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UY37758A - Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos - Google Patents

Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos

Info

Publication number
UY37758A
UY37758A UY0001037758A UY37758A UY37758A UY 37758 A UY37758 A UY 37758A UY 0001037758 A UY0001037758 A UY 0001037758A UY 37758 A UY37758 A UY 37758A UY 37758 A UY37758 A UY 37758A
Authority
UY
Uruguay
Prior art keywords
antibodies
manufacturing
bispectific
biespectific
therapeutic use
Prior art date
Application number
UY0001037758A
Other languages
English (en)
Inventor
Knopf Hans-Peter
Tina Buch
Christian Graf
Daniel Heitmann
Thomas Jostock
Rolf Koehler
Jiri Kovarik
John Oliver Stephen
Dhavalkumar Patel
Maximilian Woisetschlaeger
Otto Bardroff Michael
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of UY37758A publication Critical patent/UY37758A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La invención se refiere a anticuerpos monoclonales biespecíficos bivalentes (bbmAb) o variantes de los mismos, y a métodos para fabricar dichos anticuerpos mediante la coexpresión de derivados modificados mutados con Fc de dos anticuerpos monoclonales diferentes en líneas celulares de mamíferos.
UY0001037758A 2017-06-12 2018-06-05 Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos UY37758A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762518090P 2017-06-12 2017-06-12

Publications (1)

Publication Number Publication Date
UY37758A true UY37758A (es) 2019-01-31

Family

ID=62948274

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037758A UY37758A (es) 2017-06-12 2018-06-05 Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos

Country Status (26)

Country Link
US (3) US20190002589A1 (es)
EP (1) EP3638692A1 (es)
JP (2) JP7106234B2 (es)
KR (2) KR20200005746A (es)
CN (1) CN110730788A (es)
AR (1) AR112419A1 (es)
AU (2) AU2018284303B2 (es)
BR (1) BR112019025904A2 (es)
CA (1) CA3061097A1 (es)
CL (1) CL2019003613A1 (es)
CO (1) CO2019013838A2 (es)
CR (1) CR20190558A (es)
CU (1) CU20190100A7 (es)
EA (1) EA201992670A1 (es)
EC (1) ECSP19087580A (es)
IL (1) IL271179B2 (es)
JO (1) JOP20190283B1 (es)
MA (1) MA49394A (es)
MX (1) MX2019015021A (es)
PE (1) PE20200384A1 (es)
PH (1) PH12019502730A1 (es)
SG (1) SG10201913536TA (es)
TW (1) TWI826377B (es)
UY (1) UY37758A (es)
WO (1) WO2018229612A1 (es)
ZA (1) ZA201906757B (es)

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WO2021170060A1 (en) * 2020-02-28 2021-09-02 Wuxi Biologics (Shanghai) Co., Ltd. Purification of bispeciifc antibodies
KR20230100732A (ko) * 2020-11-04 2023-07-05 제넨테크, 인크. 항-cd20/항-cd3 이중특이성 항체의 피하 투여
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CN113980135B (zh) * 2021-12-27 2022-04-19 三优生物医药(上海)有限公司 一种结合冠状病毒双特异性抗体的抗药抗体及其制备方法和应用
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WO2024261703A1 (en) * 2023-06-23 2024-12-26 Novartis Ag Bispecific antibodies for use in treatment of patients with xiap deficiency or cdc42 mutations

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Also Published As

Publication number Publication date
EA201992670A1 (ru) 2020-07-08
CR20190558A (es) 2020-01-28
JP7106234B2 (ja) 2022-07-26
TW201906864A (zh) 2019-02-16
TWI826377B (zh) 2023-12-21
US11987644B2 (en) 2024-05-21
RU2019140335A (ru) 2021-07-13
RU2019140335A3 (es) 2021-10-04
AU2018284303A1 (en) 2019-11-07
KR102633368B1 (ko) 2024-02-06
CN110730788A (zh) 2020-01-24
US20200308309A1 (en) 2020-10-01
PE20200384A1 (es) 2020-02-24
JP2020524991A (ja) 2020-08-27
PH12019502730A1 (en) 2020-10-26
SG10201913536TA (en) 2020-02-27
IL271179B2 (en) 2024-12-01
AR112419A1 (es) 2019-10-30
JOP20190283A1 (ar) 2019-12-05
IL271179A (en) 2020-01-30
KR20220167340A (ko) 2022-12-20
JOP20190283B1 (ar) 2023-09-17
ECSP19087580A (es) 2019-12-27
CA3061097A1 (en) 2018-12-20
EP3638692A1 (en) 2020-04-22
CL2019003613A1 (es) 2020-07-03
ZA201906757B (en) 2023-03-29
AU2021206810A1 (en) 2021-08-12
MA49394A (fr) 2020-04-22
CU20190100A7 (es) 2020-11-30
US20240425617A1 (en) 2024-12-26
AU2018284303B2 (en) 2021-04-22
WO2018229612A1 (en) 2018-12-20
CO2019013838A2 (es) 2020-05-29
US20190002589A1 (en) 2019-01-03
BR112019025904A2 (pt) 2020-06-30
IL271179B1 (en) 2024-08-01
KR20200005746A (ko) 2020-01-16
JP2022116038A (ja) 2022-08-09
MX2019015021A (es) 2020-02-24

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