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WO2000054799A3 - Medicament for treating diabetes - Google Patents

Medicament for treating diabetes Download PDF

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Publication number
WO2000054799A3
WO2000054799A3 PCT/EP2000/002261 EP0002261W WO0054799A3 WO 2000054799 A3 WO2000054799 A3 WO 2000054799A3 EP 0002261 W EP0002261 W EP 0002261W WO 0054799 A3 WO0054799 A3 WO 0054799A3
Authority
WO
WIPO (PCT)
Prior art keywords
enzyme mixtures
pancreatin
digestive enzyme
relates
treating diabetes
Prior art date
Application number
PCT/EP2000/002261
Other languages
German (de)
French (fr)
Other versions
WO2000054799A2 (en
Inventor
Suntje Sander
Claus Steinborn
Martin Rudmann
Dieter Schwanitz
Friederike Henniges
Original Assignee
Solvay Pharm Gmbh
Suntje Sander
Claus Steinborn
Martin Rudmann
Dieter Schwanitz
Friederike Henniges
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK00925114T priority Critical patent/DK1162995T3/en
Priority to CA2367355A priority patent/CA2367355C/en
Priority to AT00925114T priority patent/ATE242003T1/en
Priority to SK1285-2001A priority patent/SK284677B6/en
Priority to JP2000604871A priority patent/JP4938174B2/en
Priority to PL350627A priority patent/PL199180B1/en
Priority to HK02106155.6A priority patent/HK1044477B/en
Priority to BR0009012-3A priority patent/BR0009012A/en
Priority to DE50002450T priority patent/DE50002450D1/en
Priority to AU43950/00A priority patent/AU773930B2/en
Application filed by Solvay Pharm Gmbh, Suntje Sander, Claus Steinborn, Martin Rudmann, Dieter Schwanitz, Friederike Henniges filed Critical Solvay Pharm Gmbh
Priority to NZ514826A priority patent/NZ514826A/en
Priority to EP00925114A priority patent/EP1162995B1/en
Publication of WO2000054799A2 publication Critical patent/WO2000054799A2/en
Publication of WO2000054799A3 publication Critical patent/WO2000054799A3/en
Priority to US09/953,450 priority patent/US7122357B2/en
Priority to NO20014507A priority patent/NO20014507D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The invention relates to the use of physiologically acceptable enzyme mixtures with lipolytic, proteolytic and amylolytic activity, of microbial or animal origin, but especially to the use of digestive enzyme mixtures such as pancreatin or digestive enzyme mixtures containing pancreatin, for treating diabetes. The invention also relates to the production of medicaments suitable for this treatment. One variant of the invention relates to the use of this enzyme mixture with lipolytic, proteolytic and amylolytic activity, especially digestive enzyme mixtures such as pancreatin or digestive enzyme mixtures containing pancreatin, for the adjuvant treatment of Type I and Type II Diabetes mellitus.
PCT/EP2000/002261 1999-03-17 2000-03-15 Medicament for treating diabetes WO2000054799A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE50002450T DE50002450D1 (en) 1999-03-17 2000-03-15 ENZYMES FOR TREATING DIABETES MELLITUS TYPE I
AT00925114T ATE242003T1 (en) 1999-03-17 2000-03-15 ENZYMES FOR TREATING DIABETES MELLITUS TYPE I
SK1285-2001A SK284677B6 (en) 1999-03-17 2000-03-15 Pharmaceutical preparation for the treatment of diabetes and process for its manufacture
JP2000604871A JP4938174B2 (en) 1999-03-17 2000-03-15 Pharmaceuticals for treating diabetes
PL350627A PL199180B1 (en) 1999-03-17 2000-03-15 Medicament for treating diabetes
HK02106155.6A HK1044477B (en) 1999-03-17 2000-03-15 Medicament for treating diabetes
BR0009012-3A BR0009012A (en) 1999-03-17 2000-03-15 Medication for the treatment of diabetes
DK00925114T DK1162995T3 (en) 1999-03-17 2000-03-15 Enzymes for the treatment of type I diabetes mellitus
CA2367355A CA2367355C (en) 1999-03-17 2000-03-15 Medicinal product for the treatment of diabetes
AU43950/00A AU773930B2 (en) 1999-03-17 2000-03-15 Medicament for treating diabetes
NZ514826A NZ514826A (en) 1999-03-17 2000-03-15 Medicinal product for the treatment of diabetes
EP00925114A EP1162995B1 (en) 1999-03-17 2000-03-15 Enzymes for the treatment of diabetes mellitus type i
US09/953,450 US7122357B2 (en) 1999-03-17 2001-09-17 Method for the treatment of diabetes
NO20014507A NO20014507D0 (en) 1999-03-17 2001-09-17 Medication for the treatment of diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19911778 1999-03-17
DE19911778.0 1999-03-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/953,450 Continuation US7122357B2 (en) 1999-03-17 2001-09-17 Method for the treatment of diabetes

