Ltd Compositions comprising bacterial strains
MA41010B1 (en) 2015-06-15 2020-01-31 4D Pharma Res Ltd Compositions comprising bacterial strains
PE20180243A1 (en) 2015-06-15 2018-01-31 4D Pharma Res Ltd COMPOSITIONS INCLUDING BACTERIAL STRAINS
EP4056191A1 (en) 2015-06-15 2022-09-14 4D Pharma Research Limited Compositions comprising bacterial strains
GB201520497D0 (en) 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
SG11201804161VA (en) 2015-11-20 2018-06-28 4D Pharma Res Ltd Compositions comprising bacterial strains
CA3016179C (en) 2016-03-04 2019-08-13 4D Pharma Plc Compositions comprising bacterial blautia strains for treating visceral hypersensitivity
GB201612191D0 (en) 2016-07-13 2016-08-24 4D Pharma Plc Compositions comprising bacterial strains
TW201821093A (en) 2016-07-13 2018-06-16 英商４Ｄ製藥有限公司 Composition comprising a bacterial strain
GB201621123D0 (en) 2016-12-12 2017-01-25 4D Pharma Plc Compositions comprising bacterial strains
KR20200019882A (en) 2017-05-22 2020-02-25 4디 파마 리서치 리미티드 Compositions Containing Bacterial Strains
MA41708A (en) 2017-05-24 2020-04-08 4D Pharma Res Ltd COMPOSITIONS CONTAINING BACTERIAL STRAINS
BR112019026477A2 (en) 2017-06-14 2020-07-14 4D Pharma Research Limited compositions comprising bacterial strains
JP6837581B2 (en) 2017-06-14 2021-03-03 フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ Compositions Containing Bacterial Strains of the Genus Megasphaera and Their Use
EP3638271B1 (en) 2017-06-14 2020-10-14 4D Pharma Research Limited Compositions comprising bacterial strains
CN110777215A (en) * 2019-11-07 2020-02-11 北京市心肺血管疾病研究所 A method for detecting whether food contains C2Z7 transgenic maize by using metagenomic technology
CN116143899B (en) * 2022-11-07 2024-02-20 四川农业大学 A recombinant antibacterial peptide pANG4 and its preparation method and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0904784A1 (en) * 1997-09-22 1999-03-31 N.V. Nutricia Probiotic nutritional preparation
WO2000065095A2 (en) * 1999-04-23 2000-11-02 Clontech Laboratories, Inc. Methods and compositions for performing array based hybridization assays

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0904784A1 (en) * 1997-09-22 1999-03-31 N.V. Nutricia Probiotic nutritional preparation
WO2000065095A2 (en) * 1999-04-23 2000-11-02 Clontech Laboratories, Inc. Methods and compositions for performing array based hybridization assays

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BERNET-CAMARD MARIE-FRANCOISE ET AL: "The human Lactobacillus acidophilus strain LA1 secretes a nonbacteriocin antibacterial substance(s) active in vitro and in vivo.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 63, no. 7, 1997, pages 2747 - 2753, XP002231951, ISSN: 0099-2240 *
BRY LYNN ET AL: "A model of host-microbial interactions in an open mammalian ecosystem.", SCIENCE (WASHINGTON D C), vol. 273, no. 5280, 1996, pages 1380 - 1383, XP000993528, ISSN: 0036-8075 *
ERWIN CHRISTOPHER R ET AL: "Analysis of intestinal adaptation gene expression by cDNA expression arrays.", JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, vol. 24, no. 6, November 2000 (2000-11-01), pages 311 - 316, XP009006275, ISSN: 0148-6071 *
HOOPER LORA V ET AL: "Analyzing the molecular foundations of commensalism in the mouse intestine.", CURRENT OPINION IN MICROBIOLOGY, vol. 3, no. 1, February 2000 (2000-02-01), pages 79 - 85, XP002231950, ISSN: 1369-5274 *
OGAWA HITOSHI ET AL: "Identification of genes involved in mucosal defense and inflammation associated with normal enteric bacteria.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 279, no. 3 Part 1 of 2, September 2000 (2000-09-01), pages G492 - G499, XP002231949, ISSN: 0002-9513 *
UMESAKI YOSHINORI ET AL: "Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC Class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the Ex-germ-free mouse.", MICROBIOLOGY AND IMMUNOLOGY, vol. 39, no. 8, 1995, pages 555 - 562, XP009006341, ISSN: 0385-5600 *
XINYU FU ET AL: "E2A-PBX1 INDUCES ABERRANT EXPRESSION OF TISSUE-SPECIFIC AND DEVELOPMENTALLY REGULATED GENES WHEN EXPRESSED IN NIH 3T3 FIBROBLASTS", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 17, no. 3, March 1997 (1997-03-01), pages 1503 - 1512, XP002172402, ISSN: 0270-7306 *

Also Published As

Publication number Publication date
WO2002042328A2 (en) 2002-05-30
EP1414853A2 (en) 2004-05-06
JP2004536557A (en) 2004-12-09
AU2002226984A1 (en) 2002-06-03

Similar Documents

Publication Publication Date Title
WO2002042328A3 (en) Method for studying the effects of commensal microflora on mammalian intestine and treatments of gastrointestinal-associated disease based thereon
AU2002333834A1 (en) System, method and computer program for conducting optical transmission measurements and evaluating determined measuring variables
WO2001088188A3 (en) Method for examining ischemic conditions
WO2001089361A3 (en) Diagnosis, prevention and treatment of crohn's disease using the ompc antigen
AU2001281064A1 (en) Computer based instrumentation and sensing for physical examination training
WO2004083816A3 (en) Loss of heterozygosity of the dna markers in the 12q22-23 region
HK1048737A2 (en) Method for rewarding customer loyalty with respect to a lease agreement
EP1495721A3 (en) Biological-sound data processing system, program, and recording medium
EP1321892A3 (en) Adopting Bayesian network parameters on-line in a dynamic environment
AU2002340842A1 (en) Method, device and arrangement for measuring the dynamic behavior
ATE412767T1 (en) PREBIOTIC EFFECT ANALYSIS
MXPA01005698A (en) Assay for anti transglutaminase antibodies detection useful in celiac disease diagnosis.
EP1116474A3 (en) Periodic-physical-information measuring apparatus
WO2004061419A3 (en) Systems and methods for estimating properties of a sample
EP1271341A3 (en) System for analysing textual data
CA2407760A1 (en) Methods for diagnosis of low grade astrocytoma
EP1220199A3 (en) Method for detecting and outputting tone of voice and device therefor
WO2004046382A3 (en) Product and method
WO2003087885A3 (en) Apparatus and method for true temperature estimation
WO2002075308A3 (en) A kit and method for detecting food allergies
AU2002230004A1 (en) Diagnosis of atherosclerosis
AU2002365554A1 (en) Assaying apparatus, kit, and method for lipids and associated enzymes
AU2003216804A1 (en) Optical interferometer
EP1312613A3 (en) (1--3)-beta-D-glucan binding domain protein, measuring method using the substance and assay kit
BR0110603A (en) Polyurethane-coated natural leather and preparation method of coated natural leather

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2001995938

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2002544461

Country of ref document: JP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10432819

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2001995938

Country of ref document: EP

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)