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ES2052580T3 - Nuevas formas de factor-1 estimulante de colonias. - Google Patents

Nuevas formas de factor-1 estimulante de colonias.

Info

Publication number
ES2052580T3
ES2052580T3 ES87309409T ES87309409T ES2052580T3 ES 2052580 T3 ES2052580 T3 ES 2052580T3 ES 87309409 T ES87309409 T ES 87309409T ES 87309409 T ES87309409 T ES 87309409T ES 2052580 T3 ES2052580 T3 ES 2052580T3
Authority
ES
Spain
Prior art keywords
stimulating factor
colony stimulating
new forms
forms
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87309409T
Other languages
English (en)
Inventor
Kirston Edward Koths
Robert Forgan Halenbeck
Ernest Seigo Kawasaki
Martha Ballie Ladner
Mazie Yee Coyne
Arsdell Janelle Nobel Van
George Arthur Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cetus Oncology Corp
Original Assignee
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Oncology Corp filed Critical Cetus Oncology Corp
Application granted granted Critical
Publication of ES2052580T3 publication Critical patent/ES2052580T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Luminescent Compositions (AREA)

Abstract

UN FACTOR ESTIMULANTE DE COLONIAS, CSF-1 SE OBTIENE EN CANTIDADES UTILIZABLES POR METODOS RECOMBINANTES QUE INCLUYEN LA CLONACION Y LA EXPRESION DE LAS SECUENCIAS DE ADN MURINO Y HUMANO QUE CODIFICAN ESTA PROTEINA. SE PRESENTAN LAS FORMAS "LARGA" Y "CORTA" DE ESTA PROTEINA Y MUTEINA QUE CORRESPONDEN A LAS FORMAS CODIFICADAS DEL ADNC.
ES87309409T 1986-10-24 1987-10-23 Nuevas formas de factor-1 estimulante de colonias. Expired - Lifetime ES2052580T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92306786A 1986-10-24 1986-10-24
US3965787A 1987-04-16 1987-04-16
US3965487A 1987-04-16 1987-04-16

Publications (1)

Publication Number Publication Date
ES2052580T3 true ES2052580T3 (es) 1994-07-16

Family

ID=27365583

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87309409T Expired - Lifetime ES2052580T3 (es) 1986-10-24 1987-10-23 Nuevas formas de factor-1 estimulante de colonias.

Country Status (12)

