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WO1991010364A1 - Substance a effet anti-mastite destinee aux soins des pis et des trayons - Google Patents

Substance a effet anti-mastite destinee aux soins des pis et des trayons Download PDF

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Publication number
WO1991010364A1
WO1991010364A1 PCT/DK1991/000015 DK9100015W WO9110364A1 WO 1991010364 A1 WO1991010364 A1 WO 1991010364A1 DK 9100015 W DK9100015 W DK 9100015W WO 9110364 A1 WO9110364 A1 WO 9110364A1
Authority
WO
WIPO (PCT)
Prior art keywords
oil
tree
tea
substance
utter
Prior art date
Application number
PCT/DK1991/000015
Other languages
English (en)
Inventor
Niels Erik AAMANN-CHRISTENSEN
Original Assignee
Spindel & Spinnfluegelfab Veb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spindel & Spinnfluegelfab Veb filed Critical Spindel & Spinnfluegelfab Veb
Priority to DE19914190064 priority Critical patent/DE4190064T/de
Priority to DE4190064A priority patent/DE4190064C2/de
Publication of WO1991010364A1 publication Critical patent/WO1991010364A1/fr
Priority to DK092092A priority patent/DK92092A/da
Priority to FI923258A priority patent/FI923258L/fi
Priority to NO19922859A priority patent/NO313171B1/no
Priority to GB9215391A priority patent/GB2257629B/en
Priority to SE9202205A priority patent/SE9202205L/

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/28—Myrtaceae [Myrtle family], e.g. teatree or clove

