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WO2001001951A1 - Dispositifs - Google Patents

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Publication number
WO2001001951A1
WO2001001951A1 PCT/US2000/018108 US0018108W WO0101951A1 WO 2001001951 A1 WO2001001951 A1 WO 2001001951A1 US 0018108 W US0018108 W US 0018108W WO 0101951 A1 WO0101951 A1 WO 0101951A1
Authority
WO
WIPO (PCT)
Prior art keywords
gel
skin
ofthe
sheet
negative image
Prior art date
Application number
PCT/US2000/018108
Other languages
English (en)
Inventor
Robert Stanley Dirksing
Pauline Jane Errey
Theresa Louise Johnson
Michael Jude Leblanc
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2000/009682 external-priority patent/WO2001001952A1/fr
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Priority to KR1020027000208A priority Critical patent/KR20020027478A/ko
Priority to MXPA02000267A priority patent/MXPA02000267A/es
Priority to AU57827/00A priority patent/AU5782700A/en
Priority to EP00943342A priority patent/EP1196139A1/fr
Priority to CA002373980A priority patent/CA2373980A1/fr
Priority to JP2001507446A priority patent/JP2003518009A/ja
Priority to BR0012233-5A priority patent/BR0012233A/pt
Publication of WO2001001951A1 publication Critical patent/WO2001001951A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D40/00—Casings or accessories specially adapted for storing or handling solid or pasty toiletry or cosmetic substances, e.g. shaving soaps or lipsticks
    • A45D40/26—Appliances specially adapted for applying pasty paint, e.g. using roller, using a ball
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D44/00—Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D44/00—Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
    • A45D44/002—Masks for cosmetic treatment of the face
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations

Definitions

  • patches or devices may be too wet or sticky, as the gel forming agents comprising the patch or device do not form a solid gel structure and as a result, the patches or devices are difficult to handle and apply to the skin. Others are strongly adhesive, tight and uncomfortable to wear and remove, and many patches do not provide an effective release and penetration of benefit agents.
  • the preferred pre-formed, unilamellar sheet-like devices ofthe present invention display a low level of syneresis, which makes the devices moist to the touch and helps provide a cooling sensation.
  • the surface liquid can facilitate adhesion of the devices to a target surface, thus obviating the need for either an additional adhesive overlying the gelled form or an adhesive coated substrate.
  • EP-B-507,160 relates to an external preparation for application to the skin comprising a drug retaining layer placed on a support wherein the drug retaining layer comprises lidocaine, and an adhesive gel base comprising 0.5% to 50% of a water soluble, high molecular weight substance, 20 to 70% ,water and 1 to 70 % of a water retaining agent.
  • Suitable supports are described as flexible materials such as non-woven fabrics.
  • a method of producing a pre-formed, unilamellar sheet-like device comprising the steps of providing a gel-forming mixture comprising at least one benefit agent and at least one gellable polymeric gel forming agent in a mould having at least one surface that is the negative image of the, or each, non- planar topography, the non-planar topography comprising at least two delineated regions simultaneously not having the same mean thickness or a textured surface that is the negative image of a texturing surface, the texturing surface having a texture defined by R a of greater than lO ⁇ m or both; and thereafter gelling the gel-forming mixture.
  • Fig. 10 is a schematic view of a seventh embodiment of a device according to the first or second aspect ofthe invention, in situ on a user's face.
  • Fig. 4 illustrates, in a sectional perspective, partial view, a fourth embodiment of a preformed, unilamellar sheet-like device according to the first or second or a third aspect of the invention, generally indicated as 310.
  • the device 310 has first and second spaced- apart surfaces 314, 316, the device 310 having a non-planar topography comprising a plurality of delineated thickened regions in the form of spaced-apart ridges 320 intermediate the perimeter (not shown), and a plurality of delineated thinner regions 322.
  • the illustrated non-planar topography may further comprise a textured surface, that is the negative image of a texturing surface, with texture defined by R a of greater than lO ⁇ m.
  • the silicone fluid is preferably a hydroxyl-terminated diorganopolysiloxane polymer.
  • the repeat units of the silicone fluid are R2Si ⁇ 2/2 siloxy units wherein R is independently selected from the same hydrocarbon and halogenated radicals as defined above for the silicone resin.
  • the silicone fluid can be comprised of a single polymer or copolymer or it can be a mixture of two or more such polymers.
  • the silicone fluid can be a liquid or gum at 25°C. It is preferred that at least 50%, and preferably at least 85%, of the organic radicals along the chain of the silicone fluid are methyl radicals, which can be distributed in any manner in the silicone fluid. Further, the silicone fluid can comprise up to about 10 mole percent of siloxane branching sites.
