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WO1988003173A3 - Nouvelles formes du facteur-1 de stimulation de colonies - Google Patents

Nouvelles formes du facteur-1 de stimulation de colonies Download PDF

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Publication number
WO1988003173A3
WO1988003173A3 PCT/US1987/002679 US8702679W WO8803173A3 WO 1988003173 A3 WO1988003173 A3 WO 1988003173A3 US 8702679 W US8702679 W US 8702679W WO 8803173 A3 WO8803173 A3 WO 8803173A3
Authority
WO
WIPO (PCT)
Prior art keywords
stimulating factor
colony stimulating
new forms
csf
protein
Prior art date
Application number
PCT/US1987/002679
Other languages
English (en)
Other versions
WO1988003173A2 (fr
WO1988003173A9 (fr
Inventor
Kirston E Koths
Robert F Halenbeck
Ernest S Kawasaki
Martha B Ladner
Mazie Yee Coyne
Arsdell Janelle N Van
George A Martin
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Priority to HU876048A priority Critical patent/HU215241B/hu
Publication of WO1988003173A2 publication Critical patent/WO1988003173A2/fr
Priority to NO882772A priority patent/NO301775B1/no
Priority to FI883056A priority patent/FI102190B/fi
Priority to DK198803501A priority patent/DK174237B1/da
Publication of WO1988003173A3 publication Critical patent/WO1988003173A3/fr
Publication of WO1988003173A9 publication Critical patent/WO1988003173A9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Liquid Crystal Substances (AREA)
  • Luminescent Compositions (AREA)
  • Pyrane Compounds (AREA)

Abstract

Un facteur de stimulation de colonies, le CSF-1, est un lymphokine utile dans la régulation du système immunitaire. CSF-1 est obtenu en quantités utilisables par des procédés recombinants, y compris le clonage et l'expression de séquences d'ADN humain et murin codant cette protéine. Des formes ''longues'' et ''courtes'' de cette protéine et des mutéines correspondant aux formes codées par ADNc sont décrites.
PCT/US1987/002679 1986-10-24 1987-10-16 Nouvelles formes du facteur-1 de stimulation de colonies WO1988003173A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
HU876048A HU215241B (hu) 1986-10-24 1987-10-16 Eljárás telepstimuláló faktor-1 új formáinak előállítására, valamint az eljárásban alkalmazható expressziós kazetta, vektor és rekombináns gazdasejtek előállítására
NO882772A NO301775B1 (no) 1986-10-24 1988-06-22 DNA-sekvens som koder for nye former av kolonistimulerende faktor-1, vektor, ekspresjonssystem og rekombinant vertscelle
FI883056A FI102190B (fi) 1986-10-24 1988-06-23 Menetelmä pesäkkeitä stimuloivan tekijä-1:n uusien muotojen valmistami seksi ja siinä käytettäviä DNA-sekvenssejä, vektoreita, ilmentämisjärj estelmiä ja rekombinanttisoluja
DK198803501A DK174237B1 (da) 1986-10-24 1988-06-24 DNA-sekvenser, der koder for N2- eller N3-trunkerede former af den lange form og den korte form af CSF-1 og anvendelse heraf i vektorer, ekspressionssystemer, rekombinante værtsceller, samt en fremgangsmåde til fremstilling......

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US92306786A 1986-10-24 1986-10-24
US923,067 1986-10-24
US3965487A 1987-04-16 1987-04-16
US3965787A 1987-04-16 1987-04-16
US039,654 1987-04-16
US039,657 1987-04-16

Publications (3)

Publication Number Publication Date
WO1988003173A2 WO1988003173A2 (fr) 1988-05-05
WO1988003173A3 true WO1988003173A3 (fr) 1988-07-28
WO1988003173A9 WO1988003173A9 (fr) 1998-10-08

Family

ID=27365583

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/002679 WO1988003173A2 (fr) 1986-10-24 1987-10-16 Nouvelles formes du facteur-1 de stimulation de colonies

Country Status (12)