Publications (2)

Publication Number Publication Date
WO2000054799A2 WO2000054799A2 (en) 2000-09-21
WO2000054799A3 true WO2000054799A3 (en) 2001-04-26

Family

ID=7901217

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/002261 WO2000054799A2 (en) 1999-03-17 2000-03-15 Medicament for treating diabetes

Country Status (23)

Country Link
US (1) US7122357B2 (en)
EP (1) EP1162995B1 (en)
JP (1) JP4938174B2 (en)
CN (1) CN1221284C (en)
AT (1) ATE242003T1 (en)
AU (1) AU773930B2 (en)
BR (1) BR0009012A (en)
CA (1) CA2367355C (en)
CZ (1) CZ20013345A3 (en)
DE (2) DE50002450D1 (en)
DK (1) DK1162995T3 (en)
ES (1) ES2194720T3 (en)
HK (1) HK1044477B (en)
HU (1) HUP0200556A3 (en)
NO (1) NO20014507D0 (en)
NZ (1) NZ514826A (en)
PL (1) PL199180B1 (en)
PT (1) PT1162995E (en)
RU (1) RU2268065C2 (en)
SK (1) SK284677B6 (en)
TR (1) TR200102784T2 (en)
WO (1) WO2000054799A2 (en)
ZA (1) ZA200107110B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions

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CZ20013345A3 (en) * 1999-03-17 2002-01-16 Solvay Pharmaceuticals Gmbh Medicament for treating diabetes mellitus
US7020384B1 (en) 1999-08-12 2006-03-28 Lg Electronics Inc. Method for creating and recording transport time information for data recorded on a disk
US6632429B1 (en) 1999-12-17 2003-10-14 Joan M. Fallon Methods for treating pervasive development disorders
US20070053895A1 (en) 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US8100844B2 (en) * 2002-04-25 2012-01-24 Ultraflex Systems, Inc. Ambulating ankle and knee joints with bidirectional dampening and assistance using elastomeric restraint
US7519274B2 (en) 2003-12-08 2009-04-14 Divx, Inc. File format for multiple track digital data
PT1729797E (en) 2004-03-22 2008-12-17 Solvay Pharm Gmbh Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants
JP2008500055A (en) * 2004-05-24 2008-01-10 ノボザイムス アクティーゼルスカブ Enzymes for pharmaceutical use
US20060198838A1 (en) * 2004-09-28 2006-09-07 Fallon Joan M Combination enzyme for cystic fibrosis
NZ563777A (en) * 2005-06-24 2010-08-27 Novozymes As Serine protease derived from Bacillus licheniformis optionally in combination with lipases and amylases for pharmaceutical use
CA2612648A1 (en) * 2005-06-24 2006-12-28 Novozymes A/S Lipases for pharmaceutical use
NZ563737A (en) * 2005-06-24 2010-08-27 Novozymes As Amylases derived from Bacillus stearothermophilus optionally in combination with proteases and/or lipases for pharmaceutical use
CA2616943C (en) * 2005-07-29 2016-04-12 Solvay Pharmaceuticals Gmbh Processes for the manufacture of sterilized pancreatin powder
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
PT1931316E (en) 2005-08-15 2010-03-29 Solvay Pharm Gmbh Controlled release pharmaceutical compositions for acid labile drugs
CN101242812B (en) * 2005-08-15 2012-12-26 雅培产品有限公司 Pancreatin micropellets suitable for enteric coating
RU2408364C2 (en) * 2005-08-15 2011-01-10 Зольвай Фармасьютиклз Гмбх Pancreatine micropellet nuclei to be entero-soluble coated
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
US20070116695A1 (en) * 2005-09-21 2007-05-24 Fallon Joan M Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders
WO2007053619A2 (en) * 2005-11-01 2007-05-10 Bio-Cat, Inc. A composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrous as well as people suffering from pancreatic lipase insufficiency
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
CN105112386A (en) 2006-12-21 2015-12-02 诺维信公司 Lipase variants for pharmaceutical use
US20090130063A1 (en) * 2007-11-15 2009-05-21 Solvay Pharmaceuticals Gmbh Process for separating and determining the viral load in a pancreatin sample
MX2010005690A (en) 2007-12-04 2010-06-08 Novozymes As Protease variants for pharmaceutical use.
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
GB2465814B (en) * 2008-06-19 2011-10-26 Tarig Sayed Mustafa Arbab Method,composition and device for the treatment of enzymes and saccharides disorders
US9320780B2 (en) 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
US20090324730A1 (en) * 2008-06-26 2009-12-31 Fallon Joan M Methods and compositions for the treatment of symptoms of complex regional pain syndrome
US11016104B2 (en) 2008-07-01 2021-05-25 Curemark, Llc Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US10776453B2 (en) 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
US20100092447A1 (en) 2008-10-03 2010-04-15 Fallon Joan M Methods and compositions for the treatment of symptoms of prion diseases
ES2727746T3 (en) 2009-01-06 2019-10-18 Galenagen Llc Oral compositions for the treatment or prevention of E. coli infections
ES2578618T3 (en) 2009-01-06 2016-07-28 Curelon Llc Compositions comprising protease, amylase and lipase for use in the treatment of Staphylococcus aureus infections
RU2400245C1 (en) * 2009-04-02 2010-09-27 Открытое Акционерное Общество Завод Экологической Техники И Экопитания "Диод" Preparation for controlling glycemia level and prevention of vascular complications in patients with disorders of carbohydrate metabolism and type 2 diabetes mellitus
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
US9511125B2 (en) 2009-10-21 2016-12-06 Curemark Llc Methods and compositions for the treatment of influenza
WO2011140106A1 (en) * 2010-05-03 2011-11-10 Eurand Pharmaceuticals Limited Micropellet compositions comprising pancreatin containing digestive enzyme mixtures
MX347770B (en) 2011-04-21 2017-05-12 Curemark Llc Compounds for the treatment of neuropsychiatric disorders.
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
US20130273026A1 (en) * 2012-04-12 2013-10-17 Integrative Enzymatics, Inc. Composition and method for modulating inflammatory molecules with amylase
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
AU2018250823A1 (en) 2017-04-10 2019-10-17 Curemark, Llc Compositions for treating addiction
EP3685661A4 (en) * 2017-09-19 2021-05-19 Meiji University ORGAN DEVELOPMENT PROCESS WITHOUT A SPECIFIC FUNCTIONAL CELL
CN109142728A (en) * 2018-09-04 2019-01-04 深圳市鸿美诊断技术有限公司 The kit of pancreatic elastase 1 and its application in a kind of quantitative determination excrement
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses

Citations (1)

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US3803305A (en) * 1962-12-28 1974-04-09 Rolland A Lab Process for obtaining extracts from pancreas

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Non-Patent Citations (5)

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Title
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; SIMEK I ET AL: "[Substitution therapy in insufficient external pancreatic secretion]. Substitucni lecba insuficience zevni sekrece pankreatu.", XP002150548, retrieved from STN Database accession no. 93282167 *
D'COSTA D.F. ET AL: "Diabetic neuropathic cachexia associated with malabsorption.", DIABETIC MEDICINE, (1992) 9/2 (203-205)., XP000946992 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions

Also Published As

Publication number Publication date
CN1221284C (en) 2005-10-05
WO2000054799A2 (en) 2000-09-21
CA2367355A1 (en) 2000-09-21
JP2002539173A (en) 2002-11-19
PT1162995E (en) 2003-08-29
DE50002450D1 (en) 2003-07-10
HUP0200556A2 (en) 2002-06-29
HK1044477A1 (en) 2002-10-25
US20020061302A1 (en) 2002-05-23
HK1044477B (en) 2006-02-03
SK284677B6 (en) 2005-09-08
DK1162995T3 (en) 2003-06-23
NZ514826A (en) 2003-08-29
SK12852001A3 (en) 2002-02-05
AU4395000A (en) 2000-10-04
BR0009012A (en) 2001-12-26
PL350627A1 (en) 2003-01-27
NO20014507L (en) 2001-09-17
ES2194720T3 (en) 2003-12-01
RU2268065C2 (en) 2006-01-20
CA2367355C (en) 2012-06-05
EP1162995B1 (en) 2003-06-04
PL199180B1 (en) 2008-08-29
CZ20013345A3 (en) 2002-01-16
ATE242003T1 (en) 2003-06-15
DE10012095A1 (en) 2000-09-21
HUP0200556A3 (en) 2006-06-28
TR200102784T2 (en) 2002-04-22
NO20014507D0 (en) 2001-09-17
AU773930B2 (en) 2004-06-10
EP1162995A2 (en) 2001-12-19
CN1343126A (en) 2002-04-03
US7122357B2 (en) 2006-10-17
JP4938174B2 (en) 2012-05-23
ZA200107110B (en) 2002-10-30

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