  • Silicone polymeric gel forming agents should not be confused with silicone rubbers, which are not useful in these applications. Silicone polymeric gel forming agents are usually fillerless or contain low amounts (less than 5%) of fillers. By contrast, silicone rubbers typically contain about 15 to 35% filler. Fillers are generally not required in high quantities in silicone polymeric gel forming agents, because high quantities often cause the silicone polymeric gel forming agents to lose tack and adhesiveness and to increase in dynamic viscosity, making it more difficult to apply a coating of the silicone polymeric gel forming agent.
  • Brown Seaweed Polysaccharides Polysaccharides which are classified as brown seaweed polysaccharides are isolated by extraction from various species of Phaebophyceae. Suitable brown seaweed polysaccharides for use herein include algin, alginic acid, ammonium alginate, calcium alginate, potassium alginate, sodium alginate, propylene glycol alginate, and mixtures thereof.
  • Suitable galactomannans for use herein are fenugreek gum; lucern; clover; locust bean gum known for example in the industry under the (CTFA) trade designation as carob bean gum, available as "Seagul L” from FMC (Philadelphia, PA, USA); tara gum available from Starlight Products (Rouen, France) or Bunge Foods (Atlanta, GA, USA); guar gum derived from the ground endosperms of Cyamopsis tetragonolobus, available as "Burtonite V7E” from TIC Gums (Belcamp, MD, USA), “Jaguar C” from Rhone-Poulenc (Marietta, GA, USA), or “Supercol” from Aqualon (Wilmington, DE, USA); and cassia gum available from Starlight Products (Rouen, France), or mixtures thereof.
  • Plant Fiber Derivatives A suitable example of a plant fiber derivative for use herein is cellulose.
  • Resinous Gums examples include shellac gum which is obtained from the resinous secretion of the insect Laccifer (Tachardia) lacca; damar gum; copal gum and rosin gum; or mixtures thereof.
  • the pre-formed, unilamellar sheet-like devices of the present invention are self- supporting and do not require supporting or strengthening by an occlusive or non- occlusive backing material often referred to as a substrate.
  • a substrate if present, may be combined with a unilamellar sheet-like device and would confer further support or strengthening.
  • the substrate is non-occlusive.
  • a substrate is particularly useful when the device according to the present invention has a large surface area. If the substrate is to be used to confer further support or strengthening, the substrate will be sufficiently compatible with the device ofthe present invention, so as not to delaminate therefrom.
  • a wide variety of materials can be used as the substrate. The following characteristics are desirable: (i) sufficient wet strength for use, (ii) sufficient flexibility, (iii) sufficient loft and porosity, (iv) sufficient hydrophilicity such that the gel mixture may diffuse and infiltrate into the substrate, (v) sufficient compatibility with the mixture to prevent de- lamination, (vi) sufficient transparency or translucency, and (vii) appropriate size.
  • the pre-formed, unilamellar sheet-like devices herein comprise a safe and effective amount of at least one benefit agent.
  • benefit agent means an active ingredient which provides a cosmetic and/or therapeutic effect to the area of application. Included in this definition of benefit agents are the categories listed below as well as, for example, vitamins, and humectants.
  • the pre-formed, unilamellar sheet-like devices of the present invention comprise from about 0.01% to about 60%, preferably from about 0.05% to about 30% and most preferably from about 0.1% to about 20% by weight of the device of at least one benefit agent, or mixtures thereof.
  • the condition involves inflammation of the pilosebaceous apparatus thereby resulting in lesions, which may include papules, pustules, cysts, comedones, and severe scarring.
  • lesions which may include papules, pustules, cysts, comedones, and severe scarring.
  • the bacteria Corynebacterium acnes and Staphylococcus epidermis are usually present in the pustular contents.
  • useful anti-acne actives include the keratolytics described in WO98/18444 incorporated herein by reference.