Country Link
EP (1) EP0272779B1 (fr)
JP (1) JP2644794B2 (fr)
AT (1) ATE105869T1 (fr)
AU (2) AU8007087A (fr)
CA (1) CA1339032C (fr)
DE (1) DE3789859T2 (fr)
DK (1) DK174237B1 (fr)
ES (1) ES2052580T3 (fr)
FI (1) FI102190B (fr)
HU (1) HU215241B (fr)
NO (1) NO301775B1 (fr)
WO (1) WO1988003173A2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146851A (en) * 1985-02-05 2000-11-14 Chiron Corporation DNA encoding NV2 (long form) and carboxy truncated fragments thereof
US5837229A (en) * 1985-02-05 1998-11-17 Chiron Corporation Uses of recombinant colony stimulating factor-1
US6156300A (en) * 1985-02-05 2000-12-05 Chiron Corporation Point mutants of N∇2 CSF-1 and carboxy truncated fragments thereof
US5104650A (en) * 1985-02-05 1992-04-14 Cetus Corporation Uses of recombinant colony stimulating factor-1
US5556620A (en) * 1985-02-05 1996-09-17 Cetus Oncology Corporation Use of recombinant colony stimulating factor-1 to enhance wound healing
US5422105A (en) * 1985-02-05 1995-06-06 Cetus Oncology Corporation Use of recombinant colony stimulating factor 1
US5573930A (en) 1985-02-05 1996-11-12 Cetus Oncology Corporation DNA encoding various forms of colony stimulating factor-1
AU595864B2 (en) * 1986-03-14 1990-04-12 Otsuka Pharmaceutical Co., Ltd. Il-1 alpha derivatives and drugs
JP2579981B2 (ja) * 1986-05-06 1997-02-12 ジェネティックス・インスチチュート・インコーポレーテッド Ｍ―ｃｓｆの生産方法
JP2583829B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 ヒトｍ−ｃｓｆ
US5650297A (en) * 1986-09-17 1997-07-22 Otsuka Pharmaceutical Co., Ltd. DNA encoding human colony-stimulating factors
JP2583770B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 遺伝子
DE3777623D1 (de) * 1986-12-07 1992-04-23 Morinaga Milk Industry Co Ltd Kolonie-stimulierender faktor und verfahren zu seiner herstellung.
CA1339757C (fr) 1987-04-16 1998-03-17 Robert F. Halenbeck Methode de production bacteriologique de csf-1 humain recombinant biologiquement actif pur
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
CA1317244C (fr) * 1987-07-24 1993-05-04 Ernest Seigo Kawasaki Production de formes biologiquement actives de csf a l'aide d'un systeme d'expression baculovirus (acnpv) - cellule d'insecte
DK54589A (da) * 1988-02-08 1989-08-09 Otsuka Pharma Co Ltd Humane kolonistmulerende faktorer
JPH0610137B2 (ja) * 1988-02-29 1994-02-09 新技術事業団 ヒト単球−マクロファージコロニー刺激因子を有効成分とする造血器疾患治療剤
US5171675A (en) * 1988-07-28 1992-12-15 Cerretti Douglas P Macrophage colony stimulating factor-γ
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
EP0410751B1 (fr) * 1989-07-27 1996-04-10 Denki Kagaku Kogyo Kabushiki Kaisha Gène codant pour M-CSF et systèmes recombinants pour cela
EP0452505A4 (en) * 1989-11-07 1991-10-30 Otsuka Pharmaceutical Co., Ltd. M-csf derivative, expression vector of said derivative, product of transformation by said vector, and production of them
US5714140A (en) * 1989-12-13 1998-02-03 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting the production of bioactive IL-1 by administering M-CSF
DE4014750A1 (de) * 1990-05-08 1991-11-14 Boehringer Mannheim Gmbh Muteine des granulozyten-stimulierenden faktors (g-csf)
AU639091B2 (en) * 1991-04-24 1993-07-15 Otsuka Pharmaceutical Co., Ltd. M-csf derivatives, expression vectors for said derivatives, transformants carrying said vectors and production of these
EP0955365A3 (fr) 1992-06-09 2000-12-20 Chiron Corporation Cristallisation du M-CSF
JPH08505534A (ja) * 1993-01-13 1996-06-18 森永乳業株式会社 Ｍ−ｃｓｆ２２３の製造方法
GB2355791B (en) 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
KR100371264B1 (ko) * 2000-01-25 2003-02-05 양문식 무라인 그래뉼로사이트-매크로파지 콜로니 자극 인자를포함하는 재조합 벡터와 그것을 발현하는 재조합아스퍼질러스 나이거
PT3056082T (pt) 2009-10-06 2018-12-12 Univ Yale Ratinhos modificados geneticamente e enxerto
MX338971B (es) * 2011-02-15 2016-05-06 Inst Res Biomedicine Irb Ratones de m-csf humanizada.
CN108782459B (zh) 2012-09-07 2021-11-05 再生元制药公司 经遗传修饰的非人动物及其使用方法
ES2884598T3 (es) 2012-11-05 2021-12-10 Regeneron Pharma Animales no humanos modificados genéticamente y métodos de uso de los mismos
JP6672171B2 (ja) 2014-05-19 2020-03-25 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒトｅｐｏを発現する遺伝子改変された非ヒト動物
KR102658190B1 (ko) 2015-04-13 2024-04-17 리제너론 파마슈티칼스 인코포레이티드 인간화된 sirpa-il15 녹인 마우스 및 이의 이용 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986004607A1 (fr) * 1985-02-05 1986-08-14 Cetus Corporation Facteur-1 recombinant stimulant la formation de colonies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2583770B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 遺伝子

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986004607A1 (fr) * 1985-02-05 1986-08-14 Cetus Corporation Facteur-1 recombinant stimulant la formation de colonies

Also Published As

Publication number Publication date
NO882772D0 (no) 1988-06-22
JP2644794B2 (ja) 1997-08-25
FI102190B1 (fi) 1998-10-30
AU8149491A (en) 1991-10-31
FI883056L (fi) 1988-06-23
HUT47635A (en) 1989-03-28
DE3789859T2 (de) 1994-09-15
JPH01501283A (ja) 1989-05-11
NO301775B1 (no) 1997-12-08
DK174237B1 (da) 2002-10-07
DK350188A (da) 1988-08-19
ES2052580T3 (es) 1994-07-16
DK350188D0 (da) 1988-06-24
ATE105869T1 (de) 1994-06-15
EP0272779B1 (fr) 1994-05-18
EP0272779A2 (fr) 1988-06-29
HU215241B (hu) 1998-11-30
AU646277B2 (en) 1994-02-17
NO882772L (no) 1988-08-22
DE3789859D1 (de) 1994-06-23
EP0272779A3 (en) 1988-08-03
FI883056A0 (fi) 1988-06-23
AU8007087A (en) 1988-04-28
CA1339032C (fr) 1997-04-01
FI102190B (fi) 1998-10-30
WO1988003173A2 (fr) 1988-05-05

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