Definitions

  • the present invention relates to a remedy for fighting the cattle disease summer mastitis and other ⁇ wise for care of teats and utter of milch cows.
  • the invention is based on the observation that a certain substance, which is a purely natural product, exhibits not only a good disinfecting ability, but also a pronounced insect repulsing ability, this being highly important for preventing the diseases such as mastitis which are provoked by insect attacks.
  • the substance in question is a rather expensive one, which was earlier - before the entry of moderen antibiotics - used to a certain extent as a disinfectant in the humane medicine, while due to its high price it would be excluded from use as a daily care substance in herds of cattle.
  • the particular substance is an ethereal oil named tea-tree-oil, which is won from the cultivatedn tea-tree or Melaleucha Alternifolia.
  • This oil is emulsifiable in water, though not particularly easily, and in connection with the invention it has been found that that the emul ⁇ sion has a pronounced insect repulsing effect, which has its maximum for a concentration of only some 2.5%PC%. A noticeable effect is found also at lower concentrations, e.g. down to 0.5%PC%.
  • the substance is effective also in higher concentrations, but for higher concentrations the effect will decrease, and when at the same time the price will increase, then the use of concentrations above 5-6%PC% will not be realistic.
  • the said ethereal oil has a high ability to intrude into the outer skin, from where it will disappear rather slowly, partly by evaporation and partly by admixture into the body liquid.
  • the oil therefore, may remain active during the periods between consecutive milkings, and since it is a completely non-toxic natural product it will show no dangerous side effects whatsoever, neither with respect to assimilation in the body of the animal nor with respect to possible remnants in the teat cups during the next milking; at the highest a certain smell contamination of the milk could be involved, but with the low degree of admixture this contamination will be absolutely imperceptible and totally harmless.
  • the oil is advantageously usable in admixture with pronounced skin friendly oils, e.g. in particular coconut oil, which, as already known, is usable for cleaning the skin and making it supple.
  • the coconut oil does not posses the same ability as the tea-tree-oil of easily intruding into the skin, but it will exhibit another advantageous effect, viz. to be present as a protective layer at the outside of the teat skin, whereby it will cause the evaporation of the tea-tree-oil to be retarded, though without blocking for the degree of evaporation that conditions the insect repulsing effect.
  • the tea-tree-oil is usable in different types of treating agents, viz. either in a viscid teat oinment or in a low viscid liquid adapted for teat dipping or spraying.
  • the preferred basic product is a liquid concen ⁇ trate, which, when diluted with water e.g. in the pro ⁇ portion one part of concentrate to four parts of water, will become a well suited teat dipping or spraying sub ⁇ stance.
  • the concentrate can be a non-aqueous liquid consisting predominantly of coconut oil or, optionally, of another vegetable oil such as sesam or almond oil, in admixture with an emulsifying carrier such as sorbitane-trioleate and the tea-rree-oil as well as a small volume of a preservation agent.
  • Natural coconut oil requires to be heated and violently agitated in order to be emulsified, but if the oil is used in a so-called fractionized state there are no problems in this respect, i.e. the oil should not be heated, neither by the preparation of the concentrate mixture nor by the later dilution with water. This is very important, be ⁇ cause the tea-tree-oil should not be exposed to tempera ⁇ tures above some 40°, as it will otherwise largely loose its special abilities.
  • the said concentrate may be composed as follows
  • sorbitane ester trioleate may be used, but skilled persons will know that also other non-ionic surfactants or emulsifiers may be used for making the substance effective for skin care.
  • the said ingredients can be mixed together in an uncomplicated manner
  • the said ingredients can be mixed together in an uncomplicated manner at ambient tempera ⁇ ture, just as the concentrate may later on be diluted by water in the said proportion by simple stirring, without heating or violent agitation.
  • the substance may of course also be marketed in a diluted state, ready for use.
  • the amount of preservation agent may be kept rela ⁇ tively low, because the tea-tree-oil itself exhibits a preserving effect.
  • the dipping or spraying substance should contain neither more nor less than 1-6%PC% of the tea-tree-oil, preferably 2-3%PC%, as the insect repulsing effect of the substance will other ⁇ wise be noticeably reduced, just as the price of the product will increase quite unnecessarily when a higher admixture percentage of this oil is employed.
  • the diluted liquid can be used in a dipping cup, for dipping of the teats, or in a spray dispenser for being sprayed upon the utter and the teats, whereafter the parts thus treated will be both disinfecting and insect repulsing until the next milk ⁇ ing, with a following, renewed dipping or spraying treatment of the utter or at least the teats and parti ⁇ cularly the lower tip areas thereof, where the insect attacks are normally particularly concentrated.
  • the tea-tree-oil may be mixed into almost any known, suitable ointment sub ⁇ stance, also here with an admixture of only few per- cents; a noticeable insect repulsing effect is achieved with an oil content of only some 0.5%PC%, and the con ⁇ tents of the oil should not exceed 6%PC%. If the oint ⁇ ment is prepared at an increased temperature the tea-tree-oil should not be added until the temperature has fallen to 25-30°, as the oil will not resist tempe ⁇ ratures higher than some 40°. In the ointment may well be used coconut oil which should not necessarily be of the fractionized type.
  • the tea-tree-oil moreover, exhibits both fungicide and bactericidal abilities, which are fully active by the discussed, relatively weak concentrations.
  • the oil holding preparations should contain a preservation agent, e.g. the said methylparaoxy-benzonate.
  • the discussed substance is used preferably for milch cows, as it can be applied centrally in connection with the cows being assembled for milking. It will be relevant to use the substance also on heifers to the extent this is practically possible, that is in the instances the heifers are not entirely freely held.
  • the methodic use of the skin friendly substance has the additional effect that milking can be accomplished with the use of a reduced vacuum on the teat cups compared with normal practice, this adding to the care of the teats.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Afin de prévenir la mastite, on exploite l'effet anti-insecte connu de ce qu'il convient d'appeler l'huile de l'arbre à thé, cette huile étant extraite de l'arbre à thé australien (Melaleucha Alternifolia). On peut utiliser l'huile en concentration relativement faible dans un bain pour trayons (pulvérisateur pour trayons) ou dans une pommade.
PCT/DK1991/000015 1990-01-19 1991-01-21 Substance a effet anti-mastite destinee aux soins des pis et des trayons WO1991010364A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE19914190064 DE4190064T (fr) 1990-01-19 1991-01-21
DE4190064A DE4190064C2 (de) 1990-01-19 1991-01-21 Verwendug einer Salbe oder eines Bad-/Spraymittels zur Euter- und Zitzenpflege
DK092092A DK92092A (da) 1990-01-19 1992-07-15 Yver- eller patteplejemiddel med mastitisforebyggende virkning
FI923258A FI923258L (fi) 1990-01-19 1992-07-16 Aemne avsett foer skoetsel av juver eller spene med mastitis foerhindrande effekt.
NO19922859A NO313171B1 (no) 1990-01-19 1992-07-17 Anvendelse av et preparat for jur- eller spenepleie og forebyggelse av mastitt
GB9215391A GB2257629B (en) 1990-01-19 1992-07-20 Tea-tree oil containing composition for preventing mastitis
SE9202205A SE9202205L (sv) 1990-01-19 1992-07-20 Juver- eller spenvaardsmedel med mastitisfoerebyggande verkan

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK162/90 1990-01-19
DK016290A DK16290D0 (da) 1990-01-19 1990-01-19 Pattebehandlingsmiddel navnlig til bekaempelse af mastitis

Publications (1)

Publication Number Publication Date
WO1991010364A1 true WO1991010364A1 (fr) 1991-07-25