  • retinoids such as retinoic acid (e.g., cis and/or trans) and its derivatives (e.g., esters); retinol and its esters (e.g., retinyl propionate, retinyl acetate); abietic acid, adapalene, tazarotene, allantoin, aloe extracts, arbietic acid and its salts, ASEBIOL (from Laboratories Serobiiquess, Somerville, NJ), azaleic acid, barberry extracts, bearberry extracts, belamcanda chinensis, benzoquinolinones, benzoyl peroxide, berberine, BIODERMINE (from Sederma, Brooklyn, NY), bioflavonoids as a class, bisabolol, s-carboxymethyl cysteine, carrot extracts, cassin oil, clove extracts, citral, citronellal, climazole, COMPLETECH MBA
  • Emollients examples include mineral oil, petrolatum, C7- C40 branched chain hydrocarbons, C1-C30 alcohol esters of C1-C30 carboxylic acids, C1-C30 alcohol esters of C2-C30 dicarboxylic acids, monoglycerides of C1-C30 carboxylic acids, diglycerides of C1-C30 carboxylic acids, triglycerides of C1-C30 carboxylic acids, ethylene glycol monoesters of C1-C30 carboxylic acids, ethylene glycol diesters of C1-C30 carboxylic acids, propylene glycol monoesters of C1-C30 carboxylic acids, propylene glycol diesters of C1-C30 carboxylic acids, C1-C30 carboxylic acid monoesters and polyesters of sugars, for example, sefa cottonate (sucrose polycottonseedate), polydialkylsiloxanes, polydiarylsiloxa
  • sunscreening agents examples include diethanolamine p-methoxycinnamate, dioxybenzone, ethyl dihydroxypropyl PABA, glyceryl aminobenzoate, lawsome and dihydroxyacetone, menthyl anthranilate, methyl anthranilate, octyl dimethyl PABA, red petroleum, sulisobenzone, triethanolamine salicylate, and mixtures thereof.
  • Sebum inhibitors can decrease the production of sebum in the sebaceous glands.
  • suitable sebum inhibitors include aluminium hydroxy chloride, ASEBIOL (from Laboratories Serobiiquess, Somerville, NJ), BIODERMINE (from Sederma, Brooklyn, NY), climbazole, COMPLETECH MBAC-OS (from Lipo, Peterson, NJ), corticosteroids, cucumber extracts, dehydroacetic acid and its salts, dichlorophenyl imidazoldioxolan, ketoconazole, LICHOCHALCONE LR 15 (available from Maruzen), niacinamide, nicotinic acid and its esters, nicotinyl alcohol, phloretin, PHLOROGINE (from Secma, Pontrieux, France), pyridoxine and derivatives thereof, s- carboxylmethyl cysteine, SEPICONTROL AS, spironolactone, tioxolone,
  • Protease inhibitors are compounds which inhibit the process of proteolysis, that is, the splitting of proteins into smaller peptide fractions and amino acids.
  • suitable protease inhibitors include A E COMPLEX (from Barnet Products, Englewood, NJ), ALE (from Laboratoires Seporgia, Sophia Antipolis, France), allicin, AOSAINE (from Secma Biotechnologies Marine, Pontrieux, France), APROTININ (from Pentapharm AG, Basel, Switzerland), areca catechu extracts, BLUE ALGAE EXTRACT (from Collaborative Labs Inc., East Setauket, NY), CENTAURIUM (from Sederma, Brooklyn, NY), CMST (from Bioetica Inc., Portland, ME), DERMOPROTECTLNE (from Sederma, Brooklyn, NY), DISACOSIDE HF 60 (from Barnet Products, Englewood, NJ), ELfflBIN (from Pentapharm AG, Basel, Switzerland), FLUID OUT COLLOID (from Ve
  • Desquamation Enzyme Enhancers These agents enhance the activity of endogenous desquamating enzymes.
  • desquamation enzyme enhancers include N-methyl serine, serine, trimethyl glycine, and mixtures thereof.
  • Anti-Glycation agents prevent the sugar induced crosslinking of collagen.
  • a suitable example of an anti-glycation agent includes AMADORTNE (from Barnet Products Distributor, Englewood, NJ).
  • the pre-formed, unilamellar sheet-like devices of the present invention can also optionally comprise one or more surfactants and/or emulsifiers.
  • Emulsifiers and/or surfactants generally help to disperse and suspend the discontinuous phase within the continuous phase.
  • a surfactant may also be useful if the product is intended for skin, hair or nail cleansing.
  • emulsifiers will be referred to under the term 'surfactants', thus 'surfactant(s)' will be used to refer to surface active agents whether used as emulsifiers or for other surfactant pu ⁇ oses such as skin, hair or nail cleansing.
  • Known or conventional surfactants can be used in the composition, provided that the selected agent is chemically and physically compatible with essential components of the composition, and provides the desired characteristics. Suitable surfactants include silicone materials, non-silicone materials, and mixtures thereof.
  • nonionic surfactants are the condensation products of alkylene oxides with both fatty acids and fatty alcohols [i.e. wherein the polyalkylene oxide portion is esterified on one end with a fatty acid and etherified (i.e. connected via an ether linkage) on the other end with a fatty alcohol].