Country Link
EP (1) EP0272779B1 (es)
JP (1) JP2644794B2 (es)
AT (1) ATE105869T1 (es)
AU (2) AU8007087A (es)
CA (1) CA1339032C (es)
DE (1) DE3789859T2 (es)
DK (1) DK174237B1 (es)
ES (1) ES2052580T3 (es)
FI (1) FI102190B1 (es)
HU (1) HU215241B (es)
NO (1) NO301775B1 (es)
WO (1) WO1988003173A2 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156300A (en) * 1985-02-05 2000-12-05 Chiron Corporation Point mutants of N∇2 CSF-1 and carboxy truncated fragments thereof
US5422105A (en) * 1985-02-05 1995-06-06 Cetus Oncology Corporation Use of recombinant colony stimulating factor 1
US5556620A (en) * 1985-02-05 1996-09-17 Cetus Oncology Corporation Use of recombinant colony stimulating factor-1 to enhance wound healing
US5837229A (en) * 1985-02-05 1998-11-17 Chiron Corporation Uses of recombinant colony stimulating factor-1
US5104650A (en) * 1985-02-05 1992-04-14 Cetus Corporation Uses of recombinant colony stimulating factor-1
US5573930A (en) 1985-02-05 1996-11-12 Cetus Oncology Corporation DNA encoding various forms of colony stimulating factor-1
US6103224A (en) * 1985-02-05 2000-08-15 Chiron Corporation N∇2 CSF-1 (short form) and carboxy truncated fragments thereof
AU595864B2 (en) * 1986-03-14 1990-04-12 Otsuka Pharmaceutical Co., Ltd. Il-1 alpha derivatives and drugs
DE3787020T2 (de) * 1986-05-06 1993-12-16 Genetics Inst Herstellung von m-csf.
JP2583829B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 ヒトｍ−ｃｓｆ
US5650297A (en) * 1986-09-17 1997-07-22 Otsuka Pharmaceutical Co., Ltd. DNA encoding human colony-stimulating factors
JP2583770B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 遺伝子
DE3777623D1 (de) * 1986-12-07 1992-04-23 Morinaga Milk Industry Co Ltd Kolonie-stimulierender faktor und verfahren zu seiner herstellung.
CA1339757C (en) * 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
AU2251488A (en) * 1987-07-24 1989-03-01 Cetus Corporation Production of biologically active forms of csf using a baculovirus (acnpv)-insect cell expression system
DK54589A (da) * 1988-02-08 1989-08-09 Otsuka Pharma Co Ltd Humane kolonistmulerende faktorer
JPH0610137B2 (ja) * 1988-02-29 1994-02-09 新技術事業団 ヒト単球−マクロファージコロニー刺激因子を有効成分とする造血器疾患治療剤
US5171675A (en) * 1988-07-28 1992-12-15 Cerretti Douglas P Macrophage colony stimulating factor-γ
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
DE69026440T2 (de) * 1989-07-27 1996-10-17 Denki Kagaku Kogyo Kk Für M-CSF kodierendes Gen und dazu gehörende rekombinante Systeme
KR920701253A (ko) * 1989-11-07 1992-08-11 오오쓰까 아끼히꼬 M-csf 유도체, 그 유도체의 발현 벡터, 그 벡터를 갖는 형질 전환체 및 이들의 제조방법
US5714140A (en) * 1989-12-13 1998-02-03 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting the production of bioactive IL-1 by administering M-CSF
DE4014750A1 (de) * 1990-05-08 1991-11-14 Boehringer Mannheim Gmbh Muteine des granulozyten-stimulierenden faktors (g-csf)
AU639091B2 (en) * 1991-04-24 1993-07-15 Otsuka Pharmaceutical Co., Ltd. M-csf derivatives, expression vectors for said derivatives, transformants carrying said vectors and production of these
ATE195553T1 (de) 1992-06-09 2000-09-15 Chiron Corp Kristallisierung von m-csf
AU6125294A (en) * 1993-01-13 1994-08-15 Genetics Institute Inc. Process for producing m-csf 223
GB2355791B (en) 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
KR100371264B1 (ko) * 2000-01-25 2003-02-05 양문식 무라인 그래뉼로사이트-매크로파지 콜로니 자극 인자를포함하는 재조합 벡터와 그것을 발현하는 재조합아스퍼질러스 나이거
EP3417701B1 (en) 2009-10-06 2021-12-15 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
EP3375284B1 (en) 2011-02-15 2023-03-29 Regeneron Pharmaceuticals, Inc. Humanized m-csf mice and uses thereof
RU2642319C2 (ru) 2012-09-07 2018-01-24 Йель Юниверсити Генетически модифицированные, не принадлежащие к человеческому роду животные и способ их использования
EP3556206B1 (en) 2012-11-05 2021-06-02 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals and methods of use thereof
KR102446689B1 (ko) 2014-05-19 2022-09-23 리제너론 파마슈티칼스 인코포레이티드 인간 epo를 발현하는 유전자 변형된 비-인간 동물
SG11201708380WA (en) 2015-04-13 2017-11-29 Regeneron Pharma Humanized sirpa-il15 knockin mice and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986004607A1 (en) * 1985-02-05 1986-08-14 Cetus Corporation Recombinant colony stimulating factor-1
JP2583770B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 遺伝子

Also Published As

Publication number Publication date
EP0272779A2 (en) 1988-06-29
HUT47635A (en) 1989-03-28
WO1988003173A2 (en) 1988-05-05
NO301775B1 (no) 1997-12-08
HU215241B (hu) 1998-11-30
DE3789859D1 (de) 1994-06-23
ATE105869T1 (de) 1994-06-15
DE3789859T2 (de) 1994-09-15
AU8149491A (en) 1991-10-31
CA1339032C (en) 1997-04-01
JPH01501283A (ja) 1989-05-11
FI102190B (fi) 1998-10-30
EP0272779B1 (en) 1994-05-18
NO882772L (no) 1988-08-22
NO882772D0 (no) 1988-06-22
WO1988003173A3 (en) 1988-07-28
FI883056L (fi) 1988-06-23
AU8007087A (en) 1988-04-28
FI883056A0 (fi) 1988-06-23
EP0272779A3 (en) 1988-08-03
JP2644794B2 (ja) 1997-08-25
DK350188D0 (da) 1988-06-24
FI102190B1 (fi) 1998-10-30
DK174237B1 (da) 2002-10-07
DK350188A (da) 1988-08-19
AU646277B2 (en) 1994-02-17

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