Family

ID=8090462

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1991/000015 WO1991010364A1 (fr) 1990-01-19 1991-01-21 Substance a effet anti-mastite destinee aux soins des pis et des trayons

Country Status (8)

Country Link
AU (1) AU7181591A (fr)
DE (1) DE4190064C2 (fr)
DK (1) DK16290D0 (fr)
FI (1) FI923258L (fr)
GB (1) GB2257629B (fr)
NO (1) NO313171B1 (fr)
SE (1) SE9202205L (fr)
WO (1) WO1991010364A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0734727A2 (fr) * 1995-03-29 1996-10-02 Gerhard Linnhoff Utilisation d'huile de théier pour la préparation de médicaments ou de produits d'hygiène, médicaments ou produits d'hygiène contenant de l'huile de théier
DE19537782A1 (de) * 1995-10-11 1997-04-17 Foerster Karl Heinz Desinfektionsmittel
US5826546A (en) * 1997-04-23 1998-10-27 Miraclecorp Of Australia Method for shampooing a pet using a foam-dispensed pet shampoo composition
WO1999013892A1 (fr) * 1997-09-12 1999-03-25 Laboratorios Pisa, S.A. De C.V. Composition pharmaceutique contre la mammite et procede de preparation
WO1999038521A1 (fr) * 1998-02-02 1999-08-05 Boehringer Ingelheim Vetmedica Gmbh Utilisation en medecine veterinaire, de combinaisons de principes actifs a base de substances a action antimicrobienne et d'extraits de plantes contenant du terpene
DE19729852A1 (de) * 1997-07-11 1999-09-09 Feil Mückenabweisendes hautverträgliches Mittel
WO2000025724A2 (fr) * 1998-11-03 2000-05-11 Safe 'n Sound Solutions, Inc. COMPOSITIONS CONTENANT DE L'OLEUM $i(MELALEUCA ALTERNIFOLIA)
EP1230927A1 (fr) * 2001-02-12 2002-08-14 Allegrini S.p.a. Solution désinfectante phytodérivée pour l'utilisation vétérinaire dans le traitement endomammaire contre la mastite d'animaux laitiers
EP2138171A1 (fr) * 2008-06-18 2009-12-30 Istituto Superiore Di Sanita' Composition vétérinaire contenant du terpinène-4-ol pour le traitement et la prévention de la mastite