  • RCO(X) n OR wherein R and R' are groups, X is -OCH2CH2- or -OCH2CHCH3- , and n is an integer from about 6 to about 100, examples of which include ceteth-6, ceteth-10, ceteth-12, ceteareth-6, ceteareth-10, ceteareth-12, steareth-6, steareth-10, steareth-12, PEG-6 stearate, PEG- 10 stearate, PEG- 100 stearate, PEG- 12 stearate, PEG-20 glyceryl stearate, PEG-80 glyceryl tallowate, PEG- 10 glyceryl stearate, PEG-30 glyceryl cocoate, PEG-80 glyceryl cocoate, PEG-200 glyceryl tallowate, PEG-8 dilaurate, PEG- 10 distearate, and mixtures thereof.
  • non-silicon-containing surfactants examples include: polysorbate 20, polyethylene glycol 5 soya sterol, steareth-20, ceteareth-20, PPG-2 methyl glucose ether distearate, polysorbate 80; polysorbate 60, available under the trade name "Tween 60" from ICI (Wilmington, MA, USA); glyceryl stearate, sorbitan monolaurate, polyoxyethylene 4 lauryl ether sodium stearate, polyglyceryl-4 isostearate, hexyl laurate, PPG-2 methyl glucose ether distearate, and mixtures thereof.
  • nonionic surfactants are those selected from the group consisting of ceteareth-12, sucrose cocoate, steareth-100, polysorbate 60, PEG-60 Hydrogenated Castor Oil, isoceteth-20, oleth-20, PEG- 100 stearate, and mixtures thereof.
  • hydrophilic surfactants useful herein can alternatively or additionally include any of a wide variety of cationic, anionic, zwitterionic, and amphoteric surfactants such as are known in the art. See, e.g., McCutcheon's, Detergents and Emulsifiers, North American Edition (1986), published by Allured Publishing Co ⁇ oration; US-A-5,011,681 to Ciotti et al, issued April 30, 1991; US-A-4,421,769 to Dixon et al, issued December 20, 1983; and US-A-3,755,560 to Dickert et al., issued August 28, 1973; these four references are inco ⁇ orated herein by reference in their entirety.
  • cationic surfactants are useful herein. Suitable cationic surfactants for use herein are disclosed in WO98/18444, inco ⁇ orated herein by reference.
  • dimethicone copolyols examples include alkyl-modified dimethicone copolyols, i.e., compounds which contain C2-C30 pendant side chains.
  • Still other useful dimethicone copolyols include materials having various cationic, anionic, amphoteric, and zwitterionic pendant moieties.
  • the mould has at least one of first and second mould surfaces, the at least one of first and second mould surfaces being the negative image of the at least one of first and second surfaces of the device itself and the at least one of the first and second mould surfaces being a negative image of the non-planar topography.
  • the non-planar topography is of a freely selectable shape including, but not limited to those illustrated in Figures 1-4, 6-7, 8- 9 and 10-12 of the accompanying drawings. If the non-planar topography has periodicity, the at least one of the first and second mould surfaces has periodicity, which confers a negative image of the periodicity to the at least one of first and second surfaces of the device itself.
  • the method for its production involves preparing a gel- forming mixture comprising at least one benefit agent and at least one polymeric gel forming agent and the optional components, if present, and heating said mixture to a first temperature above the gel point of the mixture, to solubilise the gel-forming mixture; placing the mixture in a suitably shaped mould having at least one of first and second mould surfaces being the negative image of at least one of the first and second surfaces of the device itself; on at least one of which first and second mould surfaces is pre- positioned a texturing surface whose negative image has a texture defined by R a of greater than lO ⁇ m; gelling the mixture at a second temperature cooler than the first temperature at or below the gel point of the gel-forming mixture; and removing the, or each, texturing surface from the device.
  • the uni-axial deformation (compression) at the gel's point of mpture is expressed as a percent of its original moulded height, i.e.
  • Textured surfaces representative of devices of the first or third aspects of the invention were prepared by making negative silicone casts (Silflo Silicone Impression Material; Flexico Developments,UK) of texturing surfaces useful in the production of pre-formed, unilamellar sheet-like devices according to a first or third aspect of the present invention. Silicone casts were used instead of actual pre-formed, unilamellar sheet-like devices because the optical properties ofthe silicone casting material are more suitable for optical surface analysis.
  • any appropriately configured x and y axis resolution less than 40 ⁇ m; z axis resolution less than 2 ⁇ m
  • surface profiling technique e.g., stylus profilometry, laser profilometry, or fringe projection
  • R a and Rq are via the line based method described in ISO4287 (1997) where R a is defined as the arithmetical mean deviation of the assessed profile and Rq is defined as the root mean- square deviation ofthe assessed profile.
  • a sample ofthe gel of interest was moulded to produce a gel disc with a thickness (depth) of 7 mm.
  • This gel disc was placed onto the transparency film printed with 4 font size and the visibility of the printed alphabet was assessed through the disc of gel. If the text was not legible through the gel disc, the disc was transfe ⁇ ed to the next largest font sizeand the assessment repeated. This process was repeated until a font size was reached that was legible through the gel. The smallest font size legible through the gel sample was then assigned the "transparency threshold" for that gel.
  • the prefe ⁇ ed "transparency threshold" for the gels used to make the devices of the present invention is 10 font size, more preferred is 7 font size and especially prefe ⁇ ed is 4 font size.
  • KelgumTM is a 1 :1 mixture of xanthan gum and locust bean gum supplied by Kelco, San Diego, CA, USA.
  • the polysaccharide gums are mixed with water to form a uniformly dispersed mixture (this can be facilitated by pre-dispersing the polysaccharides in a non-solvent e.g. polyhydric alcohol) and any additional components are added.
  • the mixture is heated with stirring to a first temperature above the gel point ofthe mixture (ca. 90 C) to fully hydrate the polysaccharide gums.
  • the liquid gel is then dispensed into a suitably shaped mould (Example 3).
  • the devices of Examples 1 and 2 are injection moulded into a suitably shaped mould. Injection moulding is prefe ⁇ ed. This eliminates any defects which may be introduced by cutting the gel and so improves the robustness of the device.
  • Injection moulding also allows the device to be readily formed into a three-dimensional structure.
  • the liquid gel is then cooled to a second temperature cooler than the first temperature at or below the gel point of the mixture (ambient temperature) to set up the gel stmcture.
  • the device may then be removed from the mould.
  • the devices of Examples 1 -3 are illustrated in, respectively, Figures 1-3 of the accompanying drawings.
  • the devices herein are then packaged into materials which have low water vapour permeability to minimise drying out of the device during storage. Suitable packaging for devices herein include sachets or sealed trays. If the device is packaged in a sachet, it is preferably protected prior to use. This protection can be provided by a substrate or by a release liner such as a plastic film, which provides easy release for the device.
  • metal ions e.g. Ca 2+ , K +
  • the metal ions may be included in the formulation to increase the gel strength ofthe device (Examples 1 and 2).
  • the metal ions are added in the form of an aqueous solution and are sti ⁇ ed into the liquid gel immediately before the dispensing step.
  • the above method may be modified as necessary depending on the nature of any additional components.
  • the liquid gel may be homogenised immediately prior to moulding or casting to ensure dispersion of the non-aqueous components.
  • the formulation should be cooled to an appropriate temperature (dependent on the ingredient) after the gum hydration step and the heat sensitive ingredient added at this stage.
  • the liquid gel may be de-gassed, e.g. by vacuum, to remove air bubbles dispersed within the liquid. This de-gassing step, if followed, would be the final step immediately prior to dispensing the liquid gel. As shown above, the pre-formed, sheet-like devices herein have excellent strength and flexibility.
  • a formulation of a pre-formed, sheet-like device has been prepared containing 50/50 (weight/weight) silicone gel forming agent and ascorbic acid and derivatives thereof as a benefit agent.
  • the formulation is prepared by condensing at 115 to 120°C, in the presence of 0.025 parts anhydrous ammonia, 67 parts of a 70wt% xylene solution of a siloxane resin copolymer consisting essentially of (CH3)3SiO ⁇ / 2 units and Si ⁇ 4/2 units in a molar ratio of approximately 0.75:1 and containing approximately 2.7 weight percent hydroxyl based on solids as determined by FTIR (ASTM E-168), 31 parts of a hydroxyl terminated polydimethylsiloxane having a viscosity of about 13,500 cP (mP.s) at 25°C and 2 parts of xylene. Following the condensation reaction, the mixture was heated to 140°C for 1 hour to remove any excess ammonia.
  • the silicone solution is transfe ⁇ ed to a suitably shaped mould and allowed to air dry overnight to allow evaporation ofthe solvents.
  • the resulting device is removed from the mould and packaged.
  • This silicone-containing pre-formed, sheet-like device was found to be suitable for delivering ascorbic acid and derivatives thereof as a benefit agent to the skin, hair or nails.