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2329583A (en) * 1997-09-25 1999-03-31 Marilyn Rydstrom Use of tea-tree oil for prophylaxis against cystitis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027623A1 (fr) * 1979-10-20 1981-04-29 Henkel Kommanditgesellschaft auf Aktien Composition pour la lutte contre la mastite d'allaitement et contre la mastite des pyogènes chez les bovins
AU559001B2 (en) * 1980-09-05 1987-02-19 Sedgewick, S.E. Skin cream containing tea tree oil
WO1988010122A1 (fr) * 1987-06-22 1988-12-29 The Commonwealth Industrial Gases Limited Traitement de systemes de climatisation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1052697A (fr) * 1974-03-29 1979-04-17 Upjohn Company (The) Compose therapeutique contre la mastite chez les mammiferes
CA1127967A (fr) * 1978-05-19 1982-07-20 John W. Duvall, Jr. Creme a base de plantes medicinales pour le traitement d'affections en application externe
JPH02145502A (ja) * 1988-11-29 1990-06-05 Ube Ind Ltd 農作物の病害防除剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027623A1 (fr) * 1979-10-20 1981-04-29 Henkel Kommanditgesellschaft auf Aktien Composition pour la lutte contre la mastite d'allaitement et contre la mastite des pyogènes chez les bovins
AU559001B2 (en) * 1980-09-05 1987-02-19 Sedgewick, S.E. Skin cream containing tea tree oil
WO1988010122A1 (fr) * 1987-06-22 1988-12-29 The Commonwealth Industrial Gases Limited Traitement de systemes de climatisation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Volume 70, No. 2, 13 January 1969, (Columbus, Ohio, US), LAAKSO P.V.: "Fractionation of Tea-Tree Oil, 'Melaleuca Alternifolia'", see page 629, Abstract 6513m; & SCI. PHARM. PROC., 25th 1965, 1966, 1, 485-492. *
DIALOG INFORMATION SERVICES, File 351, WORLD PATENT INDEX 81-90, Dialog Accession No. 5670859, (UBE INDUSTRIES KK), "Non-Noxious Pesticide - is Applicalbe to Agricultural Crops, is Prepd. from Melaleuca Tea-Tree Oil"; & JP,A,2 145 502, 05-06-1990, 9028, (Basic). *
GOULD'S MEDICAL DICTIONARY, Fifth Revised Edition, 1941, C.V. BROWNLOW et al.: see page 252, "Cajuput Oil". *
ROEMPPS CHEMIE-LEXIKON, Achte, Neubearbeitete und Erweiterte Auflage, Band 3, H-Z, 1983, OTTO-ALBRECHT NEUMUELLER: see page 2003, "Kajeputoel". *
THE MERCK INDEX, Eleventh Edition, 1989, SUSAN BUDAVARI et al.: see page 1072, No. 6700, "Oil of Cajeput". *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19511429A1 (de) * 1995-03-29 1996-10-02 Gerhard Linnhoff Pflegemittel für Haustiere und seine Anwendungen
EP0734727A3 (fr) * 1995-03-29 1998-11-11 Gerhard Linnhoff Utilisation d'huile de théier pour la préparation de médicaments ou de produits d'hygiène, médicaments ou produits d'hygiène contenant de l'huile de théier
EP0734727A2 (fr) * 1995-03-29 1996-10-02 Gerhard Linnhoff Utilisation d'huile de théier pour la préparation de médicaments ou de produits d'hygiène, médicaments ou produits d'hygiène contenant de l'huile de théier
DE19537782A1 (de) * 1995-10-11 1997-04-17 Foerster Karl Heinz Desinfektionsmittel
US5826546A (en) * 1997-04-23 1998-10-27 Miraclecorp Of Australia Method for shampooing a pet using a foam-dispensed pet shampoo composition
DE19729852A1 (de) * 1997-07-11 1999-09-09 Feil Mückenabweisendes hautverträgliches Mittel
WO1999013892A1 (fr) * 1997-09-12 1999-03-25 Laboratorios Pisa, S.A. De C.V. Composition pharmaceutique contre la mammite et procede de preparation
AU749923B2 (en) * 1998-02-02 2002-07-04 Boehringer Ingelheim Vetmedica Gmbh The use of combinations of active agents consisting of antimicrobially active substances and plant extracts containing terpene in veterinary medicine
WO1999038521A1 (fr) * 1998-02-02 1999-08-05 Boehringer Ingelheim Vetmedica Gmbh Utilisation en medecine veterinaire, de combinaisons de principes actifs a base de substances a action antimicrobienne et d'extraits de plantes contenant du terpene
AU749923C (en) * 1998-02-02 2003-01-30 Boehringer Ingelheim Vetmedica Gmbh The use of combinations of active agents consisting of antimicrobially active substances and plant extracts containing terpene in veterinary medicine
WO2000025724A2 (fr) * 1998-11-03 2000-05-11 Safe 'n Sound Solutions, Inc. COMPOSITIONS CONTENANT DE L'OLEUM $i(MELALEUCA ALTERNIFOLIA)
WO2000025724A3 (fr) * 1998-11-03 2000-07-27 Safe N Sound Solutions Inc COMPOSITIONS CONTENANT DE L'OLEUM $i(MELALEUCA ALTERNIFOLIA)
US6168794B1 (en) 1998-11-03 2001-01-02 Safe 'n Sound Solutions, Inc. Compositions comprising oleum Melaleuca
EP1126861A2 (fr) * 1998-11-03 2001-08-29 Safe 'n Sound Solutions, Inc. Compositions contenant de l'oleum melaleuca alternifolia
US6458391B1 (en) 1998-11-03 2002-10-01 Safe ′N Sound Solutions, Inc. Compositions comprising oleum Melaleuca
EP1126861A4 (fr) * 1998-11-03 2003-05-02 Safe N Sound Solutions Inc Compositions contenant de l'oleum melaleuca alternifolia
EP1230927A1 (fr) * 2001-02-12 2002-08-14 Allegrini S.p.a. Solution désinfectante phytodérivée pour l'utilisation vétérinaire dans le traitement endomammaire contre la mastite d'animaux laitiers
EP2138171A1 (fr) * 2008-06-18 2009-12-30 Istituto Superiore Di Sanita' Composition vétérinaire contenant du terpinène-4-ol pour le traitement et la prévention de la mastite

Also Published As

Publication number Publication date
GB2257629A (en) 1993-01-20
DE4190064C2 (de) 2002-10-10
FI923258A0 (fi) 1992-07-16
GB2257629B (en) 1994-08-17
AU7181591A (en) 1991-08-05
NO922859D0 (no) 1992-07-17
DK16290D0 (da) 1990-01-19
SE9202205D0 (sv) 1992-07-20
GB9215391D0 (en) 1992-09-16
NO313171B1 (no) 2002-08-26
FI923258L (fi) 1992-07-16
SE9202205L (sv) 1992-07-20
NO922859L (no) 1992-09-10

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