  • Example 6 50 parts (dry weight) of medical grade acrylic pressure sensitive adhesive (Draize scale score 0-1), dissolved in ethyl acetate and toluene, is mixed with 50 parts (ascorbic acid and derivatives thereof and sodium ascorbate, both as dry powders, in a 1 :22 (wt/wt) ratio) to form the cosmetically effective adhesive matrix. It is transferred to a suitably shaped mould and then cured at 121.2°C. This pre-formed, sheet-like device was found to be suitable for delivering at least one benefit agent to the skin, hair or nails.
  • Example 6 50 parts (dry weight) of medical grade acrylic pressure sensitive adhesive (Draize scale score 0-1), dissolved in ethyl acetate and toluene, is mixed with 50 parts (ascorbic acid and derivatives thereof and sodium ascorbate, both as dry powders, in a 1 :22 (wt/wt) ratio) to form the cosmetically effective adhesive matrix. It is transferred to a suitably
  • the polysaccharide gums are mixed with water to form a uniform dispersion and any additional components are added. Formation of a uniform dispersion can be facilitated by pre-dispersing the polysaccharides in a non-solvent, for example, polyhydric alcohol. The mixture is heated with stirring to about 90°C to fully hydrate the polysaccharide gums.
  • the liquid gel may be de-gassed, for example, by vacuum, to remove air bubbles dispersed within the liquid.
  • the liquid gel is then dispensed into a suitably shaped mould and is then cooled to ambient temperature to set up the gel stmcture. The device may then be removed from the mould.
  • the macro apertures have a teardrop pattern with 12% open area disposed in a pattern having 24 macro apertures/cm ⁇ wherein the base of each macro aperture is 1.54mm2, the tip is 0.3mm ⁇ in diameter and the micro apertures are formed on a screen having a 100 mesh pattern.
  • All textured surfaces as defined herein will have prefe ⁇ ed levels of gloss in the range of ⁇ 40, ⁇ 58, and ⁇ 65 for the 20°, 60° and 85° geometries, respectively.
  • the prefe ⁇ ed ranges of gloss for devices of the present invention are 0-10, 0-30 and 0-25 for the 20°, 60° and 85° geometries, respectively.
  • the most prefe ⁇ ed gloss ranges are 0-5, 0-25 and 0-20 for the 20°, 60° and 85° geometries, respectively.
  • the gel transparency of the present device was assessed as described above - its transparency threshold is 4 font size.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne des dispositifs en feuille unilamellaires préformés (10, 110, 210, 310, 410, 510, 610, 710, 810) destinés à l'application d'agents bénéfiques pour la peau, les cheveux ou les ongles. Ces dispositifs se présentent sous la forme de timbres autocollants ou de masques destinés à un usage cosmétique ou thérapeutique. Ils présentent une topographie non planaire sur au moins une surface (14, 114, 214, 414, 414, 514, 614, 714, 814, 16, 116, 216, 316, 416, 516, 616, 716, 816), et sont moins gênants. La présente invention concerne également des procédés de production de ces dispositifs.
PCT/US2000/018108 1999-07-06 2000-06-30 Dispositifs WO2001001951A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020027000208A KR20020027478A (ko) 1999-07-06 2000-06-30 시트형 디바이스
MXPA02000267A MXPA02000267A (es) 1999-07-06 2000-06-30 Dispositivos similares a hojas.
AU57827/00A AU5782700A (en) 1999-07-06 2000-06-30 Sheet-like devices
EP00943342A EP1196139A1 (fr) 1999-07-06 2000-06-30 Dispositifs
CA002373980A CA2373980A1 (fr) 1999-07-06 2000-06-30 Dispositifs
JP2001507446A JP2003518009A (ja) 1999-07-06 2000-06-30 シート状部材
BR0012233-5A BR0012233A (pt) 1999-07-06 2000-06-30 Dispositivo semelhante a folha, unilamelar, pre-formado, processo para produzir o mesmo e processo para distribuir pelo menos um agente de beneficiamento cosmético à pele, cabelo ou unhas

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
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DE102004058982A1 (de) * 2004-12-06 2006-08-10 Beiersdorf Ag Wirkstoffkombination
WO2006120973A1 (fr) * 2005-05-11 2006-11-16 Harasawa Pharmaceutical Co., Ltd. Feuille gelifiee destinee a proteger la peau
US7452547B2 (en) 2004-03-31 2008-11-18 Johnson&Johnson Consumer Co., Inc. Product for treating the skin comprising a polyamine microcapsule wall and a skin lightening agent
AU2004220712B2 (en) * 2003-10-16 2009-03-26 Nitto Denko Corporation Antimicrobial adhesive sheet and antimicrobial method using the same
WO2009037947A2 (fr) * 2007-09-20 2009-03-26 Fujifilm Corporation Feuille de gel adhésif pour organismes vivants et cosmétique en forme de feuille la comprenant
US9301988B2 (en) 2007-03-30 2016-04-05 Hi-Tech Pharmacal Co., Inc. Method of treatment using a therapeutic agent for intranasal administration
US9676696B2 (en) 2009-01-29 2017-06-13 The Procter & Gamble Company Regulation of mammalian keratinous tissue using skin and/or hair care actives
US10537498B2 (en) 2015-10-22 2020-01-21 The Procter & Gamble Company Barrier patch of a foamed film and methods of improving skin appearance
US10576023B2 (en) 2015-10-22 2020-03-03 The Procter & Gamble Company Barrier patch of a foamed film and methods of improving skin appearance
US10751266B2 (en) 2018-03-19 2020-08-25 The Procter & Gamble Company Method of making a barrier patch with soluble film
US10751265B2 (en) 2017-01-09 2020-08-25 The Procter & Gamble Barrier patch with soluble film and methods of improving skin appearance
US10799431B2 (en) 2017-01-09 2020-10-13 The Procter & Gamble Company Barrier patch with soluble film and methods of improving skin appearance
US10857076B2 (en) 2017-01-09 2020-12-08 The Procter & Gamble Company Barrier patch with soluble film and methods of improving skin appearance
US10959918B2 (en) 2017-06-22 2021-03-30 The Procter & Gamble Company Films including a water-soluble layer and a vapor-deposited coating

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* Cited by examiner, † Cited by third party
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JP4861677B2 (ja) * 2004-10-26 2012-01-25 三洋化成工業株式会社 創傷被覆材
JP4704764B2 (ja) * 2005-02-03 2011-06-22 日東電工株式会社 爪貼付用粘着組成物および爪用貼付剤
JP2006265105A (ja) * 2005-03-22 2006-10-05 Sanshin Rubber Shokai:Kk 金粉末を含有するシート状美容パック
EP2176067B1 (fr) 2007-08-10 2014-02-19 Little Busy Bodies, LLC Mouchoir salin et procédé pour le fabriquer
JPWO2014003183A1 (ja) * 2012-06-29 2016-06-02 積水化成品工業株式会社 パック基材、パック化粧料ならびにパック化粧料キット
JP7038448B1 (ja) 2021-07-19 2022-03-18 雅行 沼田 抗アレルギー用投与デバイス

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289125A (en) 1976-11-01 1981-09-15 International Paper Company Polymeric sheets
US4291025A (en) 1980-04-11 1981-09-22 Laclede Professional Products, Inc. Agar gel topical dressing
US4318746A (en) 1980-01-08 1982-03-09 Ipco Corporation Highly stable gel, its use and manufacture
EP0161681A2 (fr) 1984-05-17 1985-11-21 Mitsubishi Acetate Co., Ltd. Film à base d'un gel et procédé pour sa préparation
JPS63200760A (ja) 1987-02-17 1988-08-19 日本油脂株式会社 シ−ト状貼着剤の製造方法
WO1990014110A1 (fr) 1989-05-16 1990-11-29 Jean Vilain Ameliorations apportees ou se rapportant a des preparations pharmaceutiques
US5537687A (en) * 1993-10-15 1996-07-23 Garza; Jaime Protective face mask system using varying thicknesses of energy absorption & dissipation material
WO1997006788A1 (fr) * 1995-08-14 1997-02-27 Janssen Pharmaceutica N.V. Administration trans-cutanee de vorozole
WO1997017044A1 (fr) * 1995-11-03 1997-05-15 Biolaminations Pty. Ltd. Membrane pour lesion a nu
WO1997017944A1 (fr) 1995-11-16 1997-05-22 Al.Chi.Mi.A. S.R.L. Formulations cosmetiques contenant des melanges equilibres de polymeres anioniques d'origine naturelle et leur procede d'application locale
WO1998017287A1 (fr) 1996-10-18 1998-04-30 Life Medical Sciences, Inc. Coussin de silicone rempli de gaz ou de gel pour traiter les cheloides et les cicatrices hypertrophiques
FR2776518A1 (fr) * 1998-03-24 1999-10-01 Oreal Patch a matrice adhesive

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289125A (en) 1976-11-01 1981-09-15 International Paper Company Polymeric sheets
US4318746A (en) 1980-01-08 1982-03-09 Ipco Corporation Highly stable gel, its use and manufacture
US4291025A (en) 1980-04-11 1981-09-22 Laclede Professional Products, Inc. Agar gel topical dressing
EP0161681A2 (fr) 1984-05-17 1985-11-21 Mitsubishi Acetate Co., Ltd. Film à base d'un gel et procédé pour sa préparation
JPS63200760A (ja) 1987-02-17 1988-08-19 日本油脂株式会社 シ−ト状貼着剤の製造方法
WO1990014110A1 (fr) 1989-05-16 1990-11-29 Jean Vilain Ameliorations apportees ou se rapportant a des preparations pharmaceutiques
US5537687A (en) * 1993-10-15 1996-07-23 Garza; Jaime Protective face mask system using varying thicknesses of energy absorption & dissipation material
WO1997006788A1 (fr) * 1995-08-14 1997-02-27 Janssen Pharmaceutica N.V. Administration trans-cutanee de vorozole
WO1997017044A1 (fr) * 1995-11-03 1997-05-15 Biolaminations Pty. Ltd. Membrane pour lesion a nu
WO1997017944A1 (fr) 1995-11-16 1997-05-22 Al.Chi.Mi.A. S.R.L. Formulations cosmetiques contenant des melanges equilibres de polymeres anioniques d'origine naturelle et leur procede d'application locale
WO1998017287A1 (fr) 1996-10-18 1998-04-30 Life Medical Sciences, Inc. Coussin de silicone rempli de gaz ou de gel pour traiter les cheloides et les cicatrices hypertrophiques
FR2776518A1 (fr) * 1998-03-24 1999-10-01 Oreal Patch a matrice adhesive

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004220712B2 (en) * 2003-10-16 2009-03-26 Nitto Denko Corporation Antimicrobial adhesive sheet and antimicrobial method using the same
US7452547B2 (en) 2004-03-31 2008-11-18 Johnson&Johnson Consumer Co., Inc. Product for treating the skin comprising a polyamine microcapsule wall and a skin lightening agent
DE102004058982A1 (de) * 2004-12-06 2006-08-10 Beiersdorf Ag Wirkstoffkombination
GB2441252B (en) * 2005-05-11 2010-07-28 Harasawa Pharmaceutical Co Ltd Gel sheet for protecting skin
WO2006120973A1 (fr) * 2005-05-11 2006-11-16 Harasawa Pharmaceutical Co., Ltd. Feuille gelifiee destinee a proteger la peau
GB2441252A (en) * 2005-05-11 2008-02-27 Harasawa Pharmaceutical Co Ltd Gel sheet for protecting skin
US9301988B2 (en) 2007-03-30 2016-04-05 Hi-Tech Pharmacal Co., Inc. Method of treatment using a therapeutic agent for intranasal administration
WO2009037947A3 (fr) * 2007-09-20 2009-07-23 Fujifilm Corp Feuille de gel adhésif pour organismes vivants et cosmétique en forme de feuille la comprenant
WO2009037947A2 (fr) * 2007-09-20 2009-03-26 Fujifilm Corporation Feuille de gel adhésif pour organismes vivants et cosmétique en forme de feuille la comprenant
US9676696B2 (en) 2009-01-29 2017-06-13 The Procter & Gamble Company Regulation of mammalian keratinous tissue using skin and/or hair care actives
US10537498B2 (en) 2015-10-22 2020-01-21 The Procter & Gamble Company Barrier patch of a foamed film and methods of improving skin appearance
US10537499B2 (en) 2015-10-22 2020-01-21 The Procter & Gamble Company Barrier patch of a foamed film and methods of improving skin appearance
US10576023B2 (en) 2015-10-22 2020-03-03 The Procter & Gamble Company Barrier patch of a foamed film and methods of improving skin appearance
US10751265B2 (en) 2017-01-09 2020-08-25 The Procter & Gamble Barrier patch with soluble film and methods of improving skin appearance
US10799431B2 (en) 2017-01-09 2020-10-13 The Procter & Gamble Company Barrier patch with soluble film and methods of improving skin appearance
US10806681B2 (en) 2017-01-09 2020-10-20 The Procter & Gamble Company Barrier patch with soluble film and methods of improving skin appearance
US10857076B2 (en) 2017-01-09 2020-12-08 The Procter & Gamble Company Barrier patch with soluble film and methods of improving skin appearance
US10959918B2 (en) 2017-06-22 2021-03-30 The Procter & Gamble Company Films including a water-soluble layer and a vapor-deposited coating
US10751266B2 (en) 2018-03-19 2020-08-25 The Procter & Gamble Company Method of making a barrier patch with soluble film

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EP1196139A1 (fr) 2002-04-17
AU5782700A (en) 2001-01-22
JP2003518009A (ja) 2003-06-03

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